Serpinh1 (serpin family H member 1)

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Gene: Serpinh1 (serpin family H member 1) Rattus norvegicus

Analyze

Symbol:

Serpinh1

Name:

serpin family H member 1

RGD ID:

69302

Description:

Predicted to have serine-type endopeptidase inhibitor activity and unfolded protein binding activity. Predicted to be involved in several processes, including chondrocyte development involved in endochondral bone morphogenesis; collagen biosynthetic process; and collagen fibril organization. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and membrane raft. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Orthologous to human SERPINH1 (serpin family H member 1); INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

47 kDa heat shock protein; Cbp2; collagen binding protein 2; collagen-binding protein; colligin; GP46; serine (or cysteine) peptidase inhibitor, clade H, member 1; serine (or cysteine) proteinase inhibitor clade H (heat shock protein 47) member 1; serine (or cysteine) proteinase inhibitor clade H (heat shock protein 47) member 2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2; serine (or cysteine) proteinase inhibitor, clade H, member 1; serine proteinase inhibitor clade H (heat shock protein 47) member 1; serine proteinase inhibitor, clade H (heat shock protein 47), member 1; serpin H1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serpin peptidase inhibitor, clade H, member 1; Serpinh2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINH1 (serpin family H member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Serpinh1 (serine (or cysteine) peptidase inhibitor, clade H, member 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Serpinh1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINH1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINH1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpinh1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINH1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SERPINH1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpinh1 (serpin family H member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SERPINH1 (serpin family H member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Serpinh1 (serine (or cysteine) peptidase inhibitor, clade H, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	serpinh1b (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	serpinh1a (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-2	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn42Dc	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	153,643,500 - 153,650,853 (-)	NCBI
Rnor_6.0 Ensembl	1	164,301,010 - 164,308,317 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	164,301,010 - 164,308,306 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	170,503,468 - 170,510,764 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	156,666,914 - 156,674,210 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	156,745,319 - 156,752,617 (-)	NCBI
Celera	1	151,727,297 - 151,734,593 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

intellectual disability (ISO)

ischemia (ISO)

liver cirrhosis (ISO)

middle cerebral artery infarction (ISO)

osteogenesis imperfecta (ISO)

osteogenesis imperfecta type 10 (ISO)

Peritoneal Fibrosis (IEP,IMP,ISO)

preterm premature rupture of the membranes (ISO)

Schistosomiasis Japonica (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-lipoic acid (EXP)

(R)-noradrenaline (EXP)

(S)-amphetamine (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-di-tert-butyl-4-methylphenol (ISO)

2-amino-2-deoxy-D-glucopyranose (ISO)

2-butoxyethanol (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

alachlor (EXP)

aldehydo-D-glucosamine (ISO)

alendronic acid (EXP)

all-trans-retinoic acid (EXP,ISO)

aluminium oxide (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benazepril (EXP)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bexarotene (EXP)

bisphenol A (EXP)

bisphenol F (ISO)

bleomycin A2 (EXP)

cadmium atom (EXP,ISO)

cadmium sulfate (ISO)

calciol (ISO)

carbon nanotube (ISO)

carvedilol (EXP)

celecoxib (EXP)

chloropicrin (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

curcumin (EXP)

cyanocob(III)alamin (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

Diallyl sulfide (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diclofenac (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (EXP)

fenamidone (ISO)

flavonoids (EXP)

flutamide (EXP)

furan (EXP)

gentamycin (EXP)

gold atom (ISO)

gold(0) (ISO)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

ketoconazole (ISO)

levofloxacin (EXP)

lipoic acid (EXP)

lipopolysaccharide (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-acetyl-L-cysteine (ISO)

N-nitrosodimethylamine (EXP,ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nicotine (ISO)

oxaliplatin (EXP,ISO)

paracetamol (ISO)

paraquat (EXP,ISO)

pentane-2,3-dione (EXP)

PhIP (EXP)

pirinixic acid (EXP)

potassium dichromate (ISO)

raloxifene (EXP)

reactive oxygen species (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 203580 (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

Soman (EXP)

sorafenib (EXP)

streptozocin (EXP)

sunitinib (EXP)

tamoxifen (EXP,ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

wortmannin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chondrocyte development involved in endochondral bone morphogenesis (IEA,ISO)

collagen biosynthetic process (IEA,ISO)

collagen fibril organization (IBA,IEA,ISO)

negative regulation of endopeptidase activity (IBA,IEA)

protein maturation (IEA,ISO)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum (IBA,IEA,ISO)

endoplasmic reticulum lumen (IEA)

endoplasmic reticulum-Golgi intermediate compartment (IEA,ISO)

extracellular space (IEA)

membrane raft (IEA,ISO)

Molecular Function

collagen binding (IEA,TAS)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA,IEA)

unfolded protein binding (IEA,ISO)

References

References - curated


1.	Clarke EP, etal., J Biol Chem 1991 Sep 15;266(26):17230-5.
2.	Da J, etal., Biomed Pharmacother. 2020 Sep;129:110431. doi: 10.1016/j.biopha.2020.110431. Epub 2020 Jun 22.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	GOA data from the GO Consortium
5.	Huang JQ, etal., Int J Parasitol. 2014 Jan;44(1):23-35. doi: 10.1016/j.ijpara.2013.08.009. Epub 2013 Dec 1.
6.	Huang Y, etal., Parasit Vectors. 2020 May 14;13(1):254. doi: 10.1186/s13071-020-04121-2.
7.	Li L, etal., Parasitology. 2015 Feb;142(2):341-51. doi: 10.1017/S0031182014001115. Epub 2014 Aug 11.
8.	MGD data from the GO Consortium
9.	Mishima Y, etal., Perit Dial Int. 2003 Jan-Feb;23(1):14-22.
10.	Nagai N, etal., Gene 1999 Feb 18;227(2):241-8.
11.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	Nishino T, etal., Kidney Int. 2003 Sep;64(3):887-96. doi: 10.1046/j.1523-1755.2003.00169.x.
13.	OMIM Disease Annotation Pipeline
14.	RGD automated data pipeline
15.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	RGD automated import pipeline for gene-chemical interactions
17.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18.	Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
19.	Yong-Hua Z, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2019 Sep 25;31(4):382-387. doi: 10.16250/j.32.1374.2018208.
20.	Yoshio Y, etal., Kidney Int. 2004 Oct;66(4):1677-85. doi: 10.1111/j.1523-1755.2004.00935.x.

Additional References at PubMed

PMID:2158279	PMID:8018053	PMID:10862616	PMID:10995453	PMID:12477932	PMID:15033773	PMID:15308636	PMID:17054723	PMID:21412710	PMID:21606205	PMID:22082260	PMID:22492985
PMID:22658674	PMID:22718885	PMID:23376485	PMID:24650661	PMID:25204797	PMID:25526199	PMID:30092114	PMID:30361391

Genomics

Comparative Map Data

Serpinh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	153,643,500 - 153,650,853 (-)	NCBI
Rnor_6.0 Ensembl	1	164,301,010 - 164,308,317 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	164,301,010 - 164,308,306 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	170,503,468 - 170,510,764 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	156,666,914 - 156,674,210 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	156,745,319 - 156,752,617 (-)	NCBI
Celera	1	151,727,297 - 151,734,593 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

SERPINH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	75,562,056 - 75,572,783 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	75,562,253 - 75,572,783 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	75,273,298 - 75,283,828 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	74,950,818 - 74,961,494 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	74,950,817 - 74,961,492	NCBI
Celera	11	72,580,950 - 72,591,621 (+)	NCBI
Cytogenetic Map	11	q13.5	NCBI
HuRef	11	71,570,181 - 71,580,924 (+)	NCBI		HuRef
CHM1_1	11	75,156,705 - 75,167,451 (+)	NCBI		CHM1_1

Serpinh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	98,994,582 - 99,002,480 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	98,994,583 - 99,002,446 (-)	Ensembl
GRCm38	7	99,345,375 - 99,353,239 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	99,345,376 - 99,353,239 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	106,493,885 - 106,501,749 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	99,219,459 - 99,227,179 (-)	NCBI			mm8
Celera	7	99,670,192 - 99,678,104 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI

Serpinh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	16,284,845 - 16,292,963 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	16,284,845 - 16,292,828 (-)	NCBI	ChiLan1.0	ChiLan1.0

SERPINH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	73,922,617 - 73,933,379 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	11	70,621,893 - 70,632,570 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SERPINH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	23,032,761 - 23,041,649 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	23,032,767 - 23,041,625 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	22,798,470 - 22,807,285 (-)	NCBI
ROS_Cfam_1.0	21	23,235,602 - 23,244,497 (-)	NCBI
UMICH_Zoey_3.1	21	23,034,077 - 23,042,936 (-)	NCBI
UNSW_CanFamBas_1.0	21	23,230,397 - 23,239,216 (-)	NCBI
UU_Cfam_GSD_1.0	21	23,148,229 - 23,157,093 (-)	NCBI

Serpinh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	62,742,342 - 62,751,791 (+)	NCBI
SpeTri2.0	NW_004936498	4,341,944 - 4,351,432 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	9,783,036 - 9,794,483 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	9,782,939 - 9,794,485 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	10,966,800 - 10,977,248 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINH1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	66,787,978 - 66,798,930 (+)	NCBI
ChlSab1.1 Ensembl	1	66,788,240 - 66,799,072 (+)	Ensembl
Vero_WHO_p1.0	NW_023666043	59,006,758 - 59,017,494 (-)	NCBI

Serpinh1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624817	1,561,471 - 1,570,425 (-)	NCBI

Position Markers

RH128077

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	153,643,656 - 153,643,874 (+)	MAPPER
Rnor_6.0	1	164,301,159 - 164,301,376	NCBI	Rnor6.0
Rnor_5.0	1	170,503,617 - 170,503,834	UniSTS	Rnor5.0
RGSC_v3.4	1	156,667,063 - 156,667,280	UniSTS	RGSC3.4
Celera	1	151,727,446 - 151,727,663	UniSTS
RH 3.4 Map	1	1244.7	UniSTS
Cytogenetic Map	1	q32	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34993530	173445086	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	35377692	217372257	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49578577	169852184	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49578693	217054291	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	82788437	239853971	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	94201400	184846632	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	94201400	197187904	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	99983293	188289386	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	99983293	198656062	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	99983293	216213510	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	99983293	216325819	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	100131562	236763528	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	106002252	202571904	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	108057233	167517487	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	108986301	219232156	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	108986301	219232156	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	108986301	238830534	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	122614824	201146953	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	122614824	262664716	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	124090312	169090312	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	124603592	188289386	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	125875758	262433692	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	126240667	217054291	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	129208943	174208943	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130779148	198585664	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	130779148	199254774	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	130779148	199254774	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	130779148	199254774	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130779320	219238476	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	131334152	176334152	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	131334152	176334152	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	133076978	178076978	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	133076978	178076978	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	133076978	184188922	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	133946489	178946489	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	134089429	179089429	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	137787261	236763528	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	137787261	236763528	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	139523928	170246858	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	141296374	186296374	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	141296374	186296374	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	144395993	189395993	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	144395993	189395993	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	144395993	189395993	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	144634295	241482368	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144723107	174343537	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	153655976	198655976	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	153655976	198655976	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	153656062	198656062	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	153834077	232297227	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	154337847	215828102	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	156446196	214277437	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	156446196	243311614	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	156446196	274977688	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	156446783	188289244	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	156446783	189514504	Rat
8693608	Alc24	Alcohol consumption QTL 24	2.3	0.74	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	161072673	178935582	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	161321152	273792054	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	161321256	273791893	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	161321256	273791893	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	161784169	219232156	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	161784169	219232156	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	219232156	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	219232156	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	278228889	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	161784422	246226103	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	163796316	282763074	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	132
Count of miRNA genes:	97
Interacting mature miRNAs:	114
Transcripts:	ENSRNOT00000022983
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High		4								12	13
Medium	3	39	54	38	19	38	8	11	74	23	26	11	8
Low			3	3		3					2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M69246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000022983 ⟹ ENSRNOP00000022983

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	164,301,010 - 164,308,317 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086091 ⟹ ENSRNOP00000070279

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	164,301,614 - 164,307,084 (-)	Ensembl

RefSeq Acc Id:

NM_017173 ⟹ NP_058869

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	153,643,500 - 153,650,846 (-)	NCBI
Rnor_6.0	1	164,301,010 - 164,308,306 (-)	NCBI
Rnor_5.0	1	170,503,468 - 170,510,764 (-)	NCBI
RGSC_v3.4	1	156,666,914 - 156,674,210 (-)	RGD
Celera	1	151,727,297 - 151,734,593 (-)	RGD

Sequence:

show sequence

AGCGGACGCTGTCTGAGGAGTAGAGCCTGCCTGAGAGCGAGTGTCCCGTCGGTCCCGGAGCAGC
CCAGCCCGGCCCAGCCCTCACAGGTCCTCTGTGGTGCACACAGCCCACCTCCCAGCCATGCGCT
CTCTCCTTCTGGGCACCTTATGCCTCCTGGCTGTGGCCCTGGCAGCCGAGGTGAAGAAACCTGT
AGAGGCCGCAGCCCCTGGTACTGCGGAGAAGCTGAGTTCCAAGGCGACCACACTGGCAGAGCGC
AGCACAGGCCTGGCCTTCAGCCTGTATCAGGCAATGGCCAAAGATCAGGCGGTGGAGAATATCC
TCCTGTCACCCTTGGTGGTGGCCTCATCCCTGGGCCTTGTGTCACTGGGTGGTAAAGCCACCAC
AGCTTCGCAGGCGAAGGCAGTGTTGAGCGCTGAGAAGCTGCGGGATGAGGAGGTGCACACGGGG
CTGGGCGAGCTCGTGCGCTCCCTCAGTAACTCCACTGCGCGCAATGTGACCTGGAAACTGGGCA
GCCGCCTGTACGGGCCCAGCTCCGTGAGCTTCGCCGATGACTTCGTGCGCAGCAGTAAGCAACA
CTACAACTGTGAACACTCCAAGATCAACTTCCGAGACAAGCGCAGCGCGCTGCAGTCCATCAAC
GAGTGGGCCTCGCAGACCACCGACGGCAAGCTGCCAGAGGTCACCAAGGATGTGGAGCGCACGG
ATGGGGCACTGCTCGTTAATGCCATGTTCTTTAAGCCGCACTGGGATGAGAAGTTCCACCATAA
GATGGTAGACAACCGTGGCTTCATGGTGACCCGCTCCTACACTGTGGGTGTTACGATGATGCAC
CGGACAGGCCTCTACAACTACTATGACGACGAGAAGGAGAAGCTGCAGCTGGTGGAGATGCCCT
TGGCCCATAAGCTCTCCAGCCTCATCATCCTCATGCCCCACCACGTAGAACCGCTCGAGCGCCT
GGAGAAGTTGCTGACCAAGGAGCAACTAAAGACCTGGATGGGGAAGATGCAGAAGAAGGCTGTT
GCCATCTCCCTGCCCAAGGGAGTGGTGGAGGTGACCCATGACCTGCAGAAACATCTGGCCGGAC
TGGGCCTGACTGAGGCCATCGACAAGAACAAGGCAGACTTATCGCGCATGTCTGGCAAGAAGGA
TCTGTACCTGGCCAGTGTGTTCCACGCCACTGCCTTCGAGTGGGACACAGAGGGCAACCCCTTT
GACCAGGACATCTACGGGCGTGAGGAGCTGCGCAGCCCCAAGCTGTTCTATGCCGACCACCCCT
TCATCTTCCTGGTGCGAGATAATCAGAGCGGCTCCTTGCTGTTCATTGGCCGCCTGGTCCGGCC
CAAGGGAGACAAGATGCGAGACGAGTTGTAGAGTCCAAGAGTGGTCGTGGCGTGGCATGGCGGG
AAGTAGCCAGAGGTTCCTGAGACACATGGGTGCTATTGTGGGGGGAGGGGGAGGCACCAACCCT
GGATAGTCCACGGGTGGGGGGGGGTTGGCAGTGCAGATCGGAATTCCCATAGGTCTGAGTAGGT
ATTTTTAGACAAGAGTCCACTCCGTTAGACATGGAGCCCAGACACTATGAGACCAAATTCAGGG
GTGTCACAGCCATTCTAGCCCTGCCCCACAAGTTTTATATCCAATCTAGCCTCAACAGTCAATC
AGTGTTCATATTCGTGGCCAAGCATTCTGTCTGTGAGACAATCGAGTTGGGTGGGGGTAGGGCG
GCCTAGCCTCTCTGTCACCATGCCCTGAGCCCTCGGTTTTCCTGTTCACCTCTGATTCCCTTTA
ACCACAAAACTAGGAGCCTGTGGTCCCAGAACTGCCCACCCTTAAAATCGATTCTTTGCCGCAG
CAGTGGGAGTTGGGGAGACCATGCATAGGAGGGCTCCTTGGCATATCCGGCCCTAGAGCCATTA
CATTACATTGACAACTCAACTTTGCTTCTGTTTTCTCCCTTTTTGAGTTTTTCAAGGAATGGGG
GTTTGGGGAAGGGGAAGCCTTTATTGCTTTCAAAACAAGAACAGTTTGTCAATTTTTTTTGAAT
AAACCTTTTCCAATG

hide sequence

RefSeq Acc Id:

XM_039107102 ⟹ XP_038963030

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	153,643,500 - 153,650,853 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_058869	(Get FASTA)	NCBI Sequence Viewer
	XP_038963030	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41270	(Get FASTA)	NCBI Sequence Viewer
	AAH86529	(Get FASTA)	NCBI Sequence Viewer
	EDM18410	(Get FASTA)	NCBI Sequence Viewer
	EDM18411	(Get FASTA)	NCBI Sequence Viewer
	EDM18412	(Get FASTA)	NCBI Sequence Viewer
	EDM18413	(Get FASTA)	NCBI Sequence Viewer
	P29457	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_058869 ⟸ NM_017173

- Peptide Label:

precursor

- Sequence:

show sequence

MRSLLLGTLCLLAVALAAEVKKPVEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVE
NILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELVRSLSNSTARNVTWK
LGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVE
RTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVE
MPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHL
AGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYAD
HPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL

hide sequence

RefSeq Acc Id:

ENSRNOP00000022983 ⟸ ENSRNOT00000022983

RefSeq Acc Id:

ENSRNOP00000070279 ⟸ ENSRNOT00000086091

RefSeq Acc Id:	XP_038963030 ⟸ XM_039107102
- Peptide Label:	isoform X1

Protein Domains

SERPIN

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690228

Promoter ID:

EPDNEW_R751

Type:

multiple initiation site

Name:

Serpinh1_1

Description:

serpin family H member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	164,308,307 - 164,308,367	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69302	AgrOrtholog
Ensembl Genes	ENSRNOG00000016831	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000022983	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000070279	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022983	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000086091	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7303866	IMAGE-MGC_LOAD
InterPro	Serpin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_H1_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERPINH1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29345	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105471	IMAGE-MGC_LOAD
NCBI Gene	29345	ENTREZGENE
PANTHER	PTHR11461	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11461:SF27	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Serpinh1	PhenoGen
PROSITE	ER_TARGET	UniProtKB/Swiss-Prot
	SERPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56574	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC228672
UniProt	P29457	ENTREZGENE
	Q5RJR9_RAT	UniProtKB/TrEMBL
	SERPH_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpinh1	serpin family H member 1	Serpinh1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Serpinh1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	Serpinh1	serpin peptidase inhibitor, clade H, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-03-05	Serpinh1	serpin peptidase inhibitor, clade H, member 1	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	Serpinh1	serine (or cysteine) proteinase inhibitor, clade H, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Serpinh1	serine (or cysteine) proteinase inhibitor, clade H, member 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	identified as a possible hypertension gene	1559295

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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