Tbxa2r (thromboxane A2 receptor) - Rat Genome Database

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Gene: Tbxa2r (thromboxane A2 receptor) Rattus norvegicus
Analyze
Symbol: Tbxa2r
Name: thromboxane A2 receptor
RGD ID: 3825
Description: Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor); PARTICIPATES IN eicosanoid signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: prostanoid TP receptor; Thromboxane receptor; TXA2-R; TXR2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,383,347 - 8,390,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,383,378 - 8,388,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,268,951 - 11,273,739 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,144,435 - 13,149,223 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,012,082 - 11,016,867 (-)NCBIRnor_WKY
Rnor_6.0711,253,153 - 11,259,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,419,887 - 11,425,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,867,739 - 9,872,536 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,867,738 - 9,872,536 (-)NCBI
Celera76,572,330 - 6,577,127 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
acetylsalicylic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dioxygen  (ISO)
domitroban  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
flavonoids  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
melittin  (EXP)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
oleic acid  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
phenol red  (EXP)
pirinixic acid  (ISO)
propanal  (ISO)
puromycin  (ISO)
raloxifene  (ISO)
Ramatroban  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
XL147  (ISO)
zinc sulfate  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization. Abe T, etal., J Clin Invest 1995 Aug;96(2):657-64.
2. Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats. Acosta Cazal MC, etal., Gend Med. 2004 Dec;1(2):100-5.
3. Protective effects of BAY U 3405, a thromboxane A2 receptor antagonist, in endotoxin shock. Altavilla D, etal., Pharmacol Res. 1994 Aug-Sep;30(2):137-51.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. The identification and characterization of oligodendrocyte thromboxane A2 receptors. Blackman SC, etal., J Biol Chem. 1998 Jan 2;273(1):475-83.
6. Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. de Leval X, etal., J Pharmacol Exp Ther. 2006 Sep;318(3):1057-67. Epub 2006 May 23.
7. Pharmacodynamics and antithrombotic effects after intravenous administration of the new thromboxane A2 receptor antagonist sodium 4-[[1-[[[(4-chlorophenyl)sulfonyl]amino]methyl]cyclopentyl] methyl]benzeneacetate. Depin JC, etal., Arzneimittelforschung. 1994 Nov;44(11):1203-7.
8. Role for thromboxane receptors in angiotensin-II-induced hypertension. Francois H, etal., Hypertension. 2004 Feb;43(2):364-9. Epub 2004 Jan 12.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Thromboxane A2 receptor antagonist prevents pancreatic microvascular leakage in rats with caerulein-induced acute pancreatitis. Hirano T and Hirano K, Int J Surg Investig. 1999;1(3):203-10.
12. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. Hirata T, etal., J Clin Invest. 1994 Oct;94(4):1662-7.
13. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Holt S, etal., Kidney Int. 1999 Jan;55(1):271-7.
14. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. Hong SJ, etal., J Allergy Clin Immunol. 2005 Apr;115(4):758-63.
15. Effect of a novel thromboxane A2 receptor antagonist, S-145, on collagen-induced ECG changes and thrombocytopenia in rodents. Hori Y, etal., Jpn J Pharmacol. 1989 Jun;50(2):195-205.
16. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Kim SH, etal., Clin Exp Allergy. 2005 May;35(5):585-90.
17. cDNA cloning of a thromboxane A2 receptor from rat astrocytes. Kitanaka J, etal., Biochim Biophys Acta 1995 Mar 16;1265(2-3):220-3.
18. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. Kobayashi T, etal., J Clin Invest. 2004 Sep;114(6):784-94.
19. Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children. Leung TF, etal., Pediatr Allergy Immunol. 2002 Feb;13(1):10-7.
20. Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation. Li M, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101. doi: 10.1073/pnas.1002685107. Epub 2010 Oct 19.
21. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Liu T, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12692-7. doi: 10.1073/pnas.1207816109. Epub 2012 Jul 16.
22. Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Matsuda K, etal., Am J Physiol. 1994 Sep;267(3 Pt 2):H887-93.
23. Role of the thromboxane A2 receptor in the vasoactive response to ischemia-reperfusion injury. Mazolewski PJ, etal., Plast Reconstr Surg. 1999 Oct;104(5):1393-6.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. Nanji AA, etal., J Pharmacol Exp Ther. 1997 Aug;282(2):1037-43.
26. [Study of thromboxane A2 antagonist reduction in the treatment of patients with perennial allergic rhinitis]. Narita S, etal., Arerugi. 2004 Jun;53(6):601-4.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Protective effects of trans-13-APT, a thromboxane receptor antagonist, in endotoxemia. Olanoff LS, etal., J Cardiovasc Pharmacol. 1985 Jan-Feb;7(1):114-20.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Insulin preincubation effects on rat vessel contractile responses: role of the endothelium. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
33. Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides. Remuzzi G, etal., J Exp Med. 1994 Nov 1;180(5):1967-72.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Sugawara A, etal., Hypertens Res. 2001 May;24(3):229-33.
38. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. Sugawara A, etal., J Biol Chem 2002 Mar 22;277(12):9676-83.
39. Human bronchial smooth muscle cell proliferation via thromboxane A2 receptor. Suzuki Y, etal., Prostaglandins Leukot Essent Fatty Acids. 2004 Dec;71(6):375-82.
40. Immunohistochemical localization of thromboxane receptor and thromboxane synthase in rat testis. Takahashi N, etal., Endocrinology. 1995 Sep;136(9):4143-6.
41. Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Takayama K, etal., Nat Med. 2005 May;11(5):562-6. Epub 2005 Apr 17.
42. Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis. Tanaka K, etal., Biochem Biophys Res Commun. 2002 Apr 5;292(3):776-80.
43. Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). Theriault C, etal., Biochemistry. 2004 May 18;43(19):5600-7.
44. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. Thomas DW, etal., J Clin Invest. 1998 Dec 1;102(11):1994-2001.
45. Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression. Traupe T, etal., J Hypertens. 2002 Nov;20(11):2239-45.
46. Therapeutic intervention in a rat model of adult respiratory distress syndrome: III. Cyclooxygenase pathway inhibition. Turner CR, etal., Circ Shock. 1991 Jun;34(2):270-7.
47. Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells. Uruno A, etal., Hypertens Res. 2003 Oct;26(10):815-21.
48. Chronic hyperglycemia impairs functional vasodilation via increasing thromboxane-receptor-mediated vasoconstriction. Xiang L, etal., Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H231-6. Epub 2006 Aug 11.
49. Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats. Xu H, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G277-83.
Additional References at PubMed
PMID:1375456   PMID:8936585   PMID:12925702   PMID:14627611   PMID:17706224   PMID:18710937   PMID:18769070   PMID:19696359   PMID:21217826   PMID:22717688   PMID:24558106   PMID:25857252  
PMID:26708952   PMID:27178425   PMID:28415790   PMID:32530751  


Genomics

Comparative Map Data
Tbxa2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,383,347 - 8,390,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,383,378 - 8,388,176 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,268,951 - 11,273,739 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,144,435 - 13,149,223 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,012,082 - 11,016,867 (-)NCBIRnor_WKY
Rnor_6.0711,253,153 - 11,259,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,419,887 - 11,425,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,867,739 - 9,872,536 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,867,738 - 9,872,536 (-)NCBI
Celera76,572,330 - 6,577,127 (-)NCBICelera
Cytogenetic Map7q11NCBI
TBXA2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,594,507 - 3,606,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,594,507 - 3,606,875 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,594,505 - 3,606,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,545,504 - 3,557,658 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,545,503 - 3,557,658NCBI
Celera193,531,342 - 3,543,669 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,359,876 - 3,372,152 (-)NCBIHuRef
CHM1_1193,594,158 - 3,606,423 (-)NCBICHM1_1
T2T-CHM13v2.0193,572,690 - 3,584,998 (-)NCBIT2T-CHM13v2.0
Tbxa2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,164,102 - 81,171,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,164,565 - 81,171,006 (+)EnsemblGRCm39 Ensembl
GRCm381081,328,268 - 81,335,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,328,731 - 81,335,172 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,791,476 - 80,797,917 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,731,860 - 80,738,301 (+)NCBIMGSCv36mm8
Celera1082,349,466 - 82,355,970 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tbxa2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,539,889 - 5,557,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,539,382 - 5,557,441 (-)NCBIChiLan1.0ChiLan1.0
TBXA2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,572,454 - 3,581,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,570,290 - 3,581,924 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,621,606 - 2,632,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TBXA2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,819,866 - 55,829,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,824,410 - 55,828,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,545,953 - 55,554,659 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,480,706 - 56,489,446 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,480,655 - 56,490,031 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,536,340 - 55,545,063 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,019,809 - 56,028,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,218,510 - 56,227,219 (+)NCBIUU_Cfam_GSD_1.0
Tbxa2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,786,562 - 215,793,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,040,630 - 2,045,110 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365882,040,712 - 2,044,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBXA2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,068,698 - 75,087,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,068,413 - 75,081,305 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103233689
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,354,358 - 3,365,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,355,314 - 3,359,761 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,119,245 - 5,134,213 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbxa2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,291,167 - 6,309,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,291,010 - 6,312,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbxa2r
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:167
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000027932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
BI277919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,383,428 - 8,383,654 (+)MAPPERmRatBN7.2
Rnor_6.0711,253,231 - 11,253,456NCBIRnor6.0
Rnor_5.0711,419,969 - 11,420,194UniSTSRnor5.0
RGSC_v3.479,867,790 - 9,868,015UniSTSRGSC3.4
Celera76,572,381 - 6,572,606UniSTS
Cytogenetic Map7q11UniSTS
BE111403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,383,373 - 8,383,527 (+)MAPPERmRatBN7.2
Rnor_6.0711,253,176 - 11,253,329NCBIRnor6.0
Rnor_5.0711,419,914 - 11,420,067UniSTSRnor5.0
RGSC_v3.479,867,735 - 9,867,888UniSTSRGSC3.4
Celera76,572,326 - 6,572,479UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 8 2 10 4
Low 3 43 51 41 11 41 4 5 74 33 31 7 4
Below cutoff 4 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027932   ⟹   ENSRNOP00000027932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,383,378 - 8,388,176 (-)Ensembl
Rnor_6.0 Ensembl711,253,180 - 11,257,977 (-)Ensembl
RefSeq Acc Id: NM_017054   ⟹   NP_058750
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,378 - 8,388,176 (-)NCBI
Rnor_6.0711,253,180 - 11,257,977 (-)NCBI
Rnor_5.0711,419,887 - 11,425,971 (-)NCBI
RGSC_v3.479,867,739 - 9,872,536 (-)RGD
Celera76,572,330 - 6,577,127 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240846   ⟹   XP_006240908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
Rnor_6.0711,253,153 - 11,259,233 (-)NCBI
Rnor_5.0711,419,887 - 11,425,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078433   ⟹   XP_038934361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
RefSeq Acc Id: XM_039078434   ⟹   XP_038934362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,390,753 (-)NCBI
RefSeq Acc Id: XM_039078435   ⟹   XP_038934363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,383,347 - 8,389,420 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058750   ⟸   NM_017054
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240908   ⟸   XM_006240846
- Peptide Label: isoform X1
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027932   ⟸   ENSRNOT00000027932
RefSeq Acc Id: XP_038934362   ⟸   XM_039078434
- Peptide Label: isoform X1
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934363   ⟸   XM_039078435
- Peptide Label: isoform X1
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934361   ⟸   XM_039078433
- Peptide Label: isoform X1
- UniProtKB: P34978 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34978-F1-model_v2 AlphaFold P34978 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3825 AgrOrtholog
BioCyc Gene G2FUF-35015 BioCyc
Ensembl Genes ENSRNOG00000020585 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027932 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027932 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
  Thbox_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24816 UniProtKB/Swiss-Prot
NCBI Gene 24816 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB TBXA2R RGD
PhenoGen Tbxa2r PhenoGen
PRINTS PROSTANOIDR UniProtKB/Swiss-Prot
  THROMBOXANER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt P34978 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tbxa2r  Thromboxane receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in the progression of atherosclerosis 619549
gene_expression expressed in the renal glomerulus, renal arterial smooth muscle cells, and transitional cell epithelium of the renal pelvis 730225
gene_other constitutive endocytosis results in an intracellular pool of Tbxa2r which is recycled to the cell surface as needed 1578450