Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
RGD ID: 1304659
Description: Predicted to have several functions, including guanyl-nucleotide exchange factor activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of organelle organization; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Localizes to glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2); PARTICIPATES IN Reelin signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GEF-H1; guanine nucleotide exchange factor H1; LOC310635; MGC95068; rho guanine nucleotide exchange factor 2; rho/rac guanine nucleotide exchange factor (GEF) 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,061,126 - 174,118,355 (+)NCBI
Rnor_6.0 Ensembl2187,977,008 - 188,021,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02187,964,100 - 188,022,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,366,791 - 207,423,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,748,313 - 180,775,656 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,698,418 - 180,725,761 (+)NCBI
Celera2168,035,282 - 168,062,671 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
flubendazole  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
mebendazole  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
thapsigargin  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IBA,ISO,ISS)
asymmetric neuroblast division  (ISO,ISS)
cell differentiation  (IEA)
cell division  (IEA)
cell morphogenesis  (IBA,ISO,ISS)
cellular hyperosmotic response  (ISO)
cellular response to muramyl dipeptide  (ISO,ISS)
cellular response to tumor necrosis factor  (ISO)
establishment of mitotic spindle orientation  (ISO)
innate immune response  (IEA)
intracellular signal transduction  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of microtubule depolymerization  (ISO,ISS)
negative regulation of necroptotic process  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of podosome assembly  (ISO)
nervous system development  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of interleukin-6 production  (ISO,ISS)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of neuron differentiation  (IBA,ISO,ISS)
positive regulation of neuron migration  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (ISO,ISS)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of tumor necrosis factor production  (ISO,ISS)
positive regulation of wound healing  (ISO)
regulation of catalytic activity  (IEA)
regulation of Rho protein signal transduction  (IBA,ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9857026   PMID:11912491   PMID:12477932   PMID:15996550   PMID:17114649   PMID:19043560   PMID:19448628   PMID:21352810   PMID:21423176   PMID:21525035   PMID:21887730   PMID:22711822  
PMID:23389627   PMID:23611588   PMID:23648943   PMID:24356971   PMID:25447939   PMID:26866809   PMID:27003208   PMID:28453519   PMID:30053369  


Genomics

Comparative Map Data
Arhgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,061,126 - 174,118,355 (+)NCBI
Rnor_6.0 Ensembl2187,977,008 - 188,021,377 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02187,964,100 - 188,022,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,366,791 - 207,423,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,748,313 - 180,775,656 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,698,418 - 180,725,761 (+)NCBI
Celera2168,035,282 - 168,062,671 (+)NCBICelera
Cytogenetic Map2q34NCBI
ARHGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1155,946,851 - 156,007,070 (-)EnsemblGRCh38hg38GRCh38
GRCh381155,946,851 - 155,991,262 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371155,916,645 - 155,949,408 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,183,269 - 154,214,575 (-)NCBINCBI36hg18NCBI36
Build 341152,729,718 - 152,761,024NCBI
Celera1128,989,509 - 129,021,228 (-)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,277,505 - 127,309,545 (-)NCBIHuRef
CHM1_11157,312,414 - 157,344,123 (-)NCBICHM1_1
Arhgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,500,427 - 88,556,839 (+)NCBIGRCm39mm39
GRCm39 Ensembl388,513,273 - 88,555,359 (+)Ensembl
GRCm38388,593,105 - 88,649,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,605,966 - 88,648,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,425,028 - 88,451,974 (+)NCBIGRCm37mm9NCBIm37
MGSCv36388,707,065 - 88,732,841 (+)NCBImm8
Celera388,660,982 - 88,688,007 (+)NCBICelera
Cytogenetic Map3F1NCBI
Arhgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,149,107 - 2,197,153 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,149,107 - 2,192,986 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,112,040 - 135,177,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,112,040 - 135,159,299 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,282,514 - 131,326,535 (-)NCBIMhudiblu_PPA_v0panPan3
ARHGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,835,322 - 41,850,488 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,812,353 - 41,850,488 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,324,784 - 41,340,572 (+)NCBI
ROS_Cfam_1.0741,671,709 - 41,718,518 (+)NCBI
UMICH_Zoey_3.1741,482,812 - 41,498,603 (+)NCBI
UNSW_CanFamBas_1.0741,536,462 - 41,552,253 (+)NCBI
UU_Cfam_GSD_1.0741,820,637 - 41,836,427 (+)NCBI
Arhgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,182,941 - 26,216,578 (-)NCBI
SpeTri2.0NW_0049365805,213,323 - 5,230,861 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,026,385 - 94,080,422 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,026,391 - 94,082,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,769,501 - 102,823,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,884,220 - 7,927,738 (+)NCBI
ChlSab1.1 Ensembl207,905,662 - 7,930,657 (+)Ensembl
Arhgef2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,314,885 - 1,362,730 (-)NCBI

Position Markers
D2Rat42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,110,900 - 174,111,027 (+)MAPPER
Rnor_6.02188,013,923 - 188,014,049NCBIRnor6.0
Rnor_5.02207,416,346 - 207,416,472UniSTSRnor5.0
RGSC_v3.42180,768,205 - 180,768,331UniSTSRGSC3.4
RGSC_v3.42180,768,203 - 180,768,626RGDRGSC3.4
RGSC_v3.12180,718,311 - 180,718,437RGD
Celera2168,055,216 - 168,055,342UniSTS
RH 3.4 Map21154.8RGD
RH 3.4 Map21154.8UniSTS
RH 2.0 Map2504.6RGD
SHRSP x BN Map270.0198RGD
FHH x ACI Map276.5599RGD
Cytogenetic Map2q34UniSTS
RH141382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,902 - 174,118,091 (+)MAPPER
Rnor_6.02188,020,925 - 188,021,113NCBIRnor6.0
Rnor_5.02207,423,349 - 207,423,537UniSTSRnor5.0
RGSC_v3.42180,775,208 - 180,775,396UniSTSRGSC3.4
Celera2168,062,223 - 168,062,411UniSTS
RH 3.4 Map21155.2UniSTS
Cytogenetic Map2q34UniSTS
RH134330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,992 - 174,118,208 (+)MAPPER
Rnor_6.02188,021,015 - 188,021,230NCBIRnor6.0
Rnor_5.02207,423,439 - 207,423,654UniSTSRnor5.0
RGSC_v3.42180,775,298 - 180,775,513UniSTSRGSC3.4
Celera2168,062,313 - 168,062,528UniSTS
RH 3.4 Map21154.3UniSTS
Cytogenetic Map2q34UniSTS
RH124802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,117,995 - 174,118,105 (+)MAPPER
Rnor_6.02188,021,018 - 188,021,127NCBIRnor6.0
Rnor_5.02207,423,442 - 207,423,551UniSTSRnor5.0
RGSC_v3.42180,775,301 - 180,775,410UniSTSRGSC3.4
Celera2168,062,316 - 168,062,425UniSTS
Cytogenetic Map2q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256244671217498710Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828049217498710Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828236243550655Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)275687495221880419Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278321410217498710Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283754907237610852Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283819608239166203Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283819608243901375Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2116075644228737869Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2116075644228737869Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2118446646200453484Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2118446646200453484Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2118446646227707979Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2118446793228582621Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2138901276217498710Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2140566078217498545Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141583337217498710Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2142053350204585731Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2142053350228984665Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143447078188447078Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147122993240020001Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2147122993240020001Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2147522550217498710Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2149114878225501939Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2149614466205573168Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2149614466205573168Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2149614623198704357Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557237742948Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557254121739Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)2157914311204022555Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2157914409217498545Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2158159186217498710Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2158159186217498710Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2159585731204585731Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2161745602206745602Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2169852670207612467Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2169852670243026643Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2169852800217498545Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2172795683189857032Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2172795683189857032Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2172795683189857032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2172795683189857032Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2172795683189857032Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2172795683189857032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2172795683199696953Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2172795683199696953Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2172795683199696953Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2172795683199696953Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2172795683199696953Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2174160958219160958Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2175403337239166203Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2177339806222339806Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2177680772243901375Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2181522444226522444Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2181987080199696953Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2181990297240020001Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2183984665228984665Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2184730446229730446Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2184730446229730446Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2186611811189857032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2186611811198704485Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2186889035189857032Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:409
Count of miRNA genes:217
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000027182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 16 6 19 6 2 2 74 34 41 11 2
Low 41 35 35 6 9 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000027182   ⟹   ENSRNOP00000027182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,993,758 - 188,021,377 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081531   ⟹   ENSRNOP00000071595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,977,008 - 188,020,424 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2188,015,141 - 188,016,255 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092819   ⟹   ENSRNOP00000076041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,990,242 - 188,005,855 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092951   ⟹   ENSRNOP00000076060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,977,012 - 188,002,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093016   ⟹   ENSRNOP00000076058
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,988,995 - 188,006,094 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093033   ⟹   ENSRNOP00000076068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,988,925 - 188,021,377 (+)Ensembl
RefSeq Acc Id: NM_001012079   ⟹   NP_001012079
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,090,776 - 174,118,351 (+)NCBI
Rnor_6.02187,993,798 - 188,021,373 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
RGSC_v3.42180,748,313 - 180,775,656 (+)RGD
Celera2168,035,282 - 168,062,671 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232643   ⟹   XP_006232705
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,061,127 - 174,118,355 (+)NCBI
Rnor_6.02187,964,100 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232644   ⟹   XP_006232706
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,964,100 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232646   ⟹   XP_006232708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,075,324 - 174,118,355 (+)NCBI
Rnor_6.02187,978,376 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232647   ⟹   XP_006232709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,977,198 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232648   ⟹   XP_006232710
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,978,398 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232651   ⟹   XP_006232713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,098,730 - 174,118,355 (+)NCBI
Rnor_6.02188,001,773 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232652   ⟹   XP_006232714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,091,031 - 174,118,355 (+)NCBI
Rnor_6.02187,993,974 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232653   ⟹   XP_006232715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,995,193 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232654   ⟹   XP_006232716
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,994,239 - 188,022,847 (+)NCBI
Rnor_5.02207,366,791 - 207,423,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761152   ⟹   XP_008759374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,085,675 - 174,118,355 (+)NCBI
Rnor_6.02187,988,028 - 188,022,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590882   ⟹   XP_017446371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,061,126 - 174,118,355 (+)NCBI
Rnor_6.02187,977,007 - 188,022,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590883   ⟹   XP_017446372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,998,583 - 188,022,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102312   ⟹   XP_038958240
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,072,272 - 174,118,355 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012079   ⟸   NM_001012079
- UniProtKB: Q5FVC2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232706   ⟸   XM_006232644
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006232705   ⟸   XM_006232643
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232709   ⟸   XM_006232647
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006232708   ⟸   XM_006232646
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006232710   ⟸   XM_006232648
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006232714   ⟸   XM_006232652
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006232716   ⟸   XM_006232654
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006232715   ⟸   XM_006232653
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006232713   ⟸   XM_006232651
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008759374   ⟸   XM_008761152
- Peptide Label: isoform X5
- UniProtKB: A0A1B0GWY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446371   ⟸   XM_017590882
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017446372   ⟸   XM_017590883
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000076041   ⟸   ENSRNOT00000092819
RefSeq Acc Id: ENSRNOP00000076060   ⟸   ENSRNOT00000092951
RefSeq Acc Id: ENSRNOP00000071595   ⟸   ENSRNOT00000081531
RefSeq Acc Id: ENSRNOP00000076068   ⟸   ENSRNOT00000093033
RefSeq Acc Id: ENSRNOP00000076058   ⟸   ENSRNOT00000093016
RefSeq Acc Id: ENSRNOP00000027182   ⟸   ENSRNOT00000027182
RefSeq Acc Id: XP_038958240   ⟸   XM_039102312
- Peptide Label: isoform X1
Protein Domains
DH   PH   Phorbol-ester/DAG-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691452
Promoter ID:EPDNEW_R1973
Type:multiple initiation site
Name:Arhgef2_3
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1975  EPDNEW_R1974  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,977,008 - 187,977,068EPDNEW
RGD ID:13691454
Promoter ID:EPDNEW_R1974
Type:single initiation site
Name:Arhgef2_1
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1975  EPDNEW_R1973  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,988,925 - 187,988,985EPDNEW
RGD ID:13691450
Promoter ID:EPDNEW_R1975
Type:multiple initiation site
Name:Arhgef2_2
Description:Rho/Rac guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1973  EPDNEW_R1974  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,993,781 - 187,993,841EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
2 207379792 207379793 A G snv SR/JrHsd (MCW)
2 207409692 207409693 C T snv LEC/Tj (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304659 AgrOrtholog
Ensembl Genes ENSRNOG00000020027 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027182 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071595 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076041 UniProtKB/TrEMBL
  ENSRNOP00000076058 UniProtKB/TrEMBL
  ENSRNOP00000076060 UniProtKB/TrEMBL
  ENSRNOP00000076068 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027182 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081531 UniProtKB/TrEMBL
  ENSRNOT00000092819 UniProtKB/TrEMBL
  ENSRNOT00000092951 UniProtKB/TrEMBL
  ENSRNOT00000093016 UniProtKB/TrEMBL
  ENSRNOT00000093033 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125049 IMAGE-MGC_LOAD
InterPro ARHGEF2_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310635 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95068 IMAGE-MGC_LOAD
NCBI Gene 310635 ENTREZGENE
Pfam C1_1 UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef2 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0V4 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GWW1_RAT UniProtKB/TrEMBL
  A0A1B0GWX6_RAT UniProtKB/TrEMBL
  A0A1B0GWX8_RAT UniProtKB/TrEMBL
  A0A1B0GWY5 ENTREZGENE, UniProtKB/TrEMBL
  ARHG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef2  Rho/Rac guanine nucleotide exchange factor 2  Arhgef2  rho/rac guanine nucleotide exchange factor (GEF) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Arhgef2  rho/rac guanine nucleotide exchange factor (GEF) 2  Arhgef2_predicted  rho/rac guanine nucleotide exchange factor (GEF) 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Arhgef2_predicted  rho/rac guanine nucleotide exchange factor (GEF) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED