Sod2 (superoxide dismutase 2) - Rat Genome Database

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Gene: Sod2 (superoxide dismutase 2) Rattus norvegicus
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Symbol: Sod2
Name: superoxide dismutase 2
RGD ID: 3732
Description: Enables several functions, including manganese ion binding activity; oxygen binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to ethanol; hydrogen peroxide biosynthetic process; and negative regulation of membrane hyperpolarization. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2); PARTICIPATES IN hypertension pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (+)-sesamin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: manganese superoxide dismutase; mitochondrial superoxide dismutase 2; MnSOD; Superoxide dimutase 2 mitochondrial; Superoxide dimutase 2, mitochondrial; Superoxide dismutase 2 mitochondrial; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Iddm22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  (ISO)
abdominal aortic aneurysm  (IEP,ISO)
Acute Coronary Syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (IEP,ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (IEP)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISS)
anemia  (ISO)
Aortic Calcification  (IEP)
aortic disease  (ISO)
Arsenic Poisoning  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bilirubin metabolic disorder  (ISO)
bladder neck obstruction  (IEP)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Canavan disease  (ISS)
carcinoma  (ISO)
Cardiac Arrhythmias  (IDA)
Cardiogenic Shock  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
Central Nervous System Infections  (ISO)
Chemical and Drug Induced Liver Injury  (IMP,ISO)
chronic progressive external ophthalmoplegia  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (ISO,ISS)
cystitis  (IEP)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO,ISS)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Esophageal Stenosis  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (IDA)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis  (ISO)
Farber lipogranulomatosis  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (IEP)
Hyperoxia  (IEP)
hypertension  (IDA,ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypopharyngeal Neoplasms  (ISO)
hypothyroidism  (IEP)
Hypoxia  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
intestinal disease  (IDA)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leber hereditary optic neuropathy  (ISO)
Leigh disease  (ISS)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
major depressive disorder  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
MELAS syndrome  (ISO)
Mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
methylmalonic acidemia  (ISO)
middle cerebral artery infarction  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple chemical sensitivity  (ISO)
multiple myeloma  (ISO)
mycosis fungoides  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
optic neuritis  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (IEP)
primary biliary cholangitis  (ISO)
primary ciliary dyskinesia 32  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (IEP,ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (IEP,ISO)
Respiratory Tract Granuloma  (ISO)
Reticulocytosis  (ISO)
Retina Reperfusion Injury  (IEP,ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sengers syndrome  (ISO)
sensorineural hearing loss  (IEP)
Sepsis  (IEP)
sideroblastic anemia  (ISO)
Skin Abnormalities  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (IEP)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
systemic lupus erythematosus  (ISO)
Tardive Dyskinesia  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP,ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vascular disease  (ISO)
Ventricular Dysfunction, Left  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-sesamin  (EXP)
(+)-taxifolin  (EXP)
(-)-cotinine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP,ISO)
2,3,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,4-dihydroxybenzoate  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (EXP)
5-methoxytryptamine  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (EXP,ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis,11-trans-octadecadienoic acid  (EXP)
9H-xanthine  (EXP,ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acetamiprid  (EXP)
acetic acid  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (ISO)
alatrofloxacin  (ISO)
albendazole  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
Allylamine  (EXP)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ametryn  (EXP)
aminoacetone  (EXP)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
ANTIMYCIN  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
astragaloside IV  (EXP)
atazanavir sulfate  (ISO)
atenolol  (EXP,ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
barium chloride  (EXP)
Bavachalcone  (ISO)
Bay-K-8644  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP,ISO)
beta-carotene  (EXP)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (ISO)
bosentan  (ISO)
bucladesine  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium dichloride  (ISO)
calcium(0)  (EXP)
Calphostin C  (ISO)
camphene  (EXP)
camptothecin  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP)
carmustine  (ISO)
carnosic acid  (ISO)
carotenoid  (ISO)
carteolol  (ISO)
carvedilol  (EXP)
celastrol  (EXP)
celecoxib  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chicoric acid  (EXP)
Chikusetsusaponin-V  (ISO)
chloramine T  (EXP)
chlorobenzene  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP,ISO)
corticosterone  (EXP)
coumestrol  (ISO)
creatinine  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
Cyanoginosin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cysteamine  (EXP)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dapsone  (EXP,ISO)
daunorubicin  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
dehydroascorbic acid  (ISO)
dehydroepiandrosterone  (EXP)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
dichlorvos  (EXP)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrogen  (ISO)
dimethylarsinous acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithianon  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
docebenone  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
ebselen  (EXP)
eckol  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
emodin  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
enzyme inhibitor  (EXP,ISO)
epalrestat  (ISO)
eplerenone  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
febuxostat  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fraxetin  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (ISO)
galactose  (EXP,ISO)
gallocatechin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (EXP)
gliclazide  (EXP)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP,ISO)
Goe 6976  (ISO)
haloperidol  (EXP)
helenalin  (ISO)
hemin  (EXP)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexaconazole  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP,ISO)
ibuprofen  (ISO)
icariin  (EXP,ISO)
idebenone  (EXP)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (ISO)
isoflavones  (EXP)
isoflurane  (EXP,ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kainic acid  (EXP,ISO)
ketorolac tromethamine  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-dehydroascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
lenvatinib  (EXP)
Leonurine  (EXP,ISO)
leptomycin B  (ISO)
linalool  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loliolide  (ISO)
losartan  (EXP)
lutein  (ISO)
luteolin  (ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malathion  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (ISO)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP,ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP,ISO)
metam  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
morphine  (ISO)
myxothiazol  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naringin  (ISO)
nebivolol  (EXP,ISO)
nefazodone  (EXP,ISO)
nerolidol  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
nitroxoline  (ISO)
NS-398  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP,ISO)
oltipraz  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP)
peroxynitrous acid  (ISO)
phenanthrene  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP)
phenols  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (EXP)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
physostigmine  (ISO)
pioglitazone  (ISO)
pipoxolan  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
poly(vinylpyrrolidone)  (ISO)
porphyrins  (ISO)
potassium atom  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP)
potassium iodide  (ISO)
prednisolone  (ISO)
probucol  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
propofol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyridoxamine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrroloquinoline quinone  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
Rebamipide  (EXP)
rebaudioside A  (ISO)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP,ISO)
salicyl alcohol  (EXP)
Salidroside  (EXP,ISO)
salsalate  (EXP)
salvianolic acid B  (EXP)
saquinavir  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (EXP,ISO)
silicic acid  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium nitrate  (EXP,ISO)
Sodium oleate  (EXP)
Sodium salicylate  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfamethoxazole  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tartrazine  (ISO)
taurocholic acid  (EXP,ISO)
temozolomide  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thallium  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP)
thyroxine  (EXP)
Tiron  (ISO)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
topotecan  (EXP)
tramadol  (EXP)
trandolapril  (EXP)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trazodone  (EXP)
triadimefon  (EXP)
trichlorfon  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trilobatin  (EXP)
triolein  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urea  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
water  (ISO)
withaferin A  (ISO)
wortmannin  (EXP)
WR-1065  (ISO)
zearalenone  (EXP)
zebularine  (ISO)
zerumbone  (ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
apoptotic mitochondrial changes  (ISO)
cellular response to ethanol  (IEP)
cellular response to oxidative stress  (ISO,ISS)
detection of oxygen  (ISO)
erythrophore differentiation  (ISO)
glutathione metabolic process  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
hydrogen peroxide biosynthetic process  (IDA)
hydrogen peroxide metabolic process  (IMP)
intracellular oxygen homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
liver development  (ISO)
locomotory behavior  (ISO)
mitochondrion organization  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of membrane hyperpolarization  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of hydrogen peroxide biosynthetic process  (IMP)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
post-embryonic development  (ISO)
protein homotetramerization  (ISO)
regulation of blood pressure  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of transcription by RNA polymerase II  (ISO,ISS)
release of cytochrome c from mitochondria  (ISO)
removal of superoxide radicals  (IDA,ISO)
respiratory electron transport chain  (ISO)
response to activity  (IEP,ISO)
response to axon injury  (ISO)
response to cadmium ion  (IEP)
response to electrical stimulus  (IEP)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (IEP,ISO)
response to hyperoxia  (ISO)
response to hypoxia  (IEP)
response to immobilization stress  (IEP)
response to isolation stress  (IEP)
response to L-ascorbic acid  (IEP)
response to lipopolysaccharide  (IEP)
response to magnetism  (IEP)
response to manganese ion  (IEP)
response to nutrient levels  (IDA)
response to oxidative stress  (IEP,ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (IEP)
response to silicon dioxide  (IEP)
response to superoxide  (ISO)
response to xenobiotic stimulus  (IDA)
response to zinc ion  (IEP)
sensory perception of sound  (ISO)
superoxide anion generation  (ISO)
superoxide metabolic process  (ISO,ISS)
vasodilation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Effects of static magnetic field exposure on antioxidative enzymes activity and DNA in rat brain. Amara S, etal., Gen Physiol Biophys. 2009 Sep;28(3):260-5.
4. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
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11. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
12. Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung. Biaggio VS, etal., Exp Lung Res. 2010 Feb;36(1):31-44.
13. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
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15. Rat mitochondrial manganese superoxide dismutase: amino acid positions involved in covalent modifications, activity, and heat stability. Castellano I, etal., Biopolymers. 2009 Dec;91(12):1215-26.
16. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
17. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
18. Gene expression changes after hypoxic preconditioning in rat hepatocytes. Chen W, etal., Hepatobiliary Pancreat Dis Int. 2006 Aug;5(3):416-21.
19. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
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24. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
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28. Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver. Filipovic D, etal., Mol Cell Biochem. 2009 Dec 19.
29. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. Flekac M, etal., BMC Med Genet. 2008 Apr 21;9:30.
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32. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. Friedman JS, etal., J Exp Med. 2001 Apr 16;193(8):925-34.
33. Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Fujimoto K, etal., Toxicol Pathol. 2009 Feb;37(2):193-200. doi: 10.1177/0192623308329282.
34. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Fujimura M, etal., J Neurosci. 1999 May 1;19(9):3414-22.
35. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
36. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
37. Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population. Gotoh N, etal., Am J Ophthalmol. 2008 Jul;146(1):146; author reply 146-7. doi: 10.1016/j.ajo.2008.03.017.
38. Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway. Guo S, etal., Eur J Pharmacol. 2019 Apr 15;849:50-58. doi: 10.1016/j.ejphar.2019.01.057. Epub 2019 Feb 1.
39. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Hakenewerth AM, etal., Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2438-49. doi: 10.1158/1055-9965.EPI-11-0649. Epub 2011 Sep 22.
40. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Hamilton KL, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1360-8.
41. RORalpha decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Han YH, etal., Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10.
42. Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues. Heine C, etal., Biochem J. 2003 Dec 1;376(Pt 2):369-76.
43. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Hiroi S, etal., Biochem Biophys Res Commun. 1999 Aug 2;261(2):332-9.
44. Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase. Ho YS and Crapo JD, Nucleic Acids Res 1987 Dec 10;15(23):10070.
45. Molecular structure of a functional rat gene for manganese-containing superoxide dismutase. Ho YS, etal., Am J Respir Cell Mol Biol 1991 Mar;4(3):278-86.
46. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Hodge DR, etal., Cancer Biol Ther. 2005 May;4(5):585-92. Epub 2005 May 5.
47. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Holla LI, etal., Clin Biochem. 2006 Mar;39(3):299-302. Epub 2006 Jan 19.
48. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. Hu Y, etal., J Biol Chem. 2005 Nov 25;280(47):39485-92. Epub 2005 Sep 22.
49. MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. Huang C, etal., BMC Med Genomics. 2014 Jul 28;7:46. doi: 10.1186/1755-8794-7-46.
50. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Huang TT, etal., Free Radic Biol Med. 2001 Nov 1;31(9):1101-10.
51. Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis. Huang YS, etal., Alcohol Alcohol. 2016 Feb 11. pii: agw004.
52. Genetic variations of superoxide dismutase 2 and cytochrome P450 2E1 in non-alcoholic steatohepatitis. Huang YS, etal., Liver Int. 2014 Jul;34(6):931-6. doi: 10.1111/liv.12533. Epub 2014 Apr 4.
53. Time response of carboplatin-induced hearing loss in rat. Husain K, etal., Hear Res. 2004 May;191(1-2):110-8.
54. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Hwang JH, etal., Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
55. Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus. Jimenez-Ortega V, etal., Biometals. 2010 Apr;23(2):327-37. Epub 2010 Jan 27.
56. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Jin ZQ, etal., Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2986-94. Epub 2005 Jan 28.
57. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. Judge S, etal., FASEB J. 2005 Mar;19(3):419-21. Epub 2005 Jan 10.
58. SOD2 knockdown mouse model of early AMD. Justilien V, etal., Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20.
59. The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis. Kakko S, etal., Atherosclerosis. 2003 May;168(1):147-52.
60. Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. Khaper N, etal., Mol Cell Biochem. 2003 Sep;251(1-2):9-15.
61. Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents. Kienhofer J, etal., FASEB J. 2009 Feb 19.
62. Differential expression of EC-SOD, Mn-SOD and CuZn-SOD in rat lung exposed to crystalline silica. Kim H, etal., J Occup Health. 2007 May;49(3):242-8.
63. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Kim J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F461-70. Epub 2009 May 20.
64. An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia. Koistinen P, etal., Haematologica. 2006 Jun;91(6):829-32.
65. MnSOD expression within tumor cells is closely related to mode of invasion in human gastric cancer. Korenaga D, etal., Oncol Rep. 2003 Jan-Feb;10(1):27-30.
66. Involvement of superoxide dismutase isoenzymes and their genetic variants in progression of and higher susceptibility to vitiligo. Laddha NC, etal., Free Radic Biol Med. 2013 Dec;65:1110-25. doi: 10.1016/j.freeradbiomed.2013.08.189. Epub 2013 Sep 12.
67. Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats. Lawler JM, etal., Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1496-502. Epub 2009 Mar 18.
68. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Lebovitz RM, etal., Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7.
69. Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice. Lee D, etal., Arch Pharm Res. 2020 Apr;43(4):449-461. doi: 10.1007/s12272-020-01231-4. Epub 2020 Mar 31.
70. Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway. Li P, etal., Expert Opin Ther Targets. 2015 Jul;19(7):997-1010. doi: 10.1517/14728222.2015.1054806.
71. Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. Li WJ, etal., J Korean Med Sci. 2010 Nov;25(11):1652-6. Epub 2010 Oct 26.
72. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. Lin HI, etal., Chin J Physiol. 2004 Sep 30;47(3):121-7.
73. Proteomic expression analysis of mycosis fungoides (MF) skin tissues: overexpressions of SOD2, S100A8 and FABP5 in MF. Liu J, etal., J Dermatol Sci. 2010 Oct;60(1):42-4. doi: 10.1016/j.jdermsci.2010.07.014. Epub 2010 Aug 10.
74. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Liu KM, etal., Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F318-31. doi: 10.1152/ajprenal.00607.2014. Epub 2015 Jun 24.
75. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. Liu X, etal., BMC Cancer. 2010 Jul 9;10:365. doi: 10.1186/1471-2407-10-365.
76. Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion. Liu Y, etal., Free Radic Biol Med. 2012 Mar 1;52(5):909-15. doi: 10.1016/j.freeradbiomed.2011.12.013. Epub 2011 Dec 24.
77. SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Liu YM, etal., Dis Markers. 2010;28(3):137-47. doi: 10.3233/DMA-2010-0693.
78. Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. Lontz W, etal., Free Radic Biol Med. 1995 Feb;18(2):349-55.
79. Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. Lucena MI, etal., Hepatology. 2010 Jul;52(1):303-12. doi: 10.1002/hep.23668.
80. Aging and the brown Norway rat leydig cell antioxidant defense system. Luo L, etal., J Androl. 2006 Mar-Apr;27(2):240-7. Epub 2005 Nov 22.
81. Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina. Mao XW, etal., Radiat Res. 2012 Sep;178(3):118-25. Epub 2012 Jul 10.
82. Differential neuronal expression of manganese superoxide dismutase in Alzheimer's disease. Marcus DL, etal., Med Sci Monit. 2006 Jan;12(1):BR8-14. Epub 2005 Dec 19.
83. Chemoprevention of carcinogenic progression to esophageal adenocarcinoma by the manganese superoxide dismutase supplementation. Martin RC, etal., Clin Cancer Res. 2007 Sep 1;13(17):5176-82.
84. No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1). Martin RC, etal., J Surg Res. 2005 Mar;124(1):92-7.
85. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
86. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
87. A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. Mollsten A, etal., Diabetes. 2007 Jan;56(1):265-9.
88. Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study. Morello M, etal., Brain Res Bull. 2007 Nov 1;74(6):406-15. Epub 2007 Aug 2.
89. Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Munusamy S and MacMillan-Crow LA, Free Radic Biol Med. 2009 Apr 15;46(8):1149-57. Epub 2009 Feb 3.
90. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
91. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. Namikawa C, etal., J Hepatol. 2004 May;40(5):781-6.
92. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
93. Elevated serum manganese superoxide dismutase in acute leukemias. Nishiura T, etal., Cancer Lett. 1992 Mar 15;62(3):211-5.
94. In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Oberley TD, etal., Antioxid Redox Signal. 2004 Jun;6(3):537-48.
95. Wheat germ supplementation alleviates insulin resistance and cardiac mitochondrial dysfunction in an animal model of diet-induced obesity. Ojo B, etal., Br J Nutr. 2017 Aug;118(4):241-249. doi: 10.1017/S0007114517002082.
96. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
97. Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. Ono M, etal., J Lab Clin Med. 1991 Nov;118(5):476-83.
98. Reduction in superoxide dismutase expression in the epithelial mucosa of eosinophilic chronic rhinosinusitis with nasal polyps. Ono N, etal., Int Arch Allergy Immunol. 2013;162(2):173-80. doi: 10.1159/000353122. Epub 2013 Jul 31.
99. Superoxide dismutase in the prostate lobes of aging Brown Norway rats. Pechenino AS and Brown TR, Prostate. 2006 Apr 1;66(5):522-35.
100. Effect of Ca(2+) and Mg(2+) on the Mn-superoxide dismutase from rat liver and heart mitochondria. Perez-Vazquez V, etal., Amino Acids. 2002 Jun;22(4):405-16.
101. Effect of a single session of electrical stimulation on activity and expression of citrate synthase and antioxidant enzymes in rat soleus muscle. Pimenta Ada S, etal., Eur J Appl Physiol. 2007 Dec;102(1):119-26. Epub 2007 Oct 26.
102. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
103. Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells. Porntadavity S, etal., DNA Cell Biol. 2005 May;24(5):299-310.
104. SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Qi X, etal., Ann Neurol. 2004 Aug;56(2):182-91.
105. Optic neuropathy induced by reductions in mitochondrial superoxide dismutase. Qi X, etal., Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1088-96.
106. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Qi X, etal., Invest Ophthalmol Vis Sci. 2007 Feb;48(2):681-91.
107. Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. Raho G, etal., Clin Exp Dermatol. 2003 May;28(3):318-20.
108. Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents. Rana T, etal., Food Chem Toxicol. 2010 Apr;48(4):1072-7. Epub 2010 Feb 1.
109. Manganese superoxide dismutase activity in the rat adrenal. Raza FS, etal., J Endocrinol. 2005 Jan;184(1):77-84.
110. GOA pipeline RGD automated data pipeline
111. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
112. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
113. Diabetic rat testes: morphological and functional alterations. Ricci G, etal., Andrologia. 2009 Dec;41(6):361-8.
114. Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection. Ritter K, etal., J Exp Med. 1994 Nov 1;180(5):1995-8.
115. Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. Russo D, etal., J Endocrinol Invest. 2005 Feb;28(2):137-44.
116. The mitochondrial antioxidants thioredoxin-2 and Mn-superoxide dismutase are involved in the mechanisms of brain hypoxic tolerance. Samoilov MO, etal., Dokl Biol Sci 2002 Nov-Dec;387:498-500.
117. Serum manganese superoxide dismutase is a new tumour marker for malignant melanoma. Schadendorf D, etal., Melanoma Res. 1995 Oct;5(5):351-3.
118. Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection. Shilo S, etal., J Inorg Biochem. 2008 Jan;102(1):110-8. Epub 2007 Aug 1.
119. Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants. Sinha I, etal., J Surg Res. 2007 Apr;138(2):156-62. Epub 2006 Dec 29.
120. Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Sreekumar R, etal., Am J Physiol Endocrinol Metab 2002 Jul;283(1):E38-43.
121. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis. Stewart SF, etal., Hepatology. 2002 Dec;36(6):1355-60.
122. The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma. Stoehlmacher J, etal., Oncol Rep. 2002 Mar-Apr;9(2):235-8.
123. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Strassburger M, etal., Free Radic Biol Med. 2005 Jun 1;38(11):1458-70.
124. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
125. Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome. Strzalka-Mrozik B, etal., Mol Vis. 2013 Jun 12;19:1341-9. Print 2013.
126. Effects of selegiline on antioxidant systems in the nigrostriatum in rat. Takahata K, etal., J Neural Transm. 2006 Feb;113(2):151-8. Epub 2005 Jun 15.
127. Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. Tatton WG, etal., J Pharmacol Exp Ther. 2002 May;301(2):753-64.
128. Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma. Tsanou E, etal., Histol Histopathol. 2004 Jul;19(3):807-13.
129. Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles. Tsuruta Y, etal., Acta Neuropathol (Berl). 2002 Jan;103(1):59-65.
130. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S, etal., Mol Ther. 2009 May;17(5):778-86. doi: 10.1038/mt.2009.47. Epub 2009 Mar 17.
131. The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. Valenti L, etal., J Med Genet. 2004 Dec;41(12):946-50.
132. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Van Remmen H, etal., Physiol Genomics. 2003 Dec 16;16(1):29-37.
133. Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia. Venkataraman S, etal., Free Radic Res. 2004 Oct;38(10):1119-32.
134. Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease. Ventriglia M, etal., Aging Clin Exp Res. 2005 Dec;17(6):445-8.
135. Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk. Wang LI, etal., J Occup Environ Med. 2004 Jun;46(6):556-64.
136. Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. Wang R, etal., Aging (Albany NY). 2016 Jun;8(6):1184-200. doi: 10.18632/aging.100967.
137. Oxidative stress in rats with hyperhomo-cysteinemia and intervention effect of lutein. Wang S, etal., Eur Rev Med Pharmacol Sci. 2014;18(3):359-64.
138. Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus. Wang SJ, etal., Mol Med Rep. 2015 Jan;11(1):521-6. doi: 10.3892/mmr.2014.2724. Epub 2014 Oct 21.
139. Altered gene expression in neural crest cells exposed to ethanol in vitro. Wentzel P and Eriksson UJ, Brain Res. 2009 Dec 11;1305 Suppl:S50-60. Epub 2009 Aug 22.
140. Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Weydert C, etal., Mol Cancer Ther. 2003 Apr;2(4):361-9.
141. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
142. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Wheeler MD, etal., J Biol Chem. 2001 Sep 28;276(39):36664-72. Epub 2001 Jul 26.
143. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. Xiong Y, etal., J Neurochem. 2005 Nov;95(3):732-44.
144. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
145. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Yao S, etal., Breast Cancer Res Treat. 2010 Nov;124(2):433-9. doi: 10.1007/s10549-010-0840-0. Epub 2010 Mar 23.
146. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Yen JH, etal., Immunol Lett. 2003 Aug 5;88(2):113-6.
147. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. Yen JH, etal., Immunol Lett. 2003 Dec 15;90(2-3):151-4.
148. Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. Yen JH, etal., Immunol Lett. 2003 Nov 15;90(1):19-24.
149. Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat. Yoshikawa Y, etal., Toxicology. 2009 Oct 1;264(1-2):89-95. doi: 10.1016/j.tox.2009.07.017. Epub 2009 Jul 30.
150. Down-regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome. Yoshioka T, etal., J Pediatr. 1997 May;130(5):800-7.
151. Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Zarbock R, etal., Clin Chem. 2007 Oct;53(10):1734-40. Epub 2007 Aug 10.
152. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
153. Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. Zeng Z, etal., Oxid Med Cell Longev. 2015;2015:965961. doi: 10.1155/2015/965961. Epub 2015 Aug 2.
154. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5558-66.
155. Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. Zhang ZJ, etal., Psychiatr Genet. 2003 Sep;13(3):187-92.
156. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Zhao Y, etal., Oncogene. 2002 May 30;21(24):3836-46.
157. [Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1] Zotova EV, etal., Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Additional References at PubMed
PMID:7333654   PMID:7493016   PMID:9393747   PMID:9462746   PMID:9651187   PMID:9927656   PMID:10049502   PMID:11156968   PMID:11226230   PMID:11527927   PMID:11583975   PMID:11796207  
PMID:12176043   PMID:12551919   PMID:12646716   PMID:12709579   PMID:12769190   PMID:12865426   PMID:12931191   PMID:14651853   PMID:14980699   PMID:15182862   PMID:15205258   PMID:15375579  
PMID:15489334   PMID:15637112   PMID:15642323   PMID:15781740   PMID:16103131   PMID:16219542   PMID:16238459   PMID:16677818   PMID:16843623   PMID:16873728   PMID:17023425   PMID:17023572  
PMID:17145560   PMID:17215005   PMID:17322295   PMID:17349848   PMID:17367743   PMID:17597094   PMID:17634366   PMID:17670746   PMID:17923681   PMID:18218638   PMID:18559338   PMID:18614015  
PMID:19047792   PMID:19265433   PMID:19376215   PMID:19478076   PMID:19500508   PMID:19774674   PMID:19822147   PMID:19893080   PMID:20235222   PMID:20489163   PMID:20495008   PMID:20654064  
PMID:21143912   PMID:21357467   PMID:21506880   PMID:21625958   PMID:21942371   PMID:21988832   PMID:22043833   PMID:22171425   PMID:22474353   PMID:22540739   PMID:22732938   PMID:22758933  
PMID:22829583   PMID:22981416   PMID:23157833   PMID:23168492   PMID:23195678   PMID:23238024   PMID:23275324   PMID:23376485   PMID:23533145   PMID:23935993   PMID:24191052   PMID:24465521  
PMID:24527463   PMID:24563852   PMID:25978844   PMID:26071777   PMID:26231211   PMID:26316108   PMID:26721595   PMID:26770652   PMID:27021683   PMID:27067422   PMID:29116107   PMID:29775122  
PMID:29847079   PMID:30502252   PMID:30811038   PMID:33099744   PMID:34169429   PMID:34670409   PMID:36153454   PMID:36922709  


Genomics

Comparative Map Data
Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sod2
58 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Western blot//MicroarrayFunctional MTI19142192

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:127
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000025794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
RH130474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,639,557 - 47,639,751 (+)MAPPERmRatBN7.2
Rnor_6.0147,915,997 - 47,916,190NCBIRnor6.0
Rnor_5.0151,832,799 - 51,832,992UniSTSRnor5.0
RGSC_v3.4141,864,237 - 41,864,430UniSTSRGSC3.4
Celera143,324,351 - 43,324,544UniSTS
Cytogenetic Map1q21UniSTS
RH94608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,643,876 - 47,644,042 (+)MAPPERmRatBN7.2
Rnor_6.0147,920,301 - 47,920,466NCBIRnor6.0
Rnor_5.0151,828,501 - 51,828,666UniSTSRnor5.0
RGSC_v3.4141,869,041 - 41,869,206UniSTSRGSC3.4
Celera143,328,623 - 43,328,788UniSTS
Cytogenetic Map1q21UniSTS
RH140146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,638,182 - 47,638,375 (+)MAPPERmRatBN7.2
Rnor_6.0147,914,622 - 47,914,814NCBIRnor6.0
Rnor_5.0151,834,175 - 51,834,367UniSTSRnor5.0
RGSC_v3.4141,862,862 - 41,863,054UniSTSRGSC3.4
Celera143,322,976 - 43,323,168UniSTS
Cytogenetic Map1q21UniSTS
RH140197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,638,964 - 47,639,163 (+)MAPPERmRatBN7.2
Rnor_6.0147,915,404 - 47,915,602NCBIRnor6.0
Rnor_5.0151,833,387 - 51,833,585UniSTSRnor5.0
RGSC_v3.4141,863,644 - 41,863,842UniSTSRGSC3.4
Celera143,323,758 - 43,323,956UniSTS
RH 3.4 Map1537.1UniSTS
Cytogenetic Map1q21UniSTS
Sod2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2566,258,521 - 66,258,762 (-)MAPPERmRatBN7.2
Rnor_6.0565,611,977 - 65,612,217NCBIRnor6.0
Rnor_5.0570,095,646 - 70,095,886UniSTSRnor5.0
RGSC_v3.4568,929,154 - 68,929,394UniSTSRGSC3.4
Celera561,395,425 - 61,395,665UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000025794   ⟹   ENSRNOP00000025794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)Ensembl
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)Ensembl
RefSeq Acc Id: NM_017051   ⟹   NP_058747
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,043,323 - 50,050,168 (-)NCBI
mRatBN7.2147,638,318 - 47,645,163 (-)NCBI
Rnor_6.0147,914,757 - 47,921,587 (-)NCBI
Rnor_5.0151,827,380 - 51,834,232 (+)NCBI
RGSC_v3.4141,862,997 - 41,870,327 (-)RGD
Celera143,323,111 - 43,329,909 (-)RGD
Sequence:
RefSeq Acc Id: NP_058747   ⟸   NM_017051
- Peptide Label: precursor
- UniProtKB: P07895 (UniProtKB/Swiss-Prot),   A6KP26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025794   ⟸   ENSRNOT00000025794
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07895-F1-model_v2 AlphaFold P07895 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689611
Promoter ID:EPDNEW_R135
Type:multiple initiation site
Name:Sod2_1
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,921,573 - 47,921,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3732 AgrOrtholog
BioCyc Gene G2FUF-61596 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000019048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027354 UniProtKB/Swiss-Prot
  ENSRNOG00060009412 UniProtKB/Swiss-Prot
  ENSRNOG00065028871 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025794 ENTREZGENE
  ENSRNOT00000025794.5 UniProtKB/Swiss-Prot
  ENSRNOT00055047331 UniProtKB/Swiss-Prot
  ENSRNOT00060015877 UniProtKB/Swiss-Prot
  ENSRNOT00065049834 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot
  3.55.40.20 UniProtKB/Swiss-Prot
  Fe,Mn superoxide dismutase (SOD) domain UniProtKB/TrEMBL
  Iron/manganese superoxide dismutase, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104698 IMAGE-MGC_LOAD
InterPro Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91729 IMAGE-MGC_LOAD
NCBI Gene 24787 ENTREZGENE
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SOD2 RGD
PhenoGen Sod2 PhenoGen
PIRSF SODismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019048 RatGTEx
  ENSRNOG00055027354 RatGTEx
  ENSRNOG00060009412 RatGTEx
  ENSRNOG00065028871 RatGTEx
Superfamily-SCOP Fe,Mn superoxide dismutase (SOD), C-terminal domain UniProtKB/TrEMBL
  Fe,Mn superoxide dismutase (SOD), N-terminal domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF54719 UniProtKB/Swiss-Prot
UniProt A6KP26 ENTREZGENE, UniProtKB/TrEMBL
  P07895 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod2  superoxide dismutase 2  Sod2  superoxide dismutase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sod2  superoxide dismutase 2, mitochondrial    superoxide dismutase 2  Name updated 1299863 APPROVED
2003-04-09 Sod2  superoxide dismutase 2    Superoxide dismutase 2, mitochondrial  Name updated 629478 APPROVED
2001-12-21 Sod2  Superoxide dismutase 2, mitochondrial      Name updated 69729 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 628320
gene_function dismutates reactive oxygen radical species (ROS) to hydrogen peroxide and molecular oxygen 628320
gene_process prevents accumulation of superoxides in cells 628320
gene_regulation caloric restriction (CR) significantly increased mRNA (>287%) level 628320
gene_transcript contains at least 5 exons 729952