EGFR (epidermal growth factor receptor)

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Gene: EGFR (epidermal growth factor receptor) Homo sapiens

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Symbol:

EGFR

Name:

epidermal growth factor receptor

RGD ID:

69152

HGNC Page

HGNC

Description:

Enables several functions, including actin filament binding activity; enzyme binding activity; and epidermal growth factor-activated receptor activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Biomarker of several diseases, including Human papillomavirus infectious disease; breast cancer (multiple); carcinoma (multiple); chronic obstructive pulmonary disease; and pulmonary hypertension.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR vIII; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; ERRP; erythroblastic leukemia viral (v-erb-b) oncogene homolog; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	55,019,017 - 55,211,628 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	55,019,017 - 55,211,628 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	55,086,710 - 55,279,321 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	55,054,219 - 55,242,525 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	54,860,933 - 55,012,947	NCBI
Celera	7	55,192,332 - 55,380,657 (+)	NCBI
Cytogenetic Map	7	p11.2	NCBI
HuRef	7	54,924,934 - 55,112,834 (+)	NCBI		HuRef
CHM1_1	7	55,089,165 - 55,277,398 (+)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	55,092,507 - 55,280,831 (+)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM