Irx5 (Iroquois homeobox 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Irx5 (Iroquois homeobox 5) Mus musculus
Analyze
Symbol: Irx5
Name: Iroquois homeobox 5
RGD ID: 1320390
MGI Page MGI
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein self-association. Acts upstream of or within neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeodomain protein IRXB2; iroquois homeobox protein 5; Iroquois related homeobox 5; Iroquois related homeobox 5 (Drosophila); iroquois-class homeodomain protein IRX-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,084,424 - 93,088,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,084,253 - 93,102,914 (+)EnsemblGRCm39 Ensembl
GRCm38892,357,796 - 92,361,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37894,881,695 - 94,885,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,246,924 - 95,250,584 (+)NCBIMGSCv36mm8
Celera896,669,925 - 96,673,589 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Aetiology-specific patterns in end-stage heart failure patients identified by functional annotation and classification of microarray data. Beisvag V, etal., Eur J Heart Fail. 2006 Jun;8(4):381-9. doi: 10.1016/j.ejheart.2006.05.004. Epub 2006 Jun 6.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10704856   PMID:10822268   PMID:10882515   PMID:10926765   PMID:11042143   PMID:11042145   PMID:11042159   PMID:11076861   PMID:11118473   PMID:11238910   PMID:11245568  
PMID:11335133   PMID:11520674   PMID:11956760   PMID:12477932   PMID:14585979   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16182275   PMID:16239150   PMID:16299054  
PMID:16602821   PMID:16919269   PMID:17336907   PMID:17397913   PMID:17875669   PMID:18023262   PMID:18287559   PMID:18322081   PMID:18697905   PMID:19255801   PMID:19906978   PMID:20059953  
PMID:20408909   PMID:20436479   PMID:20890042   PMID:20932939   PMID:20969841   PMID:21192082   PMID:21267068   PMID:21293032   PMID:21677750   PMID:21873635   PMID:22174793   PMID:22992950  
PMID:23172916   PMID:23314057   PMID:23622242   PMID:24146773   PMID:24335256   PMID:24697899   PMID:24726282   PMID:24726283   PMID:24952961   PMID:25453830   PMID:25848055   PMID:26329601  
PMID:26450968   PMID:26959361   PMID:27329940   PMID:27453922   PMID:27606604   PMID:28052057   PMID:29463648   PMID:29540665   PMID:29853617   PMID:30063881   PMID:30071018   PMID:30246301  
PMID:30538277   PMID:31112136   PMID:31265461   PMID:31434798   PMID:31988190   PMID:32108023   PMID:32507881   PMID:32662900   PMID:32907847   PMID:33206716   PMID:33859429   PMID:33887179  
PMID:34083488   PMID:34095148   PMID:34321664   PMID:34705510   PMID:34767447   PMID:35245131   PMID:35315772   PMID:36115924   PMID:36773339   PMID:37084727   PMID:37414952   PMID:37494420  
PMID:38089586   PMID:38110169  


Genomics

Comparative Map Data
Irx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,084,424 - 93,088,084 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,084,253 - 93,102,914 (+)EnsemblGRCm39 Ensembl
GRCm38892,357,796 - 92,361,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37894,881,695 - 94,885,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,246,924 - 95,250,584 (+)NCBIMGSCv36mm8
Celera896,669,925 - 96,673,589 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.93NCBI
IRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381654,930,865 - 54,934,485 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1654,930,865 - 54,934,485 (+)EnsemblGRCh38hg38GRCh38
GRCh371654,964,777 - 54,968,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361653,522,612 - 53,525,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341653,522,611 - 53,525,894NCBI
Celera1639,479,883 - 39,483,213 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1640,851,390 - 40,854,676 (+)NCBIHuRef
CHM1_11656,372,071 - 56,375,357 (+)NCBICHM1_1
T2T-CHM13v2.01660,728,978 - 60,732,598 (+)NCBIT2T-CHM13v2.0
Irx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,812,033 - 30,816,885 (-)NCBIGRCr8
mRatBN7.21914,639,052 - 14,643,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,624,225 - 14,642,318 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1916,335,573 - 16,338,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,530,376 - 21,533,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01924,476,554 - 24,479,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,415,813 - 16,421,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,415,636 - 16,421,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,490,017 - 27,494,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,747,720 - 15,750,414 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,553,091 - 14,555,785 (-)NCBICelera
Cytogenetic Map19p11NCBI
Irx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543312,519,338 - 12,522,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543312,518,786 - 12,522,744 (+)NCBIChiLan1.0ChiLan1.0
IRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21864,359,486 - 64,363,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,278,544 - 70,282,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,164,884 - 35,168,189 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,272,272 - 54,275,431 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,272,412 - 54,275,124 (+)Ensemblpanpan1.1panPan2
IRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,957,353 - 60,978,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,968,193 - 61,041,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,609,385 - 57,612,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,516,686 - 61,520,066 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,509,877 - 61,582,135 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,341,971 - 58,345,349 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,367,066 - 59,370,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0260,245,608 - 60,248,977 (-)NCBIUU_Cfam_GSD_1.0
Irx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934952,231,182 - 52,234,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,354,642 - 7,358,553 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,354,273 - 7,358,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,511,894 - 30,514,808 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,511,263 - 30,515,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,705,061 - 40,708,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604735,643,147 - 35,667,057 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,947,032 - 1,966,352 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,962,574 - 1,966,330 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irx5
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:111
Interacting mature miRNAs:173
Transcripts:ENSMUST00000034184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse

Markers in Region
Irx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,358,361 - 92,359,579UniSTSGRCm38
MGSCv37894,884,684 - 94,884,734UniSTSGRCm37
Celera896,670,495 - 96,671,713UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS
cM Map843.3UniSTS
PMC310936P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,359,584 - 92,359,731UniSTSGRCm38
MGSCv37894,883,483 - 94,883,630UniSTSGRCm37
Celera896,671,718 - 96,671,865UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS
Irx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,360,785 - 92,360,835UniSTSGRCm38
MGSCv37894,884,684 - 94,884,734UniSTSGRCm37
Celera896,672,918 - 96,672,968UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000034184   ⟹   ENSMUSP00000034184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,084,377 - 93,088,084 (+)Ensembl
GRCm38.p6 Ensembl892,357,749 - 92,361,456 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210246   ⟹   ENSMUSP00000147339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,084,253 - 93,102,914 (+)Ensembl
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)Ensembl
RefSeq Acc Id: NM_018826   ⟹   NP_061296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,084,424 - 93,088,084 (+)NCBI
GRCm38892,357,796 - 92,361,456 (+)ENTREZGENE
MGSCv37894,881,695 - 94,885,355 (+)RGD
Celera896,669,925 - 96,673,589 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_061296   ⟸   NM_018826
- UniProtKB: Q80WV4 (UniProtKB/Swiss-Prot),   Q9JLL5 (UniProtKB/Swiss-Prot),   Q9JKQ4 (UniProtKB/Swiss-Prot),   A0A1B0GR17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034184   ⟸   ENSMUST00000034184
RefSeq Acc Id: ENSMUSP00000147339   ⟸   ENSMUST00000210246
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKQ4-F1-model_v2 AlphaFold Q9JKQ4 1-484 view protein structure

Promoters
RGD ID:8667855
Promoter ID:EPDNEW_M11958
Type:initiation region
Name:Irx5_1
Description:Mus musculus Iroquois homeobox 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38892,357,874 - 92,357,934EPDNEW
RGD ID:6843340
Promoter ID:MM_KWN:55270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_018826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36894,881,321 - 94,881,962 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859086 AgrOrtholog
Ensembl Genes ENSMUSG00000031737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034184 ENTREZGENE
  ENSMUST00000034184.12 UniProtKB/Swiss-Prot
  ENSMUST00000210246.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_KN_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iroquois_homeo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54352 UniProtKB/Swiss-Prot
MGD MGI:1859086 ENTREZGENE
NCBI Gene 54352 ENTREZGENE
PANTHER IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeobox_KN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irx5 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GR17 ENTREZGENE, UniProtKB/TrEMBL
  IRX5_MOUSE UniProtKB/Swiss-Prot
  Q80WV4 ENTREZGENE
  Q9ER76_MOUSE UniProtKB/TrEMBL
  Q9ER77_MOUSE UniProtKB/TrEMBL
  Q9JKQ4 ENTREZGENE
  Q9JLL5 ENTREZGENE
UniProt Secondary Q80WV4 UniProtKB/Swiss-Prot
  Q9JLL5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Irx5  Iroquois homeobox 5    Iroquois related homeobox 5 (Drosophila)  Symbol and/or name change 5135510 APPROVED