Fshr (follicle stimulating hormone receptor) - Rat Genome Database

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Gene: Fshr (follicle stimulating hormone receptor) Rattus norvegicus
Symbol: Fshr
Name: follicle stimulating hormone receptor
RGD ID: 2632
Description: Enables follicle-stimulating hormone receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway; response to organic cyclic compound; and transcytosis. Located in cell surface and endosome. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor); PARTICIPATES IN follicle-stimulating hormone signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 1,2-Dibromo-3-chloropropane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: follicle-stimulating hormone receptor; follitropin receptor; FSH-R
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8610,952,329 - 11,160,288 (+)NCBIGRCr8
mRatBN7.265,198,825 - 5,406,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,198,825 - 5,406,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx65,495,461 - 5,704,638 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.065,804,840 - 6,014,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,329,312 - 5,541,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,796,383 - 12,997,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,796,383 - 12,997,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0622,754,761 - 22,955,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4612,925,894 - 13,161,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1612,925,893 - 13,161,215 (-)NCBI
Celera64,990,917 - 5,196,793 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-Dibromo-3-chloropropane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
alginic acid  (ISO)
allethrin  (EXP)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlorogenic acid  (EXP)
chlorothalonil  (ISO)
Chorionic gonadotropin  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyanamide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
galaxolide  (EXP)
ginsenoside Rg1  (ISO)
glyphosate  (ISO)
graphite  (EXP)
GW 4064  (ISO)
L-ascorbic acid  (EXP)
letrozole  (ISO)
leuprolide  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
mestranol  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
Nonylphenol  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP)
picrotoxin  (EXP)
plumbagin  (EXP)
potassium dichromate  (EXP)
pyrethrins  (EXP)
rutin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
stigmasterol  (ISO)
testosterone  (ISO)
thiamethoxam  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triclosan  (EXP)
triphenylstannane  (EXP)
zearalenone  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
basement membrane organization  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO,ISS)
follicle-stimulating hormone signaling pathway  (IBA,IDA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
hormone-mediated signaling pathway  (IBA)
intracellular water homeostasis  (ISO)
locomotory behavior  (ISO)
male gonad development  (IBA,ISO)
negative regulation of bone resorption  (ISO)
neuron projection development  (ISO)
ovarian follicle development  (ISO)
ovulation cycle process  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
primary ovarian follicle growth  (ISO)
regulation of acetylcholine metabolic process  (ISO)
regulation of chromosome organization  (ISO)
regulation of hormone metabolic process  (ISO)
regulation of intracellular estrogen receptor signaling pathway  (ISO)
regulation of MAPK cascade  (ISO)
regulation of osteoclast differentiation  (ISO)
regulation of platelet-derived growth factor receptor signaling pathway  (ISO)
regulation of protein kinase A signaling  (ISO,ISS)
regulation of protein phosphorylation  (ISO)
regulation of systemic arterial blood pressure  (ISO)
response to organic cyclic compound  (IEP)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
sperm DNA condensation  (ISO)
spermatid development  (ISO)
spermatogenesis  (ISO)
transcytosis  (IDA)
uterus development  (ISO)

Cellular Component
cell surface  (IDA,ISO)
endosome  (IDA)
membrane  (ISO,ISS)
plasma membrane  (IBA,ISO,ISS)
receptor complex  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Aittomaki K, etal., Cell. 1995 Sep 22;82(6):959-68.
2. Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions. Angelova K and Puett D, Endocrine 2002 Nov;19(2):147-54.
3. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
4. Demonstration of follicle-stimulating hormone receptor in cauda epididymis of rat. Dahia CL and Rao AJ, Biol Reprod. 2006 Jul;75(1):98-106. Epub 2006 Apr 5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion. Kishi H, etal., J Biol Chem 2002 Jun 14;277(24):21939-46.
8. A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors. Kotlar TJ, etal., J Clin Endocrinol Metab. 1997 Apr;82(4):1020-6.
9. Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex. Krishnamurthy H, etal., Mol Endocrinol. 2003 Nov;17(11):2162-76. Epub 2003 Aug 7.
10. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
11. G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. Marion S, etal., J Endocrinol. 2006 Aug;190(2):341-50.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. Smits G, etal., N Engl J Med. 2003 Aug 21;349(8):760-6.
21. The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA. Sprengel R, etal., Mol Endocrinol 1990 Apr;4(4):525-30.
22. Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7. Tao YX, etal., Mol Endocrinol. 2002 Aug;16(8):1881-92.
23. Receptor-mediated transcytosis of follicle-stimulating hormone through the rat testicular microvasculature. Vu Hai MT, etal., Biol Cell. 2004 Mar;96(2):133-44.
Additional References at PubMed
PMID:1738373   PMID:7776966   PMID:9206032   PMID:9811848   PMID:10330114   PMID:10775161   PMID:10803590   PMID:11089565   PMID:11459817   PMID:11466221   PMID:11847099   PMID:12135868  
PMID:12204217   PMID:12801993   PMID:14502087   PMID:14552897   PMID:14680821   PMID:14998910   PMID:15817654   PMID:15919743   PMID:15973687   PMID:16344272   PMID:16406266   PMID:16630814  
PMID:17097219   PMID:17280718   PMID:17332067   PMID:17674129   PMID:17848411   PMID:18063689   PMID:18403489   PMID:18599597   PMID:18676690   PMID:18992787   PMID:19152639   PMID:19833718  
PMID:20068007   PMID:20201104   PMID:20467586   PMID:20535929   PMID:22431408   PMID:22850685   PMID:23500014   PMID:23709086   PMID:24058690   PMID:24692546   PMID:28605466   PMID:31352176  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8610,952,329 - 11,160,288 (+)NCBIGRCr8
mRatBN7.265,198,825 - 5,406,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,198,825 - 5,406,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx65,495,461 - 5,704,638 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.065,804,840 - 6,014,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,329,312 - 5,541,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,796,383 - 12,997,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,796,383 - 12,997,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0622,754,761 - 22,955,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4612,925,894 - 13,161,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1612,925,893 - 13,161,215 (-)NCBI
Celera64,990,917 - 5,196,793 (+)NCBICelera
Cytogenetic Map6q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38248,962,157 - 49,154,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,962,157 - 49,154,527 (-)EnsemblGRCh38hg38GRCh38
GRCh37249,189,296 - 49,381,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36249,043,156 - 49,235,134 (-)NCBINCBI36Build 36hg18NCBI36
Build 34249,101,302 - 49,293,281NCBI
Celera249,029,941 - 49,222,277 (-)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,923,221 - 49,115,367 (-)NCBIHuRef
CHM1_1249,119,818 - 49,312,179 (-)NCBICHM1_1
T2T-CHM13v2.0248,958,181 - 49,150,411 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391789,292,380 - 89,508,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1789,292,380 - 89,508,103 (-)EnsemblGRCm39 Ensembl
GRCm381788,984,952 - 89,200,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,984,952 - 89,200,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371789,384,292 - 89,600,015 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361788,893,278 - 89,109,001 (-)NCBIMGSCv36mm8
Celera1793,393,276 - 93,609,441 (-)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1758.76NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544115,422,190 - 15,585,537 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544115,422,190 - 15,585,446 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21277,216,903 - 77,416,148 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,220,871 - 77,420,116 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A49,088,450 - 49,287,688 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A50,008,328 - 50,207,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A50,008,328 - 50,207,258 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11050,765,591 - 50,938,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,770,995 - 50,938,474 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1050,612,082 - 50,785,017 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01051,634,502 - 51,807,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,638,906 - 51,807,715 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11051,337,568 - 51,510,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,622,043 - 51,795,004 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,813,298 - 51,986,246 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629232,172,613 - 32,325,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365083,601,315 - 3,753,706 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365083,601,205 - 3,754,234 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl391,607,305 - 91,774,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1391,607,236 - 91,775,255 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,500,987 - 97,591,897 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q2.2-q2.3NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11458,013,405 - 58,211,528 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1458,013,742 - 58,212,755 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604553,631,322 - 53,822,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473830,176,817 - 30,369,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473830,170,514 - 30,369,250 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fshr
1076 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:90
Interacting mature miRNAs:101
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,345,007 - 5,345,178 (-)MAPPERmRatBN7.2
Rnor_6.0612,856,626 - 12,856,796NCBIRnor6.0
Rnor_5.0622,814,965 - 22,815,135UniSTSRnor5.0
RGSC_v3.4612,988,397 - 12,988,568RGDRGSC3.4
RGSC_v3.4612,988,398 - 12,988,568UniSTSRGSC3.4
RGSC_v3.1612,988,397 - 12,988,568RGD
Celera65,135,229 - 5,135,399UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,245,951 - 5,246,214 (-)MAPPERmRatBN7.2
Rnor_6.0612,952,175 - 12,952,437NCBIRnor6.0
Rnor_5.0622,910,079 - 22,910,341UniSTSRnor5.0
RGSC_v3.4613,103,071 - 13,103,333UniSTSRGSC3.4
Celera65,037,181 - 5,037,443UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,197,695 - 5,197,930 (-)MAPPERmRatBN7.2
Rnor_6.0612,998,712 - 12,998,946NCBIRnor6.0
Rnor_5.0622,955,975 - 22,956,209UniSTSRnor5.0
RGSC_v3.4613,162,110 - 13,162,344UniSTSRGSC3.4
Celera64,989,788 - 4,990,022UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,405,997 - 5,406,301 (-)MAPPERmRatBN7.2
Rnor_6.0612,796,867 - 12,797,170NCBIRnor6.0
Rnor_5.0622,755,245 - 22,755,548UniSTSRnor5.0
RGSC_v3.4612,926,378 - 12,926,681UniSTSRGSC3.4
Celera65,196,006 - 5,196,309UniSTS
Cytogenetic Map6q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system reproductive system respiratory system
Medium 7
Low 15
Below cutoff 2 2 2 2 13 5 1


RefSeq Acc Id: ENSRNOT00000022802   ⟹   ENSRNOP00000022802
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,198,825 - 5,406,785 (+)Ensembl
Rnor_6.0 Ensembl612,796,383 - 12,997,817 (-)Ensembl
RefSeq Acc Id: NM_199237   ⟹   NP_954707
Rat AssemblyChrPosition (strand)Source
GRCr8610,952,329 - 11,160,288 (+)NCBI
mRatBN7.265,198,825 - 5,406,785 (+)NCBI
Rnor_6.0612,796,383 - 12,997,817 (-)NCBI
Rnor_5.0622,754,761 - 22,955,080 (-)NCBI
RGSC_v3.4612,925,894 - 13,161,215 (-)RGD
Celera64,990,917 - 5,196,793 (+)RGD
Protein Sequences
Protein RefSeqs NP_954707 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41175 (Get FASTA)   NCBI Sequence Viewer  
  BAA89218 (Get FASTA)   NCBI Sequence Viewer  
  EDM02615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022802
GenBank Protein P20395 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954707   ⟸   NM_199237
- Peptide Label: precursor
- UniProtKB: Q64183 (UniProtKB/Swiss-Prot),   P20395 (UniProtKB/Swiss-Prot),   A6H9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022802   ⟸   ENSRNOT00000022802
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20395-F1-model_v2 AlphaFold P20395 1-692 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2632 AgrOrtholog
BioCyc Gene G2FUF-38781 BioCyc
Ensembl Genes ENSRNOG00000016783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055019041 UniProtKB/Swiss-Prot
  ENSRNOG00060004359 UniProtKB/Swiss-Prot
  ENSRNOG00065007694 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022802 ENTREZGENE
  ENSRNOT00000022802.5 UniProtKB/Swiss-Prot
  ENSRNOT00055032478 UniProtKB/Swiss-Prot
  ENSRNOT00060007308 UniProtKB/Swiss-Prot
  ENSRNOT00065012038 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribonuclease Inhibitor UniProtKB/TrEMBL
InterPro FSH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GnHR_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25449 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24372:SF5 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GnHR_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fshr PhenoGen
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016783 RatGTEx
  ENSRNOG00055019041 RatGTEx
  ENSRNOG00060004359 RatGTEx
  ENSRNOG00065007694 RatGTEx
SMART LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q64183 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fshr  Follicle stimulating hormone receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 75 kDa 625417