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Gene: Zbtb16 (zinc finger and BTB domain containing 16) Rattus norvegicus
Symbol: Zbtb16
Name: zinc finger and BTB domain containing 16
Description: Exhibits several functions, including DNA-binding transcription factor activity; double-stranded DNA binding activity; and protein C-terminus binding activity. Involved in embryonic digit morphogenesis; embryonic hindlimb morphogenesis; and protein localization to nucleus. Localizes to the cytosol; nucleus; and plasma membrane. Predicted to colocalize with the nucleoplasm. Used to study polydactyly. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; acute myeloid leukemia pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
Also known as: Lx; Plzf; Polydactyly-luxate syndrome; Promyelocytic leukemia zinc finger; Zfp145; zinc finger and BTB domain containing 16 protein; zinc finger and BTB domain-containing protein 16; zinc finger protein 145; Znf145
Homo sapiens (human) : ZBTB16 (zinc finger and BTB domain containing 16)  HGNC  Alliance
Mus musculus (house mouse) : Zbtb16 (zinc finger and BTB domain containing 16)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zbtb16 (zinc finger and BTB domain containing 16)
Pan paniscus (bonobo/pygmy chimpanzee) : ZBTB16 (zinc finger and BTB domain containing 16)
Canis lupus familiaris (dog) : ZBTB16 (zinc finger and BTB domain containing 16)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zbtb16 (zinc finger and BTB domain containing 16)
Sus scrofa (pig) : ZBTB16 (zinc finger and BTB domain containing 16)
more info ...
Allele / Splice: Zbtb16Lx  
Is Marker For: Strains:   SHR.PD-(D8Rat42-D8Arb23)/Cub   SHR.PD-(D8Mgh9-D8Rat149)/Cub  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0852,980,226 - 53,146,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0851,573,252 - 51,740,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4851,931,530 - 52,094,813 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,110,091 - 52,110,396 (-)NCBI
Celera848,553,034 - 48,734,595 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Zbtb16
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727921
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.