Gene: Prps1 (phosphoribosyl pyrophosphate synthetase 1) Rattus norvegicus
Analyze
Symbol:
Prps1
Name:
phosphoribosyl pyrophosphate synthetase 1
Description:
Exhibits several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Localizes to the ribose phosphate diphosphokinase complex. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked nonsyndromic deafness; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PARTICIPATES IN de novo purine biosynthetic pathway; pentose phosphate pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; PRS-I; ribose-phosphate pyrophosphokinase 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):
Prps1 (phosphoribosyl pyrophosphate synthetase 1) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Prps1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Prps1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1) HGNC
OrthoDB, Panther
Homo sapiens (human):
PRPS2 (phosphoribosyl pyrophosphate synthetase 2) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Prps1 (phosphoribosyl pyrophosphate synthetase 1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Homo sapiens (human):
PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, OMA, OrthoFinder, PANTHER)
Mus musculus (house mouse):
Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
prps1b (phosphoribosyl pyrophosphate synthetase 1B)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Caenorhabditis elegans (roundworm):
R151.2
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG6767
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
PRS2
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
PRS3
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
PRS4
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 111,798,233 - 111,820,270 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 111,798,233 - 111,820,266 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 52,779,462 - 52,801,499 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 128,249,843 - 128,271,893 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 128,323,278 - 128,345,324 (+) NCBI Celera 3 43,777,612 - 43,799,661 (-) NCBI Celera Cytogenetic Map X q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:24528855 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:28492532 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:25741868 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:17701896 , PMID:8498830 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:25741868 , PMID:28492532 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:301835 ClinVar PMID:22246954 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:301835 ClinVar Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:301835 ClinVar PMID:17701896 Arts syndrome ISO RGD:736625 8554872 ClinVar Annotator: match by term: Arts syndrome ClinVar PMID:24033266 more ... autistic disorder ISO RGD:736625 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth, X-linked ClinVar PMID:25741868 , PMID:28492532 Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth, X-linked ClinVar PMID:24033266 more ... Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy X ClinVar PMID:24033266 , PMID:28492532 Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy X ClinVar PMID:17701900 more ... Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy X ClinVar PMID:20301734 more ... Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy X ClinVar PMID:28492532 Charcot-Marie-Tooth disease type X ISO RGD:736625 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth, X-linked ClinVar Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:311070 ClinVar PMID:24285972 Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 8554872 ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH NEUROPATHY, X-LINKED RECESSIVE, 5 ClinVar PMID:17701900 more ... Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:311070 ClinVar PMID:25182139 Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:311070 ClinVar PMID:17701900 Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:311070 ClinVar PMID:25491489 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, high-frequency sensorineural, X-linked ClinVar PMID:24528855 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by null ClinVar PMID:20021999 , PMID:8968763 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by null ClinVar PMID:20021999 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by null ClinVar PMID:25182139 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by null ClinVar PMID:10503584 , PMID:20021999 Deafness, High-Frequency Sensorineural, X-Linked ISO RGD:736625 8554872 ClinVar Annotator: match by null ClinVar PMID:15240907 , PMID:20021999 esophageal atresia ISO RGD:736625 8554872 ClinVar Annotator: match by term: Esophageal atresia ClinVar fundus dystrophy ISO RGD:736625 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar PMID:28967191 genetic disease ISO RGD:736625 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:12847698 more ... genetic disease ISO RGD:736625 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:12847698 more ... Hearing Loss ISO RGD:736625 8554872 ClinVar Annotator: match by term: Nonsyndromic Hearing Loss, X-Linked ClinVar PMID:24033266 more ... Hearing Loss ISO RGD:736625 8554872 ClinVar Annotator: match by term: Nonsyndromic Hearing Loss, Recessive ClinVar PMID:28492532 Hearing Loss ISO RGD:736625 8554872 ClinVar Annotator: match by term: Nonsyndromic Hearing Loss, X-Linked ClinVar PMID:25741868 , PMID:28492532 Hearing Loss ISO RGD:736625 8554872 ClinVar Annotator: match by term: Nonsyndromic Hearing Loss, X-Linked ClinVar phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:24033266 more ... phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:28492532 phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:12847698 more ... phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:25741868 , PMID:28492532 phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:7593598 , PMID:8253776 phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity ClinVar PMID:171280 phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 8554872 ClinVar Annotator: match by OMIM:300661 ClinVar syndromic X-linked intellectual disability Lubs type ISO RGD:736625 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:10503584 , PMID:20021999 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:20021999 , PMID:8968763 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:15240907 , PMID:20021999 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:24528855 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:20021999 X-linked deafness 1 ISO RGD:736625 8554872 ClinVar Annotator: match by term: Deafness, X-linked 1 ClinVar PMID:25182139
Imported Annotations - CTD
Weight Gain ISO RGD:736625 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19030233 Imported Annotations - MGI
X-linked nonsyndromic deafness ISS RGD:736625 13592920 OMIM:300030 more ... MouseDO Imported Annotations - OMIM
Arts syndrome ISO RGD:736625 7240710 OMIM Charcot-Marie-Tooth disease X-linked recessive 5 ISO RGD:736625 7240710 OMIM phosphoribosylpyrophosphate synthetase superactivity ISO RGD:736625 7240710 OMIM X-linked deafness 1 ISO RGD:736625 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRPS1 mRNA] CTD PMID:31150632 (S)-nicotine increases splicing ISO RGD:736625 6480464 Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 (Z)-3-butylidenephthalide decreases expression ISO RGD:736625 6480464 butylidenephthalide results in decreased expression of PRPS1 protein CTD PMID:23770345 17alpha-ethynylestradiol affects expression ISO RGD:62248 6480464 Ethinyl Estradiol affects the expression of PRPS1 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:736625 6480464 Estradiol results in increased expression of PRPS1 mRNA CTD PMID:19619570 17beta-estradiol multiple interactions ISO RGD:736625 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PRPS1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736625 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PRPS1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PRPS1 mRNA CTD PMID:26232522 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736625 6480464 Tetrachlorodibenzodioxin results in increased expression of PRPS1 mRNA CTD PMID:19619570 , PMID:22903824 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62248 6480464 Tetrachlorodibenzodioxin affects the expression of PRPS1 mRNA CTD PMID:21570461 3-methylcholanthrene multiple interactions ISO RGD:736625 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter] CTD PMID:20348232 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of PRPS1 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression ISO RGD:62248 6480464 Fenretinide results in decreased expression of PRPS1 mRNA CTD PMID:28973697 5-fluorouracil increases expression ISO RGD:736625 6480464 Fluorouracil results in increased expression of PRPS1 mRNA CTD PMID:16584549 afimoxifene increases expression ISO RGD:736625 6480464 afimoxifene results in increased expression of PRPS1 mRNA CTD PMID:16849584 aflatoxin B1 decreases expression ISO RGD:736625 6480464 Aflatoxin B1 results in decreased expression of PRPS1 mRNA CTD PMID:22100608 all-trans-retinoic acid decreases expression ISO RGD:736625 6480464 Tretinoin results in decreased expression of PRPS1 mRNA CTD PMID:15498508 , PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PRPS1 mRNA CTD PMID:16483693 arsane increases methylation ISO RGD:736625 6480464 Arsenic results in increased methylation of PRPS1 promoter CTD PMID:21291286 arsenic atom increases methylation ISO RGD:736625 6480464 Arsenic results in increased methylation of PRPS1 promoter CTD PMID:21291286 arsenous acid decreases expression ISO RGD:736625 6480464 Arsenic Trioxide results in decreased expression of PRPS1 protein CTD PMID:25419056 arsenous acid increases expression ISO RGD:736625 6480464 Arsenic Trioxide results in increased expression of PRPS1 mRNA CTD PMID:20458559 benzo[a]pyrene increases expression ISO RGD:62248 6480464 Benzo(a)pyrene results in increased expression of PRPS1 mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of PRPS1 mRNA CTD PMID:25031359 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PRPS1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:736625 6480464 bisphenol A results in decreased expression of PRPS1 mRNA CTD PMID:31121516 butan-1-ol multiple interactions ISO RGD:736625 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PRPS1 mRNA CTD PMID:29432896 butanal increases expression ISO RGD:736625 6480464 butyraldehyde results in increased expression of PRPS1 mRNA CTD PMID:26079696 cadmium dichloride decreases expression ISO RGD:736625 6480464 Cadmium Chloride results in decreased expression of PRPS1 mRNA CTD PMID:25596134 chloroacetaldehyde increases expression ISO RGD:736625 6480464 chloroacetaldehyde results in increased expression of PRPS1 mRNA CTD PMID:25596134 cidofovir anhydrous increases expression ISO RGD:736625 6480464 Cidofovir results in increased expression of PRPS1 mRNA CTD PMID:25596134 clofibrate decreases expression ISO RGD:62248 6480464 Clofibrate results in decreased expression of PRPS1 mRNA CTD PMID:17585979 cyclosporin A increases expression ISO RGD:736625 6480464 Cyclosporine results in increased expression of PRPS1 mRNA CTD PMID:20106945 , PMID:25596134 diarsenic trioxide increases expression ISO RGD:736625 6480464 Arsenic Trioxide results in increased expression of PRPS1 mRNA CTD PMID:20458559 diarsenic trioxide decreases expression ISO RGD:736625 6480464 Arsenic Trioxide results in decreased expression of PRPS1 protein CTD PMID:25419056 dibutyl phthalate decreases expression ISO RGD:62248 6480464 Dibutyl Phthalate results in decreased expression of PRPS1 mRNA CTD PMID:21266533 dioxygen decreases expression ISO RGD:736625 6480464 Oxygen deficiency results in decreased expression of PRPS1 mRNA CTD PMID:25596134 dorsomorphin multiple interactions ISO RGD:736625 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRPS1 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:736625 6480464 Doxorubicin results in decreased expression of PRPS1 mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:736625 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRPS1 protein CTD PMID:23301498 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of PRPS1 protein CTD PMID:19609968 ethanol affects splicing ISO RGD:62248 6480464 Ethanol affects the splicing of PRPS1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:62248 6480464 Ethanol results in increased expression of PRPS1 mRNA CTD PMID:30319688 finasteride decreases expression EXP 6480464 Finasteride results in decreased expression of PRPS1 protein CTD PMID:27750143 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PRPS1 mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:736625 6480464 Formaldehyde results in decreased expression of PRPS1 mRNA CTD PMID:23649840 genistein multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of PRPS1 mRNA CTD PMID:25031359 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of PRPS1 mRNA CTD PMID:22641619 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of PRPS1 mRNA CTD PMID:24136188 nicotine increases splicing ISO RGD:736625 6480464 Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of PRPS1 mRNA CTD PMID:24136188 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRPS1 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:62248 6480464 Acetaminophen affects the expression of PRPS1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:736625 6480464 Acetaminophen results in decreased expression of PRPS1 mRNA CTD PMID:26690555 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of PRPS1 mRNA CTD PMID:19162173 phenylmercury acetate decreases expression ISO RGD:736625 6480464 Phenylmercuric Acetate results in decreased expression of PRPS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736625 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRPS1 mRNA CTD PMID:27188386 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of PRPS1 mRNA CTD PMID:19162173 piroxicam decreases expression ISO RGD:736625 6480464 Piroxicam results in decreased expression of PRPS1 mRNA CTD PMID:21858171 SB 431542 multiple interactions ISO RGD:736625 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRPS1 mRNA CTD PMID:27188386 sodium arsenite increases expression ISO RGD:736625 6480464 sodium arsenite results in increased expression of PRPS1 mRNA CTD PMID:28595984 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PRPS1 protein CTD PMID:29459688 sunitinib decreases expression ISO RGD:736625 6480464 Sunitinib results in decreased expression of PRPS1 mRNA CTD PMID:31533062 tamibarotene affects expression ISO RGD:736625 6480464 tamibarotene affects the expression of PRPS1 mRNA CTD PMID:15498508 tamoxifen affects expression ISO RGD:62248 6480464 Tamoxifen affects the expression of PRPS1 mRNA CTD PMID:17555576 tetrachloromethane increases expression ISO RGD:62248 6480464 Carbon Tetrachloride results in increased expression of PRPS1 mRNA CTD PMID:27339419 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRPS1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PRPS1 mRNA CTD PMID:31150632 thapsigargin decreases expression ISO RGD:736625 6480464 Thapsigargin results in decreased expression of PRPS1 mRNA CTD PMID:22378314 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRPS1 mRNA CTD PMID:25729387 trimellitic anhydride increases expression ISO RGD:62248 6480464 trimellitic anhydride results in increased expression of PRPS1 mRNA CTD PMID:19042947 tunicamycin decreases expression ISO RGD:736625 6480464 Tunicamycin results in decreased expression of PRPS1 mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:736625 6480464 Urethane results in decreased expression of PRPS1 mRNA CTD PMID:28818685 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of PRPS1 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:62248 6480464 Valproic Acid affects the expression of PRPS1 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:736625 6480464 Valproic Acid results in increased expression of PRPS1 mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:736625 6480464 Valproic Acid affects the expression of PRPS1 mRNA CTD PMID:25979313
Biological Process 5-phosphoribose 1-diphosphate biosynthetic process IDA 5134981 RGD 5-phosphoribose 1-diphosphate biosynthetic process IBA PANTHER:PTN000025022 more ... 13792537 PMID:21873635 GO_Central 5-phosphoribose 1-diphosphate biosynthetic process IEA UniPathway:UPA00087 1600115 GO_REF:0000041 UniProt GO_REF:0000041 AMP biosynthetic process IDA 5134985 RGD animal organ regeneration IEP 633743 RGD hypoxanthine biosynthetic process ISO RGD:736625 1624291 (PMID:17701896) RGD PMID:17701896 nervous system development ISO RGD:736625 1624291 (PMID:17701900), (PMID:8253776) RGD PMID:17701900 , PMID:8253776 nucleoside metabolic process IEA InterPro:IPR000836 1600115 GO_REF:0000002 InterPro GO_REF:0000002 nucleotide biosynthetic process IDA 1599724 RGD nucleotide biosynthetic process IBA PANTHER:PTN000025022 more ... 13792537 PMID:21873635 GO_Central phosphorylation IEA UniProtKB-KW:KW-0418 1600115 GO_REF:0000043 UniProt GO_REF:0000043 purine nucleobase metabolic process ISO RGD:736625 1624291 (PMID:8253776) RGD PMID:8253776 purine nucleotide biosynthetic process ISO RGD:736625 1624291 (PMID:12847698) RGD PMID:12847698 purine nucleotide biosynthetic process IBA PANTHER:PTN000025022 , UniProtKB:P60891 13792537 PMID:21873635 GO_Central ribose phosphate metabolic process IDA 2291920 ; 2291928 RGD urate biosynthetic process ISO RGD:736625 1624291 (PMID:12847698) RGD PMID:12847698 Cellular Component cytoplasm IBA PANTHER:PTN000025022 more ... 13792537 PMID:21873635 GO_Central protein-containing complex IDA 5134985 ; 2291928 RGD ribose phosphate diphosphokinase complex IDA 5134985 RGD ribose phosphate diphosphokinase complex IBA PANTHER:PTN000025022 more ... 13792537 PMID:21873635 GO_Central Molecular Function ADP binding IDA 2291920 ; 2291928 RGD AMP binding IDA 2291920 ; 2291928 ; 1599724 RGD ATP binding IDA 2291920 ; 2291928 ; 1599724 ; 5134985 RGD ATP binding ISS UniProtKB:P60891 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ATP binding IBA PANTHER:PTN000811384 more ... 13792537 PMID:21873635 GO_Central ATP binding ISO RGD:736625 1624291 (PMID:16939420) RGD PMID:16939420 carbohydrate binding IDA 2291920 ; 2291928 ; 1599724 ; 5134985 RGD GDP binding IDA 2291920 ; 2291928 ; 1599724 RGD identical protein binding ISO RGD:736625 1624291 UniProtKB:P60891 (PMID:16189514), (PMID:25416956), (PMID:25502805), (PMID:25910212), (PMID:31515488) RGD PMID:16189514 more ... kinase activity IEA UniProtKB-KW:KW-0418 1600115 GO_REF:0000043 UniProt GO_REF:0000043 magnesium ion binding IDA 2291920 ; 2291928 ; 1599724 RGD protein binding IPI RGD:620206 5134981 RGD protein binding ISO RGD:736625 1624291 UniProtKB:O60256 more ... RGD PMID:16189514 more ... protein homodimerization activity ISO RGD:736625 1624291 UniProtKB:P60891 (PMID:16939420) RGD PMID:16939420 protein homodimerization activity ISS UniProtKB:P60891 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ribose phosphate diphosphokinase activity IDA 2291920 ; 2291928 ; 1599724 ; 5134985 RGD ribose phosphate diphosphokinase activity ISO RGD:736625 1624291 (PMID:12847698), (PMID:16939420), (PMID:17701896), (PMID:17701900) RGD PMID:12847698 more ... ribose phosphate diphosphokinase activity IBA PANTHER:PTN000025022 more ... 13792537 PMID:21873635 GO_Central ribose phosphate diphosphokinase activity ISS UniProtKB:P60891 1600115 GO_REF:0000024 UniProt GO_REF:0000024
Gene-Chemical Interaction Annotations
