ERBB3 (erb-b2 receptor tyrosine kinase 3) - Rat Genome Database

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Gene: ERBB3 (erb-b2 receptor tyrosine kinase 3) Canis lupus familiaris
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Symbol: ERBB3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 12260744
Description: ENCODES a protein that exhibits neuregulin binding (ortholog); neuregulin receptor activity (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); circadian rhythm (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); chronic obstructive pulmonary disease (ortholog); Colonic Neoplasms (ortholog); FOUND IN apical part of cell (ortholog); plasma membrane (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010416,919 - 431,621 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to insulin stimulus  (ISO)
circadian rhythm  (ISO)
cranial nerve development  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
mammary gland involution  (ISO)
motor neuron apoptotic process  (IEA,ISO)
myelination  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell adhesion  (IEA)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of secretion  (IEA)
negative regulation of signal transduction  (IEA)
neurogenesis  (IEA)
neuron apoptotic process  (IEA,ISO)
peripheral nervous system development  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle tissue development  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (ISO)
regulation of cell population proliferation  (IEA)
response to xenobiotic stimulus  (ISO)
Schwann cell development  (IEA)
Schwann cell differentiation  (IEA,ISO)
signal transduction  (IEA)
skeletal muscle tissue development  (ISO)
tongue development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20947393   PMID:21238975   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010416,919 - 431,621 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBIUU_Cfam_GSD_1.0
ERBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,080,108 - 56,103,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,076,799 - 56,103,505 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,473,892 - 56,497,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,760,159 - 54,783,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,760,158 - 54,783,395NCBI
Celera1256,125,560 - 56,149,315 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,512,788 - 53,536,430 (+)NCBIHuRef
CHM1_11256,441,254 - 56,464,656 (+)NCBICHM1_1
T2T-CHM13v2.01256,047,558 - 56,071,109 (+)NCBIT2T-CHM13v2.0
Erbb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)EnsemblGRCm39 Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBIMGSCv36mm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
Erbb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,579,079 - 1,600,379 (-)NCBIGRCr8
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,758,331 - 3,777,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,634,321 - 5,653,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,932,064 - 5,951,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
Erbb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,683,126 - 3,702,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,683,126 - 3,701,752 (+)NCBIChiLan1.0ChiLan1.0
ERBB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,228,227 - 38,251,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,224,995 - 38,248,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,811,533 - 32,834,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,062,681 - 33,085,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,063,434 - 33,084,994 (-)Ensemblpanpan1.1panPan2
Erbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,354,988 - 58,370,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646498,749 - 513,297 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646497,783 - 515,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,474,475 - 21,495,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,020,912 - 52,043,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,021,058 - 52,044,028 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,941,255 - 193,963,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erbb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,905,271 - 11,925,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,906,279 - 11,925,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ERBB3
135 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 5 22 6 6 6 6 6 11 8 10 6
Medium 1
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000000159   ⟹   ENSCAFP00000000139
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10406,633 - 424,264 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093289   ⟹   ENSCAFP00000058907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10421,298 - 424,264 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011031   ⟹   ENSCAFP00845008606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011108   ⟹   ENSCAFP00845008668
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10428,172 - 431,614 (+)Ensembl
RefSeq Acc Id: XM_038487745   ⟹   XP_038343673
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBI
RefSeq Acc Id: XM_038487746   ⟹   XP_038343674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110394,529 - 409,084 (+)NCBI
RefSeq Acc Id: XM_038549633   ⟹   XP_038405561
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBI
RefSeq Acc Id: XM_038549634   ⟹   XP_038405562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010761,646 - 776,205 (+)NCBI
RefSeq Acc Id: XM_038613603   ⟹   XP_038469531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBI
RefSeq Acc Id: XM_038613604   ⟹   XP_038469532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010637,438 - 651,980 (+)NCBI
RefSeq Acc Id: XM_038632526   ⟹   XP_038488454
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha10471,936 - 486,495 (+)NCBI
RefSeq Acc Id: XM_038678968   ⟹   XP_038534896
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010416,919 - 431,621 (+)NCBI
RefSeq Acc Id: XM_538226   ⟹   XP_538226
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110406,856 - 424,746 (+)NCBI
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBI
Sequence:
RefSeq Acc Id: XP_538226   ⟸   XM_538226
- Peptide Label: isoform X5
- UniProtKB: A0A8C0Q074 (UniProtKB/TrEMBL),   A0A8C0LK10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000139   ⟸   ENSCAFT00000000159
RefSeq Acc Id: ENSCAFP00000058907   ⟸   ENSCAFT00000093289
RefSeq Acc Id: XP_038343673   ⟸   XM_038487745
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038343674   ⟸   XM_038487746
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469531   ⟸   XM_038613603
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038469532   ⟸   XM_038613604
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038534896   ⟸   XM_038678968
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MRL6 (UniProtKB/TrEMBL),   A0A8P0S620 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038488454   ⟸   XM_038632526
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S620 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405561   ⟸   XM_038549633
- Peptide Label: isoform X4
- UniProtKB: A0A8C0LK10 (UniProtKB/TrEMBL),   A0A8C0Q074 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405562   ⟸   XM_038549634
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S620 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845008668   ⟸   ENSCAFT00845011108
RefSeq Acc Id: ENSCAFP00845008606   ⟸   ENSCAFT00845011031

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000097 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018380 UniProtKB/TrEMBL
  ENSCAFG00040004075 UniProtKB/TrEMBL
  ENSCAFG00845006158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000159.5 UniProtKB/TrEMBL
  ENSCAFT00030034196.1 UniProtKB/TrEMBL
  ENSCAFT00040007853.1 UniProtKB/TrEMBL
  ENSCAFT00845011031 ENTREZGENE
  ENSCAFT00845011031.1 UniProtKB/TrEMBL
  ENSCAFT00845011108.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/TrEMBL
NCBI Gene ERBB3 ENTREZGENE
PANTHER RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Furin-like UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
PIRSF TyrPK_EGF-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0LK10 ENTREZGENE
  A0A8C0Q074 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MX20_CANLF UniProtKB/TrEMBL
  A0A8P0S620 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54147 ENTREZGENE