TRAV9-2 (T cell receptor alpha variable 9-2) - Rat Genome Database

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Gene: TRAV9-2 (T cell receptor alpha variable 9-2) Homo sapiens
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Symbol: TRAV9-2
Name: T cell receptor alpha variable 9-2
RGD ID: 1345192
HGNC Page HGNC:12154
Description: Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex.
Type: gene (Ensembl: TR_V_gene)
RefSeq Status: REVIEWED
Previously known as: TCRAV22S1; TCRAV9S2; TRAV92
RGD Orthologs
Mouse
Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,941,184 - 21,941,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,941,128 - 21,941,657 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,409,369 - 22,409,848 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,479,209 - 21,479,688 (+)NCBINCBI36Build 36hg18NCBI36
Celera142,272,942 - 2,273,420 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,527,232 - 2,527,711 (+)NCBIHuRef
CHM1_11422,409,086 - 22,409,559 (+)NCBICHM1_1
T2T-CHM13v2.01416,138,817 - 16,139,290 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8188290   PMID:21873635  


Genomics

Comparative Map Data
TRAV9-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,941,184 - 21,941,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,941,128 - 21,941,657 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,409,369 - 22,409,848 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,479,209 - 21,479,688 (+)NCBINCBI36Build 36hg18NCBI36
Celera142,272,942 - 2,273,420 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,527,232 - 2,527,711 (+)NCBIHuRef
CHM1_11422,409,086 - 22,409,559 (+)NCBICHM1_1
T2T-CHM13v2.01416,138,817 - 16,139,290 (+)NCBIT2T-CHM13v2.0
Trav6-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,875,972 - 52,876,419 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,875,972 - 52,876,419 (+)EnsemblGRCm39 Ensembl
GRCm381452,638,515 - 52,638,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,638,515 - 52,638,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv371453,258,190 - 53,258,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361451,544,517 - 51,560,956 (+)NCBIMGSCv36mm8
Celera1449,616,214 - 49,616,732 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.03NCBI
Trav6-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81530,053,597 - 30,057,351 (+)NCBIGRCr8
mRatBN7.21526,712,279 - 26,713,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1526,712,109 - 26,712,910 (+)NCBImRatBN7.2 Ensembl
mRatBN7.2 Ensembl1526,712,109 - 26,712,910 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01532,146,865 - 32,148,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1529,208,606 - 29,209,270 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01535,958,637 - 35,959,211 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map15p13NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:21919243-22511027)x1 copy number loss See cases [RCV000135132] Chr14:21919243..22511027 [GRCh38]
Chr14:22387418..22980010 [GRCh37]
Chr14:21457258..22049850 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2(chr14:21854413-22495939)x1 copy number loss See cases [RCV000135900] Chr14:21854413..22495939 [GRCh38]
Chr14:22322590..22964922 [GRCh37]
Chr14:21392430..22034762 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
GRCh38/hg38 14q11.2(chr14:21919182-22201679)x3 copy number gain See cases [RCV000139288] Chr14:21919182..22201679 [GRCh38]
Chr14:22387357..22669573 [GRCh37]
Chr14:21457197..21739413 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21919182-22398359)x3 copy number gain See cases [RCV000139614] Chr14:21919182..22398359 [GRCh38]
Chr14:22387357..22866762 [GRCh37]
Chr14:21457197..21936602 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21010790-22951814)x3 copy number gain See cases [RCV000140829] Chr14:21010790..22951814 [GRCh38]
Chr14:21478949..23421023 [GRCh37]
Chr14:20548789..22490863 [NCBI36]
Chr14:14q11.2		 uncertain significance
GRCh38/hg38 14q11.2(chr14:21830995-22324997)x3 copy number gain See cases [RCV000142945] Chr14:21830995..22324997 [GRCh38]
Chr14:22299151..22793429 [GRCh37]
Chr14:21368991..21863269 [NCBI36]
Chr14:14q11.2		 pathogenic|likely benign
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1 copy number loss See cases [RCV000051483] Chr14:19755249..22741281 [GRCh38]
Chr14:20223408..23210490 [GRCh37]
Chr14:19293248..22280330 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:21919243-22442515)x1 copy number loss See cases [RCV000051207] Chr14:21919243..22442515 [GRCh38]
Chr14:22387418..22911507 [GRCh37]
Chr14:21457258..21981347 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:266
Interacting mature miRNAs:282
Transcripts:ENST00000390441
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
772 1094 759 630 1015 766 1373 1 301 1333 204 988 3063 3018 14 547 1 447 567 1034 98

Sequence


Ensembl Acc Id: ENST00000390441   ⟹   ENSP00000452011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1421,941,128 - 21,941,657 (+)Ensembl
Protein Sequences
GenBank Protein A0A087WT02 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000452011.1
Ensembl Acc Id: ENSP00000452011   ⟸   ENST00000390441
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A087WT02-F1-model_v2 AlphaFold A0A087WT02 1-112 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12154 AgrOrtholog
COSMIC TRAV9-2 COSMIC
Ensembl Genes ENSG00000211793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000390441.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000211793 GTEx
HGNC ID HGNC:12154 ENTREZGENE
Human Proteome Map TRAV9-2 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  TCR_variable_region UniProtKB/Swiss-Prot
NCBI Gene TRAV9-2 ENTREZGENE
PANTHER T CELL RECEPTOR ALPHA VARIABLE 16-RELATED UniProtKB/Swiss-Prot
  T-CELL RECEPTOR ALPHA CHAIN V REGION UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA36836 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART IGv UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A087WT02 ENTREZGENE, UniProtKB/Swiss-Prot