Il4ra (interleukin 4 receptor, alpha) - Rat Genome Database

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Gene: Il4ra (interleukin 4 receptor, alpha) Mus musculus
Analyze
Symbol: Il4ra
Name: interleukin 4 receptor, alpha
RGD ID: 10798
MGI Page MGI
Description: Predicted to enable cytokine receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in several cellular components, including centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor); PARTICIPATES IN interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD124; I; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Il4r; interleukin-4 receptor subunit alpha; MGC118473
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,151,443 - 125,178,646 (+)NCBIGRCm39mm39
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)Ensembl
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBImm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-tolyl isocyanate  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
budesonide  (ISO)
C60 fullerene  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diphenylmethane-4,4'-diisocyanate  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
hydrazines  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
phthalic anhydride  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
selenium atom  (ISO)
sildenafil citrate  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium hexachloroplatinate  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bronchus morphology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal circulating interferon-gamma level  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal macrophage activation involved in immune response  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 2 cell morphology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased core body temperature  (IAGP)
decreased fatty acids level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T-helper 2 cell number  (IAGP)
granulomatous inflammation  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased airway responsiveness  (IAGP)
increased autoantibody level  (IAGP)
increased circulating interleukin-4 level  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased monocyte cell number  (IAGP)
increased respiratory mucosa goblet cell number  (IAGP)
increased susceptibility to infection  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased transforming growth factor beta level  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
overexpanded pulmonary alveoli  (IAGP)
premature death  (IAGP)
respiratory system inflammation  (IAGP)
thick skin  (IAGP)
weight loss  (IAGP)
References

References - curated
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32. MGD and Homologene mouse data transfer
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34. MGD IEA
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43. Pipeline to import KEGG annotations from KEGG into RGD
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48. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1534014   PMID:1535334   PMID:1618140   PMID:1679753   PMID:1680807   PMID:2405398   PMID:2805066   PMID:7507973   PMID:7530740   PMID:7602126   PMID:7621883   PMID:7705393  
PMID:7927664   PMID:7929391   PMID:7959747   PMID:7964490   PMID:8096811   PMID:8390454   PMID:8499630   PMID:8552669   PMID:8613696   PMID:8626013   PMID:8757301   PMID:8820266  
PMID:8986768   PMID:9124376   PMID:9324354   PMID:9344502   PMID:9344654   PMID:9348299   PMID:9380721   PMID:9492006   PMID:9558109   PMID:9635196   PMID:9754557   PMID:9759868  
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PMID:12200373   PMID:12228294   PMID:12242343   PMID:12355446   PMID:12466851   PMID:12477932   PMID:12591901   PMID:12646651   PMID:12734362   PMID:12757709   PMID:12817750   PMID:12829795  
PMID:12835475   PMID:12847520   PMID:12874364   PMID:12902491   PMID:14557412   PMID:14635046   PMID:14688111   PMID:14707083   PMID:14991598   PMID:15034072   PMID:15096489   PMID:15128803  
PMID:15142530   PMID:15383584   PMID:15661890   PMID:15699158   PMID:15741272   PMID:15816016   PMID:15919778   PMID:15944273   PMID:15944318   PMID:16087712   PMID:16116211   PMID:16141072  
PMID:16141073   PMID:16148120   PMID:16210622   PMID:16272308   PMID:16299028   PMID:16301612   PMID:16337681   PMID:16357187   PMID:16394000   PMID:16424049   PMID:16424184   PMID:16547222  
PMID:16556895   PMID:16585215   PMID:16594735   PMID:16849611   PMID:16880257   PMID:16914507   PMID:16940042   PMID:16988272   PMID:17016559   PMID:17071593   PMID:17101734   PMID:17154265  
PMID:17164429   PMID:17177681   PMID:17182558   PMID:17182563   PMID:17189592   PMID:17200411   PMID:17222057   PMID:17241396   PMID:17330244   PMID:17339609   PMID:17500591   PMID:17640969  
PMID:17675505   PMID:17709489   PMID:17766435   PMID:17767160   PMID:17785830   PMID:17913905   PMID:17947695   PMID:17982031   PMID:18029018   PMID:18056481   PMID:18066066   PMID:18203142  
PMID:18220315   PMID:18250411   PMID:18250447   PMID:18354157   PMID:18354220   PMID:18373667   PMID:18378796   PMID:18453568   PMID:18480254   PMID:18523279   PMID:18535177   PMID:18591675  
PMID:18714000   PMID:18768873   PMID:18768889   PMID:18809669   PMID:18820682   PMID:18832447   PMID:18852293   PMID:18941236   PMID:18974110   PMID:18981153   PMID:19056736   PMID:19147811  
PMID:19155490   PMID:19190084   PMID:19191917   PMID:19249230   PMID:19299736   PMID:19342650   PMID:19349465   PMID:19380638   PMID:19488061   PMID:19535141   PMID:19592277   PMID:19592641  
PMID:19602708   PMID:19628763   PMID:19635864   PMID:19647220   PMID:19705113   PMID:19726720   PMID:19783672   PMID:19799897   PMID:19841166   PMID:19880493   PMID:19995957   PMID:20018622  
PMID:20052800   PMID:20176658   PMID:20231466   PMID:20337645   PMID:20360135   PMID:20392476   PMID:20418876   PMID:20483789   PMID:20579713   PMID:20601952   PMID:20737001   PMID:20821727  
PMID:20974984   PMID:21037078   PMID:21167580   PMID:21245915   PMID:21246055   PMID:21267068   PMID:21343358   PMID:21413004   PMID:21460847   PMID:21464224   PMID:21502330   PMID:21515798  
PMID:21825018   PMID:21947380   PMID:21949021   PMID:21983080   PMID:22000020   PMID:22014099   PMID:22101429   PMID:22245215   PMID:22245779   PMID:22262122   PMID:22282665   PMID:22292924  
PMID:22308307   PMID:22331068   PMID:22333910   PMID:22348321   PMID:22426339   PMID:22552110   PMID:22673957   PMID:22684943   PMID:22792286   PMID:22802978   PMID:22855601   PMID:22930820  
PMID:22941735   PMID:23109710   PMID:23225888   PMID:23275605   PMID:23284939   PMID:23335246   PMID:23382219   PMID:23426944   PMID:23434060   PMID:23532373   PMID:23536877   PMID:23543769  
PMID:23716700   PMID:23727894   PMID:23784081   PMID:23898202   PMID:23918982   PMID:23954132   PMID:23976880   PMID:23990998   PMID:24030977   PMID:24097110   PMID:24101381   PMID:24204255  
PMID:24204259   PMID:24244174   PMID:24251647   PMID:24280725   PMID:24403255   PMID:24465642   PMID:24475277   PMID:24534206   PMID:24620029   PMID:24643536   PMID:24717539   PMID:24792964  
PMID:24906148   PMID:24979482   PMID:25017467   PMID:25173346   PMID:25211233   PMID:25427822   PMID:25534817   PMID:25545131   PMID:25607842   PMID:25611587   PMID:25746764   PMID:25751266  
PMID:25769611   PMID:25772331   PMID:25790379   PMID:25848867   PMID:25981357   PMID:26124135   PMID:26192556   PMID:26280119   PMID:26362265   PMID:26410628   PMID:26474656   PMID:26573801  
PMID:26627255   PMID:26675736   PMID:26688514   PMID:26732561   PMID:26762460   PMID:26896776   PMID:26900854   PMID:27120970   PMID:27160906   PMID:27184849   PMID:27298446   PMID:27318131  
PMID:27357235   PMID:27421703   PMID:27438770   PMID:27479084   PMID:27505056   PMID:27551096   PMID:27568549   PMID:27592711   PMID:27626662   PMID:27670775   PMID:27797811   PMID:28192541  
PMID:28202459   PMID:28389622   PMID:28406139   PMID:28506464   PMID:28507062   PMID:28646042   PMID:28651009   PMID:28687632   PMID:28694386   PMID:28739140   PMID:28747424   PMID:28765368  
PMID:28775096   PMID:28798029   PMID:28801358   PMID:28827803   PMID:28890086   PMID:28916732   PMID:28917204   PMID:29157947   PMID:29339444   PMID:29343807   PMID:29463471   PMID:29491183  
PMID:29548765   PMID:29650672   PMID:29688375   PMID:29756681   PMID:29872141   PMID:29887373   PMID:29925696   PMID:30021144   PMID:30054470   PMID:30238872   PMID:30275010   PMID:30319610  
PMID:30337651   PMID:30353167   PMID:30517865   PMID:30530480   PMID:30575951   PMID:30610060   PMID:30619289   PMID:30849228   PMID:30919955   PMID:31027995   PMID:31109364   PMID:31116987  
PMID:31235962   PMID:31469835   PMID:31475014   PMID:31745261   PMID:31957000   PMID:32366355   PMID:32410852   PMID:32571840   PMID:32814028   PMID:32931477   PMID:33020569   PMID:33164548  
PMID:33378665   PMID:33526653   PMID:33543002   PMID:33653328   PMID:33798555   PMID:33857419   PMID:34132103  


Genomics

Comparative Map Data
Il4ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,151,443 - 125,178,646 (+)NCBIGRCm39mm39
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)Ensembl
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBImm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
IL4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1627,313,668 - 27,364,778 (+)EnsemblGRCh38hg38GRCh38
GRCh381627,313,668 - 27,364,778 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371627,325,295 - 27,376,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,232,752 - 27,283,600 (+)NCBINCBI36hg18NCBI36
Build 341627,232,751 - 27,274,031NCBI
Celera1626,102,563 - 26,153,416 (+)NCBI
Cytogenetic Map16p12.1NCBI
HuRef1625,413,538 - 25,464,524 (+)NCBIHuRef
CHM1_11628,336,783 - 28,387,655 (+)NCBICHM1_1
Il4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,115,061 - 180,139,981 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1180,115,120 - 180,139,980 (+)Ensembl
Rnor_6.01196,942,343 - 196,967,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1196,942,364 - 196,967,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01203,927,969 - 203,952,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,612,903 - 184,637,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,762,783 - 184,787,741 (+)NCBI
Celera1177,784,627 - 177,809,190 (+)NCBICelera
Cytogenetic Map1q36NCBI
Il4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554935,545,944 - 5,582,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554935,546,340 - 5,580,745 (+)NCBIChiLan1.0ChiLan1.0
IL4R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11627,686,760 - 27,737,445 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1627,642,702 - 27,737,445 (+)Ensemblpanpan1.1panPan2
IL4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1619,254,183 - 19,280,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl619,254,487 - 19,389,291 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha620,832,962 - 20,871,611 (-)NCBI
ROS_Cfam_1.0619,394,054 - 19,432,737 (-)NCBI
UMICH_Zoey_3.1619,192,194 - 19,230,822 (-)NCBI
UNSW_CanFamBas_1.0619,105,764 - 19,144,404 (-)NCBI
UU_Cfam_GSD_1.0619,451,883 - 19,490,511 (-)NCBI
Il4r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344122,927,695 - 122,960,947 (+)NCBI
SpeTri2.0NW_00493650111,025,590 - 11,058,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl319,523,564 - 19,576,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1319,526,343 - 19,576,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2319,847,322 - 19,869,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL4R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1525,019,638 - 25,069,732 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl525,046,701 - 25,070,015 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660684,625,241 - 4,675,380 (-)NCBIVero_WHO_p1.0
Il4r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478211,981,781 - 12,008,362 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,575,691 - 125,575,888UniSTSGRCm38
MGSCv377132,719,205 - 132,719,402UniSTSGRCm37
Celera7125,434,355 - 125,434,552UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
cM Map762.0UniSTS
M27960  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,576,101 - 125,576,213UniSTSGRCm38
MGSCv377132,719,615 - 132,719,727UniSTSGRCm37
Celera7125,434,765 - 125,434,877UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Whitehead/MRC_RH71287.81UniSTS
PMC18827P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,571,446 - 125,571,570UniSTSGRCm38
MGSCv377132,714,960 - 132,715,084UniSTSGRCm37
Celera7125,430,110 - 125,430,234UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Il4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS
cM Map1129.0UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,576,634 - 125,576,940UniSTSGRCm38
MGSCv377132,720,148 - 132,720,454UniSTSGRCm37
Celera7125,435,298 - 125,435,604UniSTS
Cytogenetic Map7F3UniSTS
cM Map762.0UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387125,571,448 - 125,572,924UniSTSGRCm38
MGSCv377132,714,962 - 132,716,438UniSTSGRCm37
Celera7125,430,112 - 125,431,588UniSTS
Cytogenetic Map7F3UniSTS
Il4ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105651440139651588Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105750785139750785Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7116100000128900000Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117600000134500000Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7118151499128365612Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
38501070Tip5_mtuberculosis immunophenotype 5, IFN-g level (mouse)7121000000130700000Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122651440129217600Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122651440135569172Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124700000127300000Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124914439129217600Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1066
Count of miRNA genes:558
Interacting mature miRNAs:688
Transcripts:ENSMUST00000033004
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF000304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC212685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC339001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033004   ⟹   ENSMUSP00000033004
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,292 - 125,178,646 (+)Ensembl
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205985   ⟹   ENSMUSP00000145725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,448 - 125,169,169 (+)Ensembl
GRCm38.p6 Ensembl7125,552,276 - 125,569,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206217   ⟹   ENSMUSP00000146185
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,443 - 125,166,383 (+)Ensembl
GRCm38.p6 Ensembl7125,552,271 - 125,567,211 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206681
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,443 - 125,171,452 (+)Ensembl
GRCm38.p6 Ensembl7125,552,271 - 125,572,280 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206846   ⟹   ENSMUSP00000145824
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7125,151,459 - 125,177,139 (+)Ensembl
GRCm38.p6 Ensembl7125,552,287 - 125,577,967 (+)Ensembl
RefSeq Acc Id: NM_001008700   ⟹   NP_001008700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397125,151,443 - 125,178,646 (+)NCBI
GRCm387125,552,271 - 125,579,474 (+)NCBI
MGSCv377132,695,796 - 132,722,988 (+)RGD
Celera7125,410,962 - 125,438,138 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001363983   ⟹   NP_001350912
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397125,151,443 - 125,178,646 (+)NCBI
GRCm387125,552,271 - 125,579,474 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008700   ⟸   NM_001008700
- Peptide Label: isoform 1 precursor
- UniProtKB: P16382 (UniProtKB/Swiss-Prot),   Q3U905 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350912   ⟸   NM_001363983
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000145824   ⟸   ENSMUST00000206846
RefSeq Acc Id: ENSMUSP00000146185   ⟸   ENSMUST00000206217
RefSeq Acc Id: ENSMUSP00000145725   ⟸   ENSMUST00000205985
RefSeq Acc Id: ENSMUSP00000033004   ⟸   ENSMUST00000033004
Protein Domains
Fibronectin type-III   IL4Ra_N

Promoters
RGD ID:8665563
Promoter ID:EPDNEW_M10783
Type:initiation region
Name:Il4ra_1
Description:Mus musculus interleukin 4 receptor, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387125,552,282 - 125,552,342EPDNEW
RGD ID:6841356
Promoter ID:MM_KWN:52638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK020774_A430106F20RIK,   ENSMUST00000033004,   ENSMUST00000106428,   UC009JQB.1,   UC009JQD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,694,766 - 132,696,332 (+)MPROMDB
RGD ID:6848153
Promoter ID:MM_ACW:46028
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:IL4RA.GSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,708,124 - 132,708,624 (+)MPROMDB
RGD ID:6848151
Promoter ID:MM_ACW:46030
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:IL4RA.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367132,718,226 - 132,718,726 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105367 AgrOrtholog
Ensembl Genes ENSMUSG00000030748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145725 UniProtKB/TrEMBL
  ENSMUSP00000145824 UniProtKB/Swiss-Prot
  ENSMUSP00000146185 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000205985 UniProtKB/TrEMBL
  ENSMUST00000206217 UniProtKB/TrEMBL
  ENSMUST00000206846 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4_rcpt-alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105367 ENTREZGENE
NCBI Gene 16190 ENTREZGENE
Pfam IL4Ra_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il4ra PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNW1_MOUSE UniProtKB/TrEMBL
  A0A0U1RPZ6_MOUSE UniProtKB/TrEMBL
  A2VCP1_MOUSE UniProtKB/TrEMBL
  IL4RA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U905 ENTREZGENE, UniProtKB/TrEMBL
  Q3UE66_MOUSE UniProtKB/TrEMBL
  Q544A9_MOUSE UniProtKB/TrEMBL
  Q921I3_MOUSE UniProtKB/TrEMBL
  W8DL82_MOUSE UniProtKB/TrEMBL
  W8DLM5_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54690 UniProtKB/Swiss-Prot
  Q60583 UniProtKB/Swiss-Prot
  Q8CBW5 UniProtKB/Swiss-Prot