Ifi44l (interferon-induced protein 44-like) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ifi44l (interferon-induced protein 44-like) Rattus norvegicus
Analyze
Symbol: Ifi44l
Name: interferon-induced protein 44-like
RGD ID: 1595861
Description: Predicted to be involved in immune response. Orthologous to human IFI44L (interferon induced protein 44 like); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: H28; histocompatibility 28; LOC310968; similar to histocompatibility 28
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,328,629 - 243,366,404 (+)NCBIGRCr8
mRatBN7.22240,668,742 - 240,706,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,668,713 - 240,706,359 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02256,948,722 - 256,979,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2256,964,860 - 256,978,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,622,784 - 275,657,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2232,607,742 - 232,643,820 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-phenylprop-2-enal  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
6alpha-methylprednisolone  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gadodiamide hydrate  (ISO)
gentamycin  (EXP)
hydroquinone  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
methcathinone  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11021531   PMID:21478870  


Genomics

Comparative Map Data
Ifi44l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,328,629 - 243,366,404 (+)NCBIGRCr8
mRatBN7.22240,668,742 - 240,706,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,668,713 - 240,706,359 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02256,948,722 - 256,979,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2256,964,860 - 256,978,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,622,784 - 275,657,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2232,607,742 - 232,643,820 (+)NCBICelera
Cytogenetic Map2q45NCBI
IFI44L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,620,448 - 78,646,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,619,902 - 78,646,145 (+)EnsemblGRCh38hg38GRCh38
GRCh37179,086,133 - 79,111,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,858,741 - 78,880,657 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,798,169 - 78,820,090NCBI
Celera177,325,610 - 77,351,345 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef177,217,681 - 77,243,415 (+)NCBIHuRef
CHM1_1179,202,478 - 79,228,218 (+)NCBICHM1_1
T2T-CHM13v2.0178,459,314 - 78,485,000 (+)NCBIT2T-CHM13v2.0
Ifi44l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,464,374 - 151,468,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,464,374 - 151,468,529 (-)EnsemblGRCm39 Ensembl
GRCm383151,758,737 - 151,762,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3151,758,737 - 151,762,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,421,701 - 151,425,855 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363151,696,123 - 151,700,277 (-)NCBIMGSCv36mm8
Celera3158,225,587 - 158,234,632 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map376.94NCBI
IFI44L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,249,515 - 148,275,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11147,405,954 - 147,431,788 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,833,514 - 77,855,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,914,137 - 79,936,095 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,914,051 - 79,936,084 (+)Ensemblpanpan1.1panPan2
IFI44L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1668,382,157 - 68,400,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,382,317 - 68,398,053 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha671,038,802 - 71,059,253 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0668,965,744 - 68,986,198 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1668,472,590 - 68,493,039 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0668,418,216 - 68,438,467 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0668,902,410 - 68,922,858 (-)NCBIUU_Cfam_GSD_1.0
Ifi44l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505889,846,825 - 89,865,805 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365715,357,203 - 5,376,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFI44L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6134,659,639 - 134,679,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16134,660,230 - 134,679,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26124,816,723 - 124,836,006 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFI44L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12054,563,728 - 54,586,018 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2054,561,775 - 54,586,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603362,941,726 - 62,963,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifi44l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474218,625,764 - 18,640,009 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ifi44l
526 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:123
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000073547, ENSRNOT00000075385
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat

Markers in Region
RH127622  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22240,706,118 - 240,706,323 (+)MAPPERmRatBN7.2
Rnor_6.02256,979,265 - 256,979,469NCBIRnor6.0
Rnor_5.02275,657,574 - 275,657,778UniSTSRnor5.0
Celera2232,643,512 - 232,643,716UniSTS
RH 3.4 Map21649.91UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000073547   ⟹   ENSRNOP00000064282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2240,668,713 - 240,706,359 (+)Ensembl
Rnor_6.0 Ensembl2256,964,860 - 256,978,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113466   ⟹   ENSRNOP00000091067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2240,668,775 - 240,706,359 (+)Ensembl
RefSeq Acc Id: NM_001427160   ⟹   NP_001414089
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,328,723 - 243,366,404 (+)NCBI
RefSeq Acc Id: XM_227820   ⟹   XP_227820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,328,629 - 243,366,402 (+)NCBI
mRatBN7.22240,668,742 - 240,706,425 (+)NCBI
Rnor_6.02256,948,722 - 256,979,573 (+)NCBI
Rnor_5.02275,622,784 - 275,657,880 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001414089 (Get FASTA)   NCBI Sequence Viewer  
  XP_227820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82477 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064282.2
  ENSRNOP00000091067.1
RefSeq Acc Id: XP_227820   ⟸   XM_227820
- Peptide Label: isoform X1
- UniProtKB: M0R4J5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064282   ⟸   ENSRNOT00000073547
Ensembl Acc Id: ENSRNOP00000091067   ⟸   ENSRNOT00000113466
RefSeq Acc Id: NP_001414089   ⟸   NM_001427160
- UniProtKB: A0A8I6AEX3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4J5-F1-model_v2 AlphaFold M0R4J5 1-443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595861 AgrOrtholog
BioCyc Gene G2FUF-50820 BioCyc
Ensembl Genes ENSRNOG00000049994 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073547.3 UniProtKB/TrEMBL
  ENSRNOT00000113466.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 310968 ENTREZGENE
PANTHER INTERFERON-INDUCED PROTEIN 44 UniProtKB/TrEMBL
  PTHR14241:SF2 UniProtKB/TrEMBL
PhenoGen Ifi44l PhenoGen
RatGTEx ENSRNOG00000049994 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AEX3 ENTREZGENE, UniProtKB/TrEMBL
  M0R4J5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Ifi44l  interferon-induced protein 44-like  H28  histocompatibility 28  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 H28  histocompatibility 28  LOC310968  similar to histocompatibility 28  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED