RGD Reference Report - Cloning and expression of a widely distributed (type IV) adenylyl cyclase. - Rat Genome Database

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Cloning and expression of a widely distributed (type IV) adenylyl cyclase.

Authors: Gao, BN  Gilman, AG 
Citation: Gao BN and Gilman AG, Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10178-82.
RGD ID: 69739
Pubmed: PMID:1946437   (View Abstract at PubMed)
PMCID: PMC52891   (View Article at PubMed Central)

We have cloned and expressed a cDNA that encodes a widely distributed form of mammalian adenylyl cyclase (EC 4.6.1.1). Although those adenylyl cyclases described previously have a rather narrow tissue distribution, this enzyme (type IV) is apparently synthesized in a variety of peripheral tissues and in the central nervous system. The protein resembles the other adenylyl cyclases in its proposed structure. It most resembles the type II adenylyl cyclase described in the preceding paper [Feinstein, P. G., Schrader, K. A., Bakalyar, H. A., Tang, W.-J., Krupinski, J., Gilman, A. G. & Reed, R. R. (1991) Proc. Natl. Acad. Sci. USA 88, 10173-10177] in its amino acid sequence, lack of response to calmodulin, and synergistic activation by a combination of the Gs alpha subunit and the G-protein beta gamma subunit complex.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
intracellular signal transduction  IDA 69739 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
adenylate cyclase activity  IDA 69739 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adcy4  (adenylate cyclase 4)

Objects referenced in this article
Gene Adcy4 adenylate cyclase 4 Mus musculus

Additional Information