Pdia6 (protein disulfide isomerase family A, member 6) - Rat Genome Database

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Gene: Pdia6 (protein disulfide isomerase family A, member 6) Rattus norvegicus
Analyze
Symbol: Pdia6
Name: protein disulfide isomerase family A, member 6
RGD ID: 628688
Description: Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; platelet aggregation; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum lumen and smooth endoplasmic reticulum. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CaBP1; calcium-binding protein 1; P5; protein disulfide isomerase A6; protein disulfide isomerase associated 6; protein disulfide isomerase P5; protein disulfide isomerase-related protein; protein disulfide-isomerase A6; thioredoxin domain containing 7; thioredoxin domain-containing protein 7; Txndc7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kidm49 Kidm54
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,791,704 - 45,808,947 (+)NCBIGRCr8
mRatBN7.2640,062,980 - 40,080,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,062,926 - 40,080,613 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,390,413 - 40,407,661 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,705,108 - 40,722,356 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,138,354 - 40,155,605 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,568,269 - 42,585,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,568,220 - 42,585,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,289,504 - 52,306,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera639,364,155 - 39,381,355 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenoldopam  (EXP)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
graphite  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
N-nitrosomorpholine  (EXP)
nickel subsulfide  (EXP)
nicotine  (ISO)
omeprazole  (EXP)
oxidopamine  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CaBP1, a calcium binding protein of the thioredoxin family, is a resident KDEL protein of the ER and not of the intermediate compartment. Fullekrug J, etal., J Cell Sci 1994 Oct;107 ( Pt 10):2719-27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12475965   PMID:15308636   PMID:15489334   PMID:16677074   PMID:19995400   PMID:20458337   PMID:23376485   PMID:24508390   PMID:25002582  


Genomics

Comparative Map Data
Pdia6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,791,704 - 45,808,947 (+)NCBIGRCr8
mRatBN7.2640,062,980 - 40,080,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,062,926 - 40,080,613 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,390,413 - 40,407,661 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,705,108 - 40,722,356 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,138,354 - 40,155,605 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,568,269 - 42,585,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,568,220 - 42,585,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,289,504 - 52,306,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera639,364,155 - 39,381,355 (+)NCBICelera
Cytogenetic Map6q16NCBI
PDIA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,783,391 - 10,837,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,783,391 - 10,837,977 (-)EnsemblGRCh38hg38GRCh38
GRCh37210,923,517 - 10,977,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,840,968 - 10,870,411 (-)NCBINCBI36Build 36hg18NCBI36
Build 34210,874,116 - 10,903,558NCBI
Celera210,838,663 - 10,868,105 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,774,831 - 10,804,279 (-)NCBIHuRef
CHM1_1210,853,257 - 10,882,823 (-)NCBICHM1_1
T2T-CHM13v2.0210,813,390 - 10,867,711 (-)NCBIT2T-CHM13v2.0
Pdia6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,316,590 - 17,334,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,316,546 - 17,334,771 (+)EnsemblGRCm39 Ensembl
GRCm381217,266,589 - 17,284,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,266,545 - 17,284,770 (+)EnsemblGRCm38mm10GRCm38
MGSCv371217,273,401 - 17,291,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,292,075 - 17,310,250 (+)NCBIMGSCv36mm8
Celera1221,149,080 - 21,150,652 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.06NCBI
Pdia6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,735,698 - 5,748,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,735,698 - 5,744,601 (-)NCBIChiLan1.0ChiLan1.0
PDIA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,706,366 - 115,733,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,710,350 - 115,737,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,781,671 - 10,809,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,934,756 - 10,961,880 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,934,756 - 10,986,200 (-)Ensemblpanpan1.1panPan2
PDIA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,653,834 - 7,674,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,654,175 - 7,685,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,578,609 - 7,599,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,755,030 - 7,775,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,752,150 - 7,775,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,641,284 - 7,661,933 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,643,791 - 7,664,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,657,505 - 7,678,201 (-)NCBIUU_Cfam_GSD_1.0
Pdia6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,110,948 - 52,135,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365326,865,994 - 6,881,475 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365326,865,994 - 6,887,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,751,978 - 125,776,077 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,752,079 - 125,774,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,582,105 - 134,604,259 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,801,327 - 96,828,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,801,349 - 96,828,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,463,373 - 15,490,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdia6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,695,220 - 4,710,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,695,178 - 4,711,029 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdia6
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:338
Count of miRNA genes:204
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000074829
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat

Markers in Region
RH127987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,079,807 - 40,079,996 (+)MAPPERmRatBN7.2
Rnor_6.0642,585,239 - 42,585,427NCBIRnor6.0
Rnor_5.0652,306,474 - 52,306,662UniSTSRnor5.0
Celera639,380,940 - 39,381,128UniSTS
RH125410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,075,230 - 40,076,005 (+)MAPPERmRatBN7.2
Rnor_6.0642,580,662 - 42,581,436NCBIRnor6.0
Rnor_5.0652,301,897 - 52,302,671UniSTSRnor5.0
Celera639,376,363 - 39,377,137UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000074829   ⟹   ENSRNOP00000064632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,062,970 - 40,080,221 (+)Ensembl
Rnor_6.0 Ensembl642,568,220 - 42,585,652 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099273   ⟹   ENSRNOP00000093803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,062,926 - 40,080,237 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114398   ⟹   ENSRNOP00000079392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,065,507 - 40,080,613 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115498   ⟹   ENSRNOP00000077622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,066,123 - 40,080,613 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119232   ⟹   ENSRNOP00000096777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,065,875 - 40,080,613 (+)Ensembl
RefSeq Acc Id: NM_001004442   ⟹   NP_001004442
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,791,704 - 45,808,947 (+)NCBI
mRatBN7.2640,062,980 - 40,080,223 (+)NCBI
Rnor_6.0642,568,269 - 42,585,654 (+)NCBI
Rnor_5.0652,289,504 - 52,306,889 (+)NCBI
Celera639,364,155 - 39,381,355 (+)RGD
Sequence:
RefSeq Acc Id: NP_001004442   ⟸   NM_001004442
- Peptide Label: precursor
- UniProtKB: Q641Y3 (UniProtKB/Swiss-Prot),   Q63081 (UniProtKB/Swiss-Prot),   A6HAU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064632   ⟸   ENSRNOT00000074829
RefSeq Acc Id: ENSRNOP00000096777   ⟸   ENSRNOT00000119232
RefSeq Acc Id: ENSRNOP00000093803   ⟸   ENSRNOT00000099273
RefSeq Acc Id: ENSRNOP00000077622   ⟸   ENSRNOT00000115498
RefSeq Acc Id: ENSRNOP00000079392   ⟸   ENSRNOT00000114398
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63081-F1-model_v2 AlphaFold Q63081 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694508
Promoter ID:EPDNEW_R5032
Type:initiation region
Name:Pdia6_1
Description:protein disulfide isomerase family A, member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0642,568,258 - 42,568,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628688 AgrOrtholog
BioCyc Gene G2FUF-38058 BioCyc
Ensembl Genes ENSRNOG00000050197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074829.3 UniProtKB/TrEMBL
  ENSRNOT00000099273.1 UniProtKB/TrEMBL
  ENSRNOT00000114398 ENTREZGENE
  ENSRNOT00000114398.1 UniProtKB/TrEMBL
  ENSRNOT00000115498.1 UniProtKB/TrEMBL
  ENSRNOT00000119232.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132589 IMAGE-MGC_LOAD
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95222 IMAGE-MGC_LOAD
NCBI Gene 286906 ENTREZGENE
PANTHER PROTEIN DISULFIDE-ISOMERASE A6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45815 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdia6 PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050197 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSZ5_RAT UniProtKB/TrEMBL
  A0A8I5Y7R1_RAT UniProtKB/TrEMBL
  A0A8I6AJI2_RAT UniProtKB/TrEMBL
  A0A8I6ARL6_RAT UniProtKB/TrEMBL
  A0A8I6G592_RAT UniProtKB/TrEMBL
  A6HAU2 ENTREZGENE, UniProtKB/TrEMBL
  PDIA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q641Y3 ENTREZGENE
UniProt Secondary Q641Y3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-10 Pdia6  protein disulfide isomerase family A, member 6  Pdia6  protein disulfide isomerase associated 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pdia6  protein disulfide isomerase associated 6  Txndc7  thioredoxin domain containing 7  Symbol and Name updated 1299863 APPROVED
2004-12-14 Txndc7  thioredoxin domain containing 7  P5  protein disulfide isomerase-related protein  Symbol and Name updated 1299863 APPROVED
2003-02-27 P5  protein disulfide isomerase-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL