Il4r (interleukin 4 receptor) - Rat Genome Database

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Gene: Il4r (interleukin 4 receptor) Rattus norvegicus
Analyze
Symbol: Il4r
Name: interleukin 4 receptor
RGD ID: 2899
Description: Predicted to enable cytokine receptor activity. Involved in several processes, including ovulation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor); PARTICIPATES IN interleukin-4 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Il4ra; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eae31 Pia41
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,115,061 - 180,139,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,115,120 - 180,139,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,451,734 - 188,476,590 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01195,637,762 - 195,662,619 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01188,320,992 - 188,346,016 (+)NCBIRnor_WKY
Rnor_6.01196,942,343 - 196,967,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,942,364 - 196,967,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01203,927,969 - 203,952,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,612,903 - 184,637,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,762,783 - 184,787,741 (+)NCBI
Celera1177,784,627 - 177,809,190 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tolyl isocyanate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (ISO)
C60 fullerene  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
Monobutylphthalate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
phthalic anhydride  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
selenium atom  (ISO)
sildenafil citrate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium hexachloroplatinate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris. Al Robaee AA, etal., Ann Saudi Med. 2012 Jul-Aug;32(4):349-54.
2. Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform. Bergin AM, etal., Hum Mutat. 2006 Oct;27(10):990-8.
3. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. Borish LC, etal., J Allergy Clin Immunol. 2001 Jun;107(6):963-70.
4. Common variants in genes that mediate immunity and risk of multiple myeloma. Brown EE, etal., Int J Cancer. 2007 Jun 15;120(12):2715-22.
5. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Burton OT, etal., Mucosal Immunol. 2013 Jul;6(4):740-50. doi: 10.1038/mi.2012.112. Epub 2012 Nov 14.
6. Identification of soluble interleukin-4 receptor in rat glomerular epithelial cells(1). Chen G, etal., Biochim Biophys Acta 1999 Oct 13;1452(1):79-88.
7. Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma. Chu H, etal., Ann Oncol. 2012 Aug;23(8):2114-21. doi: 10.1093/annonc/mdr607. Epub 2012 Feb 8.
8. Polymorphisms in the IL-4 and IL-4R genes and allergic asthma. Cui T, etal., Clin Chem Lab Med. 2003 Jul;41(7):888-92.
9. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. de Faria IC, etal., J Pediatr (Rio J). 2008 May-Jun;84(3):203-10. Epub 2008 Apr 18.
10. The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries. Eyster KM, etal., Vascul Pharmacol. 2007 Oct;47(4):238-47. Epub 2007 Jul 3.
11. Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases. Formentini A, etal., Int J Colorectal Dis. 2009 Jan;24(1):57-67. Epub 2008 Aug 31.
12. Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis. Forster T, etal., Hum Genet. 2004 Mar;114(4):391-5. Epub 2004 Jan 24.
13. Role of beta-defensin 2 and interleukin-4 receptor as stroke outcome biomarkers. Garcia-Berrocoso T, etal., J Neurochem. 2014 May;129(3):463-72. doi: 10.1111/jnc.12649. Epub 2014 Feb 11.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. Grimbacher B, etal., N Engl J Med. 1998 Apr 9;338(15):1073-4.
17. Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis. Hackstein H, etal., J Neuroimmunol 2001 Feb 15;113(2):240-8.
18. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. Hershey GK, etal., N Engl J Med. 1997 Dec 11;337(24):1720-5.
19. Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes. Hesselmar B, etal., Acta Paediatr. 2010 Mar;99(3):399-403. Epub 2009 Dec 11.
20. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
21. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. Hoebee B, etal., J Infect Dis. 2003 Jan 1;187(1):2-11. Epub 2002 Dec 13.
22. Gene interactions and stroke risk in children with sickle cell anemia. Hoppe C, etal., Blood. 2004 Mar 15;103(6):2391-6. Epub 2003 Nov 13.
23. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Howard TD, etal., Am J Hum Genet. 2002 Jan;70(1):230-6. Epub 2001 Nov 14.
24. Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma. Hytonen AM, etal., Clin Exp Allergy. 2004 Oct;34(10):1570-5.
25. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
26. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Ishige K, etal., Int J Cancer. 2008 Dec 15;123(12):2915-22.
27. Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. Isidoro-Garcia M, etal., Clin Mol Allergy. 2005 Nov 29;3:15.
28. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Jakubzick C, etal., Am J Pathol. 2004 Jun;164(6):1989-2001.
29. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
30. Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness. Kirstein F, etal., Infect Immun. 2010 Sep;78(9):4077-86. Epub 2010 Jul 6.
31. Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury. Lee SI, etal., J Neurosci Res. 2010 Aug 15;88(11):2409-19.
32. Increased Th17 cell frequency and poor clinical outcome in rheumatoid arthritis are associated with a genetic variant in the IL4R gene, rs1805010. Leipe J, etal., Arthritis Rheumatol. 2014 May;66(5):1165-75. doi: 10.1002/art.38343.
33. DNA array analysis of changes in preovulatory gene expression in the rat ovary. Leo CP, etal., Biol Reprod. 2001 Jul;65(1):269-76.
34. Asthma susceptible genes in Chinese population: a meta-analysis. Li X, etal., Respir Res. 2010 Sep 24;11:129.
35. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Limer KL, etal., Osteoarthritis Cartilage. 2009 Jun;17(6):782-9. doi: 10.1016/j.joca.2008.09.019. Epub 2008 Nov 1.
36. Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis. Loza MJ and Chang BL, J Allergy Clin Immunol. 2007 Sep;120(3):578-85. Epub 2007 Jun 21.
37. CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts. Mendez A, etal., Tuberculosis (Edinb). 2011 Jan 18.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Analysis of IL4R haplotypes in predisposition to multiple sclerosis. Mirel DB, etal., Genes Immun. 2004 Mar;5(2):138-41.
40. Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population. Mohan S, etal., Asian Pac J Cancer Prev. 2009 Apr-Jun;10(2):295-8.
41. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. Muller U, etal., J Infect Dis. 2008 Dec 1;198(11):1714-21.
42. Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population. Nakamura E, etal., Clin Cancer Res. 2002 Aug;8(8):2620-5.
43. IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population. Nam SI, etal., Life Sci. 2006 Jan 2;78(6):664-7. Epub 2005 Nov 8.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. IL-4 induces IL-13-independent allergic airway inflammation. Perkins C, etal., J Allergy Clin Immunol. 2006 Aug;118(2):410-9.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube dysfunction. Pollock HW, etal., Otolaryngol Head Neck Surg. 2002 Sep;127(3):169-76.
50. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
51. Cellular mechanisms involved in experimental insulin-dependent diabetes mellitus. Radu DL Roum Arch Microbiol Immunol. 2001 Jul-Sep;60(3):203-26.
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. The rat interleukin 4 receptor: coevolution of ligand and receptor. Richter G, etal., Cytokine 1995 Apr;7(3):237-41.
56. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. Ripple MJ, etal., J Immunol. 2010 Oct 15;185(8):4804-11. Epub 2010 Sep 22.
57. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. Risma KA, etal., J Immunol. 2002 Aug 1;169(3):1604-10.
58. IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4. Shandley S, etal., Clin Immunol. 2009 Aug;132(2):246-56. Epub 2009 Apr 22.
59. Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma. Shimamura T, etal., Cancer Res. 2007 Oct 15;67(20):9903-12.
60. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Shirey KA, etal., Mucosal Immunol. 2010 May;3(3):291-300. Epub 2010 Mar 10.
61. Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis. Silvestri T, etal., Osteoarthritis Cartilage. 2006 Jul;14(7):717-9. Epub 2006 Apr 27.
62. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. Tachdjian R, etal., J Exp Med. 2009 Sep 28;206(10):2191-204. Epub 2009 Sep 21.
63. Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells. Van Den Berg JG, etal., J Am Soc Nephrol 2000 Mar;11(3):413-22.
64. Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Vargiolu M, etal., Osteoarthritis Cartilage. 2010 Jun;18(6):810-6. doi: 10.1016/j.joca.2010.02.005. Epub 2010 Feb 26.
65. Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma. Wang G and Lu J, Sci China Life Sci. 2010 Oct;53(10):1215-20. Epub 2010 Oct 17.
66. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Wenzel SE, etal., Am J Respir Crit Care Med. 2007 Mar 15;175(6):570-6. Epub 2006 Dec 14.
67. A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood. Woitsch B, etal., Int Arch Allergy Immunol. 2004 Dec;135(4):319-24. Epub 2004 Nov 24.
68. IL-4 is proangiogenic in the lung under hypoxic conditions. Yamaji-Kegan K, etal., J Immunol. 2009 May 1;182(9):5469-76.
69. Association of IL4R gene polymorphisms with asthma in Chinese populations. Zhang H, etal., Hum Mutat. 2007 Oct;28(10):1046.
70. Identification of regulated genes in rat heart after myocardial infarction by means of differential mRNA display. Zhu YZ, etal., Jpn Heart J. 2000 Jan;41(1):59-66.
Additional References at PubMed
PMID:7927664   PMID:8889548   PMID:12757709   PMID:15944273   PMID:16424184   PMID:17429054   PMID:19531027   PMID:19841166   PMID:23382219   PMID:25411311  


Genomics

Comparative Map Data
Il4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,115,061 - 180,139,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,115,120 - 180,139,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,451,734 - 188,476,590 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01195,637,762 - 195,662,619 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01188,320,992 - 188,346,016 (+)NCBIRnor_WKY
Rnor_6.01196,942,343 - 196,967,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,942,364 - 196,967,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01203,927,969 - 203,952,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,612,903 - 184,637,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,762,783 - 184,787,741 (+)NCBI
Celera1177,784,627 - 177,809,190 (+)NCBICelera
Cytogenetic Map1q36NCBI
IL4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381627,313,756 - 27,364,778 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1627,313,668 - 27,364,778 (+)EnsemblGRCh38hg38GRCh38
GRCh371627,325,295 - 27,376,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,232,752 - 27,283,600 (+)NCBINCBI36Build 36hg18NCBI36
Build 341627,232,751 - 27,274,031NCBI
Celera1626,102,563 - 26,153,416 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1625,413,538 - 25,464,524 (+)NCBIHuRef
CHM1_11628,336,783 - 28,387,655 (+)NCBICHM1_1
T2T-CHM13v2.01627,592,719 - 27,643,525 (+)NCBIT2T-CHM13v2.0
Il4ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,151,443 - 125,178,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)EnsemblGRCm39 Ensembl
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBIMGSCv36mm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
Il4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554935,545,944 - 5,582,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554935,546,340 - 5,580,745 (+)NCBIChiLan1.0ChiLan1.0
IL4R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11627,686,760 - 27,737,445 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1627,642,702 - 27,737,445 (+)Ensemblpanpan1.1panPan2
IL4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1619,254,183 - 19,280,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl619,254,487 - 19,389,291 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha620,832,962 - 20,871,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0619,394,054 - 19,432,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl619,394,061 - 19,432,718 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1619,192,194 - 19,230,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0619,105,764 - 19,144,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0619,451,883 - 19,490,511 (-)NCBIUU_Cfam_GSD_1.0
Il4r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344122,927,695 - 122,960,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,025,567 - 11,058,818 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650111,025,590 - 11,058,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl319,523,564 - 19,576,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1319,526,343 - 19,576,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2319,847,322 - 19,869,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL4R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1525,019,638 - 25,069,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl525,046,701 - 25,070,015 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660684,625,241 - 4,675,380 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il4r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478211,981,781 - 12,008,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il4r
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:113
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000020994
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1178810256180814005Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat

Markers in Region
D1Smu6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q36UniSTS
PMC18827P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,133,114 - 180,133,239 (+)MAPPERmRatBN7.2
Rnor_6.01196,960,358 - 196,960,482NCBIRnor6.0
Rnor_5.01203,945,962 - 203,946,086UniSTSRnor5.0
RGSC_v3.41184,630,896 - 184,631,020UniSTSRGSC3.4
Celera1177,802,354 - 177,802,478UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 43 27 19 27 2 31 28 11
Low 9 14 14 14 8 11 72 4 13 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005499551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB015747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW527353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ204155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020994   ⟹   ENSRNOP00000020994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,115,120 - 180,139,977 (+)Ensembl
Rnor_6.0 Ensembl1196,942,367 - 196,967,220 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088073   ⟹   ENSRNOP00000073767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,127,285 - 180,139,980 (+)Ensembl
Rnor_6.0 Ensembl1196,942,364 - 196,967,218 (+)Ensembl
RefSeq Acc Id: NM_133380   ⟹   NP_596871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,117 - 180,139,981 (+)NCBI
Rnor_6.01196,942,367 - 196,967,221 (+)NCBI
Rnor_5.01203,927,969 - 203,952,929 (+)NCBI
RGSC_v3.41184,612,903 - 184,637,863 (+)RGD
Celera1177,784,627 - 177,809,190 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230215   ⟹   XP_006230277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,090 - 180,139,979 (+)NCBI
Rnor_6.01196,942,349 - 196,967,218 (+)NCBI
Rnor_5.01203,927,969 - 203,952,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230216   ⟹   XP_006230278
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,088 - 180,139,979 (+)NCBI
Rnor_6.01196,942,345 - 196,967,218 (+)NCBI
Rnor_5.01203,927,969 - 203,952,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588804   ⟹   XP_017444293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,068 - 180,139,979 (+)NCBI
Rnor_6.01196,942,343 - 196,967,218 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101306   ⟹   XP_038957234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,090 - 180,139,979 (+)NCBI
RefSeq Acc Id: XM_039101307   ⟹   XP_038957235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,131,616 - 180,139,979 (+)NCBI
RefSeq Acc Id: XR_005499551
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,115,061 - 180,139,979 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_596871   ⟸   NM_133380
- Peptide Label: precursor
- UniProtKB: Q9WTM8 (UniProtKB/Swiss-Prot),   Q63257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006230278   ⟸   XM_006230216
- Peptide Label: isoform X1
- UniProtKB: Q9WTM8 (UniProtKB/Swiss-Prot),   Q63257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006230277   ⟸   XM_006230215
- Peptide Label: isoform X1
- UniProtKB: Q9WTM8 (UniProtKB/Swiss-Prot),   Q63257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444293   ⟸   XM_017588804
- Peptide Label: isoform X1
- UniProtKB: Q9WTM8 (UniProtKB/Swiss-Prot),   Q63257 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020994   ⟸   ENSRNOT00000020994
RefSeq Acc Id: ENSRNOP00000073767   ⟸   ENSRNOT00000088073
RefSeq Acc Id: XP_038957234   ⟸   XM_039101306
- Peptide Label: isoform X1
- UniProtKB: Q9WTM8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957235   ⟸   XM_039101307
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63257-F1-model_v2 AlphaFold Q63257 1-801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690390
Promoter ID:EPDNEW_R914
Type:multiple initiation site
Name:Il4r_1
Description:interleukin 4 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01196,942,383 - 196,942,443EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2899 AgrOrtholog
BioCyc Gene G2FUF-57483 BioCyc
Ensembl Genes ENSRNOG00000015441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020994 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073767 ENTREZGENE
  ENSRNOP00000073767.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020994 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000088073 ENTREZGENE
  ENSRNOT00000088073.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4_rcpt-alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25084 UniProtKB/Swiss-Prot
NCBI Gene 25084 ENTREZGENE
Pfam IL4Ra_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il4r PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R7Z3_RAT UniProtKB/TrEMBL
  IL4RA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WTM8 ENTREZGENE
UniProt Secondary Q9R1W8 UniProtKB/Swiss-Prot
  Q9WTM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-29 Il4r  interleukin 4 receptor  Il4ra  interleukin 4 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Il4ra  interleukin 4 receptor, alpha  Il4r  interleukin 4 receptor  Symbol and Name updated 1299863 APPROVED
2002-11-06 Il4r  interleukin 4 receptor    Interleukin 4 receptor  Name updated 625702 APPROVED
2002-06-10 Il4r  Interleukin 4 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein consists of a membrane and a soluble form of the receptor 633123