Akt3 (AKT serine/threonine kinase 3) - Rat Genome Database

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Gene: Akt3 (AKT serine/threonine kinase 3) Rattus norvegicus
Analyze
Symbol: Akt3
Name: AKT serine/threonine kinase 3
RGD ID: 62390
Description: Exhibits ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of sodium ion transport; and protein phosphorylation. Predicted to localize to cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3); PARTICIPATES IN altered phosphatidylinositol 3-kinase-Akt signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AKT3 kinase; PKB gamma; Pkbg; protein kinase Akt-3; protein kinase B gamma; protein kinase B, gamma; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma); v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
Rnor_6.0 Ensembl1395,081,390 - 95,348,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01395,076,308 - 95,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01399,527,953 - 99,800,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41392,802,390 - 93,110,704 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11393,002,743 - 93,299,588 (-)NCBI
Celera1388,523,410 - 88,791,412 (-)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
oxidopamine  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
thimerosal  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zebularine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (TAS)
membrane  (IEA)
nucleoplasm  (TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Al-Saad S, etal., Anticancer Res. 2009 Oct;29(10):4175-83.
2. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
6. Joy A, etal., J Neurooncol. 2016 Oct;130(1):43-52. doi: 10.1007/s11060-016-2220-z. Epub 2016 Jul 15.
7. Kageyama K, etal., J Biol Chem 2002 May 31;277(22):19255-64.
8. Konishi H, etal., Biochem Biophys Res Commun 1995 Nov 13;216(2):526-34.
9. Lavender NA, etal., BMC Med Genomics. 2012 Apr 30;5:11. doi: 10.1186/1755-8794-5-11.
10. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
11. Morishita A, etal., Int J Oncol. 2010 Oct;37(4):829-35.
12. Mure H, etal., Neuro Oncol. 2010 Mar;12(3):221-32. doi: 10.1093/neuonc/nop026. Epub 2009 Dec 21.
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline
15. Pectasides D, etal., Anticancer Res. 2016 Dec;36(12):6347-6356.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. RGD automated data pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
22. Shu X, etal., J Natl Cancer Inst. 2013 Mar 20;105(6):424-32. doi: 10.1093/jnci/djt005. Epub 2013 Feb 2.
23. Turinsky J and Damrau-Abney A, Am J Physiol. 1999 Jan;276(1 Pt 2):R277-82.
24. Webster CR, etal., J Biol Chem 2002 Aug 9;277(32):28578-83.
Additional References at PubMed
PMID:12767043   PMID:15057822   PMID:15713641   PMID:16540465   PMID:18524868   PMID:18535289   PMID:22391142   PMID:25323119   PMID:27821807   PMID:28254819   PMID:30053369   PMID:31376943  


Genomics

Comparative Map Data
Akt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
Rnor_6.0 Ensembl1395,081,390 - 95,348,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01395,076,308 - 95,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01399,527,953 - 99,800,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41392,802,390 - 93,110,704 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11393,002,743 - 93,299,588 (-)NCBI
Celera1388,523,410 - 88,791,412 (-)NCBICelera
Cytogenetic Map13q25NCBI
AKT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1243,488,233 - 243,851,079 (-)EnsemblGRCh38hg38GRCh38
GRCh381243,488,233 - 243,851,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371243,651,535 - 244,014,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361241,718,158 - 242,073,176 (-)NCBINCBI36hg18NCBI36
Build 341239,977,575 - 240,332,594NCBI
Celera1216,939,341 - 217,293,898 (-)NCBI
Cytogenetic Map1q43-q44NCBI
HuRef1214,031,579 - 214,386,139 (-)NCBIHuRef
CHM1_11244,924,165 - 245,279,192 (-)NCBICHM1_1
Akt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,847,642 - 177,091,688 (-)NCBIGRCm39mm39
GRCm39 Ensembl1176,847,639 - 177,085,769 (-)Ensembl
GRCm381177,020,076 - 177,261,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,020,073 - 177,258,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,952,246 - 179,178,898 (-)NCBIGRCm37mm9NCBIm37
MGSCv361178,858,791 - 179,085,442 (-)NCBImm8
Celera1184,083,831 - 184,309,489 (-)NCBICelera
Cytogenetic Map1H4NCBI
Akt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554066,907,876 - 7,163,672 (-)NCBIChiLan1.0ChiLan1.0
AKT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11224,480,762 - 224,824,950 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,480,784 - 224,824,838 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01219,107,482 - 219,463,140 (-)NCBIMhudiblu_PPA_v0panPan3
AKT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1734,633,064 - 34,931,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl734,636,124 - 34,931,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha734,110,532 - 34,416,684 (-)NCBI
ROS_Cfam_1.0734,462,499 - 34,769,046 (-)NCBI
UMICH_Zoey_3.1734,299,283 - 34,606,536 (-)NCBI
UNSW_CanFamBas_1.0734,316,186 - 34,622,902 (-)NCBI
UU_Cfam_GSD_1.0734,580,988 - 34,887,190 (-)NCBI
Akt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934447,546,714 - 47,803,867 (-)NCBI
SpeTri2.0NW_0049365266,944,056 - 7,201,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1016,441,447 - 16,741,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11016,441,465 - 16,741,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,966,073 - 18,268,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKT3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12580,509,701 - 80,878,792 (-)NCBI
ChlSab1.1 Ensembl2580,515,168 - 80,816,018 (-)Ensembl
Vero_WHO_p1.0NW_02366605582,702,263 - 83,063,037 (-)NCBI
Akt3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477115,639,018 - 15,896,590 (+)NCBI

Position Markers
RH128880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,946,144 - 88,946,355 (+)MAPPER
Rnor_6.01395,078,658 - 95,078,868NCBIRnor6.0
Rnor_5.01399,530,303 - 99,530,513UniSTSRnor5.0
RGSC_v3.41392,804,740 - 92,804,950UniSTSRGSC3.4
Celera1388,525,760 - 88,525,970UniSTS
Cytogenetic Map13q24-q26UniSTS
RH132276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,927,238 - 117,927,436 (-)MAPPER
mRatBN7.25117,927,238 - 117,927,436 (+)MAPPER
mRatBN7.21388,998,731 - 88,998,929 (-)MAPPER
mRatBN7.21388,998,731 - 88,998,929 (+)MAPPER
Rnor_6.01395,130,485 - 95,130,682NCBIRnor6.0
Rnor_6.05122,693,285 - 122,693,482NCBIRnor6.0
Rnor_5.05126,558,805 - 126,559,002UniSTSRnor5.0
Rnor_5.01399,582,128 - 99,582,325UniSTSRnor5.0
RGSC_v3.45124,100,522 - 124,100,719UniSTSRGSC3.4
RGSC_v3.41392,859,717 - 92,859,914UniSTSRGSC3.4
Celera1388,578,423 - 88,578,620UniSTS
Celera5116,498,997 - 116,499,194UniSTS
RH 3.4 Map13601.4UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map13q24-q26UniSTS
RH133674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,943,493 - 88,943,684 (+)MAPPER
Rnor_6.01395,076,007 - 95,076,197NCBIRnor6.0
Rnor_5.01399,527,652 - 99,527,842UniSTSRnor5.0
RGSC_v3.41392,802,089 - 92,802,279UniSTSRGSC3.4
Celera1388,523,109 - 88,523,299UniSTS
RH 3.4 Map13592.5UniSTS
Cytogenetic Map13q25UniSTS
Cytogenetic Map13q24-q26UniSTS
RH134046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,945,795 - 88,945,995 (+)MAPPER
Rnor_6.01395,078,309 - 95,078,508NCBIRnor6.0
Rnor_5.01399,529,954 - 99,530,153UniSTSRnor5.0
RGSC_v3.41392,804,391 - 92,804,590UniSTSRGSC3.4
Celera1388,525,411 - 88,525,610UniSTS
RH 3.4 Map13593.4UniSTS
Cytogenetic Map13q24-q26UniSTS
BI301874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21389,196,220 - 89,196,424 (+)MAPPER
Rnor_6.01395,329,297 - 95,329,500NCBIRnor6.0
Rnor_5.01399,780,686 - 99,780,889UniSTSRnor5.0
RGSC_v3.41393,091,088 - 93,091,291UniSTSRGSC3.4
Celera1388,771,798 - 88,772,001UniSTS
RH 3.4 Map13601.9UniSTS
Cytogenetic Map13q24-q26UniSTS
BF416653  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1388,559,379 - 88,559,547UniSTS
RH 3.4 Map13592.5UniSTS
Cytogenetic Map13q24-q26UniSTS
AI413057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,959,407 - 88,959,568 (+)MAPPER
Rnor_6.01395,091,908 - 95,092,068NCBIRnor6.0
Rnor_5.01399,543,180 - 99,543,340UniSTSRnor5.0
RGSC_v3.41392,819,304 - 92,819,464UniSTSRGSC3.4
Celera1388,539,037 - 88,539,197UniSTS
RH 3.4 Map13593.0UniSTS
Cytogenetic Map13q24-q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:110
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000057879
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 34 22 6 19 6 2 2 74 26 41 11 2
Low 1 9 35 35 35 6 9 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057879   ⟹   ENSRNOP00000054688
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1395,087,450 - 95,348,913 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085648   ⟹   ENSRNOP00000070231
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1395,081,390 - 95,250,235 (-)Ensembl
RefSeq Acc Id: NM_031575   ⟹   NP_113763
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,215,836 (-)NCBI
Rnor_6.01395,076,308 - 95,348,913 (-)NCBI
Rnor_5.01399,527,953 - 99,800,302 (-)NCBI
RGSC_v3.41392,802,390 - 93,110,704 (-)RGD
Celera1388,523,410 - 88,791,412 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090628   ⟹   XP_038946556
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090629   ⟹   XP_038946557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,224,805 (-)NCBI
RefSeq Acc Id: XM_039090630   ⟹   XP_038946558
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090631   ⟹   XP_038946559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090632   ⟹   XP_038946560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090633   ⟹   XP_038946561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090634   ⟹   XP_038946562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,116,690 (-)NCBI
RefSeq Acc Id: XM_039090635   ⟹   XP_038946563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,075,404 (-)NCBI
RefSeq Acc Id: XM_039090636   ⟹   XP_038946564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,975,566 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090637   ⟹   XP_038946565
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21388,943,708 - 89,182,119 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113763   ⟸   NM_031575
- Sequence:
RefSeq Acc Id: ENSRNOP00000054688   ⟸   ENSRNOT00000057879
RefSeq Acc Id: ENSRNOP00000070231   ⟸   ENSRNOT00000085648
RefSeq Acc Id: XP_038946560   ⟸   XM_039090632
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946561   ⟸   XM_039090633
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946556   ⟸   XM_039090628
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946559   ⟸   XM_039090631
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946558   ⟸   XM_039090630
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946557   ⟸   XM_039090629
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946565   ⟸   XM_039090637
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038946562   ⟸   XM_039090634
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946563   ⟸   XM_039090635
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038946564   ⟸   XM_039090636
- Peptide Label: isoform X8
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62390 AgrOrtholog
Ensembl Genes ENSRNOG00000021497 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000054688 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070231 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057879 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085648 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Akt3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_PKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAC_gamma-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29414 UniProtKB/Swiss-Prot
NCBI Gene 29414 ENTREZGENE
PANTHER PTHR24351:SF199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKT3 RGD
PhenoGen Akt3 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXD7_RAT UniProtKB/TrEMBL
  AKT3_RAT UniProtKB/Swiss-Prot
  F1M6A8_RAT UniProtKB/TrEMBL
  Q63484 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt3  AKT serine/threonine kinase 3  Akt3  v-akt murine thymoma viral oncogene homolog 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Akt3  v-akt murine thymoma viral oncogene homolog 3  Akt3  v-akt murine thymoma viral oncogene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Akt3  v-akt murine thymoma viral oncogene 3  Akt3  v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt3  v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)  Akt3  thymoma viral proto-oncogene 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Akt3  thymoma viral proto-oncogene 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function capable of phosphorylating several known proteins 724707
gene_regulation activated by igf-1, which may play a role in regulating cell survival. 724707