Il4ra (interleukin 4 receptor, alpha) - Rat Genome Database

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Gene: Il4ra (interleukin 4 receptor, alpha) Mus musculus
Analyze
Symbol: Il4ra
Name: interleukin 4 receptor, alpha
RGD ID: 10798
MGI Page MGI
Description: Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD124; I; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Il4r; interleukin-4 receptor subunit alpha; MGC118473
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,151,443 - 125,178,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)EnsemblGRCm39 Ensembl
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBIMGSCv36mm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-tolyl isocyanate  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
Azoxymethane  (EXP)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
budesonide  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diphenylmethane-4,4'-diisocyanate  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
hydrazines  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phthalic anhydride  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
raloxifene  (ISO)
selenium atom  (ISO)
sildenafil citrate  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium hexachloroplatinate  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bronchus morphology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal circulating interferon-gamma level  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal macrophage activation involved in immune response  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 2 cell morphology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased core body temperature  (IAGP)
decreased fatty acids level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T-helper 2 cell number  (IAGP)
granulomatous inflammation  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased airway responsiveness  (IAGP)
increased autoantibody level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased monocyte cell number  (IAGP)
increased respiratory mucosa goblet cell number  (IAGP)
increased susceptibility to infection  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased transforming growth factor beta level  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
premature death  (IAGP)
respiratory system inflammation  (IAGP)
thick skin  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris. Al Robaee AA, etal., Ann Saudi Med. 2012 Jul-Aug;32(4):349-54.
2. Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform. Bergin AM, etal., Hum Mutat. 2006 Oct;27(10):990-8.
3. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. Borish LC, etal., J Allergy Clin Immunol. 2001 Jun;107(6):963-70.
4. Common variants in genes that mediate immunity and risk of multiple myeloma. Brown EE, etal., Int J Cancer. 2007 Jun 15;120(12):2715-22.
5. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Burton OT, etal., Mucosal Immunol. 2013 Jul;6(4):740-50. doi: 10.1038/mi.2012.112. Epub 2012 Nov 14.
6. Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma. Chu H, etal., Ann Oncol. 2012 Aug;23(8):2114-21. doi: 10.1093/annonc/mdr607. Epub 2012 Feb 8.
7. Polymorphisms in the IL-4 and IL-4R genes and allergic asthma. Cui T, etal., Clin Chem Lab Med. 2003 Jul;41(7):888-92.
8. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. de Faria IC, etal., J Pediatr (Rio J). 2008 May-Jun;84(3):203-10. Epub 2008 Apr 18.
9. Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases. Formentini A, etal., Int J Colorectal Dis. 2009 Jan;24(1):57-67. Epub 2008 Aug 31.
10. Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis. Forster T, etal., Hum Genet. 2004 Mar;114(4):391-5. Epub 2004 Jan 24.
11. Role of beta-defensin 2 and interleukin-4 receptor as stroke outcome biomarkers. Garcia-Berrocoso T, etal., J Neurochem. 2014 May;129(3):463-72. doi: 10.1111/jnc.12649. Epub 2014 Feb 11.
12. The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. Grimbacher B, etal., N Engl J Med. 1998 Apr 9;338(15):1073-4.
13. Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis. Hackstein H, etal., J Neuroimmunol 2001 Feb 15;113(2):240-8.
14. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. Hershey GK, etal., N Engl J Med. 1997 Dec 11;337(24):1720-5.
15. Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes. Hesselmar B, etal., Acta Paediatr. 2010 Mar;99(3):399-403. Epub 2009 Dec 11.
16. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
17. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. Hoebee B, etal., J Infect Dis. 2003 Jan 1;187(1):2-11. Epub 2002 Dec 13.
18. Gene interactions and stroke risk in children with sickle cell anemia. Hoppe C, etal., Blood. 2004 Mar 15;103(6):2391-6. Epub 2003 Nov 13.
19. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Howard TD, etal., Am J Hum Genet. 2002 Jan;70(1):230-6. Epub 2001 Nov 14.
20. Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma. Hytonen AM, etal., Clin Exp Allergy. 2004 Oct;34(10):1570-5.
21. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Ishige K, etal., Int J Cancer. 2008 Dec 15;123(12):2915-22.
22. Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. Isidoro-Garcia M, etal., Clin Mol Allergy. 2005 Nov 29;3:15.
23. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Jakubzick C, etal., Am J Pathol. 2004 Jun;164(6):1989-2001.
24. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
25. Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness. Kirstein F, etal., Infect Immun. 2010 Sep;78(9):4077-86. Epub 2010 Jul 6.
26. Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury. Lee SI, etal., J Neurosci Res. 2010 Aug 15;88(11):2409-19.
27. Increased Th17 cell frequency and poor clinical outcome in rheumatoid arthritis are associated with a genetic variant in the IL4R gene, rs1805010. Leipe J, etal., Arthritis Rheumatol. 2014 May;66(5):1165-75. doi: 10.1002/art.38343.
28. Asthma susceptible genes in Chinese population: a meta-analysis. Li X, etal., Respir Res. 2010 Sep 24;11:129.
29. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Limer KL, etal., Osteoarthritis Cartilage. 2009 Jun;17(6):782-9. doi: 10.1016/j.joca.2008.09.019. Epub 2008 Nov 1.
30. Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis. Loza MJ and Chang BL, J Allergy Clin Immunol. 2007 Sep;120(3):578-85. Epub 2007 Jun 21.
31. CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts. Mendez A, etal., Tuberculosis (Edinb). 2011 Jan 18.
32. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. Analysis of IL4R haplotypes in predisposition to multiple sclerosis. Mirel DB, etal., Genes Immun. 2004 Mar;5(2):138-41.
36. Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population. Mohan S, etal., Asian Pac J Cancer Prev. 2009 Apr-Jun;10(2):295-8.
37. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. Muller U, etal., J Infect Dis. 2008 Dec 1;198(11):1714-21.
38. Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1. Nabika T, etal., Mamm Genome 1997 Mar;8(3):215-7.
39. Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population. Nakamura E, etal., Clin Cancer Res. 2002 Aug;8(8):2620-5.
40. IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population. Nam SI, etal., Life Sci. 2006 Jan 2;78(6):664-7. Epub 2005 Nov 8.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. IL-4 induces IL-13-independent allergic airway inflammation. Perkins C, etal., J Allergy Clin Immunol. 2006 Aug;118(2):410-9.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube dysfunction. Pollock HW, etal., Otolaryngol Head Neck Surg. 2002 Sep;127(3):169-76.
46. Cellular mechanisms involved in experimental insulin-dependent diabetes mellitus. Radu DL Roum Arch Microbiol Immunol. 2001 Jul-Sep;60(3):203-26.
47. Mouse MP Annotation Import Pipeline RGD automated import pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. Ripple MJ, etal., J Immunol. 2010 Oct 15;185(8):4804-11. Epub 2010 Sep 22.
51. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. Risma KA, etal., J Immunol. 2002 Aug 1;169(3):1604-10.
52. IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4. Shandley S, etal., Clin Immunol. 2009 Aug;132(2):246-56. Epub 2009 Apr 22.
53. Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma. Shimamura T, etal., Cancer Res. 2007 Oct 15;67(20):9903-12.
54. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Shirey KA, etal., Mucosal Immunol. 2010 May;3(3):291-300. Epub 2010 Mar 10.
55. Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis. Silvestri T, etal., Osteoarthritis Cartilage. 2006 Jul;14(7):717-9. Epub 2006 Apr 27.
56. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. Tachdjian R, etal., J Exp Med. 2009 Sep 28;206(10):2191-204. Epub 2009 Sep 21.
57. Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Vargiolu M, etal., Osteoarthritis Cartilage. 2010 Jun;18(6):810-6. doi: 10.1016/j.joca.2010.02.005. Epub 2010 Feb 26.
58. Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma. Wang G and Lu J, Sci China Life Sci. 2010 Oct;53(10):1215-20. Epub 2010 Oct 17.
59. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Wenzel SE, etal., Am J Respir Crit Care Med. 2007 Mar 15;175(6):570-6. Epub 2006 Dec 14.
60. A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood. Woitsch B, etal., Int Arch Allergy Immunol. 2004 Dec;135(4):319-24. Epub 2004 Nov 24.
61. IL-4 is proangiogenic in the lung under hypoxic conditions. Yamaji-Kegan K, etal., J Immunol. 2009 May 1;182(9):5469-76.
62. Association of IL4R gene polymorphisms with asthma in Chinese populations. Zhang H, etal., Hum Mutat. 2007 Oct;28(10):1046.
63. Identification of regulated genes in rat heart after myocardial infarction by means of differential mRNA display. Zhu YZ, etal., Jpn Heart J. 2000 Jan;41(1):59-66.
Additional References at PubMed
PMID:1534014   PMID:1535334   PMID:1618140   PMID:1679753   PMID:1680807   PMID:2405398   PMID:2805066   PMID:7507973   PMID:7530740   PMID:7602126   PMID:7621883   PMID:7705393  
PMID:7927664   PMID:7929391   PMID:7959747   PMID:7964490   PMID:8096811   PMID:8390454   PMID:8499630   PMID:8552669   PMID:8613696   PMID:8626013   PMID:8757301   PMID:8820266  
PMID:8986768   PMID:9124376   PMID:9324354   PMID:9344502   PMID:9344654   PMID:9348299   PMID:9380721   PMID:9492006   PMID:9558109   PMID:9635196   PMID:9754557   PMID:9759868  
PMID:10098325   PMID:10229856   PMID:10349636   PMID:10358179   PMID:10384133   PMID:10452990   PMID:10586035   PMID:10679064   PMID:10706693   PMID:10922068   PMID:10992460   PMID:11003391  
PMID:11034364   PMID:11042159   PMID:11050183   PMID:11076861   PMID:11163865   PMID:11168809   PMID:11217851   PMID:11466392   PMID:11705956   PMID:11714764   PMID:11829488   PMID:12107190  
PMID:12200373   PMID:12228294   PMID:12242343   PMID:12355446   PMID:12466851   PMID:12477932   PMID:12591901   PMID:12646651   PMID:12734362   PMID:12757709   PMID:12817750   PMID:12829795  
PMID:12835475   PMID:12847520   PMID:12874364   PMID:12902491   PMID:14557412   PMID:14635046   PMID:14688111   PMID:14707083   PMID:14991598   PMID:15034072   PMID:15096489   PMID:15128803  
PMID:15142530   PMID:15383584   PMID:15661890   PMID:15699158   PMID:15741272   PMID:15816016   PMID:15919778   PMID:15944273   PMID:15944318   PMID:16087712   PMID:16116211   PMID:16141072  
PMID:16141073   PMID:16148120   PMID:16210622   PMID:16272308   PMID:16299028   PMID:16301612   PMID:16337681   PMID:16357187   PMID:16394000   PMID:16424049   PMID:16424184   PMID:16547222  
PMID:16556895   PMID:16585215   PMID:16594735   PMID:16849611   PMID:16880257   PMID:16914507   PMID:16940042   PMID:16988272   PMID:17016559   PMID:17071593   PMID:17101734   PMID:17154265  
PMID:17164429   PMID:17177681   PMID:17182558   PMID:17182563   PMID:17189592   PMID:17200411   PMID:17222057   PMID:17241396   PMID:17330244   PMID:17339609   PMID:17500591   PMID:17640969  
PMID:17675505   PMID:17709489   PMID:17766435   PMID:17767160   PMID:17785830   PMID:17913905   PMID:17947695   PMID:17982031   PMID:18029018   PMID:18056481   PMID:18066066   PMID:18203142  
PMID:18220315   PMID:18250411   PMID:18250447   PMID:18354157   PMID:18354220   PMID:18373667   PMID:18378796   PMID:18453568   PMID:18480254   PMID:18523279   PMID:18535177   PMID:18591675  
PMID:18714000   PMID:18768873   PMID:18768889   PMID:18809669   PMID:18820682   PMID:18832447   PMID:18852293   PMID:18941236   PMID:18974110   PMID:18981153   PMID:19056736   PMID:19147811  
PMID:19155490   PMID:19190084   PMID:19191917   PMID:19249230   PMID:19299736   PMID:19342650   PMID:19349465   PMID:19380638   PMID:19488061   PMID:19535141   PMID:19592277   PMID:19592641  
PMID:19602708   PMID:19628763   PMID:19635864   PMID:19647220   PMID:19705113   PMID:19726720   PMID:19783672   PMID:19799897   PMID:19841166   PMID:19880493   PMID:19995957   PMID:20018622  
PMID:20052800   PMID:20176658   PMID:20231466   PMID:20337645   PMID:20360135   PMID:20392476   PMID:20418876   PMID:20483789   PMID:20579713   PMID:20601952   PMID:20737001   PMID:20821727  
PMID:20974984   PMID:21037078   PMID:21167580   PMID:21245915   PMID:21246055   PMID:21267068   PMID:21343358   PMID:21413004   PMID:21460847   PMID:21464224   PMID:21502330   PMID:21515798  
PMID:21825018   PMID:21873635   PMID:21947380   PMID:21949021   PMID:21983080   PMID:22000020   PMID:22014099   PMID:22101429   PMID:22245215   PMID:22245779   PMID:22262122   PMID:22282665  
PMID:22292924   PMID:22308307   PMID:22331068   PMID:22333910   PMID:22348321   PMID:22412848   PMID:22426339   PMID:22552110   PMID:22673957   PMID:22684943   PMID:22792286   PMID:22802978  
PMID:22855601   PMID:22930820   PMID:22941735   PMID:23109710   PMID:23225888   PMID:23275605   PMID:23284939   PMID:23335246   PMID:23382219   PMID:23426944   PMID:23434060   PMID:23532373  
PMID:23536877   PMID:23543769   PMID:23716700   PMID:23727894   PMID:23784081   PMID:23898202   PMID:23918982   PMID:23954132   PMID:23976880   PMID:23990998   PMID:24030977   PMID:24097110  
PMID:24101381   PMID:24204255   PMID:24204259   PMID:24244174   PMID:24251647   PMID:24280725   PMID:24403255   PMID:24465642   PMID:24475277   PMID:24534206   PMID:24620029   PMID:24643536  
PMID:24717539   PMID:24792964   PMID:24906148   PMID:24979482   PMID:25017467   PMID:25082704   PMID:25173346   PMID:25211233   PMID:25427822   PMID:25534817   PMID:25545131   PMID:25607842  
PMID:25611587   PMID:25746764   PMID:25751266   PMID:25769611   PMID:25772331   PMID:25790379   PMID:25825216   PMID:25848867   PMID:25981357   PMID:26124135   PMID:26192556   PMID:26280119  
PMID:26362265   PMID:26410628   PMID:26474656   PMID:26573801   PMID:26627255   PMID:26675736   PMID:26688514   PMID:26732561   PMID:26762460   PMID:26896776   PMID:26900854   PMID:27120970  
PMID:27160906   PMID:27177780   PMID:27184849   PMID:27298446   PMID:27318131   PMID:27357235   PMID:27421703   PMID:27438770   PMID:27479084   PMID:27505056   PMID:27551096   PMID:27568549  
PMID:27592711   PMID:27626662   PMID:27670775   PMID:27797811   PMID:28192541   PMID:28202459   PMID:28389622   PMID:28406139   PMID:28495878   PMID:28506464   PMID:28507062   PMID:28646042  
PMID:28651009   PMID:28687632   PMID:28694386   PMID:28739140   PMID:28747424   PMID:28765368   PMID:28775096   PMID:28798029   PMID:28801358   PMID:28827803   PMID:28890086   PMID:28916732  
PMID:28917204   PMID:29157947   PMID:29339444   PMID:29343807   PMID:29463471   PMID:29491183   PMID:29548765   PMID:29627423   PMID:29650672   PMID:29688375   PMID:29756681   PMID:29872141  
PMID:29887373   PMID:29907154   PMID:29925696   PMID:30021144   PMID:30054470   PMID:30238872   PMID:30275010   PMID:30319610   PMID:30337651   PMID:30353167   PMID:30500858   PMID:30517865  
PMID:30530480   PMID:30575951   PMID:30610060   PMID:30619289   PMID:30849228   PMID:30919955   PMID:31027995   PMID:31109364   PMID:31116987   PMID:31235962   PMID:31469835   PMID:31475014  
PMID:31745261   PMID:31957000   PMID:32366355   PMID:32410852   PMID:32571840   PMID:32780802   PMID:32814028   PMID:32931477   PMID:33020569   PMID:33086036   PMID:33164548   PMID:33192516  
PMID:33207196   PMID:33324410   PMID:33378665   PMID:33383090   PMID:33526653   PMID:33543002   PMID:33653328   PMID:33767712   PMID:33798555   PMID:33841417   PMID:33857419   PMID:34132103  
PMID:34193600   PMID:34220793   PMID:34290377   PMID:34326406   PMID:34343540   PMID:34555336   PMID:34644537   PMID:34681866   PMID:34707292   PMID:34793707   PMID:34795444   PMID:34863091  
PMID:34921782   PMID:35021079   PMID:35154068   PMID:35210363   PMID:35210549   PMID:35245089   PMID:35301301   PMID:35371073   PMID:35427180   PMID:35488301   PMID:35587822   PMID:35657353  
PMID:35738281   PMID:35841382   PMID:35939881   PMID:36032072   PMID:36044899   PMID:36052067   PMID:36063138   PMID:36077870   PMID:36240286   PMID:36599893   PMID:36690254   PMID:36939374  
PMID:36948193   PMID:36982747   PMID:37021574   PMID:37149865   PMID:37167061   PMID:37315811   PMID:37437602   PMID:37676935   PMID:37902285   PMID:37918358   PMID:37935074   PMID:37995657  
PMID:38057662   PMID:38134932   PMID:38262419   PMID:38396021   PMID:38426866   PMID:38744291   PMID:38787155   PMID:39088319   PMID:39141517  


Genomics

Comparative Map Data
Il4ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,151,443 - 125,178,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)EnsemblGRCm39 Ensembl
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBIMGSCv36mm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
IL4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381627,313,756 - 27,364,778 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1627,313,668 - 27,364,778 (+)EnsemblGRCh38hg38GRCh38
GRCh371627,325,295 - 27,376,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,232,752 - 27,283,600 (+)NCBINCBI36Build 36hg18NCBI36
Build 341627,232,751 - 27,274,031NCBI
Celera1626,102,563 - 26,153,416 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1625,413,538 - 25,464,524 (+)NCBIHuRef
CHM1_11628,336,783 - 28,387,655 (+)NCBICHM1_1
T2T-CHM13v2.01627,592,211 - 27,643,525 (+)NCBIT2T-CHM13v2.0
Il4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81189,545,739 - 189,570,639 (+)NCBIGRCr8
mRatBN7.21180,115,061 - 180,139,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,115,120 - 180,139,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,451,734 - 188,476,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01195,637,762 - 195,662,619 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01188,320,992 - 188,346,016 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01196,942,343 - 196,967,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,942,364 - 196,967,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01203,927,969 - 203,952,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,612,903 - 184,637,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,762,783 - 184,787,741 (+)NCBI
Celera1177,784,627 - 177,809,190 (+)NCBICelera
Cytogenetic Map1q36NCBI
Il4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554935,545,944 - 5,582,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554935,546,340 - 5,580,745 (+)NCBIChiLan1.0ChiLan1.0
IL4R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21828,667,231 - 28,762,306 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11633,207,285 - 33,302,340 (+)NCBINHGRI_mPanPan1
PanPan1.11627,686,760 - 27,737,445 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1627,642,702 - 27,737,445 (+)Ensemblpanpan1.1panPan2
IL4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1619,254,183 - 19,280,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl619,254,487 - 19,389,291 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha620,832,962 - 20,871,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0619,394,054 - 19,432,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl619,394,061 - 19,432,718 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1619,192,194 - 19,230,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0619,105,764 - 19,144,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0619,451,883 - 19,490,511 (-)NCBIUU_Cfam_GSD_1.0
Il4r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344122,927,695 - 122,960,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,025,567 - 11,058,818 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,025,590 - 11,058,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl319,523,564 - 19,576,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1319,526,343 - 19,576,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2319,847,322 - 19,869,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL4R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1525,019,638 - 25,069,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl525,046,701 - 25,070,015 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660684,625,241 - 4,675,380 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il4r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478211,981,781 - 12,008,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il4ra
1397 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1066
Count of miRNA genes:558
Interacting mature miRNAs:688
Transcripts:ENSMUST00000033004
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124299223126899172Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse

Markers in Region
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,575,691 - 125,575,888UniSTSGRCm38
MGSCv377132,719,205 - 132,719,402UniSTSGRCm37
Celera7125,434,355 - 125,434,552UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
cM Map762.0UniSTS
M27960  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,576,101 - 125,576,213UniSTSGRCm38
MGSCv377132,719,615 - 132,719,727UniSTSGRCm37
Celera7125,434,765 - 125,434,877UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Whitehead/MRC_RH71287.81UniSTS
PMC18827P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,571,446 - 125,571,570UniSTSGRCm38
MGSCv377132,714,960 - 132,715,084UniSTSGRCm37
Celera7125,430,110 - 125,430,234UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS
cM Map1129.0UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,576,634 - 125,576,940UniSTSGRCm38
MGSCv377132,720,148 - 132,720,454UniSTSGRCm37
Celera7125,435,298 - 125,435,604UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,571,448 - 125,572,924UniSTSGRCm38
MGSCv377132,714,962 - 132,716,438UniSTSGRCm37
Celera7125,430,112 - 125,431,588UniSTS
Cytogenetic Map7F3UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF000304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC212685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC339001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033004   ⟹   ENSMUSP00000033004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)Ensembl
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205985   ⟹   ENSMUSP00000145725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,448 - 125,169,169 (+)Ensembl
GRCm38.p6 Ensembl7125,552,276 - 125,569,997 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206217   ⟹   ENSMUSP00000146185
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,443 - 125,166,383 (+)Ensembl
GRCm38.p6 Ensembl7125,552,271 - 125,567,211 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,443 - 125,171,452 (+)Ensembl
GRCm38.p6 Ensembl7125,552,271 - 125,572,280 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206846   ⟹   ENSMUSP00000145824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,459 - 125,177,139 (+)Ensembl
GRCm38.p6 Ensembl7125,552,287 - 125,577,967 (+)Ensembl
RefSeq Acc Id: NM_001008700   ⟹   NP_001008700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397125,151,443 - 125,178,646 (+)NCBI
GRCm387125,552,271 - 125,579,474 (+)NCBI
MGSCv377132,695,796 - 132,722,988 (+)RGD
Celera7125,410,962 - 125,438,138 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001363983   ⟹   NP_001350912
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397125,151,443 - 125,178,646 (+)NCBI
GRCm387125,552,271 - 125,579,474 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008700 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350912 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA39297 (Get FASTA)   NCBI Sequence Viewer  
  AAA39299 (Get FASTA)   NCBI Sequence Viewer  
  AAA39300 (Get FASTA)   NCBI Sequence Viewer  
  AAB59727 (Get FASTA)   NCBI Sequence Viewer  
  AAB87750 (Get FASTA)   NCBI Sequence Viewer  
  AAH12309 (Get FASTA)   NCBI Sequence Viewer  
  AAI12912 (Get FASTA)   NCBI Sequence Viewer  
  AAI28302 (Get FASTA)   NCBI Sequence Viewer  
  AAI28303 (Get FASTA)   NCBI Sequence Viewer  
  AGZ84441 (Get FASTA)   NCBI Sequence Viewer  
  AGZ84442 (Get FASTA)   NCBI Sequence Viewer  
  BAC28718 (Get FASTA)   NCBI Sequence Viewer  
  BAC31230 (Get FASTA)   NCBI Sequence Viewer  
  BAC40137 (Get FASTA)   NCBI Sequence Viewer  
  BAE28986 (Get FASTA)   NCBI Sequence Viewer  
  BAE29045 (Get FASTA)   NCBI Sequence Viewer  
  BAE29678 (Get FASTA)   NCBI Sequence Viewer  
  BAE30862 (Get FASTA)   NCBI Sequence Viewer  
  BAE31787 (Get FASTA)   NCBI Sequence Viewer  
  BAE35031 (Get FASTA)   NCBI Sequence Viewer  
  BAE35562 (Get FASTA)   NCBI Sequence Viewer  
  EDL17322 (Get FASTA)   NCBI Sequence Viewer  
  EDL17323 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000033004
  ENSMUSP00000033004.7
  ENSMUSP00000145725.2
  ENSMUSP00000145824.2
  ENSMUSP00000146185.2
GenBank Protein P16382 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008700   ⟸   NM_001008700
- Peptide Label: isoform 1 precursor
- UniProtKB: Q60583 (UniProtKB/Swiss-Prot),   O54690 (UniProtKB/Swiss-Prot),   Q8CBW5 (UniProtKB/Swiss-Prot),   P16382 (UniProtKB/Swiss-Prot),   Q3U905 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350912   ⟸   NM_001363983
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000145824   ⟸   ENSMUST00000206846
Ensembl Acc Id: ENSMUSP00000146185   ⟸   ENSMUST00000206217
Ensembl Acc Id: ENSMUSP00000145725   ⟸   ENSMUST00000205985
Ensembl Acc Id: ENSMUSP00000033004   ⟸   ENSMUST00000033004
Protein Domains
Fibronectin type-III   Interleukin-4 receptor alpha N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16382-F1-model_v2 AlphaFold P16382 1-810 view protein structure

Promoters
RGD ID:8665563
Promoter ID:EPDNEW_M10783
Type:initiation region
Name:Il4ra_1
Description:Mus musculus interleukin 4 receptor, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387125,552,282 - 125,552,342EPDNEW
RGD ID:6841356
Promoter ID:MM_KWN:52638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK020774_A430106F20RIK,   ENSMUST00000033004,   ENSMUST00000106428,   UC009JQB.1,   UC009JQD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,694,766 - 132,696,332 (+)MPROMDB
RGD ID:6848153
Promoter ID:MM_ACW:46028
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:IL4RA.GSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,708,124 - 132,708,624 (+)MPROMDB
RGD ID:6848151
Promoter ID:MM_ACW:46030
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:IL4RA.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,718,226 - 132,718,726 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105367 AgrOrtholog
Ensembl Genes ENSMUSG00000030748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033004 ENTREZGENE
  ENSMUST00000033004.8 UniProtKB/Swiss-Prot
  ENSMUST00000205985.2 UniProtKB/TrEMBL
  ENSMUST00000206217.2 UniProtKB/TrEMBL
  ENSMUST00000206846.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4_rcpt-alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105367 ENTREZGENE
NCBI Gene 16190 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL4Ra_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il4ra PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNW1_MOUSE UniProtKB/TrEMBL
  A0A0U1RPZ6_MOUSE UniProtKB/TrEMBL
  A2VCP1_MOUSE UniProtKB/TrEMBL
  IL4RA_MOUSE UniProtKB/Swiss-Prot
  O54690 ENTREZGENE
  P16382 ENTREZGENE
  Q3U905 ENTREZGENE, UniProtKB/TrEMBL
  Q3UE66_MOUSE UniProtKB/TrEMBL
  Q544A9_MOUSE UniProtKB/TrEMBL
  Q60583 ENTREZGENE
  Q8CBW5 ENTREZGENE
  Q921I3_MOUSE UniProtKB/TrEMBL
  W8DL82_MOUSE UniProtKB/TrEMBL
  W8DLM5_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54690 UniProtKB/Swiss-Prot
  Q60583 UniProtKB/Swiss-Prot
  Q8CBW5 UniProtKB/Swiss-Prot