RGD Reference Report - CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts.

Authors: Mendez, A  Hernandez-Pando, R  Contreras, S  Aguilar, D  Rook, GA 
Citation: Mendez A, etal., Tuberculosis (Edinb). 2011 Jan 18.
RGD ID: 5128510
Pubmed: PMID:21251883   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tube.2010.12.008   (Journal Full-text)

The role of Th2 cytokines and Th2-associated chemokines in tuberculosis (TB) remains controversial, though in Mexico a polymorphism causing increased production of CCL2 is a risk factor. We studied levels of the Th2-associated chemokines CCL2 and CCL18, circulating soluble IL-4 receptors (sIL-4R), IL-4 and the inhibitory splice variant of IL-4 (IL-4delta2) in a cohort of patients with pulmonary TB and their healthy contacts. These were followed for 2 years during which time 10 contacts developed pulmonary TB. Results were compared with measurements made in renal and meningeal TB, and in disease controls with bacterial pneumonias or Dengue fever that have large Th2 components. In these disease controls both chemokines were significantly raised. They were also very significantly raised in all forms of TB, irrespective of age or disease site. Levels of CCL18 were raised least in meningeal TB, and most in pulmonary patients with long histories, when levels were similar to those in disease controls. Levels of CCL2, although also raised in all three forms of TB, were negatively correlated with CCL18. We found that levels of sIL-4R were strikingly reduced in all forms of TB, particularly meningeal. Contacts who progressed could not be distinguished from contacts who remained healthy at 2 years in terms of IL-4, sIL-4R, CCL2 or CCL18. However contacts had raised expression of IL-4delta2 as previously found. These results indicate vigorous and previously unrecorded activity within the Th2 axis, and further investigation is warranted.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL4RHumanMeningeal Tuberculosis  IEP protein:decreased expression:serumRGD 
Il4rRatMeningeal Tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 
Il4raMouseMeningeal Tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 
IL4RHumanpulmonary tuberculosis  IEP protein:decreased expression:serumRGD 
Il4rRatpulmonary tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 
Il4raMousepulmonary tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 
IL4RHumanrenal tuberculosis  IEP protein:decreased expression:serumRGD 
Il4rRatrenal tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 
Il4raMouserenal tuberculosis  ISOIL4R (Homo sapiens)protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il4r  (interleukin 4 receptor)

Genes (Mus musculus)
Il4ra  (interleukin 4 receptor, alpha)

Genes (Homo sapiens)
IL4R  (interleukin 4 receptor)


Additional Information