ADCY4 (adenylate cyclase 4) - Rat Genome Database

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Gene: ADCY4 (adenylate cyclase 4) Pan paniscus
Analyze
Symbol: ADCY4
Name: adenylate cyclase 4
RGD ID: 11847001
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Breast Cancer, Familial (ortholog); cervical cancer (ortholog); colon adenocarcinoma (ortholog); FOUND IN membrane (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase type 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,673,520 - 25,690,270 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,890,012 - 24,906,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,094,899 - 5,111,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,218,178 - 23,234,861 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,218,178 - 23,234,861 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,673,520 - 25,690,270 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,890,012 - 24,906,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,094,899 - 5,111,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,218,178 - 23,234,861 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,218,178 - 23,234,861 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ADCY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,318,359 - 24,335,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,318,091 - 24,335,208 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371424,787,565 - 24,804,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,857,410 - 23,873,704 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,857,410 - 23,873,704NCBI
Celera144,652,191 - 4,668,489 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,902,443 - 4,919,171 (-)NCBIHuRef
CHM1_11424,786,147 - 24,802,872 (-)NCBICHM1_1
T2T-CHM13v2.01418,516,694 - 18,533,416 (-)NCBIT2T-CHM13v2.0
Adcy4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,006,513 - 56,021,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,006,514 - 56,021,552 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,769,056 - 55,784,095 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,769,057 - 55,784,095 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371456,387,929 - 56,402,856 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,723,163 - 54,738,090 (-)NCBIMGSCv36mm8
Celera1453,574,126 - 53,589,052 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Adcy4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,236,201 - 33,252,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,236,208 - 33,252,026 (-)EnsemblGRCr8
mRatBN7.21529,266,280 - 29,282,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,266,287 - 29,282,108 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,111,969 - 31,127,788 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,259,179 - 32,274,998 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,501,528 - 30,517,347 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1531,935,486 - 31,951,307 (-)NCBI
Lyon_Normotensive1531,640,217 - 31,656,033 (-)NCBI
Lyon_Hypertensive1531,746,711 - 31,762,530 (-)NCBI
F344_StmMcwi1530,933,432 - 30,949,249 (-)NCBI
Rnor_6.01534,453,917 - 34,469,779 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,453,915 - 34,469,746 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01538,342,429 - 38,358,268 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,930,531 - 33,946,352 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,841,216 - 28,857,037 (-)NCBICelera
RGSC_v3.11533,946,233 - 33,962,015 (-)NCBI
Cytogenetic Map15p13NCBI
Adcy4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,966,332 - 35,982,218 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540935,966,529 - 35,982,839 (+)NCBIChiLan1.0ChiLan1.0
ADCY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,288,708 - 4,304,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,288,714 - 4,304,589 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,210,485 - 4,226,167 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,399,506 - 4,415,189 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,399,531 - 4,415,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,089,855 - 4,105,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,151,682 - 4,167,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,414,264 - 4,429,941 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adcy4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1589,386,499 - 89,403,425 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440864036,158,190 - 36,175,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722213,916 - 230,906 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722213,916 - 230,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,956,220 - 74,972,196 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1774,955,410 - 74,972,440 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,226,295 - 80,243,376 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap124566,881 - 582,763 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603612,985,965 - 13,001,961 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1241,301,445 - 1,318,171 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,301,506 - 1,316,868 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Adcy4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,170,258 - 8,186,214 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248208,169,816 - 8,189,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl222,202,990 - 22,219,405 (-)Ensembl
Adcy4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11269,219,750 - 69,235,569 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000053964   ⟹   ENSPPAP00000031100
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1423,218,178 - 23,234,861 (-)Ensembl
RefSeq Acc Id: XM_008961276   ⟹   XP_008959524
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,266 (-)NCBI
NHGRI_mPanPan11424,890,012 - 24,906,736 (-)NCBI
Mhudiblu_PPA_v0145,094,899 - 5,111,601 (-)NCBI
PanPan1.11423,218,180 - 23,234,861 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034937349   ⟹   XP_034793240
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,263 (-)NCBI
NHGRI_mPanPan11424,890,012 - 24,906,722 (-)NCBI
Mhudiblu_PPA_v0145,094,899 - 5,111,588 (-)NCBI
RefSeq Acc Id: XM_034937351   ⟹   XP_034793242
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,261 (-)NCBI
NHGRI_mPanPan11424,890,012 - 24,906,733 (-)NCBI
Mhudiblu_PPA_v0145,094,899 - 5,111,600 (-)NCBI
RefSeq Acc Id: XM_034937353   ⟹   XP_034793244
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,269 (-)NCBI
NHGRI_mPanPan11424,890,012 - 24,906,738 (-)NCBI
Mhudiblu_PPA_v0145,094,962 - 5,111,602 (-)NCBI
RefSeq Acc Id: XM_063596466   ⟹   XP_063452536
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,263 (-)NCBI
RefSeq Acc Id: XM_063596467   ⟹   XP_063452537
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,270 (-)NCBI
RefSeq Acc Id: XM_063596468   ⟹   XP_063452538
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,673,520 - 25,690,261 (-)NCBI
RefSeq Acc Id: XP_008959524   ⟸   XM_008961276
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034793242   ⟸   XM_034937351
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034793240   ⟸   XM_034937349
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BN50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034793244   ⟸   XM_034937353
- Peptide Label: isoform X4
Ensembl Acc Id: ENSPPAP00000031100   ⟸   ENSPPAT00000053964
RefSeq Acc Id: XP_063452537   ⟸   XM_063596467
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063452536   ⟸   XM_063596466
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BN50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063452538   ⟸   XM_063596468
- Peptide Label: isoform X5
Protein Domains
Guanylate cyclase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038492 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050020397 ENTREZGENE
Ensembl Transcript ENSPPAT00000053964.1 UniProtKB/TrEMBL
  ENSPPAT00050043089 ENTREZGENE
  ENSPPAT00050043096 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
NCBI Gene ADCY4 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 4 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt A0A2R9BN50 ENTREZGENE, UniProtKB/TrEMBL