Dok5 (docking protein 5) - Rat Genome Database

Name: Dok5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dok5 (docking protein 5) Rattus norvegicus

Analyze

Symbol:

Dok5

Name:

docking protein 5

RGD ID:

1562846

Description:

Predicted to enable kinase activity. Predicted to be involved in Ras protein signal transduction; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within neuron differentiation and regulation of neurotrophin TRK receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human DOK5 (docking protein 5); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC502694; LOC502694; LOC690989; RGD1562846; similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5); uncharacterized protein LOC502694

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOK5 (docking protein 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Dok5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dok5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DOK5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOK5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dok5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOK5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DOK5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dok5 (docking protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DOK6 (docking protein 6)	HGNC	OrthoDB
Homo sapiens (human):	SPINK1 (serine peptidase inhibitor Kazal type 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DOK5 (docking protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dok5 (docking protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dok5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	159,515,886 - 159,652,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	159,515,893 - 159,652,810 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	163,325,199 - 163,461,738 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	171,824,765 - 171,961,310 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	169,565,982 - 169,702,535 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	168,345,116 - 168,482,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	168,345,152 - 168,482,441 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	174,447,106 - 174,579,715 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	161,654,964 - 161,729,978 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	158,734,945 - 158,869,891 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

CGP 52608 (ISO)

clothianidin (ISO)

DDT (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP,ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

levonorgestrel (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

nitrofen (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

potassium chromate (ISO)

potassium dichromate (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone undecanoate (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

neuron differentiation (ISO)

phosphorylation (IEA)

positive regulation of MAPK cascade (IBA,ISO)

Ras protein signal transduction (IBA)

regulation of neurotrophin TRK receptor signaling pathway (ISO)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA,ISO)

Cellular Component

cytoplasm (IBA)

Molecular Function

kinase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11470823	PMID:12477932	PMID:23954828

Genomics

Comparative Map Data

Dok5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	159,515,886 - 159,652,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	159,515,893 - 159,652,810 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	163,325,199 - 163,461,738 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	171,824,765 - 171,961,310 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	169,565,982 - 169,702,535 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	168,345,116 - 168,482,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	168,345,152 - 168,482,441 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	174,447,106 - 174,579,715 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	161,654,964 - 161,729,978 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	158,734,945 - 158,869,891 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

DOK5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	54,475,593 - 54,651,169 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	54,475,593 - 54,651,169 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	53,092,132 - 53,267,708 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	52,525,673 - 52,701,117 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	52,525,663 - 52,701,116	NCBI
Celera	20	49,796,955 - 49,972,466 (+)	NCBI		Celera
Cytogenetic Map	20	q13.2	NCBI
HuRef	20	49,839,614 - 50,014,934 (+)	NCBI		HuRef
CHM1_1	20	52,995,435 - 53,170,794 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	56,249,933 - 56,425,528 (+)	NCBI		T2T-CHM13v2.0

Dok5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	170,573,722 - 170,721,695 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	170,573,727 - 170,721,689 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	170,731,807 - 170,879,775 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	170,731,807 - 170,879,769 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	170,557,307 - 170,705,275 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	170,423,145 - 170,570,973 (+)	NCBI		MGSCv36	mm8
Celera	2	176,688,120 - 176,839,591 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	92.26	NCBI

Dok5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	4,438,673 - 4,601,618 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	4,439,299 - 4,601,618 (-)	NCBI	ChiLan1.0	ChiLan1.0

DOK5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	60,220,386 - 60,395,866 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	50,821,093 - 50,996,536 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	52,042,915 - 52,217,846 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	52,042,491 - 52,217,846 (+)	Ensembl	panpan1.1		panPan2

DOK5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	40,156,235 - 40,282,059 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	40,130,265 - 40,282,249 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	39,373,809 - 39,526,644 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	40,842,571 - 40,995,459 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	40,842,594 - 40,995,459 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	40,078,376 - 40,230,790 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	40,219,720 - 40,372,625 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	40,930,261 - 41,031,259 (+)	NCBI		UU_Cfam_GSD_1.0

Dok5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	185,619,508 - 185,765,999 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	1,073,002 - 1,219,659 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936514	1,073,067 - 1,219,340 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOK5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	55,390,802 - 55,583,858 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	55,391,074 - 55,541,561 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	62,396,656 - 62,547,368 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DOK5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	9,404,105 - 9,571,663 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	9,403,813 - 9,571,476 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	57,514,278 - 57,682,131 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dok5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	1,722,555 - 1,881,392 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	1,725,478 - 1,881,416 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dok5
963 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	162
Count of miRNA genes:	126
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000017654
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat

Markers in Region

RH137435

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	159,647,850 - 159,648,057 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	168,476,422 - 168,476,628	NCBI	Rnor6.0
Rnor_5.0	3	174,575,588 - 174,575,794	UniSTS	Rnor5.0
Celera	3	158,866,506 - 158,866,712	UniSTS
Cytogenetic Map	3	q42	UniSTS

AU049402

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	168,387,084 - 168,387,374	NCBI	Rnor6.0
Celera	3	158,776,467 - 158,776,734	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		24	7	4	3	4	3	4	58		3		3
Low		19	15	10	5	10	5	7	16	16	35	8	5
Below cutoff	3		21	18	6	18				9	3	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC167027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017654 ⟹ ENSRNOP00000017654

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	159,515,893 - 159,652,802 (+)	Ensembl
Rnor_6.0 Ensembl	3	168,345,152 - 168,482,441 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107853 ⟹ ENSRNOP00000097604

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	159,516,061 - 159,624,638 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113584 ⟹ ENSRNOP00000089890

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	159,556,603 - 159,652,810 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118232 ⟹ ENSRNOP00000089667

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	159,516,135 - 159,652,761 (+)	Ensembl

RefSeq Acc Id:

NM_001109344 ⟹ NP_001102814

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	159,516,133 - 159,652,811 (+)	NCBI
Rnor_6.0	3	168,345,296 - 168,482,445 (+)	NCBI
Rnor_5.0	3	174,447,106 - 174,579,715 (+)	NCBI
RGSC_v3.4	3	161,654,964 - 161,729,978 (+)	RGD
Celera	3	158,734,945 - 158,869,891 (+)	RGD

Sequence:

show sequence

CACATCCCTCCTCGAAGCCACTCAGGGTGCCTGCCTCGCGCACGCTAGGGCAGCAGGGTCACTG
TCTGTCTGGGATGGCTTCCAATTTTAATGACATAGTGAAGCAGGGGTACGTGAGGATCCGGAGC
AGACGCCTAGGGATTTATCAGCGATGCTGGTTAGTGTTCAAGAAAGCTTCCAGCAAGGGTCCAA
AGAGACTGGAGAAGTTCTCAGATGAACGGGCTGCGTACTTCAGGTGTTACCACAAGGTTACAGA
ACTCAACAATGTGAAAAACGTAGCCCGGTTGCCAAAGAGCACCAAGAAACATGCTATAGGGATT
TATTTCAATGATGACACCTCGAAGACCTTTGCTTGTGAATCAGATCTTGAGGCAGACGAATGGT
GCAAGGTTCTCCAGATAGAGTGTGTGGGGACCAGAATCAATGACATCAGCCTCGGAGAACCTGA
CTTATTGGCCACTGGGGTGGAACGAGAACAGAGCGAGAGATTCAATGTGTATTTGATGCCATCT
CCTAACTTAGATGTACATGGCGAATGTGCCTTGCAGATTACATATGAGTACATCTGTCTTTGGG
ACATCCAGAATCCCAGAGTTAAACTCATCTCTTGGCCGCTAAGTGCCCTGCGGCGGTATGGACG
TGACACCACGTGGTTCACTTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGATTATTTATT
TTTCAAACACGAGACGGCGAGGCCATCTACCAGAAGGTCCACTCTGCTGCCTTGGCCATAGCTG
AGCAGCACGAACGCTTGCTGCAGAGCGTGAAGAATTCAATGCTCCAGATGAAGAAGAGTGAGCG
GGCGGCCTCGCTGAACACCGTGGTGCCCCTGCCCCGCAGTGCCTACTGGCAGCACATCACGAGG
CAGCACAGCACAGGGCAGCTGTACCACCTACAAGATGTCACCAGCCCTCTGAAGCTTCATCGGA
CAGAGACTTTCCCAACCTACCGGTCCGAGCACTGACAGCAACCGCCAAGAGCTGTTAGCACACT
TGTGCCGTATCAGCCACAGATCCACGTGCAGGAGGACGCAGAGGGACAGCCAGGGAGAGCGCAG
AATGTGGAGAAGCGGCTTTGCACCCTGCTAACATGTGTGGCCATGGGAAATGCTACGGAACAAC
GTCTGTACATAAAATTTCCCCCCTTTCCCTTCTTTTTTTTTTGTTTTCCTTTTCTTTTTTTTTA
AAGATACAGCCCTAACCTCACAGAAACATGCCGGATTATATCAACCCACCCTGTTTTTATAGCC
AGACAGAAGGAGTCGGTGTCGCTACTACGGACTGATTTTCTATGGGTGACAGGTGCCCCCTTGT
GCCTCTCTGAGTCTGTCCTTTTGTGGATGTGTGTGATTCTCCTTGTAAGTGTTTCAGTTGTAAG
ACAGTCAACATGGACAATAAAATGCCTCTTCAGTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006235673 ⟹ XP_006235735

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	159,515,886 - 159,624,676 (+)	NCBI
Rnor_6.0	3	168,345,116 - 168,453,945 (+)	NCBI
Rnor_5.0	3	174,447,106 - 174,579,715 (+)	NCBI

Sequence:

show sequence

TGACGCCGCGCTCCAGTCTCGCCTCCCGCCGCTCTCCCCCAAAGTGGCTGCTGGGCGCCGGCGG
GCCGCCCACTTTCAGGCTTTGGGGAGACAGGGAAAGCGATGTGCGCCTTCTGACGTCTGGTTTC
ACCGCATCACCTTGTCAACTTTCACTCCCTTAGTCTCTGTCCAGACCCTCCCCACATCCCTCCT
CGAAGCCACTCAGGGTGCCTGCCTCGCGCACGCTAGGGCAGCAGGGTCACTGTCTGTCTGGGAT
GGCTTCCAATTTTAATGACATAGTGAAGCAGGGGTACGTGAGGATCCGGAGCAGACGCCTAGGG
ATTTATCAGCGATGCTGGTTAGTGTTCAAGAAAGCTTCCAGCAAGGGTCCAAAGAGACTGGAGA
AGTTCTCAGATGAACGGGCTGCGTACTTCAGGTGTTACCACAAGGTTACAGAACTCAACAATGT
GAAAAACGTAGCCCGGTTGCCAAAGAGCACCAAGAAACATGCTATAGGGATTTATTTCAATGAT
GACACCTCGAAGACCTTTGCTTGTGAATCAGATCTTGAGGCAGACGAATGGTGCAAGGTTCTCC
AGATAGAGTGTGTGGGGACCAGAATCAATGACATCAGCCTCGGAGAACCTGACTTATTGGCCAC
TGGGGTGGAACGAGAACAGAGCGAGAGATTCAATGTGTATTTGATGCCATCTCCTAACTTAGAT
GTACATGGCGAATGTGCCTTGCAGATTACATATGAGTACATCTGTCTTTGGGACATCCAGAATC
CCAGAGTTAAACTCATCTCTTGGCCGCTAAGTGCCCTGCGGCGGTATGGACGTGACACCACGTG
GTTCACTTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGATTATTTATTTTTCAAACACGA
GACGGCGAGGCCATCTACCAGAAGGTCCACTCTGCTGCCTTGGCCATAGCTGAGCAGCACGAAC
GCTTGCTGCAGAGCGTGAAGAATTCAATGGTTATGATGTTAGACAGACAGGGCCCTGCACTGGA
AGAGACTGCTTCACTCACGGTTTTGACCTGGAAGAAAGAAACCACCACCTCCTGCTGTACACTG
TACGAGAAAAGCGAGGTTCAAACCGGATCATTTGTCTGCAGCAATGGAGGCCTGATGTTCTTGG
AGCCTGGAATTCTGGGCAGTTTTGTCTGATTCCAACTCCTGTACGATTCTCTACGCTGTCTTGA
AGCATTAAAGATCCATCTGCTCAGTGCTTTCCAGTCTGACTCGCTTCCAAATCTCCCTCAGTAT
CGGAGCACCTCCCCCCAAACAACTGTTCATGTATAAAAAATAAATGAATTATTAAGGAGAGGTC
TGGGAGATGGCTCTGCCTGCAAAGTGCTAGACTTGCAAGCTTGAGGCTCGAAGGAAGGGCCATC
TCCAGAACCACATTCAAAAAACACAAAACTAGTGTGCTGGCCCAAGCTGGGAATCCTCCTCTGG
GGAGGCAGACAGGTGGAGCCATAAGCCTTGCTGGCCGGCCAACCTAGCGTAATATTAGCATGGT
CCAGGCCAATGAAAGAAGGAGTCTTAAATACATGGTGGAAAGTGTTGGAGAATGTCTTCTCACC
TTCACACTCATGTGCGTGCATGTACATCCGCGCACAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102814	(Get FASTA)	NCBI Sequence Viewer
	XP_006235735	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67027	(Get FASTA)	NCBI Sequence Viewer
	EDL85164	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102814 ⟸ NM_001109344

- UniProtKB:

B2RZ51 (UniProtKB/TrEMBL), F1LMM0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNN
VKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQIECVGTRINDISLGEPDLLA
TGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDIQNPRVKLISWPLSALRRYGRDTT
WFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKKSERAAS
LNTVVPLPRSAYWQHITRQHSTGQLYHLQDVTSPLKLHRTETFPTYRSEH

hide sequence

RefSeq Acc Id:	XP_006235735 ⟸ XM_006235673
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AWK3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNN VKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQIECVGTRINDISLGEPDLLA TGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDIQNPRVKLISWPLSALRRYGRDTT WFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMVMMLDRQGPAL EETASLTVLTWKKETTTSCCTLYEKSEVQTGSFVCSNGGLMFLEPGILGSFV hide sequence

RefSeq Acc Id:

ENSRNOP00000017654 ⟸ ENSRNOT00000017654

RefSeq Acc Id:

ENSRNOP00000089890 ⟸ ENSRNOT00000113584

RefSeq Acc Id:

ENSRNOP00000089667 ⟸ ENSRNOT00000118232

RefSeq Acc Id:

ENSRNOP00000097604 ⟸ ENSRNOT00000107853

Protein Domains

IRS-type PTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ51-F1-model_v2	AlphaFold	B2RZ51	1-306	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692703

Promoter ID:

EPDNEW_R3228

Type:

initiation region

Name:

Dok5_1

Description:

docking protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	168,345,133 - 168,345,193	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562846	AgrOrtholog
BioCyc Gene	G2FUF-46608	BioCyc
Ensembl Genes	ENSRNOG00000013196	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017654	ENTREZGENE
	ENSRNOP00000017654.6	UniProtKB/TrEMBL
	ENSRNOP00000089667.1	UniProtKB/TrEMBL
	ENSRNOP00000089890.1	UniProtKB/TrEMBL
	ENSRNOP00000097604	ENTREZGENE
	ENSRNOP00000097604.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017654	ENTREZGENE
	ENSRNOT00000017654.8	UniProtKB/TrEMBL
	ENSRNOT00000107853	ENTREZGENE
	ENSRNOT00000107853.1	UniProtKB/TrEMBL
	ENSRNOT00000113584.1	UniProtKB/TrEMBL
	ENSRNOT00000118232.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7315978	IMAGE-MGC_LOAD
InterPro	DOK4/5/6_PH	UniProtKB/TrEMBL
	Insln_rcpt_S1	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
KEGG Report	rno:502694	UniProtKB/TrEMBL
MGC_CLONE	MGC:189260	IMAGE-MGC_LOAD
NCBI Gene	502694	ENTREZGENE
PANTHER	DOCKING PROTEIN 5	UniProtKB/TrEMBL
	DOCKING PROTEIN RELATED	UniProtKB/TrEMBL
Pfam	IRS	UniProtKB/TrEMBL
PhenoGen	Dok5	PhenoGen
PROSITE	IRS_PTB	UniProtKB/TrEMBL
SMART	IRS	UniProtKB/TrEMBL
	PTBI	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
UniProt	A0A8I6A7S1_RAT	UniProtKB/TrEMBL
	A0A8I6A882_RAT	UniProtKB/TrEMBL
	A0A8I6AWK3	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ51	ENTREZGENE, UniProtKB/TrEMBL
	F1LMM0	ENTREZGENE
UniProt Secondary	F1LMM0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Dok5	docking protein 5	LOC690989	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)	Data Merged	737654	PROVISIONAL
2012-10-12	Dok5	docking protein 5	RGD1562846	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1562846	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)	RGD1562846_predicted	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5) (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-20	LOC690989	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1562846_predicted	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5) (predicted)	LOC502694	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502694	similar to Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5)			Symbol and Name status set to provisional	70820	PROVISIONAL

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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