Runx1t1 (RUNX1 partner transcriptional co-repressor 1) - Rat Genome Database
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Gene: Runx1t1 (RUNX1 partner transcriptional co-repressor 1) Rattus norvegicus
Analyze
Symbol: Runx1t1
Name: RUNX1 partner transcriptional co-repressor 1
RGD ID: 1305490
Description: Predicted to have identical protein binding activity and transcription corepressor activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of fat cell differentiation; and negative regulation of transcription, DNA-templated. Predicted to localize to nuclear matrix and nucleoplasm. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1); PARTICIPATES IN acute myeloid leukemia pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: acute myelogenous leukemia 1 translocation 1 protein; Cbfa2t1; CBFA2T1 identified gene homolog; CBFA2T1 identified gene homolog (human); core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 2, translocated to, 1; cyclin D-related; LOC362489; runt-related transcription factor 1; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1 translocation partner 1; translocated to, 1; translocated to, 1 (cyclin D-related)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2527,187,674 - 27,338,070 (+)NCBI
Rnor_6.0 Ensembl527,312,928 - 27,442,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0527,284,921 - 27,440,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0531,976,957 - 32,132,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4528,230,322 - 28,338,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1528,188,640 - 28,338,441 (+)NCBI
Celera526,502,150 - 26,607,942 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-naphthylamine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (EXP)
choline  (ISO)
cocaine  (EXP)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
panobinostat  (ISO)
PCB138  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear matrix  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10973986   PMID:15509789   PMID:23251453   PMID:25473084   PMID:26774823  


Genomics

Comparative Map Data
Runx1t1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2527,187,674 - 27,338,070 (+)NCBI
Rnor_6.0 Ensembl527,312,928 - 27,442,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0527,284,921 - 27,440,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0531,976,957 - 32,132,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4528,230,322 - 28,338,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1528,188,640 - 28,338,441 (+)NCBI
Celera526,502,150 - 26,607,942 (+)NCBICelera
Cytogenetic Map5q13NCBI
RUNX1T1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl891,954,967 - 92,103,286 (-)EnsemblGRCh38hg38GRCh38
GRCh38891,954,967 - 92,103,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37892,967,195 - 93,115,613 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37892,967,195 - 93,115,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36893,040,328 - 93,176,619 (-)NCBINCBI36hg18NCBI36
Build 34893,040,327 - 93,144,367NCBI
Celera889,157,513 - 89,293,797 (-)NCBI
Cytogenetic Map8q21.3NCBI
HuRef888,174,218 - 88,322,535 (-)NCBIHuRef
CHM1_1893,007,519 - 93,155,728 (-)NCBICHM1_1
Runx1t1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39413,742,628 - 13,895,056 (+)NCBIGRCm39mm39
GRCm38413,742,628 - 13,895,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl413,743,436 - 13,893,649 (+)EnsemblGRCm38mm10GRCm38
MGSCv37413,670,449 - 13,820,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv36413,711,929 - 13,818,264 (+)NCBImm8
Celera413,520,441 - 13,687,612 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.88NCBI
Runx1t1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554178,580,363 - 8,721,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554178,580,355 - 8,714,267 (-)NCBIChiLan1.0ChiLan1.0
RUNX1T1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1890,538,965 - 90,686,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl890,538,965 - 90,686,689 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0888,588,560 - 88,736,614 (-)NCBIMhudiblu_PPA_v0panPan3
RUNX1T1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2937,158,659 - 37,297,879 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12937,156,861 - 37,289,934 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Runx1t1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365445,381,829 - 5,514,364 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUNX1T1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl444,599,760 - 44,743,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1444,600,292 - 44,745,954 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2448,029,947 - 48,172,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RUNX1T1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1886,984,638 - 87,127,648 (-)NCBI
ChlSab1.1 Ensembl886,988,366 - 87,090,875 (-)Ensembl
Runx1t1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624744783 - 63,720 (+)NCBI

Position Markers
D5Uwm12  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,373,084 - 27,373,251NCBIRnor6.0
Rnor_5.0532,064,554 - 32,064,721UniSTSRnor5.0
RGSC_v3.4528,271,397 - 28,271,565RGDRGSC3.4
RGSC_v3.4528,271,398 - 28,271,565UniSTSRGSC3.4
RGSC_v3.1528,271,397 - 28,271,565RGD
Celera526,541,197 - 26,541,364UniSTS
Cytogenetic Map5q13UniSTS
D8S1950  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,439,025 - 27,439,130NCBIRnor6.0
Rnor_5.0532,130,177 - 32,130,282UniSTSRnor5.0
RGSC_v3.4528,337,448 - 28,337,553UniSTSRGSC3.4
Celera526,606,949 - 26,607,054UniSTS
Cytogenetic Map5q13UniSTS
RH80460  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,442,270 - 27,442,507NCBIRnor6.0
Rnor_5.0532,133,422 - 32,133,659UniSTSRnor5.0
RGSC_v3.4528,340,693 - 28,340,930UniSTSRGSC3.4
Celera526,610,194 - 26,610,431UniSTS
Cytogenetic Map5q13UniSTS
RH144682  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,396,031 - 27,396,232NCBIRnor6.0
Rnor_5.0532,087,501 - 32,087,702UniSTSRnor5.0
RGSC_v3.4528,294,243 - 28,294,444UniSTSRGSC3.4
Celera526,564,083 - 26,564,284UniSTS
RH 3.4 Map5154.7UniSTS
Cytogenetic Map5q13UniSTS
BE118933  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,342,290 - 27,342,439NCBIRnor6.0
Rnor_5.0532,034,172 - 32,034,321UniSTSRnor5.0
RGSC_v3.4528,247,382 - 28,247,531UniSTSRGSC3.4
Celera526,517,522 - 26,517,671UniSTS
RH 3.4 Map5153.6UniSTS
Cytogenetic Map5q13UniSTS
BE107258  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,369,786 - 27,369,967NCBIRnor6.0
Rnor_5.0532,061,256 - 32,061,437UniSTSRnor5.0
RGSC_v3.4528,268,100 - 28,268,281UniSTSRGSC3.4
Celera526,537,899 - 26,538,080UniSTS
RH 3.4 Map5153.6UniSTS
Cytogenetic Map5q13UniSTS
Cbfa2t1h  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,439,416 - 27,439,611NCBIRnor6.0
Rnor_5.0532,130,568 - 32,130,763UniSTSRnor5.0
RGSC_v3.4528,337,839 - 28,338,034UniSTSRGSC3.4
Celera526,607,340 - 26,607,535UniSTS
Cytogenetic Map5q13UniSTS
Runx1t1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,439,619 - 27,439,670NCBIRnor6.0
Rnor_5.0532,130,771 - 32,130,822UniSTSRnor5.0
RGSC_v3.4528,338,042 - 28,338,093UniSTSRGSC3.4
Celera526,607,543 - 26,607,594UniSTS
Cytogenetic Map5q13UniSTS
UniSTS:225014  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,438,790 - 27,438,940NCBIRnor6.0
Rnor_5.0532,129,942 - 32,130,092UniSTSRnor5.0
RGSC_v3.4528,337,213 - 28,337,363UniSTSRGSC3.4
Celera526,606,714 - 26,606,864UniSTS
Cytogenetic Map5q13UniSTS
Runx1t1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,438,510 - 27,438,931NCBIRnor6.0
Rnor_5.0532,129,662 - 32,130,083UniSTSRnor5.0
RGSC_v3.4528,336,933 - 28,337,354UniSTSRGSC3.4
Celera526,606,434 - 26,606,855UniSTS
Cytogenetic Map5q13UniSTS
UniSTS:546979  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0527,438,621 - 27,439,679NCBIRnor6.0
Rnor_5.0532,129,773 - 32,130,831UniSTSRnor5.0
Celera526,606,545 - 26,607,603UniSTS
Cytogenetic Map5q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5152509833001026Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5325132948722188Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5452573847978104Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5863228553632285Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51328888858288888Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51884791363847913Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52190436366904363Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52495621244747071Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:122
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000066191
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 4 4 4 64 4 24 3
Low 3 31 30 14 18 14 8 10 10 30 17 8 8
Below cutoff 23 23 1 23 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066191   ⟹   ENSRNOP00000063830
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl527,326,762 - 27,440,018 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078102   ⟹   ENSRNOP00000071431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl527,312,928 - 27,442,841 (+)Ensembl
RefSeq Acc Id: NM_001108657   ⟹   NP_001102127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,229,712 - 27,335,592 (+)NCBI
Rnor_6.0527,326,762 - 27,440,018 (+)NCBI
Rnor_5.0531,976,957 - 32,132,101 (+)NCBI
RGSC_v3.4528,230,322 - 28,338,441 (+)RGD
Celera526,502,150 - 26,607,942 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237901   ⟹   XP_006237963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,187,674 - 27,337,349 (+)NCBI
Rnor_6.0527,284,921 - 27,440,802 (+)NCBI
Rnor_5.0531,976,957 - 32,132,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237903   ⟹   XP_006237965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,194,854 - 27,338,070 (+)NCBI
Rnor_6.0527,286,383 - 27,440,802 (+)NCBI
Rnor_5.0531,976,957 - 32,132,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237904   ⟹   XP_006237966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,187,684 - 27,337,349 (+)NCBI
Rnor_6.0527,284,921 - 27,440,802 (+)NCBI
Rnor_5.0531,976,957 - 32,132,101 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763548   ⟹   XP_008761770
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,195,580 - 27,338,070 (+)NCBI
Rnor_6.0527,292,976 - 27,440,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763549   ⟹   XP_008761771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,210,454 - 27,338,070 (+)NCBI
Rnor_6.0527,307,561 - 27,440,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763550   ⟹   XP_008761772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,194,853 - 27,338,070 (+)NCBI
Rnor_6.0527,292,870 - 27,440,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593469   ⟹   XP_017448958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,195,677 - 27,338,070 (+)NCBI
Rnor_6.0527,293,133 - 27,440,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110219   ⟹   XP_038966147
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2527,302,596 - 27,338,070 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102127   ⟸   NM_001108657
- UniProtKB: D3ZWZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237963   ⟸   XM_006237901
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237966   ⟸   XM_006237904
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006237965   ⟸   XM_006237903
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008761772   ⟸   XM_008763550
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761771   ⟸   XM_008763549
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761770   ⟸   XM_008763548
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448958   ⟸   XM_017593469
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071431   ⟸   ENSRNOT00000078102
RefSeq Acc Id: ENSRNOP00000063830   ⟸   ENSRNOT00000066191
RefSeq Acc Id: XP_038966147   ⟸   XM_039110219
- Peptide Label: isoform X5
Protein Domains
MYND-type   TAFH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305490 AgrOrtholog
Ensembl Genes ENSRNOG00000005673 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063830 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071431 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066191 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000078102 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1110 UniProtKB/TrEMBL
InterPro ETO UniProtKB/TrEMBL
  MTG8 UniProtKB/TrEMBL
  NHR2 UniProtKB/TrEMBL
  TAFH/NHR1_dom_sf UniProtKB/TrEMBL
  TAFH_NHR1 UniProtKB/TrEMBL
  Znf_MYND UniProtKB/TrEMBL
KEGG Report rno:362489 UniProtKB/TrEMBL
NCBI Gene 362489 ENTREZGENE
PANTHER PTHR10379 UniProtKB/TrEMBL
  PTHR10379:SF5 UniProtKB/TrEMBL
Pfam NHR2 UniProtKB/TrEMBL
  TAFH UniProtKB/TrEMBL
  zf-MYND UniProtKB/TrEMBL
PhenoGen Runx1t1 PhenoGen
PRINTS ETOFAMILY UniProtKB/TrEMBL
  MTG8PROTEIN UniProtKB/TrEMBL
PROSITE TAFH UniProtKB/TrEMBL
  ZF_MYND_1 UniProtKB/TrEMBL
  ZF_MYND_2 UniProtKB/TrEMBL
SMART TAFH UniProtKB/TrEMBL
Superfamily-SCOP SSF158553 UniProtKB/TrEMBL
UniProt A0A0G2K0G0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWZ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Runx1t1  RUNX1 partner transcriptional co-repressor 1  Runx1t1  RUNX1 translocation partner 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-29 Runx1t1  RUNX1 translocation partner 1  Runx1t1  runt-related transcription factor 1; translocated to, 1 (cyclin D-related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Runx1t1  runt-related transcription factor 1; translocated to, 1 (cyclin D-related)  Cbfa2t1_predicted  CBFA2T1 identified gene homolog (human) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cbfa2t1_predicted  CBFA2T1 identified gene homolog (human) (predicted)    core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related (predicted)  Name updated 1299863 APPROVED
2005-01-12 Cbfa2t1_predicted  core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related (predicted)      Symbol and Name status set to approved 70820 APPROVED