RGD Reference Report - Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. - Rat Genome Database

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Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma.

Authors: Ito, Y  Takeda, T  Sakon, M  Tsujimoto, M  Higashiyama, S  Noda, K  Miyoshi, E  Monden, M  Matsuura, N 
Citation: Ito Y, etal., Br J Cancer. 2001 May 18;84(10):1377-83. doi: 10.1054/bjoc.2000.1580.
RGD ID: 126781769
Pubmed: PMID:11355950   (View Abstract at PubMed)
PMCID: PMC2363640   (View Article at PubMed Central)
DOI: DOI:10.1054/bjoc.2000.1580   (Journal Full-text)

In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was expressed in 68% of the HCC examined and showed correlation with the proliferating activity, stage, intrahepatic metastasis and carcinoma differentiation. c-erbB-2 was expressed in only 21% of the cases and showed no relationships with the clinicopathological parameters. c-erbB-3 protein was observed in 84% of the HCC and 38.1% of the noncancerous lesions. Its expression in HCC was equal to or greater than noncancerous lesions in 90.5% of the cases, and was related to the stage, portal invasion, cell proliferating activity, tumour size, intrahepatic metastasis and carcinoma differentiation. c-erbB-4 protein was expressed in 61.0% of HCC and in as much as 86.1% of the noncancerous lesions. Unlike the expression of c-erbB-3, that of c-erbB-4 in HCC was less than that of the adjacent noncancerous lesions in 51.2% of the cases. No statistical significance could be established between this protein expression in HCC and clinicopathological features. EGF-R and c-erbB-3 affected disease-free survival, but were not recognized as independent prognostic factors by multivariate analysis. The present study suggests that, of the four receptors, EGF-R and c-erbB-3 play important roles in the progression of HCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EGFRHumanhepatocellular carcinoma disease_progressionIEP  RGD 
ERBB3Humanhepatocellular carcinoma disease_progressionIEP  RGD 
EgfrRathepatocellular carcinoma disease_progressionISOEGFR (Homo sapiens) RGD 
EgfrMousehepatocellular carcinoma disease_progressionISOEGFR (Homo sapiens) RGD 
Erbb3Rathepatocellular carcinoma disease_progressionISOERBB3 (Homo sapiens) RGD 
Erbb3Mousehepatocellular carcinoma disease_progressionISOERBB3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)
Erbb3  (erb-b2 receptor tyrosine kinase 3)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)
Erbb3  (erb-b2 receptor tyrosine kinase 3)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)
ERBB3  (erb-b2 receptor tyrosine kinase 3)


Additional Information