Zbtb16 (zinc finger and BTB domain containing 16) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Zbtb16 (zinc finger and BTB domain containing 16) Rattus norvegicus
Analyze
Symbol: Zbtb16
Name: zinc finger and BTB domain containing 16
RGD ID: 727921
Description: Enables several functions, including DNA-binding transcription factor activity; double-stranded DNA binding activity; and type 2 angiotensin receptor binding activity. Involved in embryonic limb morphogenesis; ossification involved in bone maturation; and protein localization to nucleus. Predicted to be located in PML body; male germ cell nucleus; and nuclear speck. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Used to study caudal regression syndrome and polydactyly. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; acute myeloid leukemia pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Lx; Plzf; Polydactyly-luxate syndrome; Promyelocytic leukemia zinc finger; Zfp145; zinc finger and BTB domain containing 16 protein; zinc finger and BTB domain-containing protein 16; zinc finger protein 145; Znf145
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Zbtb16Lx ; Zbtb16em1Ipcv
Genetic Models: SHR-Zbtb16em1Ipcv+/-
Is Marker For: Strains:   SHR.PD-(D8Rat42-D8Arb23)/Cub   SHR.PD-(D8Mgh9-D8Rat149)/Cub  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8857,885,886 - 58,073,507 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl857,891,081 - 58,073,507 (-)EnsemblGRCr8
mRatBN7.2848,989,376 - 49,177,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx854,500,313 - 54,682,843 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,779,162 - 52,961,700 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,643,426 - 50,825,960 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,980,226 - 53,146,765 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)Ensemblrn6Rnor6.0
Rnor_5.0851,573,252 - 51,740,759 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4851,931,530 - 52,094,813 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera848,553,034 - 48,734,595 (-)NCBICelera
RGSC_v3.1852,110,091 - 52,110,396 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amoxicillin  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bromobenzene  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
glycidol  (EXP)
GSK-J4  (ISO)
GW 4064  (ISO)
hexaconazole  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
purine-6-thiol  (EXP)
resmethrin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
stigmasterol  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
cartilage development  (IEA,ISO,ISS)
cell population proliferation  (IEA)
central nervous system development  (IEA,ISO,ISS)
embryonic digit morphogenesis  (IMP)
embryonic hindlimb morphogenesis  (IEA,IMP,ISO)
embryonic pattern specification  (IEA,ISO)
forelimb morphogenesis  (IEA,ISO)
hemopoiesis  (IEA,ISO,ISS)
hindlimb morphogenesis  (IEA,ISO)
male germ-line stem cell asymmetric division  (IEA,ISO)
mesonephros development  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of myeloid cell differentiation  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
ossification involved in bone maturation  (IMP)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cartilage development  (IEA,ISO,ISS)
positive regulation of chondrocyte differentiation  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of fat cell differentiation  (IEA,ISO,ISS)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of multicellular organismal process  (IEA)
positive regulation of NK T cell differentiation  (IEA,ISO)
positive regulation of ossification  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA)
protein localization to nucleus  (IDA)
regulation of cell differentiation  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of multicellular organismal development  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
skeletal system development  (IEA,ISO)

Cellular Component
male germ cell nucleus  (IEA)
nuclear body  (IEA,ISO,ISS)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)
PML body  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
transcription repressor complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. Chen SJ, etal., J Clin Invest. 1993 May;91(5):2260-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). Hyman J, etal., J Cell Biol. 2000 May 1;149(3):537-46.
5. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Liska F, etal., Dev Dyn. 2009 Mar;238(3):673-84.
6. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Liška F, etal., Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.
7. Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats. Liška F, etal., PLoS One. 2016 Oct 11;11(10):e0164206. doi: 10.1371/journal.pone.0164206. eCollection 2016.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein. Nagy I, etal., Hear Res. 2005 Jun;204(1-2):216-22.
10. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
17. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. Senbonmatsu T, etal., EMBO J. 2003 Dec 15;22(24):6471-82.
18. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Yada Y, etal., Int J Dev Biol 2002;46(7):975-82.
Additional References at PubMed
PMID:6068186   PMID:8541544   PMID:8622986   PMID:9294197   PMID:10835630   PMID:10980608   PMID:11929873   PMID:12802276   PMID:15156142   PMID:15156143   PMID:16564520   PMID:18262754  
PMID:18660811   PMID:19648967   PMID:20731660   PMID:21501682   PMID:21547890   PMID:23975223   PMID:24359566   PMID:25416956   PMID:26306672   PMID:27107012   PMID:36786377  


Genomics

Comparative Map Data
Zbtb16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8857,885,886 - 58,073,507 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl857,891,081 - 58,073,507 (-)EnsemblGRCr8
mRatBN7.2848,989,376 - 49,177,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx854,500,313 - 54,682,843 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,779,162 - 52,961,700 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,643,426 - 50,825,960 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,980,226 - 53,146,765 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)Ensemblrn6Rnor6.0
Rnor_5.0851,573,252 - 51,740,759 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4851,931,530 - 52,094,813 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera848,553,034 - 48,734,595 (-)NCBICelera
RGSC_v3.1852,110,091 - 52,110,396 (-)NCBI
Cytogenetic Map8q23NCBI
ZBTB16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811114,059,711 - 114,256,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11114,058,335 - 114,256,765 (+)Ensemblhg38GRCh38
GRCh3711113,930,433 - 114,127,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,435,641 - 113,626,608 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411113,435,658 - 113,626,568NCBI
Celera11111,083,317 - 111,274,300 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,859,046 - 110,049,950 (+)NCBIHuRef
CHM1_111113,814,520 - 114,005,500 (+)NCBICHM1_1
T2T-CHM13v2.011114,070,066 - 114,267,135 (+)NCBIT2T-CHM13v2.0
Zbtb16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,563,097 - 48,747,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl948,565,597 - 48,747,522 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38948,651,797 - 48,836,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,654,297 - 48,836,222 (-)Ensemblmm10GRCm38
MGSCv37948,462,402 - 48,644,050 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36948,406,264 - 48,587,864 (-)NCBIMGSCv36mm8
Celera945,948,793 - 46,132,024 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.47NCBI
Zbtb16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,668,332 - 15,845,372 (+)Ensembl
ChiLan1.0NW_00495541215,668,332 - 15,845,384 (+)NCBIChiLan1.0ChiLan1.0
ZBTB16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,803,098 - 114,998,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,897,024 - 116,092,398 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,938,414 - 109,133,819 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,780,446 - 112,977,164 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,780,380 - 112,977,164 (+)EnsemblpanPan2panpan1.1
ZBTB16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,082,594 - 19,284,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,087,154 - 19,267,628 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha519,007,960 - 19,195,854 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0519,104,312 - 19,292,747 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,106,853 - 19,291,539 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,168,970 - 19,356,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,070,647 - 19,258,747 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,117,162 - 19,305,163 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zbtb16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494796,135,014 - 96,315,732 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936612395,177 - 570,595 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936612389,877 - 570,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,639,701 - 41,836,742 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1941,639,536 - 41,839,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,454,490 - 46,459,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,446,067 - 105,648,771 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,449,994 - 105,643,344 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604320,384,628 - 20,582,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,546,509 - 9,726,960 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247849,545,529 - 9,726,960 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zbtb16
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1843,145,301 - 43,324,830 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zbtb16
988 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:30
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000045356
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
D1Rat405  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8857,926,583 - 57,926,820 (+)Marker Load Pipeline
mRatBN7.2849,030,069 - 49,030,308 (+)MAPPERmRatBN7.2
Rnor_6.0853,020,897 - 53,021,133NCBIRnor6.0
Rnor_5.0851,613,918 - 51,614,154UniSTSRnor5.0
RGSC_v3.4851,967,008 - 51,967,244UniSTSRGSC3.4
RGSC_v3.4851,967,007 - 51,967,244RGDRGSC3.4
Celera848,588,505 - 48,588,741UniSTS
RGSC_v3.1851,986,061 - 51,986,298RGD
SHRSP x BN Map140.11RGD
SHRSP x BN Map140.11UniSTS
Cytogenetic Map8q23UniSTS
D8Got72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,147,812 - 49,147,989 (+)MAPPERmRatBN7.2
Rnor_6.0853,117,444 - 53,117,620NCBIRnor6.0
Rnor_5.0851,710,465 - 51,710,641UniSTSRnor5.0
RGSC_v3.4852,065,614 - 52,065,790UniSTSRGSC3.4
RGSC_v3.4852,065,613 - 52,065,790RGDRGSC3.4
Celera848,704,993 - 48,705,171UniSTS
RGSC_v3.1852,084,668 - 52,084,844RGD
RH 3.4 Map8535.2UniSTS
RH 3.4 Map8535.2RGD
RH 2.0 Map8394.8RGD
Cytogenetic Map8q23UniSTS
D8Got333  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8858,062,858 - 58,063,005 (+)Marker Load Pipeline
mRatBN7.2849,166,364 - 49,166,511 (+)MAPPERmRatBN7.2
Rnor_6.0853,136,117 - 53,136,263NCBIRnor6.0
Rnor_5.0851,729,138 - 51,729,284UniSTSRnor5.0
RGSC_v3.4852,084,165 - 52,084,311UniSTSRGSC3.4
Celera848,723,464 - 48,723,610UniSTS
Cytogenetic Map8q23UniSTS
BE106999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,101,920 - 49,102,105 (+)MAPPERmRatBN7.2
Rnor_6.0853,093,236 - 53,093,420NCBIRnor6.0
Rnor_5.0851,686,257 - 51,686,441UniSTSRnor5.0
RGSC_v3.4852,040,589 - 52,040,773UniSTSRGSC3.4
Celera848,660,504 - 48,660,688UniSTS
RH 3.4 Map8537.5UniSTS
Cytogenetic Map8q23UniSTS
mMaCIR130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,088,967 - 49,090,544 (+)MAPPERmRatBN7.2
Rnor_6.0853,080,031 - 53,081,607NCBIRnor6.0
Rnor_5.0851,673,052 - 51,674,628UniSTSRnor5.0
Celera848,647,488 - 48,649,064UniSTS
Cytogenetic Map8q23UniSTS


Related Rat Strains
The following Strains have been annotated to Zbtb16
SHR.PD-(D8Mgh9-D8Rat149)/Cub     SHR.PD-(D8Rat42-D8Arb23)/Cub    


Genetic Models
This gene Zbtb16 is modified in the following models/strains:
SHR-Zbtb16em1Ipcv+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000045356   ⟹   ENSRNOP00000043640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl857,891,081 - 58,073,507 (-)Ensembl
mRatBN7.2 Ensembl848,994,566 - 49,177,011 (-)Ensembl
Rnor_6.0 Ensembl852,985,313 - 53,146,953 (-)Ensembl
RefSeq Acc Id: NM_001013181   ⟹   NP_001013199
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,891,106 - 58,073,507 (-)NCBI
mRatBN7.2848,994,591 - 49,177,011 (-)NCBI
Rnor_6.0852,985,444 - 53,146,765 (-)NCBI
Rnor_5.0851,573,252 - 51,740,759 (-)NCBI
RGSC_v3.4851,931,530 - 52,094,813 (-)RGD
Celera848,553,034 - 48,734,595 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595705   ⟹   XP_017451194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,885,886 - 58,073,412 (-)NCBI
mRatBN7.2848,989,376 - 49,176,918 (-)NCBI
Rnor_6.0852,980,226 - 53,146,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595707   ⟹   XP_017451196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,885,886 - 58,072,869 (-)NCBI
mRatBN7.2848,992,264 - 49,176,366 (-)NCBI
Rnor_6.0852,980,226 - 53,146,138 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001013199   ⟸   NM_001013181
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451194   ⟸   XM_017595705
- Peptide Label: isoform X1
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451196   ⟸   XM_017595707
- Peptide Label: isoform X1
- UniProtKB: Q5S3S9 (UniProtKB/TrEMBL),   F7EQW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043640   ⟸   ENSRNOT00000045356
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5S3S9-F1-model_v2 AlphaFold Q5S3S9 1-673 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695938
Promoter ID:EPDNEW_R6463
Type:single initiation site
Name:Zbtb16_1
Description:zinc finger and BTB domain containing 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0853,146,866 - 53,146,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727921 AgrOrtholog
BioCyc Gene G2FUF-30597 BioCyc
Ensembl Genes ENSRNOG00000029980 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045356 ENTREZGENE
  ENSRNOT00000045356.5 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  ZnFinger_BTB_dom_contain UniProtKB/TrEMBL
KEGG Report rno:353227 UniProtKB/TrEMBL
NCBI Gene 353227 ENTREZGENE
PANTHER AGAP004733-PA UniProtKB/TrEMBL
  RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 771 UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PharmGKB ZBTB16 RGD
PhenoGen Zbtb16 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029980 RatGTEx
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F7EQW2 ENTREZGENE, UniProtKB/TrEMBL
  F7IXA3_RAT UniProtKB/TrEMBL
  M5AK03_RAT UniProtKB/TrEMBL
  Q5S3S9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-28 Zbtb16  zinc finger and BTB domain containing 16  Zfp145  zinc finger protein 145  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-02-28 Zfp145  zinc finger protein 145  Lx  Polydactyly-luxate syndrome  Data merged from RGD:3021 737654 APPROVED
2002-06-10 Lx  Polydactyly-luxate syndrome      Symbol and Name status set to approved 70586 APPROVED