Gene: Akt3 (AKT serine/threonine kinase 3) Rattus norvegicus
Analyze
Symbol:
Akt3
Name:
AKT serine/threonine kinase 3
Description:
Exhibits ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of sodium ion transport; and protein phosphorylation. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3); PARTICIPATES IN altered phosphatidylinositol 3-kinase-Akt signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
AKT3 kinase; PKB gamma; Pkbg; protein kinase Akt-3; protein kinase B gamma; protein kinase B, gamma; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma); v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AKT3 (AKT serine/threonine kinase 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Akt3 (thymoma viral proto-oncogene 3) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Akt3 (AKT serine/threonine kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AKT3 (AKT serine/threonine kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AKT3 (AKT serine/threonine kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Akt3 (AKT serine/threonine kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AKT3 (AKT serine/threonine kinase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Akt3 (thymoma viral proto-oncogene 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
AKT3 (AKT serine/threonine kinase 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
akt3b (v-akt murine thymoma viral oncogene homolog 3b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
akt3a (v-akt murine thymoma viral oncogene homolog 3a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Akt1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
YPK1
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):
YPK2
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoInspector)
Caenorhabditis elegans (roundworm):
akt-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
akt-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 95,076,308 - 95,348,913 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 13 99,527,953 - 99,800,302 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 92,802,390 - 93,110,704 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 93,002,743 - 93,299,588 (-) NCBI Celera 13 88,523,410 - 88,791,412 (-) NCBI Celera Cytogenetic Map 13 q25 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Bardet-Biedl syndrome ISO RGD:735623 8554872 ClinVar Annotator: match by term: Bardet-Biedl syndrome ClinVar Developmental Disabilities ISO RGD:735623 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:10208883 more ... genetic disease ISO RGD:735623 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10208883 more ... genetic disease ISO RGD:735623 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10208883 more ... Megalencephaly Cutis Marmorata Telangiectatica Congenita ISO RGD:735623 8554872 ClinVar Annotator: match by term: MACROCEPHALY-CAPILLARY MALFORMATION ClinVar PMID:22729224 more ... Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly polymicrogyria-polydactyly hydrocephalus syndrome ClinVar PMID:22729224 more ... Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome ISO RGD:735623 8554872 ClinVar Annotator: match by term: MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME, SOMATIC ClinVar PMID:22500628 , PMID:22729223 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly polymicrogyria-polydactyly hydrocephalus syndrome ClinVar PMID:10208883 more ... Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:25741868 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:22500628 , PMID:22729223 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:22729224 more ... Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:28492532 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:10208883 more ... Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 ClinVar PMID:25087610 Neurodevelopmental Disorders ISO RGD:735623 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 Polymicrogyria ISO RGD:735623 8554872 ClinVar Annotator: match by term: Polymicrogyria ClinVar PMID:10208883 more ... Senior-Loken syndrome ISO RGD:735623 8554872 ClinVar Annotator: match by term: Renal dysplasia and retinal aplasia ClinVar Senior-Loken Syndrome 7 ISO RGD:735623 8554872 ClinVar Annotator: match by term: Senior-Loken syndrome 7 ClinVar PMID:28492532
Imported Annotations - CTD
complex cortical dysplasia with other brain malformations ISO RGD:735623 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22729223 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome ISO RGD:735623 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22729224 Imported Annotations - OMIM
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 ISO RGD:735623 7240710 OMIM
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735623 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKT3 mRNA CTD PMID:22079256 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE affects response to substance ISO RGD:735623 6480464 AKT3 protein affects the susceptibility to Topotecan CTD PMID:16217747 17beta-estradiol multiple interactions ISO RGD:735623 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of AKT3 mRNA CTD PMID:30165855 2,2',4,4',5,5'-hexachlorobiphenyl affects expression ISO RGD:735623 6480464 2 more ... CTD PMID:20638727 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:62395 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:62395 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62395 6480464 Tetrachlorodibenzodioxin affects the expression of AKT3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735623 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKT3 mRNA CTD PMID:29704546 2-ethoxyethanol increases expression EXP 6480464 2-ethoxyethanol results in increased expression of AKT3 mRNA CTD PMID:19643169 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of AKT3 mRNA CTD PMID:19643169 4-hydroxyphenyl retinamide increases expression ISO RGD:62395 6480464 Fenretinide results in increased expression of AKT3 mRNA CTD PMID:28973697 6-propyl-2-thiouracil increases expression ISO RGD:62395 6480464 Propylthiouracil results in increased expression of AKT3 mRNA CTD PMID:20951798 aflatoxin B2 decreases methylation ISO RGD:735623 6480464 aflatoxin B2 results in decreased methylation of AKT3 intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:735623 6480464 Tretinoin results in increased expression of AKT3 mRNA CTD PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AKT3 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:735623 6480464 Arsenic affects the methylation of AKT3 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:735623 6480464 Arsenic affects the methylation of AKT3 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:735623 6480464 Arsenic affects the methylation of AKT3 gene CTD PMID:25304211 arsenite(3-) decreases expression ISO RGD:735623 6480464 arsenite results in decreased expression of AKT3 mRNA CTD PMID:23974009 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of AKT3 gene CTD PMID:28931070 benzo[a]pyrene increases expression ISO RGD:62395 6480464 Benzo(a)pyrene results in increased expression of AKT3 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:735623 6480464 Benzo(a)pyrene affects the methylation of AKT3 intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AKT3 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:735623 6480464 bisphenol A results in decreased expression of AKT3 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of AKT3 gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKT3 protein CTD PMID:24884420 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased expression of AKT3 protein CTD PMID:24884420 bisphenol F decreases expression EXP 6480464 4, 4'-bisphenol F results in decreased expression of AKT3 mRNA CTD PMID:26186136 butanal decreases expression ISO RGD:735623 6480464 butyraldehyde results in decreased expression of AKT3 mRNA CTD PMID:26079696 cadmium dichloride decreases expression ISO RGD:735623 6480464 Cadmium Chloride results in decreased expression of AKT3 mRNA CTD PMID:26472689 carbon nanotube decreases expression ISO RGD:62395 6480464 Nanotubes, Carbon analog results in decreased expression of AKT3 mRNA, Nanotubes, Carbon results in decreased expression of AKT3 mRNA CTD PMID:25554681 casticin decreases expression ISO RGD:735623 6480464 casticin results in decreased expression of AKT3 mRNA CTD PMID:27862857 chromium(6+) decreases expression ISO RGD:735623 6480464 chromium hexavalent ion results in decreased expression of AKT3 mRNA CTD PMID:30690063 cisplatin multiple interactions ISO RGD:735623 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of AKT3 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:735623 6480464 Cisplatin results in decreased expression of AKT3 mRNA CTD PMID:27392435 clenbuterol multiple interactions EXP 6480464 Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 cobalt dichloride decreases expression ISO RGD:735623 6480464 cobaltous chloride results in decreased expression of AKT3 mRNA CTD PMID:19320972 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 cyclosporin A increases expression ISO RGD:735623 6480464 Cyclosporine results in increased expression of AKT3 mRNA CTD PMID:20106945 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of AKT3 mRNA CTD PMID:23640034 dobutamine multiple interactions EXP 6480464 Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 dorsomorphin multiple interactions ISO RGD:735623 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects response to substance ISO RGD:735623 6480464 AKT3 protein affects the susceptibility to Doxorubicin CTD PMID:18071906 entinostat decreases expression ISO RGD:735623 6480464 entinostat results in decreased expression of AKT3 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:735623 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT3 mRNA CTD PMID:27188386 formaldehyde decreases expression ISO RGD:735623 6480464 Formaldehyde results in decreased expression of AKT3 mRNA CTD PMID:23649840 geldanamycin increases expression ISO RGD:735623 6480464 geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 genistein multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased expression of AKT3 protein CTD PMID:24884420 lead(0) increases expression ISO RGD:735623 6480464 Lead results in increased expression of AKT3 mRNA CTD PMID:19921347 lead(2+) increases expression ISO RGD:735623 6480464 Lead results in increased expression of AKT3 mRNA CTD PMID:19921347 methyl methanesulfonate decreases expression ISO RGD:735623 6480464 Methyl Methanesulfonate results in decreased expression of AKT3 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:735623 6480464 methylmercuric chloride results in decreased expression of AKT3 mRNA CTD PMID:26272509 methylmercury chloride increases expression ISO RGD:735623 6480464 methylmercuric chloride results in increased expression of AKT3 mRNA CTD PMID:28001369 methylmercury chloride multiple interactions ISO RGD:735623 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT3 mRNA CTD PMID:27188386 microcystin-LR decreases expression ISO RGD:62395 6480464 cyanoginosin LR results in decreased expression of AKT3 mRNA, cyanoginosin LR results in decreased expression of AKT3 protein CTD PMID:28414124 microcystin-LR decreases expression ISO RGD:735623 6480464 cyanoginosin LR results in decreased expression of AKT3 mRNA CTD PMID:29518473 oxidopamine decreases phosphorylation EXP 6480464 Oxidopamine results in decreased phosphorylation of AKT3 protein CTD PMID:16339297 oxidopamine multiple interactions EXP 6480464 Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] more ... CTD PMID:16339297 p-menthan-3-ol increases expression ISO RGD:735623 6480464 Menthol results in increased expression of AKT3 mRNA CTD PMID:26760959 paclitaxel affects response to substance ISO RGD:735623 6480464 AKT3 protein affects the susceptibility to Paclitaxel CTD PMID:18071906 paracetamol increases expression ISO RGD:735623 6480464 Acetaminophen results in increased expression of AKT3 mRNA CTD PMID:29067470 potassium chromate multiple interactions ISO RGD:735623 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKT3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:735623 6480464 potassium chromate(VI) results in decreased expression of AKT3 mRNA CTD PMID:22079256 , PMID:22714537 resveratrol decreases expression ISO RGD:735623 6480464 resveratrol results in decreased expression of AKT3 mRNA CTD PMID:25667456 SB 431542 multiple interactions ISO RGD:735623 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenate increases expression ISO RGD:62395 6480464 sodium arsenate results in increased expression of AKT3 mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:735623 6480464 sodium arsenite results in decreased expression of and affects the splicing of AKT3 mRNA CTD PMID:25879800 sodium arsenite affects methylation ISO RGD:735623 6480464 sodium arsenite affects the methylation of AKT3 gene CTD PMID:28589171 thimerosal decreases expression ISO RGD:735623 6480464 Thimerosal results in decreased expression of AKT3 mRNA CTD PMID:27188386 topotecan affects response to substance ISO RGD:735623 6480464 AKT3 protein affects the susceptibility to Topotecan CTD PMID:16217747 torcetrapib increases expression ISO RGD:735623 6480464 torcetrapib results in increased expression of AKT3 mRNA CTD PMID:23228038 trichloroethene decreases methylation EXP 6480464 Trichloroethylene results in decreased methylation of AKT3 gene CTD PMID:27618143 trichostatin A decreases expression ISO RGD:735623 6480464 trichostatin A results in decreased expression of AKT3 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:735623 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT3 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:735623 6480464 Valproic Acid results in decreased expression of AKT3 mRNA CTD PMID:23179753 valproic acid increases expression ISO RGD:735623 6480464 Valproic Acid results in increased expression of AKT3 mRNA CTD PMID:29501571 vorinostat decreases expression ISO RGD:735623 6480464 vorinostat results in decreased expression of AKT3 mRNA CTD PMID:27188386 zearalenone decreases expression ISO RGD:62395 6480464 Zearalenone results in decreased expression of AKT3 mRNA CTD PMID:30717214 zinc atom decreases expression ISO RGD:62395 6480464 Zinc deficiency results in decreased expression of AKT3 mRNA CTD PMID:20857495 zinc(0) decreases expression ISO RGD:62395 6480464 Zinc deficiency results in decreased expression of AKT3 mRNA CTD PMID:20857495
Biological Process brain morphogenesis ISO RGD:62395 1624291 MGI:MGI:3574346 (MGI:MGI:3531618 , PMID:15713641) RGD MGI:MGI:3531618 , PMID:15713641 brain morphogenesis IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to insulin stimulus IMP 8553574 PMID:17715136 MGI homeostasis of number of cells within a tissue ISO RGD:62395 1624291 MGI:MGI:3574346 (MGI:MGI:3531618 , PMID:15713641) RGD MGI:MGI:3531618 , PMID:15713641 homeostasis of number of cells within a tissue IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular signal transduction IEA InterPro:IPR039029 1600115 GO_REF:0000002 InterPro GO_REF:0000002 intracellular signal transduction IBA FB:FBgn0003744 more ... 13792537 PMID:21873635 GO_Central mitochondrial genome maintenance ISO RGD:735623 1624291 (PMID:18524868) RGD PMID:18524868 negative regulation of cellular senescence ISO RGD:735623 1624291 (PMID:25323119) RGD PMID:25323119 peptidyl-serine phosphorylation IBA MGI:MGI:87986 more ... 13792537 PMID:21873635 GO_Central positive regulation of angiogenesis IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of angiogenesis ISO RGD:62395 1624291 (MGI:MGI:6115146, PMID:28254819) RGD MGI:MGI:6115146 , PMID:28254819 positive regulation of artery morphogenesis IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of artery morphogenesis ISO RGD:62395 1624291 (MGI:MGI:6115146, PMID:28254819) RGD MGI:MGI:6115146 , PMID:28254819 positive regulation of blood vessel endothelial cell migration ISO RGD:735623 1624291 (PMID:28254819) RGD PMID:28254819 positive regulation of cell migration involved in sprouting angiogenesis ISO RGD:735623 1624291 (PMID:25323119) RGD PMID:25323119 positive regulation of cell size ISO RGD:62395 1624291 MGI:MGI:3574346 (MGI:MGI:3531618 , PMID:15713641) RGD MGI:MGI:3531618 , PMID:15713641 positive regulation of cell size IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endothelial cell proliferation ISO RGD:735623 1624291 (PMID:25323119) RGD PMID:25323119 positive regulation of sodium ion transport IMP 8553574 PMID:17715136 MGI positive regulation of TOR signaling ISO RGD:62395 1624291 MGI:MGI:3574346 (MGI:MGI:3531618 , PMID:15713641) RGD MGI:MGI:3531618 , PMID:15713641 positive regulation of TOR signaling IEA UniProtKB:Q9WUA6 , ensembl:ENSMUSP000001067891600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of vascular endothelial cell proliferation ISO RGD:735623 1624291 (PMID:28254819) RGD PMID:28254819 protein phosphorylation IDA 2306431 RGD protein phosphorylation IEA InterPro:IPR000719 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein phosphorylation IEA InterPro:IPR000719 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 signal transduction ISO RGD:735623 1624291 (PMID:18524868) RGD PMID:18524868 Cellular Component cytosol TAS 1600115 Reactome:R-RNO-198333 Reactome Reactome:R-RNO-198333 membrane IEA UniProtKB-SubCell:SL-0162 1600115 GO_REF:0000039 UniProt GO_REF:0000039 nucleoplasm TAS 1600115 Reactome:R-RNO-198333 Reactome Reactome:R-RNO-198333 Molecular Function ATP binding IDA 2306431 RGD ATP binding ISO RGD:735623 1624291 (PMID:16540465) RGD PMID:16540465 ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000038 UniProt GO_REF:0000038 protein binding ISO RGD:735623 1624291 UniProtKB:P42574 more ... RGD PMID:12176997 more ... protein binding ISO RGD:62395 1624291 UniProtKB:Q80X66 more ... RGD MGI:MGI:5586787 more ... protein kinase C binding IPI RGD:2081 62386 RGD protein kinase C binding IPI RGD:2082 62386 RGD protein serine/threonine kinase activity IDA 62386 ; 2306431 RGD protein serine/threonine kinase activity IBA FB:FBgn0003091 more ... 13792537 PMID:21873635 GO_Central protein serine/threonine kinase activity ISO RGD:735623 1624291 (PMID:16540465) RGD PMID:16540465 protein serine/threonine kinase activity IEA UniProtKB-KW:KW-0723 1600115 GO_REF:0000038 UniProt GO_REF:0000038
Gene-Chemical Interaction Annotations
