EGFR (epidermal growth factor receptor) - Rat Genome Database

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Gene: EGFR (epidermal growth factor receptor) Homo sapiens
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Symbol: EGFR
Name: epidermal growth factor receptor
RGD ID: 69152
HGNC Page HGNC
Description: Enables several functions, including actin filament binding activity; enzyme binding activity; and epidermal growth factor-activated receptor activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Biomarker of several diseases, including Human papillomavirus infectious disease; breast cancer (multiple); carcinoma (multiple); chronic obstructive pulmonary disease; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR vIII; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; ERRP; erythroblastic leukemia viral (v-erb-b) oncogene homolog; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl755,019,017 - 55,211,628 (+)EnsemblGRCh38hg38GRCh38
GRCh38755,019,017 - 55,211,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37755,086,710 - 55,279,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,054,219 - 55,242,525 (+)NCBINCBI36hg18NCBI36
Build 34754,860,933 - 55,012,947NCBI
Celera755,192,332 - 55,380,657 (+)NCBI
Cytogenetic Map7p11.2NCBI
HuRef754,924,934 - 55,112,834 (+)NCBIHuRef
CHM1_1755,089,165 - 55,277,398 (+)NCBICHM1_1
CRA_TCAGchr7v2755,092,507 - 55,280,831 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model