Lpgat1 (lysophosphatidylglycerol acyltransferase 1) - Rat Genome Database

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Gene: Lpgat1 (lysophosphatidylglycerol acyltransferase 1) Rattus norvegicus
Analyze
Symbol: Lpgat1
Name: lysophosphatidylglycerol acyltransferase 1
RGD ID: 1585897
Description: Predicted to enable 2-acylglycerol O-acyltransferase activity; 2-acylglycerophosphocholine O-acyltransferase activity; and lysophosphatidylethanolamine acyltransferase activity. Predicted to be involved in glycerolipid metabolic process and positive regulation of fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acyl-CoA:lysophosphatidylglycerol acyltransferase 1; LOC679692; similar to lysophosphatidylglycerol acyltransferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Lpgat1l1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,825,630 - 105,896,366 (+)NCBIGRCr8
mRatBN7.213103,294,622 - 103,365,372 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,294,528 - 103,362,333 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,815,783 - 105,882,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,199,634 - 107,266,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,414,724 - 104,481,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,397,353 - 110,470,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,398,800 - 110,467,834 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,962,169 - 115,028,639 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,782,231 - 107,851,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera13102,735,511 - 102,802,662 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
aristolochic acid A  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
thimerosal  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10942595   PMID:19946888   PMID:23749231  


Genomics

Comparative Map Data
Lpgat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,825,630 - 105,896,366 (+)NCBIGRCr8
mRatBN7.213103,294,622 - 103,365,372 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,294,528 - 103,362,333 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,815,783 - 105,882,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,199,634 - 107,266,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,414,724 - 104,481,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,397,353 - 110,470,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,398,800 - 110,467,834 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,962,169 - 115,028,639 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,782,231 - 107,851,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera13102,735,511 - 102,802,662 (+)NCBICelera
Cytogenetic Map13q27NCBI
LPGAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381211,743,457 - 211,830,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1211,743,457 - 211,830,763 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,916,799 - 212,004,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361209,984,952 - 210,070,737 (-)NCBINCBI36Build 36hg18NCBI36
Build 341208,306,723 - 208,392,509NCBI
Celera1185,143,875 - 185,229,750 (-)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1182,594,012 - 182,681,317 (-)NCBIHuRef
CHM1_11213,189,206 - 213,276,528 (-)NCBICHM1_1
T2T-CHM13v2.01210,989,592 - 211,076,889 (-)NCBIT2T-CHM13v2.0
Lpgat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,449,682 - 191,516,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,449,946 - 191,516,367 (+)EnsemblGRCm39 Ensembl
GRCm381191,717,554 - 191,784,255 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,717,834 - 191,784,255 (+)EnsemblGRCm38mm10GRCm38
MGSCv371193,541,903 - 193,608,134 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,419,112 - 193,479,245 (+)NCBIMGSCv36mm8
Celera1198,669,571 - 198,735,196 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.78NCBI
Lpgat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,441,316 - 5,522,546 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,441,923 - 5,506,575 (+)NCBIChiLan1.0ChiLan1.0
LPGAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,571,917 - 37,660,410 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,536,420 - 37,624,903 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,312,071 - 187,399,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,172,723 - 192,262,799 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,179,164 - 192,262,799 (-)Ensemblpanpan1.1panPan2
LPGAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,091,628 - 10,205,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,094,069 - 10,198,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha79,669,275 - 9,783,091 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.079,797,952 - 9,879,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl79,795,669 - 9,890,585 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.179,720,389 - 9,801,756 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.079,822,810 - 9,904,226 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.079,947,369 - 10,029,077 (-)NCBIUU_Cfam_GSD_1.0
Lpgat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,316,244 - 64,387,197 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,556,526 - 1,621,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,520,692 - 1,627,479 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPGAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,426,119 - 131,504,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,383,684 - 131,505,988 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,423,367 - 144,543,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPGAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,674,441 - 17,767,522 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,675,115 - 17,762,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,197,582 - 18,292,914 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpgat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,387,248 - 17,451,466 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,389,141 - 17,451,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpgat1
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:530
Count of miRNA genes:254
Interacting mature miRNAs:342
Transcripts:ENSRNOT00000064492
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
BE115526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213103,361,038 - 103,361,197 (+)MAPPERmRatBN7.2
Rnor_6.013110,466,540 - 110,466,698NCBIRnor6.0
Rnor_5.013115,027,345 - 115,027,503UniSTSRnor5.0
RGSC_v3.413107,850,059 - 107,850,217UniSTSRGSC3.4
Celera13102,801,368 - 102,801,526UniSTS
RH 3.4 Map13748.2UniSTS
Cytogenetic Map13q27UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 41 57 41 19 41 5 6 74 35 38 11 5
Low 2 2 3 5 3 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000064492   ⟹   ENSRNOP00000062474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13103,294,528 - 103,362,333 (+)Ensembl
Rnor_6.0 Ensembl13110,398,800 - 110,467,834 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094196   ⟹   ENSRNOP00000079025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13103,337,491 - 103,362,333 (+)Ensembl
RefSeq Acc Id: NM_001109376   ⟹   NP_001102846
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,826,825 - 105,893,327 (+)NCBI
mRatBN7.213103,295,821 - 103,362,333 (+)NCBI
Rnor_6.013110,398,800 - 110,467,834 (+)NCBI
Rnor_5.013114,962,169 - 115,028,639 (+)NCBI
RGSC_v3.413107,782,231 - 107,851,353 (+)RGD
Celera13102,735,511 - 102,802,662 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091090   ⟹   XP_038947018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,826,013 - 105,896,366 (+)NCBI
mRatBN7.213103,295,010 - 103,365,372 (+)NCBI
RefSeq Acc Id: XM_039091091   ⟹   XP_038947019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,825,630 - 105,896,366 (+)NCBI
mRatBN7.213103,294,626 - 103,365,372 (+)NCBI
RefSeq Acc Id: XM_063272597   ⟹   XP_063128667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,825,630 - 105,896,366 (+)NCBI
RefSeq Acc Id: XM_063272598   ⟹   XP_063128668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,826,373 - 105,896,366 (+)NCBI
RefSeq Acc Id: NP_001102846   ⟸   NM_001109376
- UniProtKB: A6JH01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062474   ⟸   ENSRNOT00000064492
RefSeq Acc Id: XP_038947019   ⟸   XM_039091091
- Peptide Label: isoform X1
- UniProtKB: A6JH01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947018   ⟸   XM_039091090
- Peptide Label: isoform X1
- UniProtKB: A6JH01 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079025   ⟸   ENSRNOT00000094196
RefSeq Acc Id: XP_063128667   ⟸   XM_063272597
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128668   ⟸   XM_063272598
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTX8-F1-model_v2 AlphaFold F1LTX8 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699120
Promoter ID:EPDNEW_R9645
Type:initiation region
Name:Lpgat1_1
Description:lysophosphatidylglycerol acyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013110,398,743 - 110,398,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585897 AgrOrtholog
BioCyc Gene G2FUF-16834 BioCyc
Ensembl Genes ENSRNOG00000004402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064492.2 UniProtKB/TrEMBL
  ENSRNOT00000094196.1 UniProtKB/TrEMBL
InterPro Acyltransf_C UniProtKB/TrEMBL
  Acyltransferase UniProtKB/TrEMBL
KEGG Report rno:679692 UniProtKB/TrEMBL
NCBI Gene 679692 ENTREZGENE
PANTHER 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED UniProtKB/TrEMBL
  ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1 UniProtKB/TrEMBL
Pfam Acyltransf_C UniProtKB/TrEMBL
  Acyltransferase UniProtKB/TrEMBL
PhenoGen Lpgat1 PhenoGen
RatGTEx ENSRNOG00000004402 RatGTEx
SMART PlsC UniProtKB/TrEMBL
Superfamily-SCOP Glycerol-3-phosphate (1)-acyltransferase UniProtKB/TrEMBL
UniProt A0A8I6G2Q6_RAT UniProtKB/TrEMBL
  A6JH01 ENTREZGENE, UniProtKB/TrEMBL
  F1LTX8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Lpgat1  lysophosphatidylglycerol acyltransferase 1  LOC683760  similar to lysophosphatidylglycerol acyltransferase 1  Data merged from RGD:1583334 1643240 APPROVED
2010-04-21 Lpgat1  lysophosphatidylglycerol acyltransferase 1  LOC679692  similar to lysophosphatidylglycerol acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679692  similar to lysophosphatidylglycerol acyltransferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683760  similar to lysophosphatidylglycerol acyltransferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL