Nupr1 (nuclear protein 1, transcriptional regulator) - Rat Genome Database

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Gene: Nupr1 (nuclear protein 1, transcriptional regulator) Rattus norvegicus
Analyze
Symbol: Nupr1
Name: nuclear protein 1, transcriptional regulator
RGD ID: 69363
Description: Predicted to enable several functions, including acetyltransferase activator activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; negative regulation of autophagy; and regulation of apoptotic process. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator); INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: candidate of metastasis 1; LOC100912108; nuclear protein 1; nuclear protein 1-like; nuclear protein, transcriptional regulator, 1; nuclear proten 1; nuclear transcriptional regulator protein 1; p8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: This single-copy gene is duplicated in the RGSC5.0 assembly; GeneID:100912108 represents the intended location for the rat Nupr1 gene while GeneID:113900 is most likely an artifact in the RGSC5.0 assembly, based on syntenic gene analysis. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIRnor_WKY
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropropane  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-fluorouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
C-peptide  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorendic acid  (EXP)
chloropicrin  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxepin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (ISO)
glycine betaine  (EXP)
haloperidol  (ISO)
hydralazine  (ISO)
imipramine  (ISO)
indole-3-methanol  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
loratadine  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
myriocin  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
ofloxacin  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perhexiline  (ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
quinidine  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sotalol  (ISO)
SR 144528  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
fibroblast apoptotic process  (ISO)
fibroblast proliferation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of autophagosome assembly  (ISO,ISS)
negative regulation of autophagy  (IMP,ISO,ISS)
negative regulation of cardiac muscle cell apoptotic process  (IMP,ISO,ISS)
negative regulation of cell cycle  (IBA,ISO,ISS)
negative regulation of cell population proliferation  (IBA)
negative regulation of DNA-binding transcription factor activity  (IMP,ISO,ISS)
negative regulation of epithelial cell apoptotic process  (ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO,ISS)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of glycolytic process  (ISO,ISS)
negative regulation of programmed necrotic cell death  (ISO,ISS)
negative regulation of type B pancreatic cell proliferation  (ISO,ISS)
positive regulation of cell cycle  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IMP,ISO,ISS)
positive regulation of neuroinflammatory response  (ISO,ISS)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of oxidative phosphorylation  (ISO,ISS)
positive regulation of proteasomal protein catabolic process  (ISO,ISS)
positive regulation of protein modification process  (ISO)
protein acetylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of autophagy  (IMP)
regulation of female gonad development  (ISO)
regulation of response to endoplasmic reticulum stress  (IMP,ISO,ISS)
response to toxic substance  (ISO)
skeletal muscle cell differentiation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Kong DK, etal., Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.e09-09-0818. Epub 2010 Feb 24.
4. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. Mallo GV, etal., J Biol Chem 1997 Dec 19;272(51):32360-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
Additional References at PubMed
PMID:7667285   PMID:10092851   PMID:11056169   PMID:11896600   PMID:11940591   PMID:12374743   PMID:14660681   PMID:14749270   PMID:15016802   PMID:15632090   PMID:16300740   PMID:16374777  
PMID:16478804   PMID:16480983   PMID:16981138   PMID:17116693   PMID:18495683   PMID:18690848   PMID:19723804   PMID:19775616   PMID:23900510   PMID:27451286   PMID:30451898   PMID:31914690  
PMID:34830471  


Genomics

Comparative Map Data
Nupr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIRnor_WKY
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
NUPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,532,708 - 28,538,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1628,532,708 - 28,539,008 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,544,029 - 28,550,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,456,163 - 28,457,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,456,162 - 28,457,831NCBI
Celera1627,653,286 - 27,655,119 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,574,331 - 26,576,164 (-)NCBIHuRef
CHM1_11629,560,413 - 29,562,246 (-)NCBICHM1_1
T2T-CHM13v2.01628,856,812 - 28,863,107 (+)NCBIT2T-CHM13v2.0
Nupr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,222,418 - 126,224,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,222,421 - 126,230,033 (-)EnsemblGRCm39 Ensembl
GRCm387126,623,246 - 126,625,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,623,249 - 126,630,861 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,766,760 - 133,768,984 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,414,394 - 126,416,618 (-)NCBIMGSCv36mm8
Celera7126,472,385 - 126,474,623 (-)NCBICelera
Cytogenetic Map7F3NCBI
Nupr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBIChiLan1.0ChiLan1.0
NUPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11634,949,566 - 34,951,364 (+)NCBINHGRI_mPanPan1
PanPan1.11629,015,155 - 29,016,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,015,155 - 29,016,987 (-)Ensemblpanpan1.1panPan2
NUPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,222,367 - 18,224,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,222,515 - 18,224,014 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,801,224 - 19,802,818 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,358,557 - 18,360,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,358,631 - 18,360,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,157,477 - 18,159,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,072,694 - 18,074,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,388,742 - 18,390,336 (+)NCBIUU_Cfam_GSD_1.0
Nupr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,900,204 - 123,901,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,997,834 - 11,999,709 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493650111,998,064 - 11,999,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NUPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,382,125 - 26,385,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,382,132 - 26,385,348 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,184,304 - 3,186,193 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nupr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,042,939 - 13,044,267 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,042,938 - 13,044,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nupr1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000072875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat

Markers in Region
RH131382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,213,400 - 181,214,661 (+)MAPPERmRatBN7.2
Rnor_6.01198,043,226 - 198,044,486NCBIRnor6.0
Rnor_6.01194,767,593 - 194,768,853NCBIRnor6.0
Rnor_5.01201,816,842 - 201,818,102UniSTSRnor5.0
Rnor_5.01205,021,986 - 205,023,246UniSTSRnor5.0
RGSC_v3.41185,770,419 - 185,771,679UniSTSRGSC3.4
Celera1178,871,400 - 178,872,660UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system musculoskeletal system renal system reproductive system
High
Medium
Low
Below cutoff 1 1 1 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025988   ⟹   ENSRNOP00000025988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)Ensembl
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)Ensembl
RefSeq Acc Id: NM_053611   ⟹   NP_446063
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21181,213,292 - 181,215,327 (-)NCBI
Rnor_6.01194,767,484 - 194,769,519 (-)NCBI
Rnor_5.01205,021,877 - 205,023,912 (-)NCBI
RGSC_v3.41185,770,310 - 185,772,313 (-)RGD
Celera1178,871,291 - 178,873,326 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446063 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB94673 (Get FASTA)   NCBI Sequence Viewer  
  EDM17430 (Get FASTA)   NCBI Sequence Viewer  
  EDM17431 (Get FASTA)   NCBI Sequence Viewer  
  EDM17432 (Get FASTA)   NCBI Sequence Viewer  
  O54842 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446063   ⟸   NM_053611
- UniProtKB: O54842 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025988   ⟸   ENSRNOT00000025988

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54842-F1-model_v2 AlphaFold O54842 1-80 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690384
Promoter ID:EPDNEW_R909
Type:single initiation site
Name:Nupr1_1
Description:nuclear protein 1, transcriptional regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01194,769,481 - 194,769,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69363 AgrOrtholog
BioCyc Gene G2FUF-57436 BioCyc
Ensembl Genes ENSRNOG00000019206 Ensembl
InterPro NUPR1-like UniProtKB/Swiss-Prot
KEGG Report rno:100912108 UniProtKB/Swiss-Prot
NCBI Gene Nupr1 ENTREZGENE
PANTHER NUCLEAR PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR17149 UniProtKB/Swiss-Prot
Pfam Phospho_p8 UniProtKB/Swiss-Prot
PhenoGen Nupr1 PhenoGen
TIGR TC204889
UniProt NUPR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Nupr1  nuclear protein 1, transcriptional regulator  Nupr1  nuclear protein, transcriptional regulator, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-08 Nupr1  nuclear protein, transcriptional regulator, 1  LOC100912108  nuclear protein 1-like  Data Merged 737654 APPROVED
2014-07-08 Nupr1  nuclear protein, transcriptional regulator, 1  Nupr1  nuclear protein, transcriptional regulator, 1  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2012-07-05 LOC100912108  nuclear protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Nupr1  nuclear protein, transcriptional regulator, 1  Nupr1  nuclear protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Nupr1  nuclear protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression displays increased pancreatic acinar cell expression in pancreatitis, during development, and in response to cell injury and regeneration 68826