Sgpp1 (sphingosine-1-phosphate phosphatase 1)

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Gene: Sgpp1 (sphingosine-1-phosphate phosphatase 1) Rattus norvegicus

Analyze

Symbol:

Sgpp1

Name:

sphingosine-1-phosphate phosphatase 1

RGD ID:

727829

Description:

Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in several processes, including ER to Golgi ceramide transport; phospholipid dephosphorylation; and sphingosine metabolic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway; and sphinganine-1-phosphate metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC81536; sphingosine-1-phosphatase 1; sphingosine-1-phosphate phosphohydrolase; Spp1; SPPase1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sgpp1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgpp1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgpp1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgpp1 (sphingosine-1-phosphate phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SGPP1 (sphingosine-1-phosphate phosphatase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgpp1 (sphingosine-1-phosphate phosphatase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-212g7.6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	sgpp1 (sphingosine-1-phosphate phosphatase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LCB3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YSR3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	94,425,339 - 94,446,534 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,425,339 - 94,446,534 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	94,818,696 - 94,839,851 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	95,117,168 - 95,138,323 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	94,546,078 - 94,567,225 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	98,675,324 - 98,696,492 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	98,675,326 - 98,695,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	108,093,013 - 108,114,339 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	98,306,168 - 98,327,175 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	98,311,877 - 98,330,264 (-)	NCBI
Celera	6	92,851,441 - 92,872,597 (-)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

buspirone (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clofibric acid (EXP)

daidzein (ISO)

deoxynivalenol (ISO)

diazinon (EXP)

dibutyl phthalate (ISO)

dieldrin (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

fenthion (ISO)

flutamide (EXP,ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glycitein (ISO)

lamivudine (ISO)

methapyrilene (EXP)

methidathion (ISO)

methylmercury chloride (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nickel dichloride (EXP)

nicotine (ISO)

nimesulide (EXP)

p-toluidine (EXP)

panobinostat (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

Phenelzine (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ER to Golgi ceramide transport (IEA,ISO,ISS)

extrinsic apoptotic signaling pathway (IEA,ISO)

intrinsic apoptotic signaling pathway (IEA,ISO)

phospholipid dephosphorylation (IBA)

regulation of epidermis development (ISO,ISS)

regulation of keratinocyte differentiation (IEA,ISO,ISS)

sphinganine-1-phosphate metabolic process (IEA,ISO)

sphingolipid metabolic process (ISO)

sphingosine metabolic process (IBA,IEA,ISO)

Cellular Component

actin cytoskeleton (ISO)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IBA)

Golgi apparatus (ISO)

membrane (IEA,ISO)

mitochondrion (ISO)

plasma membrane (IEA)

Molecular Function

dihydrosphingosine-1-phosphate phosphatase activity (IEA)

sphingosine-1-phosphate phosphatase activity (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

sphingolipid metabolic pathway (IEA)

sphingosine 1-phosphate signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.	Le Stunff H, etal., J Biol Chem 2004 Aug 13;279(33):34290-7. Epub 2004 Jun 04.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10563330	PMID:10859351	PMID:11756451	PMID:12235122	PMID:15057822	PMID:15271294	PMID:16782891	PMID:23637227

Genomics

Comparative Map Data

Sgpp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	94,425,339 - 94,446,534 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,425,339 - 94,446,534 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	94,818,696 - 94,839,851 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	95,117,168 - 95,138,323 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	94,546,078 - 94,567,225 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	98,675,324 - 98,696,492 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	98,675,326 - 98,695,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	108,093,013 - 108,114,339 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	98,306,168 - 98,327,175 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	98,311,877 - 98,330,264 (-)	NCBI
Celera	6	92,851,441 - 92,872,597 (-)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

SGPP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	63,684,216 - 63,728,065 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	63,684,216 - 63,728,065 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	64,150,934 - 64,194,783 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	63,220,687 - 63,264,509 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	63,220,688 - 63,264,509	NCBI
Celera	14	44,201,594 - 44,245,417 (-)	NCBI		Celera
Cytogenetic Map	14	q23.2	NCBI
HuRef	14	44,317,325 - 44,361,142 (-)	NCBI		HuRef
CHM1_1	14	64,089,953 - 64,133,737 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	57,891,616 - 57,935,465 (-)	NCBI		T2T-CHM13v2.0

Sgpp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	75,761,022 - 75,782,503 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	75,761,023 - 75,782,503 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	75,714,248 - 75,735,729 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	75,714,249 - 75,735,729 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	76,815,235 - 76,836,716 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	76,633,105 - 76,654,502 (-)	NCBI		MGSCv36	mm8
Celera	12	76,819,194 - 76,840,277 (-)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	32.95	NCBI

Sgpp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955466	6,075,507 - 6,103,739 (+)	NCBI	ChiLan1.0	ChiLan1.0

SGPP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	14	64,011,967 - 64,055,847 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	44,265,017 - 44,308,897 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	62,521,010 - 62,566,309 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SGPP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	38,195,649 - 38,228,299 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	38,197,532 - 38,228,406 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	37,888,039 - 37,921,345 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	38,422,209 - 38,455,539 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	38,422,214 - 38,455,507 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	38,038,844 - 38,072,143 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	38,111,070 - 38,144,393 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	38,471,314 - 38,504,624 (-)	NCBI		UU_Cfam_GSD_1.0

Sgpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	66,663,173 - 66,690,708 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	7,502,859 - 7,528,515 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936495	7,500,991 - 7,528,520 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGPP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	194,352,001 - 194,380,907 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	194,351,971 - 194,380,910 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	216,298,626 - 216,383,691 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGPP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	40,885,464 - 40,926,992 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	40,885,276 - 40,926,937 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	29,080,236 - 29,121,462 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgpp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	37,297,806 - 37,335,553 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	37,297,954 - 37,337,830 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sgpp1
105 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	68
Count of miRNA genes:	62
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000006913
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	83190345	106747639	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	89762877	106752806	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat

Markers in Region

D6Rat164

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	94,449,600 - 94,449,948 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	98,699,575 - 98,699,922	NCBI	Rnor6.0
Rnor_5.0	6	108,117,430 - 108,117,777	UniSTS	Rnor5.0
RGSC_v3.4	6	98,330,395 - 98,330,742	UniSTS	RGSC3.4
RGSC_v3.4	6	98,330,394 - 98,330,743	RGD	RGSC3.4
Celera	6	92,875,677 - 92,876,024	UniSTS
RH 3.4 Map	6	668.4	RGD
RH 3.4 Map	6	668.4	UniSTS
SHRSP x BN Map	6	56.7098	UniSTS
SHRSP x BN Map	6	56.7098	RGD
Cytogenetic Map	6	q24	UniSTS

AI229520

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	94,437,126 - 94,437,344 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	98,687,115 - 98,687,332	NCBI	Rnor6.0
Rnor_5.0	6	108,104,970 - 108,105,187	UniSTS	Rnor5.0
RGSC_v3.4	6	98,317,932 - 98,318,149	UniSTS	RGSC3.4
Celera	6	92,863,238 - 92,863,455	UniSTS
RH 3.4 Map	6	669.1	UniSTS
Cytogenetic Map	6	q24	UniSTS

RH136984

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	94,425,377 - 94,425,576 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	98,675,363 - 98,675,561	NCBI	Rnor6.0
Rnor_5.0	6	108,093,052 - 108,093,250	UniSTS	Rnor5.0
RGSC_v3.4	6	98,306,207 - 98,306,405	UniSTS	RGSC3.4
Celera	6	92,851,480 - 92,851,678	UniSTS
RH 3.4 Map	6	667.29	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	57	41	19	41	6	7	66	35	38	11	6
Low		23					2	4	8		3		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001080791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_343081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF329638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000006913 ⟹ ENSRNOP00000006913

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	94,425,339 - 94,446,534 (-)	Ensembl
Rnor_6.0 Ensembl	6	98,675,326 - 98,695,988 (-)	Ensembl

RefSeq Acc Id:

NM_030874 ⟹ NP_110501

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	94,425,339 - 94,446,534 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_110501	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK07473	(Get FASTA)	NCBI Sequence Viewer
	EDM03639	(Get FASTA)	NCBI Sequence Viewer
	EDM03640	(Get FASTA)	NCBI Sequence Viewer
	Q99P55	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000006913 ⟸ ENSRNOT00000006913

RefSeq Acc Id:	NP_110501 ⟸ NM_030874
- UniProtKB:	Q99P55 (UniProtKB/Swiss-Prot), F1LPB0 (UniProtKB/TrEMBL), A6HC84 (UniProtKB/TrEMBL)

Protein Domains

Phosphatidic acid phosphatase type 2/haloperoxidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99P55-F1-model_v2	AlphaFold	Q99P55	1-430	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727829	AgrOrtholog
BioCyc Gene	G2FUF-37074	BioCyc
BioCyc Pathway	PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism]	BioCyc
Ensembl Genes	ENSRNOG00000005175	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000006913	ENTREZGENE
	ENSRNOP00000006913.7	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006913	ENTREZGENE
	ENSRNOT00000006913.7	UniProtKB/TrEMBL
Gene3D-CATH	Phosphatidic acid phosphatase type 2/haloperoxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	P_Acid_Pase_2/haloperoxi_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_Acid_Pase_2/haloperoxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	81536	ENTREZGENE
PANTHER	SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAP2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sgpp1	PhenoGen
SMART	acidPPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48317	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6HC84	ENTREZGENE, UniProtKB/TrEMBL
	A6HC85_RAT	UniProtKB/TrEMBL
	F1LPB0	ENTREZGENE, UniProtKB/TrEMBL
	Q99P55	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-04-22	Sgpp1	sphingosine-1-phosphate phosphatase 1	LOC81536	sphingosine-1-phosphate phosphohydrolase	Symbol and Name updated to reflect Human and Mouse nomenclature	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)