Epm2aip1 (EPM2A interacting protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Epm2aip1 (EPM2A interacting protein 1) Rattus norvegicus
Analyze
Symbol: Epm2aip1
Name: EPM2A interacting protein 1
RGD ID: 1310977
Description: Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of glycogen biosynthetic process. Predicted to act upstream of or within positive regulation of glycogen (starch) synthase activity and response to insulin. Predicted to be located in cytoplasmic side of endoplasmic reticulum membrane and nucleus. Orthologous to human EPM2AIP1 (EPM2A interacting protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EPM2A (laforin) interacting protein 1; EPM2A-interacting protein 1; LOC316021
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28111,233,871 - 111,241,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8111,233,826 - 111,241,871 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,849,883 - 116,857,233 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08115,049,114 - 115,056,464 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08112,891,938 - 112,899,288 (+)NCBIRnor_WKY
Rnor_6.08119,524,039 - 119,531,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,524,039 - 119,531,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,865,643 - 118,872,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,653,794 - 115,656,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,673,241 - 115,721,997 (+)NCBI
Celera8110,515,491 - 110,522,839 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
leflunomide  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15102711   PMID:24142699   PMID:25416956  


Genomics

Comparative Map Data
Epm2aip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28111,233,871 - 111,241,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8111,233,826 - 111,241,871 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,849,883 - 116,857,233 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08115,049,114 - 115,056,464 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08112,891,938 - 112,899,288 (+)NCBIRnor_WKY
Rnor_6.08119,524,039 - 119,531,387 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,524,039 - 119,531,387 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,865,643 - 118,872,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,653,794 - 115,656,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,673,241 - 115,721,997 (+)NCBI
Celera8110,515,491 - 110,522,839 (+)NCBICelera
Cytogenetic Map8q32NCBI
EPM2AIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38336,985,043 - 36,993,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl336,985,043 - 36,993,131 (-)EnsemblGRCh38hg38GRCh38
GRCh37337,026,534 - 37,034,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,004,233 - 37,009,799 (-)NCBINCBI36Build 36hg18NCBI36
Build 34337,004,232 - 37,009,799NCBI
Celera336,970,125 - 36,977,560 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef336,968,039 - 36,975,475 (-)NCBIHuRef
CHM1_1336,978,987 - 36,986,425 (-)NCBICHM1_1
T2T-CHM13v2.0336,986,417 - 36,994,504 (-)NCBIT2T-CHM13v2.0
Epm2aip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399111,100,913 - 111,108,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9111,100,997 - 111,108,161 (+)EnsemblGRCm39 Ensembl
GRCm389111,271,845 - 111,279,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,271,929 - 111,279,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv379111,174,349 - 111,181,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369111,116,745 - 111,123,905 (+)NCBIMGSCv36mm8
Celera9110,995,011 - 111,002,246 (+)NCBICelera
Cytogenetic Map9F3NCBI
Epm2aip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554213,888,007 - 3,889,833 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554213,882,486 - 3,889,851 (-)NCBIChiLan1.0ChiLan1.0
EPM2AIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1337,181,452 - 37,189,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl337,187,354 - 37,189,177 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0336,894,383 - 36,899,772 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EPM2AIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,880,996 - 6,888,863 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl236,886,885 - 6,888,711 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha236,920,696 - 6,929,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,166,293 - 7,174,683 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,172,187 - 7,174,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1236,986,257 - 6,994,111 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0237,128,462 - 7,136,312 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,118,608 - 7,126,995 (-)NCBIUU_Cfam_GSD_1.0
Epm2aip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118193,410,275 - 193,417,791 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647326,548,849 - 26,556,333 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647326,548,847 - 26,556,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPM2AIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1321,878,146 - 21,879,972 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11321,877,863 - 21,886,210 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21323,777,539 - 23,782,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPM2AIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,418,518 - 2,422,637 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,418,630 - 2,420,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606311,155,386 - 11,162,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epm2aip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478815,108,361 - 15,110,187 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478815,102,663 - 15,110,354 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epm2aip1
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000056050
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
BE102062  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28111,243,415 - 111,243,583 (+)MAPPERmRatBN7.2
Rnor_6.08119,533,583 - 119,533,750NCBIRnor6.0
Rnor_5.08118,874,782 - 118,874,949UniSTSRnor5.0
RGSC_v3.48115,663,805 - 115,663,972UniSTSRGSC3.4
Celera8110,525,047 - 110,525,214UniSTS
RH 3.4 Map81191.5UniSTS
Cytogenetic Map8q32UniSTS
BF391074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28111,236,644 - 111,236,798 (+)MAPPERmRatBN7.2
Rnor_6.08119,526,813 - 119,526,966NCBIRnor6.0
Rnor_5.08118,868,012 - 118,868,165UniSTSRnor5.0
RGSC_v3.48115,656,371 - 115,656,524UniSTSRGSC3.4
Celera8110,518,265 - 110,518,418UniSTS
RH 3.4 Map81190.09UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 55 39 19 39 8 11 74 34 36 11 8
Low 1 2 2 2 1 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056050   ⟹   ENSRNOP00000052902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8111,233,826 - 111,241,871 (+)Ensembl
Rnor_6.0 Ensembl8119,524,039 - 119,531,387 (+)Ensembl
RefSeq Acc Id: NM_001271384   ⟹   NP_001258313
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28111,233,871 - 111,241,219 (+)NCBI
Rnor_6.08119,524,039 - 119,531,387 (+)NCBI
Rnor_5.08118,865,643 - 118,872,586 (+)NCBI
Celera8110,515,491 - 110,522,839 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258313 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77035 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258313   ⟸   NM_001271384
- UniProtKB: F1M471 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052902   ⟸   ENSRNOT00000056050
Protein Domains
zf-C2H2_12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M471-F1-model_v2 AlphaFold F1M471 1-606 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696346
Promoter ID:EPDNEW_R6870
Type:initiation region
Name:Epm2aip1_1
Description:EPM2A interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,524,120 - 119,524,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310977 AgrOrtholog
BioCyc Gene G2FUF-29022 BioCyc
Ensembl Genes ENSRNOG00000043006 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052902 ENTREZGENE
  ENSRNOP00000052902.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056050 ENTREZGENE
  ENSRNOT00000056050.5 UniProtKB/TrEMBL
InterPro EPM2A-int_1 UniProtKB/TrEMBL
  SPIN-DOC_Znf-C2H2 UniProtKB/TrEMBL
KEGG Report rno:316021 UniProtKB/TrEMBL
NCBI Gene 316021 ENTREZGENE
PANTHER PTHR45913 UniProtKB/TrEMBL
Pfam zf-C2H2_12 UniProtKB/TrEMBL
PhenoGen Epm2aip1 PhenoGen
UniProt F1M471 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Epm2aip1  EPM2A interacting protein 1  Epm2aip1  EPM2A (laforin) interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Epm2aip1  EPM2A (laforin) interacting protein 1   Epm2aip1_predicted  EPM2A (laforin) interacting protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Epm2aip1_predicted  EPM2A (laforin) interacting protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED