Adcy4 (adenylate cyclase 4) - Rat Genome Database

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Gene: Adcy4 (adenylate cyclase 4) Rattus norvegicus
Analyze
Symbol: Adcy4
Name: adenylate cyclase 4
RGD ID: 2034
Description: Enables G-protein beta/gamma-subunit complex binding activity and adenylate cyclase activity. Involved in cAMP biosynthetic process and intracellular signal transduction. Located in membrane and nucleus. Part of protein-containing complex. Orthologous to human ADCY4 (adenylate cyclase 4); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase type 4; adenylate cyclase type IV; adenylyl cyclase 4; ATP pyrophosphate-lyase 4; MGC93493
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21529,266,280 - 29,282,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,266,287 - 29,282,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,111,969 - 31,127,788 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01532,259,179 - 32,274,998 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01530,501,528 - 30,517,347 (-)NCBIRnor_WKY
Rnor_6.01534,453,917 - 34,469,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,453,915 - 34,469,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,342,429 - 38,358,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,930,531 - 33,946,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,946,233 - 33,962,015 (-)NCBI
Celera1528,841,216 - 28,857,037 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
dendrite  (IEA,ISO)
membrane  (IDA)
nucleus  (IDA)
plasma membrane  (IBA,IEA)
protein-containing complex  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy. Bagavandoss P and Grimshaw S, Anat Rec (Hoboken). 2012 Oct;295(10):1717-26. doi: 10.1002/ar.22550. Epub 2012 Aug 16.
2. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Gao BN and Gilman AG, Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10178-82.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
14. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
18. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits. Zimmermann G and Taussig R, J Biol Chem. 1996 Oct 25;271(43):27161-6.
Additional References at PubMed
PMID:9870949   PMID:11549699   PMID:17081159  


Genomics

Comparative Map Data
Adcy4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21529,266,280 - 29,282,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,266,287 - 29,282,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,111,969 - 31,127,788 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01532,259,179 - 32,274,998 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01530,501,528 - 30,517,347 (-)NCBIRnor_WKY
Rnor_6.01534,453,917 - 34,469,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,453,915 - 34,469,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,342,429 - 38,358,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,930,531 - 33,946,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,946,233 - 33,962,015 (-)NCBI
Celera1528,841,216 - 28,857,037 (-)NCBICelera
Cytogenetic Map15p13NCBI
ADCY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,318,359 - 24,335,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1424,318,349 - 24,335,093 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,787,565 - 24,804,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,857,410 - 23,873,704 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,857,410 - 23,873,704NCBI
Celera144,652,191 - 4,668,489 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,902,443 - 4,919,171 (-)NCBIHuRef
CHM1_11424,786,147 - 24,802,872 (-)NCBICHM1_1
T2T-CHM13v2.01418,516,694 - 18,533,416 (-)NCBIT2T-CHM13v2.0
Adcy4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,006,513 - 56,021,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,006,514 - 56,021,552 (-)EnsemblGRCm39 Ensembl
GRCm381455,769,056 - 55,784,095 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,769,057 - 55,784,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,387,929 - 56,402,856 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,723,163 - 54,738,090 (-)NCBIMGSCv36mm8
Celera1453,574,126 - 53,589,052 (-)NCBICelera
Cytogenetic Map14C3NCBI
Adcy4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,966,332 - 35,982,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,966,529 - 35,982,839 (+)NCBIChiLan1.0ChiLan1.0
ADCY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11423,218,178 - 23,234,861 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,218,178 - 23,234,861 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0145,094,899 - 5,111,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADCY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,288,708 - 4,304,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,288,714 - 4,304,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,210,485 - 4,226,167 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,399,506 - 4,415,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,399,531 - 4,415,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,089,855 - 4,105,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,151,682 - 4,167,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,414,264 - 4,429,941 (-)NCBIUU_Cfam_GSD_1.0
Adcy4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,158,190 - 36,175,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722213,916 - 230,906 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936722213,916 - 230,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,956,220 - 74,972,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,955,410 - 74,972,440 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,226,295 - 80,243,376 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,301,445 - 1,318,171 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,301,506 - 1,316,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,985,965 - 13,001,961 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,169,816 - 8,189,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,170,258 - 8,186,214 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy4
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:41
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000027719, ENSRNOT00000067536
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat

Markers in Region
RH129786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,283,184 - 29,283,381 (+)MAPPERmRatBN7.2
Rnor_6.01534,470,819 - 34,471,015NCBIRnor6.0
Rnor_5.01538,359,330 - 38,359,526UniSTSRnor5.0
RGSC_v3.41533,947,429 - 33,947,625UniSTSRGSC3.4
Celera1528,858,114 - 28,858,310UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS
Adcy4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,266,291 - 29,266,420 (+)MAPPERmRatBN7.2
Rnor_6.01534,453,929 - 34,454,057NCBIRnor6.0
Rnor_5.01538,342,441 - 38,342,569UniSTSRnor5.0
RGSC_v3.41533,930,539 - 33,930,667UniSTSRGSC3.4
Celera1528,841,224 - 28,841,352UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 2 2 11 2 14 17 11
Low 3 12 55 39 8 39 8 11 74 21 17 8
Below cutoff 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027719   ⟹   ENSRNOP00000027719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,266,287 - 29,282,108 (-)Ensembl
Rnor_6.0 Ensembl1534,453,915 - 34,469,746 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067536   ⟹   ENSRNOP00000059696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,453,977 - 34,469,350 (-)Ensembl
RefSeq Acc Id: NM_019285   ⟹   NP_062158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21529,266,284 - 29,282,108 (-)NCBI
Rnor_6.01534,453,921 - 34,469,742 (-)NCBI
Rnor_5.01538,342,429 - 38,358,268 (-)NCBI
RGSC_v3.41533,930,531 - 33,946,352 (-)RGD
Celera1528,841,216 - 28,857,037 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093610   ⟹   XP_038949538
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21529,266,280 - 29,280,040 (-)NCBI
RefSeq Acc Id: XM_039093611   ⟹   XP_038949539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21529,266,280 - 29,277,631 (-)NCBI
RefSeq Acc Id: XM_039093612   ⟹   XP_038949540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21529,266,280 - 29,281,749 (-)NCBI
RefSeq Acc Id: XR_359917
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21529,266,284 - 29,282,153 (-)NCBI
Rnor_6.01534,453,921 - 34,469,779 (-)NCBI
Rnor_5.01538,342,429 - 38,358,268 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062158   ⟸   NM_019285
- UniProtKB: Q66HK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059696   ⟸   ENSRNOT00000067536
RefSeq Acc Id: ENSRNOP00000027719   ⟸   ENSRNOT00000027719
RefSeq Acc Id: XP_038949540   ⟸   XM_039093612
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949538   ⟸   XM_039093610
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949539   ⟸   XM_039093611
- Peptide Label: isoform X2
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26770-F1-model_v2 AlphaFold P26770 1-1064 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699690
Promoter ID:EPDNEW_R10213
Type:single initiation site
Name:Adcy4_1
Description:adenylate cyclase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,469,729 - 34,469,789EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2034 AgrOrtholog
BioCyc Gene G2FUF-13686 BioCyc
Ensembl Genes ENSRNOG00000020401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027719 ENTREZGENE
  ENSRNOP00000027719.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027719 ENTREZGENE
  ENSRNOT00000027719.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125413 IMAGE-MGC_LOAD
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54223 UniProtKB/TrEMBL
MGC_CLONE MGC:93493 IMAGE-MGC_LOAD
NCBI Gene 54223 ENTREZGENE
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy4 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208929
UniProt ADCY4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HK5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Adcy4  adenylate cyclase 4    adenylyl cyclase 4  Name updated 1299863 APPROVED
2002-06-10 Adcy4  adenylyl cyclase 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the central nervous system and other tissues 69739
gene_function catalyzes the conversion of ATP to 3,5-cyclic AMP + diphosphate 69739
gene_process plays a role in intracellular signaling 69739
gene_regulation not regulated by calmodulin 69739
gene_regulation activated by the Gs alpha and G-protein beta gamma subunit complex 69739