Ctsh (cathepsin H) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ctsh (cathepsin H) Rattus norvegicus
Analyze
Symbol: Ctsh
Name: cathepsin H
RGD ID: 2447
Description: Enables aminopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to thyroid hormone stimulus; response to odorant; and spermatogenesis. Located in cytoskeleton; extracellular space; and secretory granule. Biomarker of polycystic kidney disease. Orthologous to human CTSH (cathepsin H); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathepsin B3; cathepsin BA; pro-cathepsin H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2890,608,941 - 90,627,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx896,288,760 - 96,307,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,488,180 - 94,507,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,330,819 - 92,349,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,439,155 - 97,458,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,439,161 - 97,458,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,939,702 - 96,958,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,971,689 - 94,990,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1894,991,143 - 95,009,889 (+)NCBI
Celera890,152,207 - 90,170,963 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. Brasch F, etal., Am J Respir Cell Mol Biol 2002 Jun;26(6):659-70.
2. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Dahlmann B, etal., Biochim Biophys Acta. 1989 May 31;991(2):253-62.
3. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
4. Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1. Fukada Y, etal., Brain Res. 2007 Jul 30;1160:1-10. Epub 2007 Jun 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation. Gonzalez-Rivera R, etal., Neurosci Lett. 2006 Nov 20;408(3):178-82. Epub 2006 Oct 5.
7. Expression of cathepsin H in differentiating rat spermatids: immunoelectron microscopic study. Haraguchi CM, etal., Histochem Cell Biol. 2003 Jul;120(1):63-71. Epub 2003 Jul 1.
8. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
9. Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases. Ishidoh K, etal., FEBS Lett 1987 Dec 21;226(1):33-7.
10. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. Ishii Y, etal., J Histochem Cytochem. 1991 Apr;39(4):461-8.
11. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
12. Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. Mantle D, etal., J Neurol Sci. 1995 Jul;131(1):65-70.
13. Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring. Mathur PP, etal., Biochem Mol Biol Int. 1997 Jun;42(2):217-33.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
16. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Nagai A, etal., Clin Chim Acta. 2003 Mar;329(1-2):53-60.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Biochemical properties and intracellular processing of lysosomal cathepsins B and H. Nishimura Y, etal., Biol Pharm Bull. 1995 Jun;18(6):829-36.
19. Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma. Qian F, etal., Int J Biochem 1990;22(12):1457-64.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Studies on the aminopeptidase activity of rat cathepsin H. Rothe M and Dodt J, Eur J Biochem. 1992 Dec 15;210(3):759-64.
23. Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat. Schaefer L, etal., Kidney Int. 1996 Aug;50(2):424-31.
24. Expression and the role of cathepsin H in human glioma progression and invasion. Sivaparvathi M, etal., Cancer Lett 1996 Jun 24;104(1):121-6.
25. Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. Staack A, etal., Urology. 2004 Jun;63(6):1089-94.
26. Functional interface between cathepsins and growth factors in the kidney development. Vattimo Mde F and Santos OF, Ren Fail. 2005;27(5):615-22.
27. Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Wu SM, etal., Oncogene. 2011 Apr 28;30(17):2057-69. doi: 10.1038/onc.2010.585. Epub 2011 Jan 10.
Additional References at PubMed
PMID:1837142   PMID:2759235   PMID:6203523   PMID:6574504   PMID:8811434   PMID:9050938   PMID:12189169   PMID:12477932   PMID:14766755   PMID:15127951   PMID:15196205   PMID:15489334  
PMID:16502470   PMID:16822283   PMID:17500053   PMID:18216060   PMID:20435891   PMID:20731543   PMID:23376485   PMID:23533145   PMID:24982147   PMID:27998776  


Genomics

Comparative Map Data
Ctsh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2890,608,941 - 90,627,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx896,288,760 - 96,307,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,488,180 - 94,507,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,330,819 - 92,349,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,439,155 - 97,458,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,439,161 - 97,458,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,939,702 - 96,958,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,971,689 - 94,990,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1894,991,143 - 95,009,889 (+)NCBI
Celera890,152,207 - 90,170,963 (+)NCBICelera
Cytogenetic Map8q31NCBI
CTSH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,921,058 - 78,945,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,921,058 - 78,949,574 (-)EnsemblGRCh38hg38GRCh38
GRCh371579,213,400 - 79,237,388 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,001,147 - 77,024,475 (-)NCBINCBI36Build 36hg18NCBI36
Build 341577,001,162 - 77,024,475NCBI
Celera1556,150,437 - 56,173,763 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,974,005 - 55,997,318 (-)NCBIHuRef
CHM1_11579,332,284 - 79,355,627 (-)NCBICHM1_1
T2T-CHM13v2.01576,784,722 - 76,808,716 (-)NCBIT2T-CHM13v2.0
Ctsh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,936,320 - 89,958,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl989,936,205 - 89,958,142 (+)EnsemblGRCm39 Ensembl
GRCm38990,054,267 - 90,076,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl990,054,152 - 90,076,089 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,949,105 - 89,970,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36989,852,402 - 89,873,982 (+)NCBIMGSCv36mm8
Celera989,669,599 - 89,691,657 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.4NCBI
Ctsh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553339,284 - 54,837 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495553339,237 - 54,881 (-)NCBIChiLan1.0ChiLan1.0
CTSH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11572,343,872 - 72,367,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,893,379 - 57,917,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,853,433 - 76,876,976 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,852,668 - 76,876,976 (-)Ensemblpanpan1.1panPan2
CTSH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1358,103,284 - 58,113,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl358,103,291 - 58,113,718 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,761,041 - 60,775,398 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0358,537,356 - 58,551,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,537,379 - 58,551,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1358,034,248 - 58,048,592 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,242,514 - 58,256,878 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,591,033 - 58,605,384 (+)NCBIUU_Cfam_GSD_1.0
Ctsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,287,137 - 119,308,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647137,131,817 - 37,156,476 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647137,135,200 - 37,156,081 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl748,083,572 - 48,106,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1748,084,882 - 48,106,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,623,062 - 53,644,262 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,451,731 - 4,473,220 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,451,774 - 4,472,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,378,814 - 137,400,510 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462494182,209 - 98,182 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462494182,209 - 98,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctsh
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000019285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat

Markers in Region
RH127737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,626,654 - 90,627,524 (+)MAPPERmRatBN7.2
Rnor_6.0897,457,124 - 97,457,993NCBIRnor6.0
Rnor_5.0896,957,660 - 96,958,529UniSTSRnor5.0
RGSC_v3.4894,989,267 - 94,990,136UniSTSRGSC3.4
Celera890,169,796 - 90,170,665UniSTS
RH 3.4 Map81001.6UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 34 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC085352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM135658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN800263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019285   ⟹   ENSRNOP00000019285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)Ensembl
Rnor_6.0 Ensembl897,439,216 - 97,458,287 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080142   ⟹   ENSRNOP00000074611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,613,409 - 90,627,824 (+)Ensembl
Rnor_6.0 Ensembl897,439,161 - 97,458,267 (+)Ensembl
RefSeq Acc Id: NM_012939   ⟹   NP_037071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2890,608,941 - 90,627,824 (+)NCBI
Rnor_6.0897,439,204 - 97,458,291 (+)NCBI
Rnor_5.0896,939,702 - 96,958,829 (+)NCBI
RGSC_v3.4894,971,689 - 94,990,434 (+)RGD
Celera890,152,207 - 90,170,963 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037071   ⟸   NM_012939
- Peptide Label: precursor
- UniProtKB: P00786 (UniProtKB/Swiss-Prot),   A6I215 (UniProtKB/TrEMBL),   A0A0H2UHL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074611   ⟸   ENSRNOT00000080142
RefSeq Acc Id: ENSRNOP00000019285   ⟸   ENSRNOT00000019285
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00786-F1-model_v2 AlphaFold P00786 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2447 AgrOrtholog
BioCyc Gene G2FUF-29569 BioCyc
Ensembl Genes ENSRNOG00000014064 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019285 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000074611.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019285 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000080142.2 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115929 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25425 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105498 IMAGE-MGC_LOAD
NCBI Gene 25425 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRO-CATHEPSIN H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsh PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8H6_RAT UniProtKB/TrEMBL
  A0A0H2UHL6 ENTREZGENE, UniProtKB/TrEMBL
  A6I214_RAT UniProtKB/TrEMBL
  A6I215 ENTREZGENE, UniProtKB/TrEMBL
  CATH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctsh  Cathepsin H      Symbol and Name status set to approved 70586 APPROVED