Adcy4 (adenylate cyclase 4) - Rat Genome Database

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Gene: Adcy4 (adenylate cyclase 4) Ictidomys tridecemlineatus
Analyze
Symbol: Adcy4
Name: adenylate cyclase 4
RGD ID: 12494691
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); lysinuric protein intolerance (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase 4, transcript variant X1; adenylate cyclase 4, transcript variant X2; adenylate cyclase type 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,158,190 - 36,175,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722213,916 - 230,906 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722213,916 - 230,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adcy4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,158,190 - 36,175,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722213,916 - 230,906 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722213,916 - 230,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,318,359 - 24,335,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,318,349 - 24,335,093 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,787,565 - 24,804,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,857,410 - 23,873,704 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,857,410 - 23,873,704NCBI
Celera144,652,191 - 4,668,489 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,902,443 - 4,919,171 (-)NCBIHuRef
CHM1_11424,786,147 - 24,802,872 (-)NCBICHM1_1
T2T-CHM13v2.01418,516,694 - 18,533,416 (-)NCBIT2T-CHM13v2.0
Adcy4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,006,513 - 56,021,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,006,514 - 56,021,552 (-)EnsemblGRCm39 Ensembl
GRCm381455,769,056 - 55,784,095 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,769,057 - 55,784,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,387,929 - 56,402,856 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,723,163 - 54,738,090 (-)NCBIMGSCv36mm8
Celera1453,574,126 - 53,589,052 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Adcy4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,236,201 - 33,252,070 (-)NCBIGRCr8
mRatBN7.21529,266,280 - 29,282,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,266,287 - 29,282,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,111,969 - 31,127,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,259,179 - 32,274,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,501,528 - 30,517,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,453,917 - 34,469,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,453,915 - 34,469,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,342,429 - 38,358,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,930,531 - 33,946,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,946,233 - 33,962,015 (-)NCBI
Celera1528,841,216 - 28,857,037 (-)NCBICelera
Cytogenetic Map15p13NCBI
Adcy4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,966,332 - 35,982,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,966,529 - 35,982,839 (+)NCBIChiLan1.0ChiLan1.0
ADCY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,673,520 - 25,690,270 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,890,012 - 24,906,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,094,899 - 5,111,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,218,178 - 23,234,861 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,218,178 - 23,234,861 (-)Ensemblpanpan1.1panPan2
ADCY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,288,708 - 4,304,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,288,714 - 4,304,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,210,485 - 4,226,167 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,399,506 - 4,415,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,399,531 - 4,415,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,089,855 - 4,105,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,151,682 - 4,167,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,414,264 - 4,429,941 (-)NCBIUU_Cfam_GSD_1.0
ADCY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,956,220 - 74,972,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,955,410 - 74,972,440 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,226,295 - 80,243,376 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,301,445 - 1,318,171 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,301,506 - 1,316,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,985,965 - 13,001,961 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,169,816 - 8,189,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,170,258 - 8,186,214 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002435   ⟹   ENSSTOP00000002179
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936722213,916 - 230,906 (+)Ensembl
RefSeq Acc Id: XM_013364503   ⟹   XP_013219957
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
SpeTri2.0NW_004936722213,916 - 230,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275173   ⟹   XP_040131107
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
RefSeq Acc Id: XM_040275174   ⟹   XP_040131108
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
RefSeq Acc Id: XM_040275175   ⟹   XP_040131109
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
RefSeq Acc Id: XM_040275176   ⟹   XP_040131110
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
RefSeq Acc Id: XM_040275177   ⟹   XP_040131111
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,190 - 36,175,108 (-)NCBI
RefSeq Acc Id: XM_040275178   ⟹   XP_040131112
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,479 - 36,175,109 (-)NCBI
RefSeq Acc Id: XM_040275179   ⟹   XP_040131113
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,480 - 36,175,109 (-)NCBI
RefSeq Acc Id: XM_040275180   ⟹   XP_040131114
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,159,392 - 36,175,109 (-)NCBI
RefSeq Acc Id: XM_040275181   ⟹   XP_040131115
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,158,480 - 36,175,109 (-)NCBI
RefSeq Acc Id: XR_005729334
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864036,159,235 - 36,175,109 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013219957   ⟸   XM_013364503
- Peptide Label: isoform X1
- UniProtKB: I3M0F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131107   ⟸   XM_040275173
- Peptide Label: isoform X1
- UniProtKB: I3M0F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040131110   ⟸   XM_040275176
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040131111   ⟸   XM_040275177
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040131108   ⟸   XM_040275174
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040131109   ⟸   XM_040275175
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040131112   ⟸   XM_040275178
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040131113   ⟸   XM_040275179
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040131115   ⟸   XM_040275181
- Peptide Label: isoform X7
RefSeq Acc Id: XP_040131114   ⟸   XM_040275180
- Peptide Label: isoform X7
RefSeq Acc Id: ENSSTOP00000002179   ⟸   ENSSTOT00000002435
Protein Domains
Guanylate cyclase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002428 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002435.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
NCBI Gene Adcy4 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 4 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt I3M0F0 ENTREZGENE, UniProtKB/TrEMBL