Zbtb16 (zinc finger and BTB domain containing 16) - Rat Genome Database

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Gene: Zbtb16 (zinc finger and BTB domain containing 16) Rattus norvegicus
Analyze
Symbol: Zbtb16
Name: zinc finger and BTB domain containing 16
RGD ID: 727921
Description: Enables several functions, including DNA-binding transcription factor activity; double-stranded DNA binding activity; and type 2 angiotensin receptor binding activity. Involved in embryonic limb morphogenesis; ossification involved in bone maturation; and protein localization to nucleus. Predicted to be located in PML body; male germ cell nucleus; and nuclear speck. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Used to study caudal regression syndrome and polydactyly. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; acute myeloid leukemia pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Lx; Plzf; Polydactyly-luxate syndrome; Promyelocytic leukemia zinc finger; Zfp145; zinc finger and BTB domain containing 16 protein; zinc finger and BTB domain-containing protein 16; zinc finger protein 145; Znf145
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Zbtb16Lx   Zbtb16em1Ipcv  
Genetic Models: SHR-Zbtb16em1Ipcv+/-
Is Marker For: Strains:   SHR.PD-(D8Rat42-D8Arb23)/Cub   SHR.PD-(D8Mgh9-D8Rat149)/Cub  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2848,989,376 - 49,177,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx854,500,313 - 54,682,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,779,162 - 52,961,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,643,426 - 50,825,960 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,980,226 - 53,146,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,573,252 - 51,740,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4851,931,530 - 52,094,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,110,091 - 52,110,396 (-)NCBI
Celera848,553,034 - 48,734,595 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glycidol  (EXP)
GW 4064  (ISO)
hexaconazole  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
purine-6-thiol  (EXP)
resmethrin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
stigmasterol  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenylstannane  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. Chen SJ, etal., J Clin Invest. 1993 May;91(5):2260-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). Hyman J, etal., J Cell Biol. 2000 May 1;149(3):537-46.
5. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Liska F, etal., Dev Dyn. 2009 Mar;238(3):673-84.
6. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Liška F, etal., Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.
7. Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats. Liška F, etal., PLoS One. 2016 Oct 11;11(10):e0164206. doi: 10.1371/journal.pone.0164206. eCollection 2016.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein. Nagy I, etal., Hear Res. 2005 Jun;204(1-2):216-22.
10. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
17. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. Senbonmatsu T, etal., EMBO J. 2003 Dec 15;22(24):6471-82.
18. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Yada Y, etal., Int J Dev Biol 2002;46(7):975-82.
Additional References at PubMed
PMID:6068186   PMID:8541544   PMID:8622986   PMID:9294197   PMID:10835630   PMID:10980608   PMID:11929873   PMID:12802276   PMID:15156142   PMID:15156143   PMID:16564520   PMID:18262754  
PMID:18660811   PMID:19648967   PMID:20731660   PMID:21501682   PMID:21547890   PMID:23975223   PMID:24359566   PMID:25416956   PMID:26306672   PMID:27107012   PMID:36786377  


Genomics

Comparative Map Data
Zbtb16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2848,989,376 - 49,177,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx854,500,313 - 54,682,843 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,779,162 - 52,961,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,643,426 - 50,825,960 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,980,226 - 53,146,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,573,252 - 51,740,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4851,931,530 - 52,094,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,110,091 - 52,110,396 (-)NCBI
Celera848,553,034 - 48,734,595 (-)NCBICelera
Cytogenetic Map8q23NCBI
ZBTB16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811114,059,711 - 114,256,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11114,059,041 - 114,256,765 (+)EnsemblGRCh38hg38GRCh38
GRCh3711113,930,433 - 114,127,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,435,641 - 113,626,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411113,435,658 - 113,626,568NCBI
Celera11111,083,317 - 111,274,300 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,859,046 - 110,049,950 (+)NCBIHuRef
CHM1_111113,814,520 - 114,005,500 (+)NCBICHM1_1
T2T-CHM13v2.011114,070,066 - 114,267,135 (+)NCBIT2T-CHM13v2.0
Zbtb16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,563,097 - 48,747,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl948,565,597 - 48,747,522 (-)EnsemblGRCm39 Ensembl
GRCm38948,651,797 - 48,836,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,654,297 - 48,836,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37948,462,402 - 48,644,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36948,406,264 - 48,587,864 (-)NCBIMGSCv36mm8
Celera945,948,793 - 46,132,024 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.47NCBI
Zbtb16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,668,332 - 15,845,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,668,332 - 15,845,384 (+)NCBIChiLan1.0ChiLan1.0
ZBTB16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111115,897,024 - 116,092,398 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,938,414 - 109,133,819 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,780,446 - 112,977,164 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,780,380 - 112,977,164 (+)Ensemblpanpan1.1panPan2
ZBTB16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,082,594 - 19,284,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,087,154 - 19,267,628 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,007,960 - 19,195,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,104,312 - 19,292,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,106,853 - 19,291,539 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,168,970 - 19,356,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,070,647 - 19,258,747 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,117,162 - 19,305,163 (-)NCBIUU_Cfam_GSD_1.0
Zbtb16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494796,135,014 - 96,315,732 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936612395,177 - 570,595 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936612389,877 - 570,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,639,701 - 41,836,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,639,536 - 41,839,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,454,490 - 46,459,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,446,067 - 105,648,771 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,449,994 - 105,643,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604320,384,628 - 20,582,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,546,509 - 9,726,960 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247849,545,529 - 9,726,960 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zbtb16
860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:30
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000045356
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1582229Stl20Serum triglyceride level QTL 203.20.0033blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84863013149147989Rat

Markers in Region
D1Rat405  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,030,069 - 49,030,308 (+)MAPPERmRatBN7.2
Rnor_6.0853,020,897 - 53,021,133NCBIRnor6.0
Rnor_5.0851,613,918 - 51,614,154UniSTSRnor5.0
RGSC_v3.4851,967,007 - 51,967,244RGDRGSC3.4
RGSC_v3.4851,967,008 - 51,967,244UniSTSRGSC3.4
RGSC_v3.1851,986,061 - 51,986,298RGD
Celera848,588,505 - 48,588,741UniSTS
SHRSP x BN Map140.11RGD
SHRSP x BN Map140.11UniSTS
Cytogenetic Map8q23UniSTS
D8Got72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,147,812 - 49,147,989 (+)MAPPERmRatBN7.2
Rnor_6.0853,117,444 - 53,117,620NCBIRnor6.0
Rnor_5.0851,710,465 - 51,710,641UniSTSRnor5.0
RGSC_v3.4852,065,613 - 52,065,790RGDRGSC3.4
RGSC_v3.4852,065,614 - 52,065,790UniSTSRGSC3.4
RGSC_v3.1852,084,668 - 52,084,844RGD
Celera848,704,993 - 48,705,171UniSTS
RH 3.4 Map8535.2UniSTS
RH 3.4 Map8535.2RGD
RH 2.0 Map8394.8RGD
Cytogenetic Map8q23UniSTS
D8Got333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,166,364 - 49,166,511 (+)MAPPERmRatBN7.2
Rnor_6.0853,136,117 - 53,136,263NCBIRnor6.0
Rnor_5.0851,729,138 - 51,729,284UniSTSRnor5.0
RGSC_v3.4852,084,165 - 52,084,311UniSTSRGSC3.4
Celera848,723,464 - 48,723,610UniSTS
Cytogenetic Map8q23UniSTS
BE106999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,101,920 - 49,102,105 (+)MAPPERmRatBN7.2
Rnor_6.0853,093,236 - 53,093,420NCBIRnor6.0
Rnor_5.0851,686,257 - 51,686,441UniSTSRnor5.0
RGSC_v3.4852,040,589 - 52,040,773UniSTSRGSC3.4
Celera848,660,504 - 48,660,688UniSTS
RH 3.4 Map8537.5UniSTS
Cytogenetic Map8q23UniSTS
mMaCIR130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,088,967 - 49,090,544 (+)MAPPERmRatBN7.2
Rnor_6.0853,080,031 - 53,081,607NCBIRnor6.0
Rnor_5.0851,673,052 - 51,674,628UniSTSRnor5.0
Celera848,647,488 - 48,649,064UniSTS
Cytogenetic Map8q23UniSTS


Related Rat Strains
The following Strains have been annotated to Zbtb16


Genetic Models
This gene Zbtb16 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 7 5 7 15 8 9 5
Low 3 27 47 39 18 39 3 4 59 33 33 2 3
Below cutoff 12 3 2 1 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB568265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB568266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY286410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY781102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY781103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY781104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY879593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY879594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY879595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY879596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000045356   ⟹   ENSRNOP00000043640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)Ensembl
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)Ensembl
RefSeq Acc Id: NM_001013181   ⟹   NP_001013199
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2848,994,591 - 49,177,011 (-)NCBI
Rnor_6.0852,985,444 - 53,146,765 (-)NCBI
Rnor_5.0851,573,252 - 51,740,759 (-)NCBI
RGSC_v3.4851,931,530 - 52,094,813 (-)RGD
Celera848,553,034 - 48,734,595 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595705   ⟹   XP_017451194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2848,989,376 - 49,176,918 (-)NCBI
Rnor_6.0852,980,226 - 53,146,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595706   ⟹   XP_017451195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2848,989,376 - 49,176,918 (-)NCBI
Rnor_6.0852,980,226 - 53,146,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595707   ⟹   XP_017451196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2848,992,264 - 49,176,366 (-)NCBI
Rnor_6.0852,980,226 - 53,146,138 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001013199   ⟸   NM_001013181
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451195   ⟸   XM_017595706
- Peptide Label: isoform X1
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451194   ⟸   XM_017595705
- Peptide Label: isoform X1
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451196   ⟸   XM_017595707
- Peptide Label: isoform X1
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043640   ⟸   ENSRNOT00000045356
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5S3S9-F1-model_v2 AlphaFold Q5S3S9 1-673 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727921 AgrOrtholog
BioCyc Gene G2FUF-30597 BioCyc
Ensembl Genes ENSRNOG00000029980 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043640 ENTREZGENE
  ENSRNOP00000043640.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045356 ENTREZGENE
  ENSRNOT00000045356.4 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:353227 UniProtKB/TrEMBL
NCBI Gene 353227 ENTREZGENE
PANTHER AGAP004733-PA UniProtKB/TrEMBL
  AGAP004733-PA UniProtKB/TrEMBL
  IP01015P-RELATED UniProtKB/TrEMBL
  LD05664P UniProtKB/TrEMBL
  PLZFA UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PharmGKB ZBTB16 RGD
PhenoGen Zbtb16 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F7EQW2 ENTREZGENE, UniProtKB/TrEMBL
  F7IXA3_RAT UniProtKB/TrEMBL
  M5AK03_RAT UniProtKB/TrEMBL
  Q5S3S9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-28 Zbtb16  zinc finger and BTB domain containing 16  Zfp145  zinc finger protein 145  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-02-28 Zfp145  zinc finger protein 145  Lx  Polydactyly-luxate syndrome  Data Merged 737654 APPROVED
2002-06-10 Lx  Polydactyly-luxate syndrome      Symbol and Name status set to approved 70586 APPROVED