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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69363
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nupr1
Name: nuclear protein 1, transcriptional regulator
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nupr1decreases expressionISONUPR1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of NUPR1 mRNAPMID:17175557 PMID:29154799
Nupr1decreases methylationISONUPR1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of NUPR1 genePMID:29154799
Nupr1increases expressionISONUPR1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of NUPR1 mRNAPMID:23527032
Nupr1multiple interactionsISONUPR1 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of NUPR1 mRNAPMID:17183730
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