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Gene: Il4ra (interleukin 4 receptor, alpha) Mus musculus
Symbol: Il4ra
Name: interleukin 4 receptor, alpha
RGD ID: 10798
Description: Predicted to have cytokine receptor activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; positive regulation of myoblast fusion; and regulation of leukocyte activation. Predicted to localize to several cellular components, including centriolar satellite; extracellular space; and nucleoplasm. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; human immunodeficiency virus infectious disease; multiple sclerosis (multiple); and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor); PARTICIPATES IN interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD124; I; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Il4r; interleukin-4 receptor subunit alpha; MGC118473
Homo sapiens (human) : IL4R (interleukin 4 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il4r (interleukin 4 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il4r (interleukin 4 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IL4R (interleukin 4 receptor)
Canis lupus familiaris (dog) : IL4R (interleukin 4 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il4r (interleukin 4 receptor)
Sus scrofa (pig) : IL4R (interleukin 4 receptor)
Chlorocebus sabaeus (African green monkey) : IL4R (interleukin 4 receptor)
Heterocephalus glaber (naked mole-rat) : Il4r (interleukin 4 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl7125,552,120 - 125,579,474 (+)EnsemblGRCm38mm10GRCm38
GRCm387125,552,271 - 125,579,474 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377132,695,796 - 132,722,988 (+)NCBIGRCm37mm9NCBIm37
MGSCv367125,343,387 - 125,369,113 (+)NCBImm8
Celera7125,410,962 - 125,438,138 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map768.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il4ra
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10798
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.