Tbxa2r (thromboxane A2 receptor) - Rat Genome Database

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Gene: Tbxa2r (thromboxane A2 receptor) Rattus norvegicus
Analyze
Symbol: Tbxa2r
Name: thromboxane A2 receptor
RGD ID: 3825
Description: Exhibits thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Localizes to acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor); PARTICIPATES IN eicosanoid signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: prostanoid TP receptor; Thromboxane receptor; TXA2-R; TXR2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,383,347 - 8,390,753 (-)NCBI
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0711,253,153 - 11,259,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,419,887 - 11,425,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,867,739 - 9,872,536 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,867,738 - 9,872,536 (-)NCBI
Celera76,572,330 - 6,577,127 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abe T, etal., J Clin Invest 1995 Aug;96(2):657-64.
2. Acosta Cazal MC, etal., Gend Med. 2004 Dec;1(2):100-5.
3. Altavilla D, etal., Pharmacol Res. 1994 Aug-Sep;30(2):137-51.
4. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Blackman SC, etal., J Biol Chem. 1998 Jan 2;273(1):475-83.
6. de Leval X, etal., J Pharmacol Exp Ther. 2006 Sep;318(3):1057-67. Epub 2006 May 23.
7. Depin JC, etal., Arzneimittelforschung. 1994 Nov;44(11):1203-7.
8. Francois H, etal., Hypertension. 2004 Feb;43(2):364-9. Epub 2004 Jan 12.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. GOA data from the GO Consortium
11. Hirano T and Hirano K, Int J Surg Investig. 1999;1(3):203-10.
12. Hirata T, etal., J Clin Invest. 1994 Oct;94(4):1662-7.
13. Holt S, etal., Kidney Int. 1999 Jan;55(1):271-7.
14. Hong SJ, etal., J Allergy Clin Immunol. 2005 Apr;115(4):758-63.
15. Hori Y, etal., Jpn J Pharmacol. 1989 Jun;50(2):195-205.
16. Kim SH, etal., Clin Exp Allergy. 2005 May;35(5):585-90.
17. Kitanaka J, etal., Biochim Biophys Acta 1995 Mar 16;1265(2-3):220-3.
18. Kobayashi T, etal., J Clin Invest. 2004 Sep;114(6):784-94.
19. Leung TF, etal., Pediatr Allergy Immunol. 2002 Feb;13(1):10-7.
20. Li M, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101. doi: 10.1073/pnas.1002685107. Epub 2010 Oct 19.
21. Liu T, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12692-7. doi: 10.1073/pnas.1207816109. Epub 2012 Jul 16.
22. Matsuda K, etal., Am J Physiol. 1994 Sep;267(3 Pt 2):H887-93.
23. Mazolewski PJ, etal., Plast Reconstr Surg. 1999 Oct;104(5):1393-6.
24. MGD data from the GO Consortium
25. Nanji AA, etal., J Pharmacol Exp Ther. 1997 Aug;282(2):1037-43.
26. Narita S, etal., Arerugi. 2004 Jun;53(6):601-4.
27. NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Olanoff LS, etal., J Cardiovasc Pharmacol. 1985 Jan-Feb;7(1):114-20.
29. OMIM Disease Annotation Pipeline
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
33. Remuzzi G, etal., J Exp Med. 1994 Nov 1;180(5):1967-72.
34. RGD automated data pipeline
35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. Sugawara A, etal., Hypertens Res. 2001 May;24(3):229-33.
38. Sugawara A, etal., J Biol Chem 2002 Mar 22;277(12):9676-83.
39. Suzuki Y, etal., Prostaglandins Leukot Essent Fatty Acids. 2004 Dec;71(6):375-82.
40. Takahashi N, etal., Endocrinology. 1995 Sep;136(9):4143-6.
41. Takayama K, etal., Nat Med. 2005 May;11(5):562-6. Epub 2005 Apr 17.
42. Tanaka K, etal., Biochem Biophys Res Commun. 2002 Apr 5;292(3):776-80.
43. Theriault C, etal., Biochemistry. 2004 May 18;43(19):5600-7.
44. Thomas DW, etal., J Clin Invest. 1998 Dec 1;102(11):1994-2001.
45. Traupe T, etal., J Hypertens. 2002 Nov;20(11):2239-45.
46. Turner CR, etal., Circ Shock. 1991 Jun;34(2):270-7.
47. Uruno A, etal., Hypertens Res. 2003 Oct;26(10):815-21.
48. Xiang L, etal., Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H231-6. Epub 2006 Aug 11.
49. Xu H, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G277-83.
Additional References at PubMed
PMID:1375456   PMID:8936585   PMID:12925702   PMID:14627611   PMID:17706224   PMID:18710937   PMID:18769070   PMID:19696359   PMID:21217826   PMID:22717688   PMID:24558106   PMID:25857252  
PMID:26708952   PMID:27178425   PMID:28415790   PMID:32530751  


Genomics

Comparative Map Data
Tbxa2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,383,347 - 8,390,753 (-)NCBI
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0711,253,153 - 11,259,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,419,887 - 11,425,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,867,739 - 9,872,536 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,867,738 - 9,872,536 (-)NCBI
Celera76,572,330 - 6,577,127 (-)NCBICelera
Cytogenetic Map7q11NCBI
TBXA2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl193,594,506 - 3,606,840 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl193,594,507 - 3,606,875 (-)EnsemblGRCh38hg38GRCh38
GRCh38193,594,507 - 3,608,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37193,594,505 - 3,606,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,545,504 - 3,557,658 (-)NCBINCBI36hg18NCBI36
Build 34193,545,503 - 3,557,658NCBI
Celera193,531,342 - 3,543,669 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef193,359,876 - 3,372,152 (-)NCBIHuRef
CHM1_1193,594,158 - 3,606,423 (-)NCBICHM1_1
Tbxa2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,164,102 - 81,171,008 (+)NCBIGRCm39mm39
GRCm39 Ensembl1081,164,565 - 81,171,006 (+)Ensembl
GRCm381081,328,268 - 81,335,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,328,731 - 81,335,172 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,791,476 - 80,797,917 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,731,860 - 80,738,301 (+)NCBImm8
Celera1082,349,466 - 82,355,970 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tbxa2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,539,889 - 5,557,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,539,382 - 5,557,441 (-)NCBIChiLan1.0ChiLan1.0
TBXA2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,572,454 - 3,581,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,570,290 - 3,581,924 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,621,606 - 2,632,800 (-)NCBIMhudiblu_PPA_v0panPan3
TBXA2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,819,866 - 55,829,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,824,410 - 55,828,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,545,953 - 55,554,659 (+)NCBI
ROS_Cfam_1.02056,480,706 - 56,489,446 (+)NCBI
UMICH_Zoey_3.12055,536,340 - 55,545,063 (+)NCBI
UNSW_CanFamBas_1.02056,019,809 - 56,028,498 (+)NCBI
UU_Cfam_GSD_1.02056,218,510 - 56,227,219 (+)NCBI
Tbxa2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,786,562 - 215,793,960 (+)NCBI
SpeTri2.0NW_0049365882,040,712 - 2,044,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBXA2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,068,698 - 75,087,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,068,413 - 75,081,305 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103233689
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,354,358 - 3,365,779 (-)NCBI
ChlSab1.1 Ensembl63,355,314 - 3,359,761 (-)Ensembl
Tbxa2r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,291,010 - 6,312,438 (-)NCBI

Position Markers
BI277919  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,253,231 - 11,253,456NCBIRnor6.0
Rnor_5.0711,419,969 - 11,420,194UniSTSRnor5.0
RGSC_v3.479,867,790 - 9,868,015UniSTSRGSC3.4
Celera76,572,381 - 6,572,606UniSTS
Cytogenetic Map7q11UniSTS
BE111403  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,253,176 - 11,253,329NCBIRnor6.0
Rnor_5.0711,419,914 - 11,420,067UniSTSRnor5.0
RGSC_v3.479,867,735 - 9,867,888UniSTSRGSC3.4
Celera76,572,326 - 6,572,479UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:167
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000027932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 8 2 10 4
Low 3 43 51 41 11 41 4 5 74 33 31 7 4
Below cutoff 4 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027932   ⟹   ENSRNOP00000027932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)Ensembl
RefSeq Acc Id: NM_017054   ⟹   NP_058750
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,378 - 8,388,176 (-)NCBI
Rnor_6.0711,253,180 - 11,257,977 (-)NCBI
Rnor_5.0711,419,887 - 11,425,971 (-)NCBI
RGSC_v3.479,867,739 - 9,872,536 (-)RGD
Celera76,572,330 - 6,577,127 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240846   ⟹   XP_006240908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
Rnor_6.0711,253,153 - 11,259,233 (-)NCBI
Rnor_5.0711,419,887 - 11,425,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078433   ⟹   XP_038934361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
RefSeq Acc Id: XM_039078434   ⟹   XP_038934362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,390,753 (-)NCBI
RefSeq Acc Id: XM_039078435   ⟹   XP_038934363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058750   ⟸   NM_017054
- Sequence:
RefSeq Acc Id: XP_006240908   ⟸   XM_006240846
- Peptide Label: isoform X1
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027932   ⟸   ENSRNOT00000027932
RefSeq Acc Id: XP_038934362   ⟸   XM_039078434
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934363   ⟸   XM_039078435
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934361   ⟸   XM_039078433
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3825 AgrOrtholog
Ensembl Genes ENSRNOG00000020585 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027932 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027932 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
  Thbox_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24816 UniProtKB/Swiss-Prot
NCBI Gene 24816 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB TBXA2R RGD
PhenoGen Tbxa2r PhenoGen
PRINTS PROSTANOIDR UniProtKB/Swiss-Prot
  THROMBOXANER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt P34978 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tbxa2r  Thromboxane receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in the progression of atherosclerosis 619549
gene_expression expressed in the renal glomerulus, renal arterial smooth muscle cells, and transitional cell epithelium of the renal pelvis 730225
gene_other constitutive endocytosis results in an intracellular pool of Tbxa2r which is recycled to the cell surface as needed 1578450