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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10798
Species: Mus musculus
RGD Object: Gene
Symbol: Il4ra
Name: interleukin 4 receptor, alpha
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4radecreases expressionISOIL4R (Homo sapiens)6480464CTDGenistein results in decreased expression of IL4R mRNAPMID:16705744
Il4raincreases expressionISOIl4r (Rattus norvegicus)6480464CTDGenistein results in increased expression of IL4RA mRNAPMID:12075121
Il4raincreases expressionISOIL4R (Homo sapiens)6480464CTDGenistein results in increased expression of IL4R mRNAPMID:23019147
Il4ramultiple interactionsISOIl4r (Rattus norvegicus)6480464CTD[Genistein co-treated with Methoxychlor] results in decreased expression of IL4RA mRNAPMID:21782745
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