Gene: Cacna1d (calcium voltage-gated channel subunit alpha1 D) Rattus norvegicus
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Symbol:
Cacna1d
Name:
calcium voltage-gated channel subunit alpha1 D
Description:
Exhibits PDZ domain binding activity; ankyrin binding activity; and high voltage-gated calcium channel activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of CREB transcription factor activity; and positive regulation of transport. Localizes to several cellular components, including apical plasma membrane; dendrite membrane; and sarcolemma. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
brain class D; calcium channel alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, voltage-dependent, L type, alpha 1D subunit; CaV1.3alpha1; RBD; voltage-dependent calcium channel subunit alpha1D; voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; voltage-gated calcium channel subunit alpha Cav1.3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Cacna1d (calcium channel, voltage-dependent, L type, alpha 1D subunit) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cacna1d (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cacna1d (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CACNA1D (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cacna1d (calcium voltage-gated channel subunit alpha1 D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CACNA1C (calcium voltage-gated channel subunit alpha1 C) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
CACNA1F (calcium voltage-gated channel subunit alpha1 F) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1E (calcium voltage-gated channel subunit alpha1 E) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1A (calcium voltage-gated channel subunit alpha1 A) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1S (calcium voltage-gated channel subunit alpha1 S) HGNC
OrthoMCL
Homo sapiens (human):
CACNA1B (calcium voltage-gated channel subunit alpha1 B) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
CACNA1D (calcium voltage-gated channel subunit alpha1 D)
Alliance
DIOPT (Ensembl Compara|InParanoid|Hieranoid|PhylomeDB|OMA|PANTHER|TreeFam|HGNC|OrthoInspector|OrthoFinder)
Mus musculus (house mouse):
Cacna1d (calcium channel, voltage-dependent, L type, alpha 1D subunit)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|TreeFam|OrthoFinder|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
cacna1da (calcium channel, voltage-dependent, L type, alpha 1D subunit, a)
Alliance
DIOPT (PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CCH1
Alliance
DIOPT (InParanoid|PhylomeDB|PANTHER|OrthoInspector|OrthoFinder|Hieranoid)
Drosophila melanogaster (fruit fly):
Ca-alpha1D
Alliance
DIOPT (InParanoid|PhylomeDB|OMA|PANTHER|TreeFam|Hieranoid)
Caenorhabditis elegans (roundworm):
egl-19
Alliance
DIOPT (InParanoid|PhylomeDB|OMA|PANTHER|TreeFam|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 6,110,294 - 6,405,022 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 6,112,150 - 6,405,117 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 6,044,524 - 6,339,170 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 5,383,259 - 5,703,361 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 5,383,256 - 5,703,359 NCBI Celera 16 9,667,490 - 9,955,564 (+) NCBI Celera Cytogenetic Map 16 p16 NCBI RH 3.4 Map 16 1.3 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
genetic disease ISO RGD:735457 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10929716 more ... Primary Aldosteronism, Seizures, and Neurologic Abnormalities ISO RGD:735457 8554872 ClinVar Annotator: match by term: Primary aldosteronism, seizures, and neurologic abnormalities ClinVar PMID:25741868 Primary Aldosteronism, Seizures, and Neurologic Abnormalities ISO RGD:735457 8554872 ClinVar Annotator: match by OMIM:615474 ClinVar PMID:23913001 prostate cancer ISO RGD:735457 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 8554872 ClinVar Annotator: match by term: Sinoatrial node dysfunction and deafness ClinVar PMID:25741868 Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 8554872 ClinVar Annotator: match by term: Sinoatrial node dysfunction and deafness ClinVar PMID:24033266 , PMID:28492532 Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 8554872 ClinVar Annotator: match by term: Sinoatrial node dysfunction and deafness ClinVar PMID:24033266 Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 8554872 ClinVar Annotator: match by term: Sinoatrial node dysfunction and deafness ClinVar Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 8554872 ClinVar Annotator: match by OMIM:614896 ClinVar PMID:21131953
Imported Annotations - CTD
adenoma ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23913001 , PMID:23913004 Animal Disease Models ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26831068 bipolar disorder ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28194001 Bradycardia ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26831068 Deafness ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15357422 Heart Block ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26831068 primary hyperaldosteronism ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23913001 sick sinus syndrome ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26831068 Tachycardia, Supraventricular ISO RGD:735457 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26831068 Imported Annotations - OMIM
Primary Aldosteronism, Seizures, and Neurologic Abnormalities ISO RGD:735457 7240710 OMIM Sinoatrial Node Dysfunction and Deafness ISO RGD:735457 7240710 OMIM
(+)-pilocarpine decreases expression ISO RGD:735458 6480464 Pilocarpine results in decreased expression of CACNA1D protein CTD PMID:17265461 (+)-pilocarpine increases expression ISO RGD:735458 6480464 Pilocarpine results in increased expression of CACNA1D protein CTD PMID:17265461 (S)-nicotine increases expression ISO RGD:735458 6480464 Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of CACNA1D mRNA CTD PMID:12832660 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of CACNA1D mRNA CTD PMID:15834898 , PMID:17351261 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of CACNA1D mRNA CTD PMID:26945725 17beta-estradiol decreases expression ISO RGD:735458 6480464 Estradiol results in decreased expression of CACNA1D mRNA CTD PMID:19484750 17beta-estradiol multiple interactions ISO RGD:735457 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CACNA1D mRNA CTD PMID:19619570 17beta-estradiol increases expression ISO RGD:735457 6480464 Estradiol results in increased expression of CACNA1D mRNA CTD PMID:19619570 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of CACNA1D mRNA CTD PMID:26496021 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735457 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CACNA1D mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735457 6480464 Tetrachlorodibenzodioxin results in increased expression of CACNA1D mRNA CTD PMID:19619570 , PMID:22903824 3,4-methylenedioxymethamphetamine increases expression ISO RGD:735458 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CACNA1D mRNA CTD PMID:20188158 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of CACNA1D mRNA CTD PMID:19162173 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of CACNA1D mRNA CTD PMID:31881176 aflatoxin B1 decreases methylation ISO RGD:735457 6480464 Aflatoxin B1 results in decreased methylation of CACNA1D intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:735457 6480464 aflatoxin B2 results in increased methylation of CACNA1D intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:735457 6480464 Tretinoin results in increased expression of CACNA1D mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CACNA1D mRNA CTD PMID:16483693 amphetamine multiple interactions ISO RGD:735458 6480464 CACNA1D protein affects the reaction [Amphetamine results in increased expression of DRD2 mRNA alternative form] CTD PMID:17026527 amphetamine affects response to substance ISO RGD:735458 6480464 CACNA1D protein affects the susceptibility to Amphetamine CTD PMID:17026527 androgen antagonist multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA CTD PMID:25607892 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CACNA1D mRNA CTD PMID:21472459 Aroclor 1254 multiple interactions EXP 6480464 Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of CACNA1D mRNA] CTD PMID:21472459 arsenite(3-) decreases methylation ISO RGD:735457 6480464 arsenite results in decreased methylation of CACNA1D promoter CTD PMID:23974009 barium(0) affects transport ISO RGD:735458 6480464 CACNA1D protein affects the transport of Barium CTD PMID:15357422 barium(0) multiple interactions ISO RGD:735458 6480464 CACNA2D2 gene mutant form inhibits the reaction [CACNA1D protein results in increased import of Barium] CTD PMID:27798183 barium(0) increases transport EXP 6480464 CACNA1D protein results in increased transport of Barium CTD PMID:17567805 benzo[a]pyrene increases expression ISO RGD:735457 6480464 Benzo(a)pyrene results in increased expression of CACNA1D mRNA CTD PMID:22316170 benzo[a]pyrene affects methylation ISO RGD:735457 6480464 Benzo(a)pyrene affects the methylation of CACNA1D intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:735457 6480464 benzo(e)pyrene results in increased methylation of CACNA1D intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735457 6480464 Diethylhexyl Phthalate results in decreased expression of CACNA1D mRNA CTD PMID:31163220 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA more ... CTD PMID:25607892 , PMID:26496021 bisphenol A increases expression ISO RGD:735458 6480464 bisphenol A results in increased expression of CACNA1D mRNA CTD PMID:30245210 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CACNA1D gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CACNA1D mRNA CTD PMID:25181051 , PMID:30816183 buta-1,3-diene decreases expression ISO RGD:735458 6480464 1, 3-butadiene results in decreased expression of CACNA1D mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:735457 6480464 butyraldehyde results in decreased expression of CACNA1D mRNA CTD PMID:26079696 Butylparaben multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1D mRNA CTD PMID:25607892 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of CACNA1D mRNA CTD PMID:19167457 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CACNA1D mRNA CTD PMID:18308070 calcium atom affects transport ISO RGD:735458 6480464 CACNA1D protein affects the transport of Calcium CTD PMID:15357422 calcium atom multiple interactions ISO RGD:735458 6480464 CACNA2D2 gene mutant form inhibits the reaction [CACNA1D protein results in increased import of Calcium] CTD PMID:27798183 calcium atom multiple interactions EXP 6480464 [CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium more ... CTD PMID:17272349 , PMID:19796812 calcium(0) affects transport ISO RGD:735458 6480464 CACNA1D protein affects the transport of Calcium CTD PMID:15357422 calcium(0) multiple interactions ISO RGD:735458 6480464 CACNA2D2 gene mutant form inhibits the reaction [CACNA1D protein results in increased import of Calcium] CTD PMID:27798183 calcium(0) multiple interactions EXP 6480464 [CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium more ... CTD PMID:17272349 , PMID:19796812 chloroprene decreases expression ISO RGD:735458 6480464 Chloroprene results in decreased expression of CACNA1D mRNA CTD PMID:23125180 cisplatin multiple interactions ISO RGD:735457 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CACNA1D mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:735457 6480464 Cisplatin results in decreased expression of CACNA1D mRNA CTD PMID:27392435 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of CACNA1D mRNA CTD PMID:24386269 cocaine affects response to substance ISO RGD:735457 6480464 CACNA1D polymorphism affects the susceptibility to Cocaine CTD PMID:28194001 copper atom increases expression EXP 6480464 Copper results in increased expression of CACNA1D mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of CACNA1D mRNA CTD PMID:30556269 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 deoxynivalenol increases expression ISO RGD:735457 6480464 deoxynivalenol results in increased expression of CACNA1D mRNA CTD PMID:23792671 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1D mRNA CTD PMID:25607892 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 formaldehyde decreases expression EXP 6480464 Formaldehyde results in decreased expression of CACNA1D protein CTD PMID:30974163 gabapentin multiple interactions EXP 6480464 CACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]] more ... CTD PMID:19796812 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 MeIQx decreases expression ISO RGD:735457 6480464 2-amino-3 more ... CTD PMID:20816883 metformin decreases expression EXP 6480464 Metformin results in decreased expression of CACNA1D mRNA CTD PMID:25596134 methapyrilene increases methylation ISO RGD:735457 6480464 Methapyrilene results in increased methylation of CACNA1D intron CTD PMID:30157460 nickel atom decreases expression ISO RGD:735457 6480464 Nickel results in decreased expression of CACNA1D mRNA CTD PMID:24768652 nicotine increases expression ISO RGD:735458 6480464 Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of CACNA1D mRNA CTD PMID:20638522 p-menthan-3-ol decreases expression ISO RGD:735457 6480464 Menthol results in decreased expression of CACNA1D mRNA CTD PMID:26760959 paracetamol multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA CTD PMID:25607892 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CACNA1D mRNA CTD PMID:19162173 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CACNA1D mRNA CTD PMID:12832660 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of CACNA1D mRNA CTD PMID:12832660 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:735458 6480464 Pregnenolone Carbonitrile results in increased expression of CACNA1D mRNA CTD PMID:22698814 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 progesterone increases expression ISO RGD:735458 6480464 Progesterone results in increased expression of CACNA1D mRNA CTD PMID:22238285 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of CACNA1D mRNA] CTD PMID:21472459 scopolamine increases expression EXP 6480464 Scopolamine results in increased expression of CACNA1D mRNA CTD PMID:12818353 silicon dioxide decreases expression ISO RGD:735457 6480464 Silicon Dioxide analog results in decreased expression of CACNA1D mRNA CTD PMID:25895662 sodium arsenite affects expression ISO RGD:735457 6480464 sodium arsenite affects the expression of CACNA1D mRNA CTD PMID:29319823 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of CACNA1D mRNA CTD PMID:22110744 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of CACNA1D mRNA CTD PMID:25993096 tebuconazole decreases expression ISO RGD:735457 6480464 tebuconazole results in decreased expression of CACNA1D mRNA CTD PMID:30458266 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CACNA1D mRNA CTD PMID:26496021 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CACNA1D mRNA CTD PMID:31150632 triclosan decreases expression ISO RGD:735457 6480464 Triclosan results in decreased expression of CACNA1D mRNA CTD PMID:30510588 trimellitic anhydride decreases expression ISO RGD:735458 6480464 trimellitic anhydride results in decreased expression of CACNA1D mRNA CTD PMID:19042947 tris(2-butoxyethyl) phosphate affects expression ISO RGD:735457 6480464 tris(2-butoxyethyl) phosphate affects the expression of CACNA1D mRNA CTD PMID:29024780 valproic acid increases methylation ISO RGD:735457 6480464 Valproic Acid results in increased methylation of CACNA1D gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:735457 6480464 Valproic Acid results in decreased expression of CACNA1D mRNA CTD PMID:29501571 valproic acid affects methylation ISO RGD:735457 6480464 Valproic Acid affects the methylation of CACNA1D gene CTD PMID:29501571 valproic acid increases expression ISO RGD:735457 6480464 Valproic Acid results in increased expression of CACNA1D mRNA CTD PMID:28001369 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CACNA1D mRNA CTD PMID:23034163 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:3625375 , PMID:16706838) RGD MGI:MGI:3625375 , PMID:16706838 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 aging IEP 6906923 RGD calcium ion import IMP 6906921 RGD calcium ion import IBA PANTHER:PTN001295314 more ... 13792537 PMID:21873635 GO_Central calcium ion import IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium ion import ISO RGD:735457 1624291 (PMID:1309651) RGD PMID:1309651 calcium ion transmembrane transport ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:3583874 , PMID:12700358) RGD MGI:MGI:3583874 , PMID:12700358 calcium ion transmembrane transport IEA UniProtKB-KW:KW-0107 1600115 GO_REF:0000043 UniProt GO_REF:0000043 calcium ion transmembrane transport IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium ion transport IDA 6767284 PMID:21859974 BHF-UCL calcium ion transport IBA CGD:CAL0000177769 more ... 13792537 PMID:21873635 GO_Central calcium ion transport ISO RGD:735457 1624291 (PMID:11160515) RGD PMID:11160515 calcium-mediated signaling IDA 634679 RGD cardiac muscle cell action potential involved in contraction IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac muscle cell action potential involved in contraction ISO RGD:735457 1624291 (PMID:21131953) RGD PMID:21131953 cellular response to amyloid-beta IEP 13782265 RGD divalent metal ion transport IMP 6906920 RGD heart development IEP 6906917 RGD induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration IEA GO:0099635 1600115 GO_REF:0000108 GOC GO_REF:0000108 membrane depolarization during cardiac muscle cell action potential IC GO:0005245 6767284 PMID:21859974 BHF-UCL membrane depolarization during SA node cell action potential ISO RGD:735457 1624291 (PMID:21131953) RGD PMID:21131953 membrane depolarization during SA node cell action potential IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane depolarization during SA node cell action potential IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane depolarization during SA node cell action potential ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:3583874 , PMID:12700358) RGD MGI:MGI:3583874 , PMID:12700358 memory IEP 704382 RGD positive regulation of adenylate cyclase activity ISS UniProtKB:Q99246 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of adenylate cyclase activity IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of adenylate cyclase activity ISO RGD:735458 1624291 (MGI:MGI:6243790, PMID:24086669) RGD MGI:MGI:6243790 , PMID:24086669 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP 13782366 RGD positive regulation of calcium ion transport ISO RGD:735457 1624291 (PMID:1309651) RGD PMID:1309651 positive regulation of calcium ion transport IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of CREB transcription factor activity IMP 6906921 RGD positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP 13506727 RGD regulation of atrial cardiac muscle cell membrane repolarization ISO RGD:735458 1624291 (MGI:MGI:3771286, PMID:17110593) RGD MGI:MGI:3771286 , PMID:17110593 regulation of atrial cardiac muscle cell membrane repolarization IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of calcium ion transport IDA 6767284 PMID:21859974 BHF-UCL regulation of heart rate by cardiac conduction ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:3583874 , PMID:12700358) RGD MGI:MGI:3583874 , PMID:12700358 regulation of heart rate by cardiac conduction IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of heart rate by cardiac conduction IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of heart rate by cardiac conduction ISO RGD:735457 1624291 (PMID:21131953) RGD PMID:21131953 regulation of ion transmembrane transport IEA UniProtKB-KW:KW-0851 1600115 GO_REF:0000043 UniProt GO_REF:0000043 regulation of potassium ion transmembrane transport ISO RGD:735458 1624291 (MGI:MGI:3771286, PMID:17110593) RGD MGI:MGI:3771286 , PMID:17110593 regulation of potassium ion transmembrane transporter activity ISO RGD:735458 1624291 (MGI:MGI:3771286, PMID:17110593) RGD MGI:MGI:3771286 , PMID:17110593 regulation of potassium ion transmembrane transporter activity IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to estradiol IEP 13782367 RGD sensory perception of sound ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:3697555 , PMID:17074442) RGD MGI:MGI:3697555 , PMID:17074442 sensory perception of sound IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 sensory perception of sound IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 sensory perception of sound ISO RGD:735457 1624291 (PMID:21131953) RGD PMID:21131953 Cellular Component apical plasma membrane IDA 2308883 ; 7205458 RGD basolateral plasma membrane ISO RGD:8747352 1624291 RGD RGD:11556226 cell surface IDA 13782265 MMO:0000669 RGD cochlear hair cell ribbon synapse IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 cochlear hair cell ribbon synapse ISO RGD:735458 1624291 (MGI:MGI:1861088 more ... RGD MGI:MGI:1861088 more ... cytoplasm IDA 13782368 MMO:0000662 RGD dendrite ISO RGD:8747352 1624291 RGD RGD:11556226 dendrite IDA 7205457 RGD dendrite membrane IDA 6906921 RGD integral component of presynaptic active zone membrane IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of presynaptic active zone membrane ISO RGD:735458 1624291 (MGI:MGI:6189469, PMID:16354915) RGD MGI:MGI:6189469 , PMID:16354915 L-type voltage-gated calcium channel complex ISO RGD:735457 1624291 (PMID:1309651) RGD PMID:1309651 L-type voltage-gated calcium channel complex IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection terminus ISO RGD:8747352 1624291 RGD RGD:11554335 neuronal cell body ISO RGD:8747352 1624291 RGD RGD:11556226 neuronal cell body IDA 7205457 RGD nucleus IDA 6906917 RGD plasma membrane IDA 7205457 RGD plasma membrane ISO RGD:735458 1624291 (MGI:MGI:3703420 more ... RGD MGI:MGI:3703420 more ... sarcolemma IDA 6906917 RGD voltage-gated calcium channel complex ISO RGD:735457 1624291 (PMID:11160515) RGD PMID:11160515 voltage-gated calcium channel complex IEA InterPro:IPR002077 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Z disc ISO RGD:735458 1624291 (MGI:MGI:3771286, PMID:17110593) RGD MGI:MGI:3771286 , PMID:17110593 Z disc IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function alpha-actinin binding ISO RGD:735457 1624291 UniProtKB:P35609 (PMID:17110593) RGD PMID:17110593 alpha-actinin binding IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 ankyrin binding ISO RGD:735458 1624291 UniProtKB:Q01484 (MGI:MGI:5427070 , PMID:21859974) RGD MGI:MGI:5427070 , PMID:21859974 ankyrin binding IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 ankyrin binding IPI UniProtKB:Q01484 6767284 PMID:21859974 BHF-UCL calcium channel activity ISO RGD:735457 1624291 (PMID:25620733), (PMID:28472301) RGD PMID:25620733 , PMID:28472301 high voltage-gated calcium channel activity IDA 7207845 RGD high voltage-gated calcium channel activity IBA MGI:MGI:88293 more ... 13792537 PMID:21873635 GO_Central high voltage-gated calcium channel activity IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 high voltage-gated calcium channel activity IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 high voltage-gated calcium channel activity contributes_to ISO RGD:735457 1624291 (PMID:1309651) RGD PMID:1309651 high voltage-gated calcium channel activity ISO RGD:735458 1624291 (MGI:MGI:2678967, PMID:12900400) RGD MGI:MGI:2678967 , PMID:12900400 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 PDZ domain binding IDA 6906920 RGD protein binding ISO RGD:735458 1624291 PR:O35526 (MGI:MGI:3703420, PMID:10468580) RGD MGI:MGI:3703420 , PMID:10468580 protein binding IPI UniProtKB:Q9QX74-7 14402445 PMID:30058071 IntAct protein binding ISO RGD:735457 1624291 UniProtKB:Q9BYB0-1 (PMID:30058071) RGD PMID:30058071 protein binding IPI UniProtKB:O88871 8554172 PMID:20627102 IntAct voltage-gated calcium channel activity IDA 727563 RGD voltage-gated calcium channel activity IBA FB:FBgn0001991 more ... 13792537 PMID:21873635 GO_Central voltage-gated calcium channel activity ISO RGD:735457 1624291 (PMID:11160515), (PMID:21131953) RGD PMID:11160515 , PMID:21131953 voltage-gated calcium channel activity IEA InterPro:IPR002077 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 voltage-gated calcium channel activity IDA 6767284 PMID:21859974 BHF-UCL voltage-gated calcium channel activity involved in cardiac muscle cell action potential IC GO:0005245 6767284 PMID:21859974 BHF-UCL voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels ISO RGD:735458 1624291 (MGI:MGI:1861088, PMID:10929716) RGD MGI:MGI:1861088 , PMID:10929716 voltage-gated calcium channel activity involved SA node cell action potential ISO RGD:735457 1624291 (PMID:21131953) RGD PMID:21131953 voltage-gated calcium channel activity involved SA node cell action potential IEA UniProtKB:Q99246 , ensembl:ENSMUSP000001078691600115 GO_REF:0000107 Ensembl GO_REF:0000107 voltage-gated calcium channel activity involved SA node cell action potential IEA UniProtKB:Q01668 , ensembl:ENSP000002881391600115 GO_REF:0000107 Ensembl GO_REF:0000107 voltage-gated calcium channel activity involved SA node cell action potential ISO RGD:735458 1624291 MGI:MGI:2180141 (MGI:MGI:4354492 , PMID:15932895) RGD MGI:MGI:4354492 , PMID:15932895
Gene-Chemical Interaction Annotations
