AKT3 (AKT serine/threonine kinase 3) - Rat Genome Database

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Gene: AKT3 (AKT serine/threonine kinase 3) Sus scrofa
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Symbol: AKT3
Name: AKT serine/threonine kinase 3
RGD ID: 14043276
Description: ENCODES a protein that exhibits ATP binding (ortholog); protein kinase C binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN brain morphogenesis (ortholog); homeostasis of number of cells within a tissue (ortholog); positive regulation of blood vessel endothelial cell migration (ortholog); PARTICIPATES IN altered phosphatidylinositol 3-kinase-Akt signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bardet-Biedl syndrome 16 (ortholog); colon cancer (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PKBgamma; protein kinase B gamma; RAC-gamma serine/threonine-protein kinase; v-akt murine thymoma viral oncogene-like 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1016,441,447 - 16,741,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11016,441,465 - 16,741,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,966,073 - 18,268,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:14681463   PMID:16189199   PMID:17145712  


Genomics

Comparative Map Data
AKT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1016,441,447 - 16,741,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11016,441,465 - 16,741,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,966,073 - 18,268,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1243,488,233 - 243,851,079 (-)EnsemblGRCh38hg38GRCh38
GRCh381243,488,233 - 243,851,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371243,651,535 - 244,014,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361241,718,158 - 242,073,176 (-)NCBINCBI36hg18NCBI36
Build 341239,977,575 - 240,332,594NCBI
Celera1216,939,341 - 217,293,898 (-)NCBI
Cytogenetic Map1q43-q44NCBI
HuRef1214,031,579 - 214,386,139 (-)NCBIHuRef
CHM1_11244,924,165 - 245,279,192 (-)NCBICHM1_1
Akt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,847,642 - 177,091,688 (-)NCBIGRCm39mm39
GRCm39 Ensembl1176,847,639 - 177,085,769 (-)Ensembl
GRCm381177,020,076 - 177,261,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,020,073 - 177,258,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,952,246 - 179,178,898 (-)NCBIGRCm37mm9NCBIm37
MGSCv361178,858,791 - 179,085,442 (-)NCBImm8
Celera1184,083,831 - 184,309,489 (-)NCBICelera
Cytogenetic Map1H4NCBI
Akt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
Rnor_6.0 Ensembl1395,081,390 - 95,348,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01395,076,308 - 95,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01399,527,953 - 99,800,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41392,802,390 - 93,110,704 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11393,002,743 - 93,299,588 (-)NCBI
Celera1388,523,410 - 88,791,412 (-)NCBICelera
Cytogenetic Map13q25NCBI
Akt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554066,907,876 - 7,163,672 (-)NCBIChiLan1.0ChiLan1.0
AKT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11224,480,762 - 224,824,950 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,480,784 - 224,824,838 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01219,107,482 - 219,463,140 (-)NCBIMhudiblu_PPA_v0panPan3
AKT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1734,633,064 - 34,931,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl734,636,124 - 34,931,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha734,110,532 - 34,416,684 (-)NCBI
ROS_Cfam_1.0734,462,499 - 34,769,046 (-)NCBI
UMICH_Zoey_3.1734,299,283 - 34,606,536 (-)NCBI
UNSW_CanFamBas_1.0734,316,186 - 34,622,902 (-)NCBI
UU_Cfam_GSD_1.0734,580,988 - 34,887,190 (-)NCBI
Akt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934447,546,714 - 47,803,867 (-)NCBI
SpeTri2.0NW_0049365266,944,056 - 7,201,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12580,509,701 - 80,878,792 (-)NCBI
ChlSab1.1 Ensembl2580,515,168 - 80,816,018 (-)Ensembl
Vero_WHO_p1.0NW_02366605582,702,263 - 83,063,037 (-)NCBI
Akt3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477115,639,018 - 15,896,590 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 3 5 23 3 1
Low 8 2 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011894   ⟹   ENSSSCP00000011590
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,443,425 - 16,741,339 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000033298   ⟹   ENSSSCP00000028845
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,459,857 - 16,741,339 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000035590   ⟹   ENSSSCP00000029466
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,443,425 - 16,741,339 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045011   ⟹   ENSSSCP00000045368
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,441,447 - 16,740,649 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055643   ⟹   ENSSSCP00000053897
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,443,427 - 16,740,691 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000071933   ⟹   ENSSSCP00000071150
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,443,426 - 16,608,378 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000072064   ⟹   ENSSSCP00000065653
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1016,483,847 - 16,730,320 (-)Ensembl
RefSeq Acc Id: NM_001256146   ⟹   NP_001243075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,446,791 - 16,730,247 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005667942   ⟹   XP_005667999
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,441,465 - 16,740,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005667943   ⟹   XP_005668000
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,459,317 - 16,740,766 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005667945   ⟹   XP_005668002
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,441,486 - 16,740,766 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013980051   ⟹   XP_013835505
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,441,465 - 16,740,819 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063994   ⟹   XP_020919653
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,441,465 - 16,741,745 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063995   ⟹   XP_020919654
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,441,465 - 16,697,628 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002336106
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11016,443,423 - 16,740,766 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020919653   ⟸   XM_021063994
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005667999   ⟸   XM_005667942
- Peptide Label: isoform X1
- UniProtKB: G9BWQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835505   ⟸   XM_013980051
- Peptide Label: isoform X4
- UniProtKB: A0A287BC23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919654   ⟸   XM_021063995
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005668002   ⟸   XM_005667945
- Peptide Label: isoform X3
- UniProtKB: A0A287AN96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243075   ⟸   NM_001256146
- UniProtKB: G9BWQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668000   ⟸   XM_005667943
- Peptide Label: isoform X2
- UniProtKB: K7GLV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053897   ⟸   ENSSSCT00000055643
RefSeq Acc Id: ENSSSCP00000029466   ⟸   ENSSSCT00000035590
RefSeq Acc Id: ENSSSCP00000045368   ⟸   ENSSSCT00000045011
RefSeq Acc Id: ENSSSCP00000011590   ⟸   ENSSSCT00000011894
RefSeq Acc Id: ENSSSCP00000065653   ⟸   ENSSSCT00000072064
RefSeq Acc Id: ENSSSCP00000071150   ⟸   ENSSSCT00000071933
RefSeq Acc Id: ENSSSCP00000028845   ⟸   ENSSSCT00000033298
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070006417 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011590 UniProtKB/TrEMBL
  ENSSSCP00000028845 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000029466 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000045368 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053897 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000065653 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000071150 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070010217 UniProtKB/TrEMBL
  ENSSSCP00070010239 UniProtKB/TrEMBL
  ENSSSCP00070010244 UniProtKB/TrEMBL
  ENSSSCP00070010260 UniProtKB/TrEMBL
  ENSSSCP00070010271 UniProtKB/TrEMBL
  ENSSSCP00070010280 UniProtKB/TrEMBL
  ENSSSCP00070010291 UniProtKB/TrEMBL
  ENSSSCP00070010295 UniProtKB/TrEMBL
  ENSSSCP00070010310 UniProtKB/TrEMBL
  ENSSSCP00070010323 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011894 UniProtKB/TrEMBL
  ENSSSCT00000033298 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000035590 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045011 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055643 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000071933 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000072064 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070012422 UniProtKB/TrEMBL
  ENSSSCT00070012448 UniProtKB/TrEMBL
  ENSSSCT00070012453 UniProtKB/TrEMBL
  ENSSSCT00070012474 UniProtKB/TrEMBL
  ENSSSCT00070012487 UniProtKB/TrEMBL
  ENSSSCT00070012496 UniProtKB/TrEMBL
  ENSSSCT00070012512 UniProtKB/TrEMBL
  ENSSSCT00070012516 UniProtKB/TrEMBL
  ENSSSCT00070012534 UniProtKB/TrEMBL
  ENSSSCT00070012548 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Akt3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_PKB UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RAC_gamma-like UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100513811 UniProtKB/TrEMBL
NCBI Gene AKT3 ENTREZGENE
PANTHER PTHR24351:SF199 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AN96 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BC23 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T4H6_PIG UniProtKB/TrEMBL
  A0A4X1T4I6_PIG UniProtKB/TrEMBL
  A0A4X1T5Q4_PIG UniProtKB/TrEMBL
  A0A4X1T5S8_PIG UniProtKB/TrEMBL
  A0A4X1T5U2_PIG UniProtKB/TrEMBL
  A0A4X1T5V2_PIG UniProtKB/TrEMBL
  A0A4X1T5Y4_PIG UniProtKB/TrEMBL
  A0A4X1T5Z6_PIG UniProtKB/TrEMBL
  A0A4X1T699_PIG UniProtKB/TrEMBL
  A0A5G2QM32_PIG UniProtKB/TrEMBL
  A0A5G2RAJ3_PIG UniProtKB/TrEMBL
  F1S8M5_PIG UniProtKB/TrEMBL
  G9BWQ3 ENTREZGENE, UniProtKB/TrEMBL
  K7GLV8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary K7GNL2 UniProtKB/TrEMBL
VGNC ID VGNC:96306 ENTREZGENE