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Gene: Mme (membrane metallo-endopeptidase) Rattus norvegicus
Symbol: Mme
Name: membrane metallo-endopeptidase
RGD ID: 3098
Description: Exhibits oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; animal organ development; and proteolysis. Localizes to plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; kallikrein-kinin cascade pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Type: protein-coding
Also known as: atriopeptidase; CD10; enkephalinase; membrane metallo endopeptidase; Membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); MGC93576; Nep; neprilysin; neutral endopeptidase 24.11; SFE; skin fibroblast elastase
Homo sapiens (human) : MME (membrane metalloendopeptidase)  HGNC  Alliance
Mus musculus (house mouse) : Mme (membrane metallo endopeptidase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mme (membrane metalloendopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : MME (membrane metalloendopeptidase)
Canis lupus familiaris (dog) : MME (membrane metalloendopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mme (membrane metalloendopeptidase)
Sus scrofa (pig) : MME (membrane metalloendopeptidase)
Chlorocebus sabaeus (African green monkey) : MME (membrane metalloendopeptidase)
Heterocephalus glaber (naked mole-rat) : Mme (membrane metalloendopeptidase)
more info ...
Is Marker For: Strains:   SS.WKY-(D2N35-Mme)/Mco   SS.MNS-(Mme-Gca)/Ayd   SS.MNS-(Mme-D2Mit14)/Ayd   SS.MNS-(Mme-D2Rat131)/Ayd   SS.WKY-(Mme-D2Wox18)/Mco  
QTLs:   Bp90   Bp73   Bp368  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02153,799,203 - 153,880,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2153,803,349 - 153,880,738 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,193,501 - 173,278,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,031,724 - 153,114,515 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12152,981,686 - 153,064,477 (+)NCBI
Celera2142,009,686 - 142,090,693 (+)NCBICelera
Cytogenetic Map2q31NCBI
RH 3.4 Map2955.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mme
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3098
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.