Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Topbp1 (DNA topoisomerase II binding protein 1) Rattus norvegicus
Analyze
Symbol: Topbp1
Name: DNA topoisomerase II binding protein 1
Description: Predicted to have identical protein binding activity. Predicted to be involved in cellular response to DNA damage stimulus; mitotic DNA replication checkpoint; and response to ionizing radiation. Predicted to localize to the actin cytoskeleton; nucleus; and plasma membrane. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA topoisomerase 2-binding protein 1; LOC315969; RGD1562949; similar to mKIAA0259 protein; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
Orthologs:
Homo sapiens (human) : TOPBP1 (DNA topoisomerase II binding protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Topbp1 (topoisomerase (DNA) II binding protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topbp1 (DNA topoisomerase II binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPBP1 (DNA topoisomerase II binding protein 1)
Canis lupus familiaris (dog) : TOPBP1 (DNA topoisomerase II binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topbp1 (DNA topoisomerase II binding protein 1)
Sus scrofa (pig) : TOPBP1 (DNA topoisomerase II binding protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08111,790,655 - 111,835,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,790,678 - 111,827,151 (+)Ensembl
Rnor_5.08111,182,214 - 111,226,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48108,316,569 - 108,360,753 (+)NCBIRGSC3.4rn4RGSC3.4
Celera8103,263,981 - 103,308,109 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Topbp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1562949
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.