Irx5 (iroquois homeobox 5) - Rat Genome Database

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Gene: Irx5 (iroquois homeobox 5) Rattus norvegicus
Analyze
Symbol: Irx5
Name: iroquois homeobox 5
RGD ID: 1565518
Description: Enables DNA-binding transcription factor binding activity and identical protein binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human IRX5 (iroquois homeobox 5); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: iroquois homeobox protein 5; iroquois-class homeodomain protein IRX-5; LOC498918
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,812,033 - 30,816,885 (-)NCBIGRCr8
mRatBN7.21914,639,052 - 14,643,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,624,225 - 14,642,318 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1916,335,573 - 16,338,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,530,376 - 21,533,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01924,476,554 - 24,479,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,415,813 - 16,421,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,415,636 - 16,421,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,490,017 - 27,494,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,747,720 - 15,750,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,553,091 - 14,555,785 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Irx5Ratdilated cardiomyopathy  ISOIRX5 (Homo sapiens)329950575mRNA:increased expression:heart left ventricle (human)RGD 
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Irx5RatChromosome 16q12 Duplication Syndrome  ISOIRX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868 and PMID:33891002
Irx5Ratgenetic disease  ISOIRX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Irx5RatHamamy Syndrome  ISOIRX5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17230486 more ...
Irx5RatJoubert syndrome 1  ISOIRX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:17558409 and PMID:28492532
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Irx5Ratanodontia  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5RatBone Fractures  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5Ratcongenital heart disease  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5RatCraniofacial Abnormalities  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5Ratfrontonasal dysplasia  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5RatHamamy Syndrome  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Irx5Rathypochromic microcytic anemia  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5Ratlacrimal apparatus disease  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5Ratlung disease  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21238641
Irx5Ratmyopia  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
Irx5Ratsensorineural hearing loss  ISOIRX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22581230
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Original Reference(s)
Irx5RatHamamy Syndrome  ISOIRX5 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Irx5Rat17beta-estradiol increases expressionISOIrx5 (Mus musculus)6480464Estradiol results in increased expression of IRX5 mRNACTDPMID:19484750
Irx5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOIrx5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of IRX5 mRNACTDPMID:24058054
Irx5Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOIRX5 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of IRX5 mRNACTDPMID:29704546
Irx5Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOIRX5 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of IRX5 mRNACTDPMID:19684285
Irx5Rat2-hydroxypropanoic acid increases expressionISOIRX5 (Homo sapiens)6480464Lactic Acid results in increased expression of IRX5 mRNACTDPMID:30851411
Irx5Rat2-palmitoylglycerol increases expressionISOIRX5 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of IRX5 mRNACTDPMID:37199045
Irx5Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of IRX5 mRNACTDPMID:24780913 and PMID:30047161
Irx5Rat6-propyl-2-thiouracil multiple interactionsISOIrx5 (Mus musculus)6480464[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of IRX5 mRNACTDPMID:36706583
Irx5Ratacetaldehyde affects expressionISOIrx5 (Mus musculus)6480464Acetaldehyde affects the expression of IRX5 mRNACTDPMID:22634333
Irx5Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of IRX5 mRNACTDPMID:28959563
Irx5Rataflatoxin B1 increases expressionISOIrx5 (Mus musculus)6480464Aflatoxin B1 results in increased expression of IRX5 mRNACTDPMID:19770486
Irx5Ratall-trans-retinoic acid decreases expressionISOIRX5 (Homo sapiens)6480464Tretinoin results in decreased expression of IRX5 mRNACTDPMID:33167477
Irx5Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of IRX5 mRNACTDPMID:35163327
Irx5Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of IRX5 mRNACTDPMID:30047161
Irx5Ratarsenite(3-) increases methylationISOIRX5 (Homo sapiens)6480464arsenite results in increased methylation of IRX5 promoterCTDPMID:23974009
Irx5Ratbenzo[a]pyrene increases expressionISOIRX5 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of IRX5 mRNACTDPMID:20064835
Irx5Ratbenzo[a]pyrene increases expressionISOIrx5 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of IRX5 mRNACTDPMID:19770486
Irx5Ratbis(2-ethylhexyl) phthalate multiple interactionsEXP 6480464[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of IRX5 promoterCTDPMID:23359474
Irx5Ratbis(2-ethylhexyl) phthalate decreases expressionISOIrx5 (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of IRX5 mRNACTDPMID:34319233
Irx5Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of IRX5 promoterCTDPMID:23359474

1 to 20 of 83 rows

Biological Process
1 to 20 of 20 rows

  
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Original Reference(s)
Irx5Ratanimal organ development involved_inIEAARBA:ARBA000292471600115GO_REF:0000117UniProtGO_REF:0000117
Irx5Ratcell development acts_upstream_of_or_withinIEAUniProtKB:Q9JKQ4 and ensembl:ENSMUSP000000341841600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratcell development acts_upstream_of_or_withinISOIrx5 (Mus musculus)1624291MGI:3610374 PMID:16182275RGDPMID:16182275
Irx5Ratcell development involved_inIBAFB:FBgn0014343 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irx5Ratembryonic cranial skeleton morphogenesis involved_inISOIRX5 (Homo sapiens)1624291 PMID:22581230RGDPMID:22581230
Irx5Ratembryonic cranial skeleton morphogenesis involved_inIEAUniProtKB:P78411 and ensembl:ENSP000003781321600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratgonad development involved_inISOIRX5 (Homo sapiens)1624291 PMID:22581230RGDPMID:22581230
Irx5Ratgonad development involved_inIEAUniProtKB:P78411 and ensembl:ENSP000003781321600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratneuron differentiation involved_inIBAFB:FBgn0014343 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irx5Ratneuron maturation acts_upstream_of_or_withinISOIrx5 (Mus musculus)1624291MGI:1890816 PMID:18322081RGDPMID:18322081
Irx5Ratneuron maturation acts_upstream_of_or_withinIEAUniProtKB:Q9JKQ4 and ensembl:ENSMUSP000000341841600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR003893 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Irx5Ratregulation of gene expression acts_upstream_of_or_withinISOIrx5 (Mus musculus)1624291MGI:3610374 PMID:16239150RGDPMID:16239150
Irx5Ratregulation of gene expression acts_upstream_of_or_withinIEAUniProtKB:Q9JKQ4 and ensembl:ENSMUSP000000341841600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratregulation of heart rate acts_upstream_of_or_withinIEAUniProtKB:Q9JKQ4 and ensembl:ENSMUSP000000341841600115GO_REF:0000107EnsemblGO_REF:0000107
Irx5Ratregulation of heart rate acts_upstream_of_or_withinISOIrx5 (Mus musculus)1624291MGI:3610374 PMID:16239150RGDPMID:16239150
Irx5Ratregulation of transcription by RNA polymerase II  IDA 329950576 RGD 
Irx5Ratregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0014343 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irx5Ratretinal bipolar neuron differentiation acts_upstream_of_or_withinISOIrx5 (Mus musculus)1624291MGI:1890816 PMID:18322081RGDPMID:18322081
Irx5Ratretinal bipolar neuron differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9JKQ4 and ensembl:ENSMUSP000000341841600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
Object Symbol
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Reference
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Source
Original Reference(s)
Irx5Ratnucleus located_inIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Irx5Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Irx5Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Irx5Ratnucleus is_active_inIBAMGI:1197522 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irx5Ratnucleus located_inIEAInterPro:IPR0038931600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function
1 to 11 of 11 rows

  
1 to 11 of 11 rows


#
Reference Title
Reference Citation
1. Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data. Beisvag V, etal., Eur J Heart Fail. 2006 Jun;8(4):381-9. doi: 10.1016/j.ejheart.2006.05.004. Epub 2006 Jun 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription. He W, etal., Cardiovasc Res. 2009 Jan 1;81(1):64-71. doi: 10.1093/cvr/cvn259. Epub 2008 Sep 24.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:16182275   PMID:16239150   PMID:16412459   PMID:18322081   PMID:22581230   PMID:27170637  



Irx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,812,033 - 30,816,885 (-)NCBIGRCr8
mRatBN7.21914,639,052 - 14,643,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,624,225 - 14,642,318 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1916,335,573 - 16,338,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,530,376 - 21,533,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01924,476,554 - 24,479,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,415,813 - 16,421,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,415,636 - 16,421,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,490,017 - 27,494,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,747,720 - 15,750,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,553,091 - 14,555,785 (-)NCBICelera
Cytogenetic Map19p11NCBI
IRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381654,930,865 - 54,934,485 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1654,930,865 - 54,934,485 (+)EnsemblGRCh38hg38GRCh38
GRCh371654,964,777 - 54,968,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361653,522,612 - 53,525,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341653,522,611 - 53,525,894NCBI
Celera1639,479,883 - 39,483,213 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1640,851,390 - 40,854,676 (+)NCBIHuRef
CHM1_11656,372,071 - 56,375,357 (+)NCBICHM1_1
T2T-CHM13v2.01660,728,978 - 60,732,598 (+)NCBIT2T-CHM13v2.0
Irx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,084,424 - 93,088,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,084,253 - 93,102,914 (+)EnsemblGRCm39 Ensembl
GRCm38892,357,796 - 92,361,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37894,881,695 - 94,885,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,246,924 - 95,250,584 (+)NCBIMGSCv36mm8
Celera896,669,925 - 96,673,589 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.93NCBI
Irx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543312,519,338 - 12,522,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543312,518,786 - 12,522,744 (+)NCBIChiLan1.0ChiLan1.0
IRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21864,359,486 - 64,363,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,278,544 - 70,282,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,164,884 - 35,168,189 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,272,272 - 54,275,431 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,272,412 - 54,275,124 (+)Ensemblpanpan1.1panPan2
IRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,957,353 - 60,978,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,968,193 - 61,041,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,609,385 - 57,612,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,516,686 - 61,520,066 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,509,877 - 61,582,135 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,341,971 - 58,345,349 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,367,066 - 59,370,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0260,245,608 - 60,248,977 (-)NCBIUU_Cfam_GSD_1.0
Irx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934952,231,182 - 52,234,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,354,642 - 7,358,553 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,354,273 - 7,358,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,511,894 - 30,514,808 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,511,263 - 30,515,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,705,061 - 40,708,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604735,643,147 - 35,667,057 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,947,032 - 1,966,352 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,962,574 - 1,966,330 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Irx5
15 total Variants

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000015272
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat

1 to 10 of 21 rows
Irx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,639,221 - 14,639,272 (-)MAPPERmRatBN7.2
Rnor_6.01916,420,400 - 16,420,450NCBIRnor6.0
Rnor_5.01927,494,543 - 27,494,593UniSTSRnor5.0
RGSC_v3.41915,747,781 - 15,747,831UniSTSRGSC3.4
Celera1914,553,152 - 14,553,202UniSTS
Cytogenetic Map19p11UniSTS
Irx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,640,477 - 14,641,678 (-)MAPPERmRatBN7.2
Rnor_6.01916,417,994 - 16,419,194NCBIRnor6.0
Rnor_5.01927,492,137 - 27,493,337UniSTSRnor5.0
Celera1914,554,408 - 14,555,608UniSTS
Cytogenetic Map19p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 49 105 75 74 43 24 43 6 198 96 85 45 60 31



Ensembl Acc Id: ENSRNOT00000015272   ⟹   ENSRNOP00000015272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,624,225 - 14,642,318 (-)Ensembl
Rnor_6.0 Ensembl1916,417,817 - 16,420,511 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089975   ⟹   ENSRNOP00000072299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,638,527 - 14,642,318 (-)Ensembl
Rnor_6.0 Ensembl1916,415,636 - 16,421,191 (+)Ensembl
RefSeq Acc Id: NM_001030044   ⟹   NP_001025215
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,812,136 - 30,814,830 (-)NCBI
mRatBN7.21914,639,161 - 14,641,855 (-)NCBI
Rnor_6.01916,417,817 - 16,420,511 (+)NCBI
Rnor_5.01927,490,017 - 27,494,759 (+)NCBI
RGSC_v3.41915,747,720 - 15,750,414 (-)RGD
Celera1914,553,091 - 14,555,785 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255197   ⟹   XP_006255259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,812,033 - 30,816,885 (-)NCBI
mRatBN7.21914,639,052 - 14,643,911 (-)NCBI
Rnor_6.01916,415,813 - 16,421,088 (+)NCBI
Rnor_5.01927,490,017 - 27,494,759 (+)NCBI
Sequence:
Protein RefSeqs NP_001025215 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255259 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAZ20811 (Get FASTA)   NCBI Sequence Viewer  
  EDL87565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015272.2
  ENSRNOP00000072299
  ENSRNOP00000072299.2
RefSeq Acc Id: NP_001025215   ⟸   NM_001030044
- UniProtKB: Q45V74 (UniProtKB/TrEMBL),   A0A0G2K2M1 (UniProtKB/TrEMBL),   A6KD61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255259   ⟸   XM_006255197
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2M1 (UniProtKB/TrEMBL),   A6KD61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072299   ⟸   ENSRNOT00000089975
Ensembl Acc Id: ENSRNOP00000015272   ⟸   ENSRNOT00000015272
Homeobox

Name Modeler Protein Id AA Range Protein Structure
AF-G3V7I4-F1-model_v2 AlphaFold G3V7I4 1-484 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-6384 BioCyc
Ensembl Genes ENSRNOG00000011180 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015272.3 UniProtKB/TrEMBL
  ENSRNOT00000089975 ENTREZGENE
  ENSRNOT00000089975.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_KN_domain UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Iroquois_homeo UniProtKB/TrEMBL
KEGG Report rno:498918 UniProtKB/TrEMBL
NCBI Gene 498918 ENTREZGENE
PANTHER IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX UniProtKB/TrEMBL
  IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5 UniProtKB/TrEMBL
Pfam Homeobox_KN UniProtKB/TrEMBL
PhenoGen Irx5 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011180 RatGTEx
SMART HOX UniProtKB/TrEMBL
  IRO UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2K2M1 ENTREZGENE, UniProtKB/TrEMBL
  A6KD61 ENTREZGENE, UniProtKB/TrEMBL
  G3V7I4_RAT UniProtKB/TrEMBL
  Q45V74 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Irx5  iroquois homeobox 5  LOC498918  iroquois homeobox protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498918  iroquois homeobox protein 5      Symbol and Name status set to provisional 70820 PROVISIONAL