Irx5 (Iroquois homeobox 5) - Rat Genome Database
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Gene: Irx5 (Iroquois homeobox 5) Mus musculus
Analyze
Symbol: Irx5
Name: Iroquois homeobox 5
RGD ID: 1320390
MGI Page MGI
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to localize to nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeodomain protein IRXB2; iroquois homeobox protein 5; Iroquois related homeobox 5; Iroquois related homeobox 5 (Drosophila); iroquois-class homeodomain protein IRX-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,084,424 - 93,088,084 (+)NCBIGRCm39mm39
GRCm38892,357,796 - 92,361,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37894,881,695 - 94,885,355 (+)NCBIGRCm37mm9NCBIm37
MGSCv36895,246,924 - 95,250,584 (+)NCBImm8
Celera896,669,925 - 96,673,589 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:10349636   PMID:10704856   PMID:10822268   PMID:10882515   PMID:10926765   PMID:11042143   PMID:11042145   PMID:11042159   PMID:11076861   PMID:11118473   PMID:11238910   PMID:11245568  
PMID:11335133   PMID:11520674   PMID:11956760   PMID:12477932   PMID:14585979   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16182275   PMID:16239150   PMID:16299054  
PMID:16602821   PMID:16919269   PMID:17336907   PMID:17397913   PMID:17875669   PMID:18023262   PMID:18256137   PMID:18287559   PMID:18322081   PMID:18697905   PMID:19255801   PMID:19906978  
PMID:20059953   PMID:20408909   PMID:20436479   PMID:20890042   PMID:20932939   PMID:20969841   PMID:21192082   PMID:21267068   PMID:21293032   PMID:21677750   PMID:21873635   PMID:22174793  
PMID:22992950   PMID:23172916   PMID:23314057   PMID:23622242   PMID:24146773   PMID:24335256   PMID:24726282   PMID:24726283   PMID:24952961   PMID:25453830   PMID:25848055   PMID:26329601  
PMID:26450968   PMID:26959361   PMID:27329940   PMID:27453922   PMID:27606604   PMID:28052057   PMID:29463648   PMID:29853617   PMID:30063881   PMID:30071018   PMID:30246301   PMID:30538277  
PMID:31112136   PMID:31265461   PMID:31988190   PMID:32108023   PMID:32507881   PMID:33206716  


Genomics

Comparative Map Data
Irx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,084,424 - 93,088,084 (+)NCBIGRCm39mm39
GRCm38892,357,796 - 92,361,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37894,881,695 - 94,885,355 (+)NCBIGRCm37mm9NCBIm37
MGSCv36895,246,924 - 95,250,584 (+)NCBImm8
Celera896,669,925 - 96,673,589 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.93NCBI
IRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1654,930,865 - 54,934,485 (+)EnsemblGRCh38hg38GRCh38
GRCh381654,930,865 - 54,934,485 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371654,965,111 - 54,968,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361653,522,612 - 53,525,898 (+)NCBINCBI36hg18NCBI36
Build 341653,522,611 - 53,525,894NCBI
Celera1639,479,883 - 39,483,213 (+)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1640,851,390 - 40,854,676 (+)NCBIHuRef
CHM1_11656,372,071 - 56,375,357 (+)NCBICHM1_1
Irx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01916,415,813 - 16,421,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,415,636 - 16,421,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,490,017 - 27,494,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,747,720 - 15,750,414 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1914,553,091 - 14,555,785 (-)NCBICelera
Cytogenetic Map19p11NCBI
Irx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543312,519,338 - 12,522,118 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543312,518,786 - 12,522,744 (+)NCBIChiLan1.0ChiLan1.0
IRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11654,272,272 - 54,275,431 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,272,412 - 54,275,124 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01635,164,884 - 35,168,189 (+)NCBIMhudiblu_PPA_v0panPan3
IRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl260,968,193 - 61,041,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1260,957,353 - 60,978,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Irx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364757,354,273 - 7,358,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,511,894 - 30,515,097 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,511,263 - 30,515,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRX5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,705,061 - 40,708,749 (+)NCBI
Irx5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247571,962,574 - 1,966,330 (-)NCBI

Position Markers
Irx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,358,361 - 92,359,579UniSTSGRCm38
MGSCv37894,884,684 - 94,884,734UniSTSGRCm37
Celera896,670,495 - 96,671,713UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS
cM Map843.3UniSTS
PMC310936P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,359,584 - 92,359,731UniSTSGRCm38
MGSCv37894,883,483 - 94,883,630UniSTSGRCm37
Celera896,671,718 - 96,671,865UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS
Irx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38892,360,785 - 92,360,835UniSTSGRCm38
MGSCv37894,884,684 - 94,884,734UniSTSGRCm37
Celera896,672,918 - 96,672,968UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1a-1mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI17397913
Mir1a-2mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI17397913

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:111
Interacting mature miRNAs:173
Transcripts:ENSMUST00000034184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034184   ⟹   ENSMUSP00000034184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl892,357,749 - 92,361,456 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210246   ⟹   ENSMUSP00000147339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl892,357,625 - 92,376,286 (+)Ensembl
RefSeq Acc Id: NM_018826   ⟹   NP_061296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,084,424 - 93,088,084 (+)NCBI
GRCm38892,357,796 - 92,361,456 (+)ENTREZGENE
MGSCv37894,881,695 - 94,885,355 (+)RGD
Celera896,669,925 - 96,673,589 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061296   ⟸   NM_018826
- UniProtKB: Q9JKQ4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034184   ⟸   ENSMUST00000034184
RefSeq Acc Id: ENSMUSP00000147339   ⟸   ENSMUST00000210246
Protein Domains
Homeobox

Promoters
RGD ID:8667855
Promoter ID:EPDNEW_M11958
Type:initiation region
Name:Irx5_1
Description:Mus musculus Iroquois homeobox 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38892,357,874 - 92,357,934EPDNEW
RGD ID:6843340
Promoter ID:MM_KWN:55270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_018826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36894,881,321 - 94,881,962 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859086 AgrOrtholog
Ensembl Genes ENSMUSG00000031737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034184 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147339 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034184 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210246 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_KN_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iroquois_homeo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54352 UniProtKB/Swiss-Prot
MGD MGI:1859086 ENTREZGENE
NCBI Gene 54352 ENTREZGENE
Pfam Homeobox_KN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irx5 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.101153 ENTREZGENE
UniProt A0A1B0GR17_MOUSE UniProtKB/TrEMBL
  IRX5_MOUSE UniProtKB/Swiss-Prot
  Q9ER76_MOUSE UniProtKB/TrEMBL
  Q9ER77_MOUSE UniProtKB/TrEMBL
  Q9JKQ4 ENTREZGENE
UniProt Secondary Q80WV4 UniProtKB/Swiss-Prot
  Q9JLL5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Irx5  Iroquois homeobox 5    Iroquois related homeobox 5 (Drosophila)  Symbol and/or name change 5135510 APPROVED