Cd226 (CD226 molecule) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cd226 (CD226 molecule) Rattus norvegicus
Analyze
Symbol: Cd226
Name: CD226 molecule
RGD ID: 1311513
Description: Predicted to have integrin binding activity and protein kinase binding activity. Predicted to be involved in positive regulation of immune response; positive regulation of interferon-gamma production; and positive regulation of mast cell activation. Predicted to localize to external side of plasma membrane. Orthologous to human CD226 (CD226 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD226 antigen; LOC307199
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cd226Tn(sb-T2/Bart3)2.141Mcwi  
Genetic Models: F344-Cd226Tn(sb-T2/Bart3)2.141Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21882,449,924 - 82,545,107 (+)NCBI
Rnor_6.0 Ensembl1886,299,463 - 86,394,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01886,299,392 - 86,394,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01885,337,942 - 85,433,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41886,064,574 - 86,157,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11886,157,214 - 86,230,246 (+)NCBI
Celera1881,000,246 - 81,093,141 (+)NCBICelera
Cytogenetic Map18q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12913096   PMID:15752754   PMID:16304049   PMID:16831868   PMID:19648922   PMID:22728856   PMID:24658051   PMID:26755705  


Genomics

Comparative Map Data
Cd226
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21882,449,924 - 82,545,107 (+)NCBI
Rnor_6.0 Ensembl1886,299,463 - 86,394,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01886,299,392 - 86,394,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01885,337,942 - 85,433,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41886,064,574 - 86,157,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11886,157,214 - 86,230,246 (+)NCBI
Celera1881,000,246 - 81,093,141 (+)NCBICelera
Cytogenetic Map18q13NCBI
CD226
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1869,831,158 - 69,961,803 (-)EnsemblGRCh38hg38GRCh38
GRCh381869,853,274 - 69,962,086 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371867,520,510 - 67,624,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361865,681,172 - 65,775,139 (-)NCBINCBI36hg18NCBI36
Build 341865,681,174 - 65,775,140NCBI
Celera1864,377,737 - 64,472,107 (-)NCBI
Cytogenetic Map18q22.2NCBI
HuRef1864,248,832 - 64,343,180 (-)NCBIHuRef
CHM1_11867,525,491 - 67,619,626 (-)NCBICHM1_1
Cd226
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391889,195,078 - 89,290,356 (+)NCBIGRCm39mm39
GRCm39 Ensembl1889,195,091 - 89,290,353 (+)Ensembl
GRCm381889,176,954 - 89,272,232 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1889,176,967 - 89,272,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv371889,366,819 - 89,439,719 (+)NCBIGRCm37mm9NCBIm37
MGSCv361889,331,620 - 89,404,520 (+)NCBImm8
Celera1890,925,452 - 90,998,347 (+)NCBICelera
Cytogenetic Map18E4NCBI
Cd226
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540253,473,131 - 53,560,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540253,408,861 - 53,560,896 (-)NCBIChiLan1.0ChiLan1.0
CD226
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11866,533,949 - 66,627,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1866,533,949 - 66,627,580 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01863,238,477 - 63,379,346 (-)NCBIMhudiblu_PPA_v0panPan3
CD226
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl18,351,207 - 8,435,145 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.118,348,628 - 8,437,520 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CD226
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,882,761 - 152,979,848 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,872,878 - 152,977,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21169,304,334 - 169,418,889 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD226
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1189,790,483 - 9,900,376 (+)NCBI
ChlSab1.1 Ensembl189,811,168 - 9,901,830 (+)Ensembl
Cd226
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480611,324,239 - 11,390,487 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181569587287080053Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181569587287080053Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)182028575887080053Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182260373687074531Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183267035287080053Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184500219488201929Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184631947688201929Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184913092088201929Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184913092088201929Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184913092088201929Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185137581688201929Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185137581688201929Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185303349487080053Rat
1558649Bw58Body weight QTL 583.40.0005body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
6893359Bw103Body weight QTL 1031.20.12body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
6893368Bw107Body weight QTL 1070.30.5body mass (VT:0001259)body weight (CMO:0000012)185744867888201929Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185819630088201929Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)186198564888201929Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186300981288201929Rat


Genetic Models
This gene Cd226 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:91
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000058152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 4 18 4
Low 2 23 29 24 1 24 9 6 19 11
Below cutoff 1 18 16 13 13 8 8 65 29 22 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058152   ⟹   ENSRNOP00000054956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1886,299,463 - 86,392,713 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091778   ⟹   ENSRNOP00000073108
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1886,307,646 - 86,394,765 (+)Ensembl
RefSeq Acc Id: NM_001107370   ⟹   NP_001100840
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,450,568 - 82,543,051 (+)NCBI
Rnor_6.01886,299,463 - 86,392,713 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
RGSC_v3.41886,064,574 - 86,157,909 (+)RGD
Celera1881,000,246 - 81,093,141 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255025   ⟹   XP_006255087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255028   ⟹   XP_006255090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255029   ⟹   XP_006255091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255031   ⟹   XP_006255093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255032   ⟹   XP_006255094
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,956 - 82,545,107 (+)NCBI
Rnor_6.01886,299,394 - 86,394,772 (+)NCBI
Rnor_5.01885,337,942 - 85,433,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600934   ⟹   XP_017456423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,394 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600935   ⟹   XP_017456424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,394 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600936   ⟹   XP_017456425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,394 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600937   ⟹   XP_017456426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600938   ⟹   XP_017456427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,395 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600939   ⟹   XP_017456428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,393 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600940   ⟹   XP_017456429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,362,230 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600941   ⟹   XP_017456430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,299,392 - 86,394,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096758   ⟹   XP_038952686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,456,291 - 82,545,107 (+)NCBI
RefSeq Acc Id: XM_039096759   ⟹   XP_038952687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,958 - 82,545,107 (+)NCBI
RefSeq Acc Id: XR_005496022
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21882,449,924 - 82,541,898 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100840   ⟸   NM_001107370
- Peptide Label: precursor
- UniProtKB: D3ZS97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255087   ⟸   XM_006255025
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255091   ⟸   XM_006255029
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255094   ⟸   XM_006255032
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255090   ⟸   XM_006255028
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255093   ⟸   XM_006255031
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456430   ⟸   XM_017600941
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017456428   ⟸   XM_017600939
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017456423   ⟸   XM_017600934
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456424   ⟸   XM_017600935
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456425   ⟸   XM_017600936
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456426   ⟸   XM_017600937
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456427   ⟸   XM_017600938
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456429   ⟸   XM_017600940
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000054956   ⟸   ENSRNOT00000058152
RefSeq Acc Id: ENSRNOP00000073108   ⟸   ENSRNOT00000091778
RefSeq Acc Id: XP_038952687   ⟸   XM_039096759
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952686   ⟸   XM_039096758
- Peptide Label: isoform X1
Protein Domains
Ig-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700909
Promoter ID:EPDNEW_R11422
Type:single initiation site
Name:Cd226_1
Description:CD226 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01886,307,693 - 86,307,753EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 85429185 85429186 A C snv F344/NRrrc (Illumina) (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), SDLEF7/Barth (UDEL), F344/Jcl (KyushuU), F344/DuCrlCrlj (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU), Crl:SD (UDEL)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 86390662 86390663 A C snv CDR


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 86155858 86155859 A C snv F344/NRrrc (KNAW), F344/NHsd (ICAHN), HCR/2Mco (UMich), F344/NCrl (ICL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311513 AgrOrtholog
Ensembl Genes ENSRNOG00000038197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000054956 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073108 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058152 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000091778 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD226 UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:307199 UniProtKB/TrEMBL
NCBI Gene 307199 ENTREZGENE
PANTHER PTHR47011 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Cd226 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
Transposagen Cd226_predicted Transposagen
UniProt A0A0G2K4N2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS97 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-18 Cd226  CD226 antigen  Cd226_predicted  CD226 antigen (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Cd226_predicted  CD226 antigen (predicted)      Symbol and Name status set to approved 70820 APPROVED