Nupr1 (nuclear protein 1, transcriptional regulator) - Rat Genome Database

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Gene: Nupr1 (nuclear protein 1, transcriptional regulator) Chinchilla lanigera
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Symbol: Nupr1
Name: nuclear protein 1, transcriptional regulator
RGD ID: 8898363
Description: ENCODES a protein that exhibits acetyltransferase activator activity (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN acute inflammatory response (ortholog); fibroblast apoptotic process (ortholog); fibroblast proliferation (ortholog); ASSOCIATED WITH Brody myopathy (ortholog); diastolic heart failure (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); intercellular bridge (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear protein 1; nuclear protein, transcriptional regulator, 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
fibroblast apoptotic process  (ISO)
fibroblast proliferation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagosome assembly  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of programmed necrotic cell death  (ISO)
negative regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of oxidative phosphorylation  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein modification process  (ISO)
protein acetylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of autophagy  (ISO)
regulation of female gonad development  (ISO)
regulation of response to endoplasmic reticulum stress  (ISO)
response to toxic substance  (ISO)
skeletal muscle cell differentiation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nupr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBIChiLan1.0ChiLan1.0
NUPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,532,708 - 28,538,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,532,708 - 28,539,008 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,544,029 - 28,550,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,456,163 - 28,457,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,456,162 - 28,457,831NCBI
Celera1627,653,286 - 27,655,119 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,574,331 - 26,576,164 (-)NCBIHuRef
CHM1_11629,560,413 - 29,562,246 (-)NCBICHM1_1
T2T-CHM13v2.01628,856,812 - 28,863,107 (+)NCBIT2T-CHM13v2.0
Nupr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,222,418 - 126,224,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,222,421 - 126,230,033 (-)EnsemblGRCm39 Ensembl
GRCm387126,623,246 - 126,625,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,623,249 - 126,630,861 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,766,760 - 133,768,984 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,414,394 - 126,416,618 (-)NCBIMGSCv36mm8
Celera7126,472,385 - 126,474,623 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.21NCBI
Nupr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,643,866 - 190,645,901 (-)NCBIGRCr8
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
NUPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,142,620 - 31,144,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,949,566 - 34,951,364 (+)NCBINHGRI_mPanPan1
PanPan1.11629,015,155 - 29,016,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,015,155 - 29,016,987 (-)Ensemblpanpan1.1panPan2
NUPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,222,367 - 18,224,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,222,515 - 18,224,014 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,801,224 - 19,802,818 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,358,557 - 18,360,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,358,631 - 18,360,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,157,477 - 18,159,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,072,694 - 18,074,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,388,742 - 18,390,336 (+)NCBIUU_Cfam_GSD_1.0
Nupr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,900,204 - 123,901,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,997,834 - 11,999,709 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,998,064 - 11,999,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NUPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,382,125 - 26,385,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,382,132 - 26,385,348 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,184,304 - 3,186,193 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nupr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,042,939 - 13,044,267 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,042,938 - 13,044,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Ensembl Acc Id: ENSCLAT00000013828   ⟹   ENSCLAP00000013673
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)Ensembl
RefSeq Acc Id: XM_005405174   ⟹   XP_005405231
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405231 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013673
  ENSCLAP00000013673.1
RefSeq Acc Id: XP_005405231   ⟸   XM_005405174
- UniProtKB: A0A8C2VEE9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000013673   ⟸   ENSCLAT00000013828


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009448 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013828 ENTREZGENE
  ENSCLAT00000013828.1 UniProtKB/TrEMBL
InterPro NUPR1-like UniProtKB/TrEMBL
NCBI Gene Nupr1 ENTREZGENE
PANTHER NUCLEAR PROTEIN 1 UniProtKB/TrEMBL
  PTHR17149 UniProtKB/TrEMBL
Pfam Phospho_p8 UniProtKB/TrEMBL
UniProt A0A8C2VEE9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nupr1  nuclear protein 1, transcriptional regulator    nuclear protein, transcriptional regulator, 1  Symbol and/or name change 5135510 APPROVED