1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine decreases expression EXP 6480464 chlorcyclizine results in decreased expression of NUCKS1 mRNA CTD PMID:21058326 17alpha-ethynylestradiol affects expression ISO RGD:1616667 6480464 Ethinyl Estradiol affects the expression of NUCKS1 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736162 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NUCKS1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1616667 6480464 Tetrachlorodibenzodioxin affects the expression of NUCKS1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1616667 6480464 [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of NUCKS1 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736162 6480464 Tetrachlorodibenzodioxin results in increased expression of NUCKS1 mRNA CTD PMID:19684285 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of NUCKS1 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:736162 6480464 Lactic Acid results in decreased expression of NUCKS1 mRNA CTD PMID:30851411 4,4'-sulfonyldiphenol decreases expression ISO RGD:736162 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of NUCKS1 mRNA CTD PMID:25912373 4-hydroxyphenyl retinamide decreases expression ISO RGD:736162 6480464 Fenretinide results in decreased expression of NUCKS1 mRNA CTD PMID:16671099 4-hydroxyphenyl retinamide decreases expression ISO RGD:1616667 6480464 Fenretinide results in decreased expression of NUCKS1 mRNA CTD PMID:28973697 5-fluorouracil multiple interactions ISO RGD:736162 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of NUCKS1 mRNA] CTD PMID:15016801 5-fluorouracil decreases expression ISO RGD:736162 6480464 Fluorouracil results in decreased expression of NUCKS1 protein CTD PMID:15585135 , PMID:16803524 aflatoxin B1 increases methylation ISO RGD:736162 6480464 Aflatoxin B1 results in increased methylation of NUCKS1 gene CTD PMID:27153756 aflatoxin B2 increases methylation ISO RGD:736162 6480464 aflatoxin B2 results in increased methylation of NUCKS1 intron CTD PMID:30157460 aflatoxin M1 increases expression ISO RGD:736162 6480464 Aflatoxin M1 results in increased expression of NUCKS1 mRNA CTD PMID:30928695 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NUCKS1 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:736162 6480464 Arsenic affects the methylation of NUCKS1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:736162 6480464 Arsenic affects the methylation of NUCKS1 gene CTD PMID:25304211 arsenite(3-) affects expression ISO RGD:736162 6480464 arsenite affects the expression of NUCKS1 mRNA CTD PMID:22959463 benzo[e]pyrene increases methylation ISO RGD:736162 6480464 benzo(e)pyrene results in increased methylation of NUCKS1 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:736162 6480464 Mustard Gas results in increased phosphorylation of NUCKS1 protein CTD PMID:19845377 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NUCKS1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:736162 6480464 bisphenol A results in decreased expression of NUCKS1 mRNA CTD PMID:29275510 bortezomib decreases expression ISO RGD:736162 6480464 Bortezomib results in decreased expression of NUCKS1 mRNA CTD PMID:20977926 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of NUCKS1 protein CTD PMID:28903499 butanal decreases expression ISO RGD:736162 6480464 butyraldehyde results in decreased expression of NUCKS1 mRNA CTD PMID:26079696 cadmium atom decreases expression ISO RGD:736162 6480464 Cadmium results in decreased expression of NUCKS1 mRNA CTD PMID:24284285 cadmium dichloride decreases expression ISO RGD:736162 6480464 Cadmium Chloride results in decreased expression of NUCKS1 mRNA CTD PMID:18560533 cadmium dichloride increases expression ISO RGD:736162 6480464 Cadmium Chloride results in increased expression of NUCKS1 mRNA CTD PMID:26472689 cadmium sulfate decreases expression ISO RGD:1616667 6480464 cadmium sulfate results in decreased expression of NUCKS1 mRNA CTD PMID:19274763 calciol increases expression ISO RGD:1616667 6480464 Cholecalciferol results in increased expression of NUCKS1 mRNA CTD PMID:16508948 carbon nanotube increases expression ISO RGD:1616667 6480464 Nanotubes, Carbon analog results in increased expression of NUCKS1 mRNA, Nanotubes, Carbon results in increased expression of NUCKS1 mRNA CTD PMID:25620056 chloropicrin increases expression ISO RGD:736162 6480464 chloropicrin results in increased expression of NUCKS1 mRNA CTD PMID:26352163 clofibrate decreases expression ISO RGD:1616667 6480464 Clofibrate results in decreased expression of NUCKS1 mRNA CTD PMID:17585979 cobalt dichloride decreases expression ISO RGD:736162 6480464 cobaltous chloride results in decreased expression of NUCKS1 mRNA CTD PMID:19320972 cocaine decreases expression ISO RGD:736162 6480464 Cocaine results in decreased expression of NUCKS1 mRNA CTD PMID:15009677 , PMID:16710320 copper atom multiple interactions ISO RGD:736162 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NUCKS1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:736162 6480464 [NSC 689534 binds to Copper] which results in decreased expression of NUCKS1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:736162 6480464 Copper Sulfate results in decreased expression of NUCKS1 mRNA CTD PMID:19549813 CU-O LINKAGE decreases phosphorylation ISO RGD:736162 6480464 cupric oxide results in decreased phosphorylation of NUCKS1 protein CTD PMID:25470785 cycloheximide multiple interactions ISO RGD:736162 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NUCKS1 mRNA CTD PMID:19684285 deoxynivalenol decreases phosphorylation ISO RGD:1616667 6480464 deoxynivalenol results in decreased phosphorylation of NUCKS1 protein CTD PMID:23352502 deoxynivalenol affects phosphorylation ISO RGD:1616667 6480464 deoxynivalenol affects the phosphorylation of NUCKS1 protein CTD PMID:23811945 diethylstilbestrol increases expression ISO RGD:1616667 6480464 Diethylstilbestrol results in increased expression of NUCKS1 mRNA CTD PMID:14648872 dioxygen decreases expression ISO RGD:736162 6480464 Oxygen deficiency results in decreased expression of NUCKS1 mRNA CTD PMID:17175027 dorsomorphin multiple interactions ISO RGD:736162 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:736162 6480464 Doxorubicin results in decreased expression of NUCKS1 mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:736162 6480464 Selenium results in decreased expression of NUCKS1 mRNA CTD PMID:19244175 ethanol multiple interactions ISO RGD:1616667 6480464 Ethanol affects the expression of and affects the splicing of NUCKS1 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of NUCKS1 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of NUCKS1 mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:736162 6480464 Formaldehyde results in decreased expression of NUCKS1 mRNA CTD PMID:23649840 heroin decreases expression ISO RGD:736162 6480464 Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 hexadecanoic acid decreases phosphorylation ISO RGD:736162 6480464 Palmitic Acid results in decreased phosphorylation of NUCKS1 protein CTD PMID:28073184 hydrogen peroxide affects expression ISO RGD:736162 6480464 Hydrogen Peroxide affects the expression of NUCKS1 mRNA CTD PMID:20044591 manganese atom decreases expression ISO RGD:736162 6480464 Manganese results in decreased expression of NUCKS1 mRNA CTD PMID:17175027 manganese(0) decreases expression ISO RGD:736162 6480464 Manganese results in decreased expression of NUCKS1 mRNA CTD PMID:17175027 manganese(II) chloride decreases expression ISO RGD:736162 6480464 manganese chloride results in decreased expression of NUCKS1 mRNA CTD PMID:17175027 methapyrilene increases methylation ISO RGD:736162 6480464 Methapyrilene results in increased methylation of NUCKS1 intron CTD PMID:30157460 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of NUCKS1 mRNA CTD PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:736162 6480464 Methyl Methanesulfonate results in decreased expression of NUCKS1 mRNA CTD PMID:23649840 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of NUCKS1 mRNA CTD PMID:24136188 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of NUCKS1 mRNA CTD PMID:22546817 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of NUCKS1 mRNA CTD PMID:25729387 phenobarbital decreases expression ISO RGD:1616667 6480464 Phenobarbital results in decreased expression of NUCKS1 mRNA CTD PMID:23091169 phenylmercury acetate decreases expression ISO RGD:736162 6480464 Phenylmercuric Acetate results in decreased expression of NUCKS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736162 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA CTD PMID:27188386 pirinixic acid increases expression ISO RGD:1616667 6480464 pirinixic acid results in increased expression of NUCKS1 mRNA CTD PMID:18445702 potassium dichromate increases expression ISO RGD:736162 6480464 Potassium Dichromate results in increased expression of NUCKS1 protein CTD PMID:23718831 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1616667 6480464 Pregnenolone Carbonitrile results in increased expression of NUCKS1 mRNA CTD PMID:22698814 propanal decreases expression ISO RGD:736162 6480464 propionaldehyde results in decreased expression of NUCKS1 mRNA CTD PMID:26079696 rac-lactic acid decreases expression ISO RGD:736162 6480464 Lactic Acid results in decreased expression of NUCKS1 mRNA CTD PMID:30851411 rotenone increases expression EXP 6480464 Rotenone results in increased expression of NUCKS1 mRNA CTD PMID:28374803 Salinomycin decreases expression ISO RGD:736162 6480464 salinomycin results in decreased expression of NUCKS1 mRNA CTD PMID:19682730 SB 431542 multiple interactions ISO RGD:736162 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NUCKS1 mRNA CTD PMID:27188386 selenium atom decreases expression ISO RGD:736162 6480464 Selenium results in decreased expression of NUCKS1 mRNA CTD PMID:19244175 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of NUCKS1 mRNA CTD PMID:25993096 Soman increases expression EXP 6480464 Soman results in increased expression of NUCKS1 mRNA CTD PMID:19281266 tamoxifen affects expression ISO RGD:1616667 6480464 Tamoxifen affects the expression of NUCKS1 mRNA CTD PMID:17555576 titanium dioxide increases expression ISO RGD:1616667 6480464 titanium dioxide results in increased expression of NUCKS1 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of NUCKS1 mRNA CTD PMID:25729387 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of NUCKS1 gene CTD PMID:27618143 trichostatin A decreases expression ISO RGD:736162 6480464 trichostatin A results in decreased expression of NUCKS1 mRNA CTD PMID:24935251 trimellitic anhydride increases expression ISO RGD:1616667 6480464 trimellitic anhydride results in increased expression of NUCKS1 mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:1616667 6480464 troglitazone results in decreased expression of NUCKS1 mRNA CTD PMID:28973697 valproic acid decreases methylation ISO RGD:736162 6480464 Valproic Acid results in decreased methylation of NUCKS1 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:736162 6480464 Valproic Acid results in decreased expression of NUCKS1 mRNA CTD PMID:19101580 more ... vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of NUCKS1 mRNA CTD PMID:19015723
Biological Process cellular glucose homeostasis ISO RGD:1616667 1624291 (MGI:MGI:5695791, PMID:26205492) RGD MGI:MGI:5695791 , PMID:26205492 cellular glucose homeostasis IEA UniProtKB:Q80XU3 , ensembl:ENSMUSP000000625761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to X-ray ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 cellular response to X-ray IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin organization ISO RGD:1616667 1624291 (MGI:MGI:5576396 more ... RGD MGI:MGI:5576396 more ... chromatin organization IEA UniProtKB:Q80XU3 , ensembl:ENSMUSP000000625761600115 GO_REF:0000107 Ensembl GO_REF:0000107 double-strand break repair via homologous recombination ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 double-strand break repair via homologous recombination IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 glucose homeostasis ISO RGD:1616667 1624291 MGI:MGI:5634908 (MGI:MGI:5576396 , PMID:24931609) RGD MGI:MGI:5576396 , PMID:24931609 interstrand cross-link repair ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 interstrand cross-link repair IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 modulation by host of RNA binding by virus ISO RGD:736162 1624291 (PMID:25116364) RGD PMID:25116364 modulation by host of RNA binding by virus IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 modulation by host of viral RNA-binding transcription factor activity ISO RGD:736162 1624291 UniProtKB:P04608 (PMID:25116364) RGD PMID:25116364 modulation by host of viral RNA-binding transcription factor activity IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation by host of viral genome replication ISO RGD:736162 1624291 (PMID:25116364) RGD PMID:25116364 positive regulation by host of viral genome replication IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation by host of viral transcription ISO RGD:736162 1624291 UniProtKB:P04608 (PMID:25116364) RGD PMID:25116364 positive regulation by host of viral transcription IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of insulin receptor signaling pathway ISO RGD:1616667 1624291 (MGI:MGI:5576396, PMID:24931609) RGD MGI:MGI:5576396 , PMID:24931609 positive regulation of insulin receptor signaling pathway IEA UniProtKB:Q80XU3 , ensembl:ENSMUSP000000625761600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1616667 1624291 (MGI:MGI:5576396, PMID:24931609) RGD MGI:MGI:5576396 , PMID:24931609 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q80XU3 , ensembl:ENSMUSP000000625761600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cell cycle TAS 1298022 RGD regulation of DNA replication ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 regulation of DNA replication IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of DNA strand elongation ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 regulation of DNA strand elongation IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of insulin receptor signaling pathway ISO RGD:1616667 1624291 (MGI:MGI:5695791, PMID:26205492) RGD MGI:MGI:5695791 , PMID:26205492 release from viral latency ISO RGD:736162 1624291 (PMID:25116364) RGD PMID:25116364 release from viral latency IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 replication fork processing ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 replication fork processing IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cell IEA GO:0001678 1600115 GO_REF:0000108 GOC GO_REF:0000108 chromatin ISO RGD:1616667 1624291 (MGI:MGI:5695791, PMID:26205492) RGD MGI:MGI:5695791 , PMID:26205492 cytoplasm IDA 1298022 RGD cytoplasm ISO RGD:736162 1624291 (PMID:17604136) RGD PMID:17604136 cytoplasm ISO RGD:1616667 1624291 (MGI:MGI:5785001, PMID:3000779) RGD MGI:MGI:5785001 , PMID:3000779 nuclear chromatin ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 nuclear chromatin IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus ISO RGD:736162 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:736162 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1298022 RGD nucleus ISO RGD:736162 1624291 (PMID:11298763), (PMID:17604136), (PMID:25116364), (PMID:26323318) RGD PMID:11298763 more ... nucleus TAS 11344951 PMID:1627131 ParkinsonsUK-UCL nucleus ISO RGD:1616667 1624291 (MGI:MGI:1933693 more ... RGD MGI:MGI:1933693 more ... Molecular Function chromatin binding ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 chromatin binding IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1616667 1624291 (MGI:MGI:5576396, PMID:24931609) RGD MGI:MGI:5576396 , PMID:24931609 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:Q80XU3 , ensembl:ENSMUSP000000625761600115 GO_REF:0000107 Ensembl GO_REF:0000107 double-stranded DNA binding TAS 1298022 RGD double-stranded DNA binding ISO RGD:736162 1624291 (PMID:26323318) RGD PMID:26323318 double-stranded DNA binding NAS 11344951 PMID:1627131 ParkinsonsUK-UCL single-stranded DNA binding TAS 1298022 RGD single-stranded DNA binding IDA 11344951 PMID:1627131 ParkinsonsUK-UCL transcription factor binding ISO RGD:736162 1624291 UniProtKB:P04608 (PMID:25116364) RGD PMID:25116364 transcription factor binding IEA UniProtKB:Q9H1E3 , ensembl:ENSP000003561101600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
