Irx5 (Iroquois homeobox 5) - Rat Genome Database

Name: Irx5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Irx5 (Iroquois homeobox 5) Mus musculus

Analyze

Symbol:

Irx5

Name:

Iroquois homeobox 5

RGD ID:

1320390

MGI Page

MGI

Description:

Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to localize to nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetaldehyde.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

homeodomain protein IRXB2; iroquois homeobox protein 5; Iroquois related homeobox 5; Iroquois related homeobox 5 (Drosophila); iroquois-class homeodomain protein IRX-5

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IRX5 (iroquois homeobox 5)	HGNC	EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Irx5 (iroquois homeobox 5)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Irx5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IRX5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IRX5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Irx5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IRX5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	IRX5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Irx5 (iroquois homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IRX2 (iroquois homeobox 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	IRX5 (iroquois homeobox 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Rattus norvegicus (Norway rat):	Irx5 (iroquois homeobox 5)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	irx5b (iroquois homeobox 5b)	Alliance	DIOPT (ZFIN)
Danio rerio (zebrafish):	irx5a (iroquois homeobox 5a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Caenorhabditis elegans (roundworm):	irx-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|Roundup)
Drosophila melanogaster (fruit fly):	ara	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	caup	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	mirr	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	93,084,424 - 93,088,084 (+)	NCBI	GRCm39		mm39
GRCm38	8	92,357,796 - 92,361,456 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	92,357,625 - 92,376,286 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	94,881,695 - 94,885,355 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	95,246,924 - 95,250,584 (+)	NCBI			mm8
Celera	8	96,669,925 - 96,673,589 (+)	NCBI		Celera
Cytogenetic Map	8	C5	NCBI
cM Map	8	44.93	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anodontia (ISO)

Bone Fractures (ISO)

congenital heart disease (ISO)

Craniofacial Abnormalities (ISO)

Frontonasal Dysplasia (ISO)

Hamamy Syndrome (ISO)

hypochromic microcytic anemia (ISO)

lacrimal apparatus disease (ISO)

lung disease (ISO)

myopia (ISO)

sensorineural hearing loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

6-propyl-2-thiouracil (ISO)

acetaldehyde (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (EXP)

choline (EXP)

clothianidin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (EXP)

cytarabine (ISO)

dibutyl phthalate (ISO)

dioxygen (EXP)

dorsomorphin (ISO)

endosulfan (ISO)

entinostat (ISO)

flusilazole (EXP)

folic acid (EXP)

furan (ISO)

L-methionine (EXP)

menadione (ISO)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (EXP)

Monobutylphthalate (EXP)

nickel atom (ISO)

nickel sulfate (EXP)

nitrofen (ISO)

pirinixic acid (EXP)

rac-lactic acid (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silver atom (EXP)

silver(0) (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (EXP)

triazines (EXP)

trichostatin A (ISO)

triclosan (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (IBA,IMP)

embryonic cranial skeleton morphogenesis (ISO)

gonad development (ISO)

neuron differentiation (IBA)

neuron maturation (IGI)

regulation of gene expression (IMP)

regulation of heart rate (IMP)

regulation of transcription by RNA polymerase II (IBA)

regulation of transcription, DNA-templated (IEA)

retinal bipolar neuron differentiation (IGI)

visual perception (IEA)

Cellular Component

nucleus (IBA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cardiac outflow tract development (IAGP)

abnormal heart development (IAGP)

abnormal heart septum morphology (IAGP)

abnormal interatrial septum morphology (IAGP)

abnormal retinal cone bipolar cell morphology (IAGP)

atrial septal defect (IAGP)

atrioventricular septal defect (IAGP)

decreased body size (IAGP)

double outlet right ventricle (IAGP)

lethality throughout fetal growth and development, complete penetrance (IAGP)

narrow eye opening (IAGP)

persistent truncus arteriosis (IAGP)

prolonged PR interval (IAGP)

prolonged QRS complex duration (IAGP)

References

References - curated


1.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD data from the GO Consortium
4.	MGD IEA
5.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline
7.	RGD automated import pipeline
8.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:10704856	PMID:10822268	PMID:10882515	PMID:10926765	PMID:11042143	PMID:11042145	PMID:11042159	PMID:11076861	PMID:11118473	PMID:11238910	PMID:11245568
PMID:11335133	PMID:11520674	PMID:11956760	PMID:12477932	PMID:14585979	PMID:15489334	PMID:15782199	PMID:16141072	PMID:16141073	PMID:16182275	PMID:16239150	PMID:16299054
PMID:16602821	PMID:16919269	PMID:17336907	PMID:17397913	PMID:17875669	PMID:18023262	PMID:18256137	PMID:18287559	PMID:18322081	PMID:18697905	PMID:19255801	PMID:19906978
PMID:20059953	PMID:20408909	PMID:20436479	PMID:20890042	PMID:20932939	PMID:20969841	PMID:21192082	PMID:21267068	PMID:21293032	PMID:21677750	PMID:21873635	PMID:22174793
PMID:22992950	PMID:23172916	PMID:23314057	PMID:23622242	PMID:24146773	PMID:24335256	PMID:24726282	PMID:24726283	PMID:24952961	PMID:25453830	PMID:25848055	PMID:26329601
PMID:26450968	PMID:26959361	PMID:27329940	PMID:27453922	PMID:27606604	PMID:28052057	PMID:29463648	PMID:29853617	PMID:30063881	PMID:30071018	PMID:30246301	PMID:30538277
PMID:31112136	PMID:31265461	PMID:31988190	PMID:32108023	PMID:32507881	PMID:33206716

Genomics

Comparative Map Data

Irx5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	93,084,424 - 93,088,084 (+)	NCBI	GRCm39		mm39
GRCm38	8	92,357,796 - 92,361,456 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	92,357,625 - 92,376,286 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	94,881,695 - 94,885,355 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	95,246,924 - 95,250,584 (+)	NCBI			mm8
Celera	8	96,669,925 - 96,673,589 (+)	NCBI		Celera
Cytogenetic Map	8	C5	NCBI
cM Map	8	44.93	NCBI

IRX5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	16	54,930,865 - 54,934,485 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	16	54,930,865 - 54,934,485 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	54,965,111 - 54,968,397 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	53,522,612 - 53,525,898 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	53,522,611 - 53,525,894	NCBI
Celera	16	39,479,883 - 39,483,213 (+)	NCBI
Cytogenetic Map	16	q12.2	NCBI
HuRef	16	40,851,390 - 40,854,676 (+)	NCBI		HuRef
CHM1_1	16	56,372,071 - 56,375,357 (+)	NCBI		CHM1_1

Irx5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	16,415,813 - 16,421,088 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	16,415,636 - 16,421,191 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	27,490,017 - 27,494,759 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	15,747,720 - 15,750,414 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	19	14,553,091 - 14,555,785 (-)	NCBI		Celera
Cytogenetic Map	19	p11	NCBI

Irx5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	12,519,338 - 12,522,118 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	12,518,786 - 12,522,744 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRX5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	54,272,272 - 54,275,431 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	54,272,412 - 54,275,124 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	16	35,164,884 - 35,168,189 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

IRX5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	2	60,968,193 - 61,041,385 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	2	60,957,353 - 60,978,782 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Irx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936475	7,354,273 - 7,358,328 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRX5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	30,511,894 - 30,515,097 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	30,511,263 - 30,515,015 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

IRX5
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	40,705,061 - 40,708,749 (+)	NCBI

Irx5
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624757	1,962,574 - 1,966,330 (-)	NCBI

Position Markers

Irx5

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	92,358,361 - 92,359,579	UniSTS	GRCm38
MGSCv37	8	94,884,684 - 94,884,734	UniSTS	GRCm37
Celera	8	96,670,495 - 96,671,713	UniSTS
Cytogenetic Map	8	C5	UniSTS
cM Map	8	43.3	UniSTS
cM Map	8	43.3	UniSTS

PMC310936P4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	92,359,584 - 92,359,731	UniSTS	GRCm38
MGSCv37	8	94,883,483 - 94,883,630	UniSTS	GRCm37
Celera	8	96,671,718 - 96,671,865	UniSTS
Cytogenetic Map	8	C5	UniSTS
cM Map	8	43.3	UniSTS

Irx5

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	92,360,785 - 92,360,835	UniSTS	GRCm38
MGSCv37	8	94,884,684 - 94,884,734	UniSTS	GRCm37
Celera	8	96,672,918 - 96,672,968	UniSTS
Cytogenetic Map	8	C5	UniSTS
cM Map	8	43.3	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	78518613	112518703	Mouse
1301808	Nhdlq1_m	non-HDL QTL 1 (mouse)			Not determined		8	75685348	109685497	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	81619151	115619151	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
10045619	Heal14_m	wound healing/regeneration 14 (mouse)			Not determined		8	85716921	119717069	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
1301766	Desp1_m	despair 1 (mouse)			Not determined		8	84759576	118759741	Mouse
27226796	Scvln16_m	sacral vertebrae length 2, 16 week (mouse)					8	89000000	130800000	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	75685348	109685497	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79082178	113082403	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73202495	107202598	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	75675517	109675623	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81092664	115092664	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
1302049	Heal1_m	wound healing/regeneration 1 (mouse)			Not determined		8	85716921	119717069	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	73400000	126100000	Mouse
1301253	Skmw2_m	skeletal muscle weight 2 (mouse)			Not determined		8	85716921	119717069	Mouse

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mir1a-1	mmu-miR-1a-3p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//qRT-PCR//We	Functional MTI	17397913
Mir1a-2	mmu-miR-1a-3p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//qRT-PCR//We	Functional MTI	17397913

Predicted Target Of

	Summary Value
Count of predictions:	194
Count of miRNA genes:	111
Interacting mature miRNAs:	173
Transcripts:	ENSMUST00000034184
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_018826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC155166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF165985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF230074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ271053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ271054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK200036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK208318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK213017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC051959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC056994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000034184 ⟹ ENSMUSP00000034184

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	92,357,749 - 92,361,456 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000210246 ⟹ ENSMUSP00000147339

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	92,357,625 - 92,376,286 (+)	Ensembl

RefSeq Acc Id:

NM_018826 ⟹ NP_061296

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	93,084,424 - 93,088,084 (+)	NCBI
GRCm38	8	92,357,796 - 92,361,456 (+)	ENTREZGENE
MGSCv37	8	94,881,695 - 94,885,355 (+)	RGD
Celera	8	96,669,925 - 96,673,589 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

AGTCCCCCCACCGACTACACCCCGGGAAGGAGGAGCTTCGCGCGCACACAAGGCGTCAGAATCC
TCAATTTCCAACTTAGCATCTTGGCAGGACCTTTGCAAAGCCAAAAGCAGAGCCCCCCGGTGCA
AAGAGCGAGGGAGGGGGGTGGGGGGAGAGAAAGCCTAGCCCGGGCAAGCGGGGCGCGCAGAGGA
GCGGGCGCGGCGGTCGCAGCCAGAGGCGCGCGGGAAGCCAACCAGGAGGCGCCGCGGGCCGGAG
CCCGGGAGCCGGGGCTCGAAGAGCTGCGGCCCGGGGCAGCCAGAAGCCAGGTGCCCTCTCGCTC
GCCCTCGCAGGGCGCCGCCCGGCTCGTTGGCCGCCGCGGCGCGGCGCGCCCCATGCCCGTGTGT
GGCCATGTCCTACCCGCAGGGCTACTTGTACCAGCCGTCCGCCTCGCTGGCGCTCTACTCGTGC
CCCGCATACAGCACCAGCGTCATTTCGGGGCCCCGCACGGATGAGCTCGGCCGCTCTTCTTCGG
GCTCCGCGTTCTCGCCCTACGCTGGCTCCACTGCCTTCACGGCTCCCTCGCCCGGCTACAACTC
GCACCTCCAGTACGGCGCCGACCCCGCGGCTGCGGCCGCCGCTGCCTTCTCTTACGTGGGCTCT
CCCTACGACCACACTCCCGGTATGGCAGGTTCCTTGGGATATCACCCTTATGCAGCACCTCTGG
GCTCCTATCCTTATGGGGACCCCGCGTACCGGAAGAATGCCACTCGGGACGCTACAGCCACTCT
CAAGGCCTGGCTCAACGAGCACCGCAAGAACCCGTACCCCACCAAGGGAGAGAAGATCATGCTG
GCCATTATCACCAAGATGACCCTCACCCAGGTGTCCACCTGGTTTGCCAACGCGCGCCGGCGCC
TCAAGAAAGAGAACAAGATGACGTGGACGCCACGGAACCGCAGCGAGGACGAGGAGGAGGAGGA
GAACATCGATCTGGAGAAGAACGACGAGGACGAGCCACAGAAGCCCGAGGACAAGGGCGACCTC
GAGGGCCCCGAATCAGGAGGAGCAGAGCAGAAGGCGACTGCGGGCTGCGAACGGCTGCAGGGGC
CGCTCAGCCCCGCCGGCAAGGAGACCGAAGGCAGCCTCAGCGACTCGGATTTTAAGGAGTCGTC
CTCCGAAGGCCGCCACGATGAGCTGCCCAGGCCCCCGCGCGCGGGCGAGTCCTCCCCGGCTGGG
CCCGCAACCGCTCGTCTGGCGGAAGACGCGGGTCCTCACTACCCCGCGAGTGTGCCGGCTCCCG
GCCCGCACCCATCAGCCGGAGAGCTGCCCCCCGGCTCGGGCGGATCCTCGGTCATCCACTCGCC
ACCGCCACCTCCGCCACCGCCTCCGGCCGTGCTAGCCAAGCCCAAACTGTGGTCTCTGGCCGAG
ATCGCCACATCCTCGGACAAGGTCAAGGACGGGGGCGGAGGGAGCGAGGGCTCTCCATGCCCAC
CGTGCCCAGGGCCCATGGGCGGGCAAACGCTTGGAGGCAGCCGCGCGTCTCCTGCCCCAGCGCC
CGCACGCTCACCCTCCGCGCAGTGTCCCTTTCCGGGCGGGACGGTGCTGTCCCGGCCTCTTTAT
TACACGGCGCCCTTCTATCCGGGCTACACGAACTATGGCTCCTTCGGACATCTTCACGGCCACC
CAGGGCCAGGGCCAAGCCCTACAGCGGGTCCTGGCTCTCATTTCAATGGATTAAACCAGACGGT
GTTGAATCGTGCGGACGTTTTGGCTAAAGACCCGAAAATGTTGCGGAGCCAGTCTCAGCTAGAC
CTGTGCAAAGACTCCCCCTATGAGTTGAAGAAAGGTATGTCCGACATTTAACTCTGGTGCGGTA
TCCCCGGACTTTCCTAATTTATTAAAACCATGGCCTTGGCAGTTATTTTTCCATCACCAAGAGA
GAGAAAGAAAAAAGAAATAAACTACCCCTCTTATTCAGAAGTTTATAGTTTATGGAGATGGATG
GCATAAAAATGTATACATCTCCACACTCGAAAAAATTGTTTTAGCCAACTGAAAAGAAAAAAAA
ACTTAAAAGGATTTGTATTAAATCTTATTCTGTATATTTAATGTAGCATTTTTGTATTTAAATT
GATAATTCAGTATCTTTGAAGTAAATTATGAAATCAAGACACCTGTACAGGCATTTAATGTTTT
TGTAATATAAATATATACATTTGTGTTCCCCCAAAACTGTTTCATAGTTTAAAAATACAAGTTT
AATTTAATTTTTTACACCTATTGATTTTTTTCCTGGGTATGAGCTAAAATATTATTACAGAAAG
GAAGCAGGTTATACGCTTAGATTTAAAAAAAAAAGTAAGAGAAACTGCAGTGGTCTTTGTAAAA
TGCAAAATATTTAATTAAAGGAGATTTTAACATAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_061296	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF42871	(Get FASTA)	NCBI Sequence Viewer
	AAF63955	(Get FASTA)	NCBI Sequence Viewer
	AAH51959	(Get FASTA)	NCBI Sequence Viewer
	AAH56994	(Get FASTA)	NCBI Sequence Viewer
	BAB23528	(Get FASTA)	NCBI Sequence Viewer
	CAC10447	(Get FASTA)	NCBI Sequence Viewer
	CAC14462	(Get FASTA)	NCBI Sequence Viewer
	EDL11086	(Get FASTA)	NCBI Sequence Viewer
	Q9JKQ4	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_061296 ⟸ NM_018826

- UniProtKB:

Q9JKQ4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSH
LQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLK
AWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEEN
IDLEKNDEDEPQKPEDKGDLEGPESGGAEQKATAGCERLQGPLSPAGKETEGSLSDSDFKESSS
EGRHDELPRPPRAGESSPAGPATARLAEDAGPHYPASVPAPGPHPSAGELPPGSGGSSVIHSPP
PPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGGQTLGGSRASPAPAPA
RSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPSPTAGPGSHFNGLNQTVL
NRADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI

hide sequence

RefSeq Acc Id:

ENSMUSP00000034184 ⟸ ENSMUST00000034184

RefSeq Acc Id:

ENSMUSP00000147339 ⟸ ENSMUST00000210246

Protein Domains

Homeobox

Promoters

RGD ID:

8667855

Promoter ID:

EPDNEW_M11958

Type:

initiation region

Name:

Irx5_1

Description:

Mus musculus Iroquois homeobox 5 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	92,357,874 - 92,357,934	EPDNEW

RGD ID:

6843340

Promoter ID:

MM_KWN:55270

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, Brain, Kidney, Lung, MEF_B4, MEF_B6

Transcripts:

NM_018826

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	94,881,321 - 94,881,962 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1859086	AgrOrtholog
Ensembl Genes	ENSMUSG00000031737	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000034184	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000147339	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000034184	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000210246	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_KN_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Iroquois_homeo	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:54352	UniProtKB/Swiss-Prot
MGD	MGI:1859086	ENTREZGENE
NCBI Gene	54352	ENTREZGENE
Pfam	Homeobox_KN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Irx5	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IRO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.101153	ENTREZGENE
UniProt	A0A1B0GR17_MOUSE	UniProtKB/TrEMBL
	IRX5_MOUSE	UniProtKB/Swiss-Prot
	Q9ER76_MOUSE	UniProtKB/TrEMBL
	Q9ER77_MOUSE	UniProtKB/TrEMBL
	Q9JKQ4	ENTREZGENE
UniProt Secondary	Q80WV4	UniProtKB/Swiss-Prot
	Q9JLL5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-10-31	Irx5	Iroquois homeobox 5		Iroquois related homeobox 5 (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM