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Gene: Topbp1 (DNA topoisomerase II binding protein 1) Rattus norvegicus
Symbol: Topbp1
Name: DNA topoisomerase II binding protein 1
Description: Predicted to have identical protein binding activity. Predicted to be involved in cellular response to DNA damage stimulus; mitotic DNA replication checkpoint; and response to ionizing radiation. Predicted to localize to the actin cytoskeleton; nucleus; and plasma membrane. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA topoisomerase 2-binding protein 1; LOC315969; RGD1562949; similar to mKIAA0259 protein; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
Homo sapiens (human) : TOPBP1 (DNA topoisomerase II binding protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Topbp1 (topoisomerase (DNA) II binding protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topbp1 (DNA topoisomerase II binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPBP1 (DNA topoisomerase II binding protein 1)
Canis lupus familiaris (dog) : TOPBP1 (DNA topoisomerase II binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topbp1 (DNA topoisomerase II binding protein 1)
Sus scrofa (pig) : TOPBP1 (DNA topoisomerase II binding protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08111,790,655 - 111,835,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,790,678 - 111,827,151 (+)Ensembl
Rnor_5.08111,182,214 - 111,226,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48108,316,569 - 108,360,753 (+)NCBIRGSC3.4rn4RGSC3.4
Celera8103,263,981 - 103,308,109 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Topbp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1562949
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.