RGD Reference Report - Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data. - Rat Genome Database

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Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data.

Authors: Beisvag, Vidar  Lehre, Per Kristian  Midelfart, Herman  Aass, Halfdan  Geiran, Odd  Sandvik, Arne Kristian  Laegreid, Astrid  Komorowski, Jan  Ellingsen, Oyvind 
Citation: Beisvag V, etal., Eur J Heart Fail. 2006 Jun;8(4):381-9. doi: 10.1016/j.ejheart.2006.05.004. Epub 2006 Jun 6.
RGD ID: 329950575
Pubmed: PMID:16753336   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejheart.2006.05.004   (Journal Full-text)


BACKGROUND: The objective of the present study was to use gene expression profiling, functional annotations and classification to identify aetiology-specific biological processes and potential molecular markers for different aetiologies of end-stage heart failure.
METHODS AND RESULTS: Individual left ventricular myocardial samples from eleven coronary artery disease and nine dilated cardiomyopathy transplant patients were co-hybridized with pooled RNA from four non-failing hearts on custom-made arrays of 7000 human genes. Significance analysis identified differential expression of 153 and 147 genes, respectively, in coronary artery disease or dilated cardiomyopathy versus non-failing hearts. Analysis of Gene Ontology biological process annotations indicated aetiology-specific patterns, primarily related to genes involved in catabolism and in regulation of protein kinase activity. Gene expression classifiers were obtained and used for class prediction of random samples of coronary artery diseased and dilated cardiomyopathic hearts. Best classifiers frequently included matrix metalloproteinase 3, fibulin 1, ATP-binding cassette, sub-family B member 1 and iroquois homeobox protein 5.
CONCLUSION: Combining functional annotation from microarray data and classification analysis constitutes a potent strategy to identify disease-specific biological processes and gene expression markers in e.g. end-stage coronary artery disease and dilated cardiomyopathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dilated cardiomyopathy  IEP 329950575mRNA:increased expression:heart left ventricle (human)RGD 
dilated cardiomyopathy  ISOIRX5 (Homo sapiens)329950575; 329950575mRNA:increased expression:heart left ventricle (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Irx5  (iroquois homeobox 5)

Genes (Mus musculus)
Irx5  (Iroquois homeobox 5)

Genes (Homo sapiens)
IRX5  (iroquois homeobox 5)


Additional Information