Mme (membrane metallo-endopeptidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mme (membrane metallo-endopeptidase) Rattus norvegicus
Analyze
Symbol: Mme
Name: membrane metallo-endopeptidase
RGD ID: 3098
Description: Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; placenta development; and response to estrogen. Located in plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; kallikrein-kinin cascade pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: atriopeptidase; CD10; enkephalinase; membrane metallo endopeptidase; Membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); MGC93576; Nep; neprilysin; neutral endopeptidase 24.11; SFE; skin fibroblast elastase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SS.WKY-(D2N35-Mme)/Mco   SS.MNS-(Mme-Gca)/Ayd   SS.MNS-(Mme-D2Mit14)/Ayd   SS.MNS-(Mme-D2Rat131)/Ayd   SS.WKY-(Mme-D2Wox18)/Mco  
QTLs:   Bp90   Bp73   Bp368  
Candidate Gene For: Prcr1 Bp368
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22147,686,913 - 147,803,808 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2147,722,086 - 147,803,792 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2154,412,545 - 154,499,268 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02152,461,414 - 152,548,760 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02147,094,065 - 147,181,452 (+)NCBIRnor_WKY
Rnor_6.02153,799,203 - 153,880,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2153,803,349 - 153,880,738 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,193,501 - 173,278,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,031,724 - 153,114,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12152,981,686 - 153,064,477 (+)NCBI
Celera2142,009,686 - 142,090,693 (+)NCBICelera
RH 3.4 Map2955.0RGD
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
candoxatrilat  (ISO)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (EXP)
dextran sulfate  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
enilconazole  (EXP)
entinostat  (ISO)
estrogen  (EXP)
ethanol  (ISO)
fipronil  (EXP)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydralazine  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
mitomycin C  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP)
naloxone  (EXP)
Naltrindole  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
omapatrilat  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiacloprid  (EXP)
thioacetamide  (EXP)
Thiorphan  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
XL147  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
brush border  (IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytoplasmic vesicle  (ISO)
dendrite  (IEA,ISO,ISS)
early endosome  (IEA,ISO)
membrane  (IDA,ISO)
membrane raft  (IEA,ISO)
neuron projection terminus  (IEA,ISO,ISS)
neuronal cell body  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
presynapse  (ISO)
synapse  (ISO,ISS)
synaptic vesicle  (IEA,ISO,ISS)
trans-Golgi network  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential response of neutral endopeptidase 24.11 ("enkephalinase"), and cholinergic and opioidergic markers to hypoglossal axotomy. Back SA and Gorenstein C, J Comp Neurol. 1994 Feb 8;340(2):149-60. doi: 10.1002/cne.903400202.
2. Evaluation of neprilysin sequence variation in relation to CSF ß-Amyloid levels and Alzheimer disease risk. Blomqvist ME, etal., Int J Mol Epidemiol Genet. 2010 Oct 15;1(1):47-52.
3. Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak. Carpenter TC and Stenmark KR, Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L941-8. doi: 10.1152/ajplung.2001.281.4.L941.
4. Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition. Chappell MC, etal., Hypertension. 2000 Jan;35(1 Pt 2):348-52.
5. Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Debiec H, etal., Lancet. 2004 Oct 2-8;364(9441):1252-9.
6. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
7. A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice. Devi L and Ohno M, Mol Brain. 2015 Mar 25;8:19. doi: 10.1186/s13041-015-0110-5.
8. Increased expression of neprilysin (neutral endopeptidase 24.11) in rat and human hepatocellular carcinomas. Dragovic T, etal., Lab Invest. 1994 Jan;70(1):107-13.
9. Pre- and post-natal ontogeny of neutral endopeptidase 24-11 ('enkephalinase') studied by in vitro autoradiography in the rat. Dutriez I, etal., Experientia. 1992 Mar 15;48(3):290-300.
10. Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease. El-Sayed NS and Bayan Y, Adv Exp Med Biol. 2015;822:107-18. doi: 10.1007/978-3-319-08927-0_12.
11. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Fukami S, etal., Neurosci Res. 2002 May;43(1):39-56.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Estrogen regulates neprilysin activity in rat brain. Huang J, etal., Neurosci Lett. 2004 Aug 26;367(1):85-7.
15. Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents. Jackson DG and Hersh LB, J Biol Chem. 1986 Jul 5;261(19):8649-54.
16. Increased expression of renal neutral endopeptidase in severe heart failure. Knecht M, etal., Life Sci. 2002 Oct 25;71(23):2701-12.
17. Accumulation of murine amyloid-ß mimics early Alzheimer's disease. Krohn M, etal., Brain. 2015 Aug;138(Pt 8):2370-82. doi: 10.1093/brain/awv137. Epub 2015 May 18.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
20. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
21. No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients. Lilius L, etal., Neurosci Lett. 2003 Feb 6;337(2):111-3.
22. The Association of MME microRNA Binding Site Polymorphism with the Risk of Late Onset Alzheimer's Disease in Northern Han Chinese. Liu CX, etal., Curr Neurovasc Res. 2017;14(2):90-95. doi: 10.2174/1567202614666170313110301.
23. Molecular cloning and amino acid sequence of rat enkephalinase. Malfroy B, etal., Biochem Biophys Res Commun 1987 Apr 14;144(1):59-66.
24. Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. Marçais-Collado H, etal., Eur J Pharmacol. 1987 Dec 1;144(2):125-32.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Neprilysin protects against cerebral amyloid angiopathy and Aß-induced degeneration of cerebrovascular smooth muscle cells. Miners JS, etal., Brain Pathol. 2011 Sep;21(5):594-605. doi: 10.1111/j.1750-3639.2011.00486.x. Epub 2011 Apr 3.
27. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. Miners JS, etal., J Neuropathol Exp Neurol. 2006 Oct;65(10):1012-21.
28. Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. Miners JS, etal., J Neuropathol Exp Neurol. 2009 Aug;68(8):902-14. doi: 10.1097/NEN.0b013e3181afe475.
29. Genetic variation in MME in relation to neprilysin protein and enzyme activity, Aß levels, and Alzheimer's disease risk. Miners S, etal., Int J Mol Epidemiol Genet. 2012;3(1):30-8. Epub 2012 Feb 5.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Expression of neprilysin in periodontitis-affected gingival tissues. Nezu A, etal., Arch Oral Biol. 2017 Jul;79:35-41. doi: 10.1016/j.archoralbio.2017.03.003. Epub 2017 Mar 6.
32. Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease. Oda M, etal., Neurosci Lett. 2002 Mar 1;320(1-2):105-7.
33. Effects of a selective neutral endopeptidase and a nonselective neutral endopeptidase/endothelin-converting enzyme inhibitor on lipopolysaccharide-induced endotoxaemia in anaesthetized Sprague-Dawley rats. Pham D, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S362-6.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. Pu Q, etal., J Hypertens. 2002 May;20(5):899-907.
36. Intracardiac expression of neutral endopeptidase. Raizada V, etal., Mol Cell Biochem 2002 Mar;232(1-2):129-31.
37. A place in our hearts for the lowly angiotensin 1-7 peptide? Reudelhuber TL Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6.
38. GOA pipeline RGD automated data pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells. Schmid C, etal., Regul Pept. 2005 Aug 15;130(1-2):57-66.
41. Mutation screening and association study of the neprilysin gene in sporadic Alzheimer's disease in Chinese persons. Shi J, etal., J Gerontol A Biol Sci Med Sci. 2005 Mar;60(3):301-6.
42. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, etal., J Immunol. 2008 Nov 1;181(9):6503-13.
43. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
44. Association between neprilysin polymorphisms and sporadic Alzheimer's disease. Wood LS, etal., Neurosci Lett. 2007 Nov 5;427(2):103-6. doi: 10.1016/j.neulet.2007.09.019. Epub 2007 Sep 20.
45. [Effects of Naoerkang on expressions of beta-amyloid peptide 1-42 and neprilysin in hippocampus in a rat model of Alzheimer's disease]. Yuan HF, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):152-7.
46. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. Zhao WQ, etal., J Biol Chem. 2009 Jul 10;284(28):18742-53. doi: 10.1074/jbc.M109.011015. Epub 2009 Apr 30.
Additional References at PubMed
PMID:2521388   PMID:2531377   PMID:2703483   PMID:6208535   PMID:7890699   PMID:8168535   PMID:9751784   PMID:12477932   PMID:12657655   PMID:12835417   PMID:14749444   PMID:15005274  
PMID:15100223   PMID:15194566   PMID:15283675   PMID:15489334   PMID:15838282   PMID:15838331   PMID:15944124   PMID:16226260   PMID:16636059   PMID:16827801   PMID:17952634   PMID:18346198  
PMID:18539150   PMID:18602473   PMID:18607539   PMID:19056867   PMID:19057576   PMID:19468242   PMID:20137687   PMID:20414044   PMID:20876573   PMID:21423176   PMID:22024547   PMID:22183801  
PMID:22272689   PMID:23376485   PMID:23533145   PMID:23624023   PMID:24189506   PMID:24508800   PMID:24825898   PMID:26983277   PMID:27373199   PMID:27588448   PMID:29702204   PMID:30531704  
PMID:33433852   PMID:35344141  


Genomics

Comparative Map Data
Mme
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22147,686,913 - 147,803,808 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2147,722,086 - 147,803,792 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2154,412,545 - 154,499,268 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02152,461,414 - 152,548,760 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02147,094,065 - 147,181,452 (+)NCBIRnor_WKY
Rnor_6.02153,799,203 - 153,880,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2153,803,349 - 153,880,738 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,193,501 - 173,278,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42153,031,724 - 153,114,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12152,981,686 - 153,064,477 (+)NCBI
Celera2142,009,686 - 142,090,693 (+)NCBICelera
RH 3.4 Map2955.0RGD
Cytogenetic Map2q31NCBI
MME
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,024,202 - 155,183,729 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3155,024,124 - 155,183,704 (+)EnsemblGRCh38hg38GRCh38
GRCh373154,741,991 - 154,901,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363156,280,130 - 156,384,212 (+)NCBINCBI36Build 36hg18NCBI36
Build 343156,280,756 - 156,384,194NCBI
Celera3153,217,556 - 153,321,523 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3152,191,860 - 152,295,862 (+)NCBIHuRef
CHM1_13154,760,481 - 154,864,540 (+)NCBICHM1_1
T2T-CHM13v2.03157,798,155 - 157,957,709 (+)NCBIT2T-CHM13v2.0
Mme
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,202,632 - 63,291,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,148,958 - 63,293,451 (+)EnsemblGRCm39 Ensembl
GRCm38363,295,211 - 63,383,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,241,537 - 63,386,030 (+)EnsemblGRCm38mm10GRCm38
MGSCv37363,099,794 - 63,186,153 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36363,383,801 - 63,470,160 (+)NCBIMGSCv36mm8
Celera362,969,256 - 63,055,608 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.97NCBI
Mme
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554486,226,059 - 6,314,949 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554486,193,113 - 6,311,666 (+)NCBIChiLan1.0ChiLan1.0
MME
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13159,637,965 - 160,292,119 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,197,566 - 160,292,119 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03152,085,694 - 152,240,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MME
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12348,966,222 - 49,059,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2348,971,066 - 49,059,919 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2348,843,474 - 48,934,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02349,596,559 - 49,692,908 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2349,593,076 - 49,694,136 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,187,708 - 49,279,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02349,238,095 - 49,328,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02349,521,230 - 49,612,145 (+)NCBIUU_Cfam_GSD_1.0
Mme
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,138,054 - 87,220,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365192,513,704 - 2,595,971 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365192,513,896 - 2,595,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MME
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1395,019,081 - 95,126,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11395,018,395 - 95,122,977 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213103,025,551 - 103,128,284 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MME
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11535,577,460 - 35,681,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1535,580,714 - 35,633,914 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660418,227,922 - 8,338,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mme
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473032,601,488 - 32,689,080 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473032,601,835 - 32,691,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mme
447 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:97
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000042576
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat

Markers in Region
D2Mco32  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02153,832,556 - 153,832,878NCBIRnor6.0
Rnor_5.02173,226,472 - 173,226,794UniSTSRnor5.0
RGSC_v3.42153,065,089 - 153,065,413RGDRGSC3.4
RGSC_v3.42153,065,090 - 153,065,413UniSTSRGSC3.4
RGSC_v3.12153,015,052 - 153,015,376RGD
Celera2142,042,277 - 142,042,642UniSTS
Cytogenetic Map2q31UniSTS
D2Mco33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22147,752,777 - 147,753,017 (+)MAPPERmRatBN7.2
Rnor_6.02153,829,897 - 153,830,138NCBIRnor6.0
Rnor_5.02173,223,813 - 173,224,054UniSTSRnor5.0
RGSC_v3.42153,062,292 - 153,062,721RGDRGSC3.4
RGSC_v3.42153,062,431 - 153,062,672UniSTSRGSC3.4
RGSC_v3.12153,012,394 - 153,012,635RGD
Celera2142,039,618 - 142,039,859UniSTS
RH 3.4 Map2953.8UniSTS
RH 3.4 Map2953.8RGD
Cytogenetic Map2q31UniSTS
D2Wox43  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02153,832,553 - 153,832,887NCBIRnor6.0
Rnor_5.02173,226,469 - 173,226,803UniSTSRnor5.0
RGSC_v3.42153,065,087 - 153,065,422UniSTSRGSC3.4
Celera2142,042,274 - 142,042,651UniSTS
Cytogenetic Map2q31UniSTS
RH132069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22147,803,084 - 147,803,304 (+)MAPPERmRatBN7.2
Rnor_6.02153,880,187 - 153,880,406NCBIRnor6.0
Rnor_5.02173,274,304 - 173,274,523UniSTSRnor5.0
RGSC_v3.42153,113,792 - 153,114,011UniSTSRGSC3.4
Celera2142,089,970 - 142,090,189UniSTS
RH 3.4 Map2954.1UniSTS
Cytogenetic Map2q31UniSTS
39.MHAa90d3.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22147,741,027 - 147,741,208 (+)MAPPERmRatBN7.2
Rnor_6.02153,817,767 - 153,817,947NCBIRnor6.0
Rnor_5.02173,211,683 - 173,211,863UniSTSRnor5.0
RGSC_v3.42153,050,377 - 153,050,557UniSTSRGSC3.4
Celera2142,027,874 - 142,028,054UniSTS
Cytogenetic Map2q31UniSTS
RH94409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22147,803,242 - 147,803,394 (+)MAPPERmRatBN7.2
Rnor_6.02153,880,345 - 153,880,496NCBIRnor6.0
Rnor_5.02173,274,462 - 173,274,613UniSTSRnor5.0
RGSC_v3.42153,113,950 - 153,114,101UniSTSRGSC3.4
Celera2142,090,128 - 142,090,279UniSTS
RH 3.4 Map2955.0UniSTS
Cytogenetic Map2q31UniSTS
RH140580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22147,801,884 - 147,802,041 (+)MAPPERmRatBN7.2
Rnor_6.02153,878,987 - 153,879,143NCBIRnor6.0
Rnor_5.02173,273,104 - 173,273,260UniSTSRnor5.0
RGSC_v3.42153,112,592 - 153,112,748UniSTSRGSC3.4
Celera2142,088,770 - 142,088,926UniSTS
RH 3.4 Map2956.1UniSTS
Cytogenetic Map2q31UniSTS




Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 12 11 7 2 2 8 35 35 11 2
Low 1 30 23 18 12 18 6 9 66 6 6
Below cutoff 1 23 23 23

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042576   ⟹   ENSRNOP00000044578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2147,722,086 - 147,803,792 (+)Ensembl
Rnor_6.0 Ensembl2153,830,586 - 153,880,738 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088565   ⟹   ENSRNOP00000074307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2153,803,349 - 153,879,826 (+)Ensembl
RefSeq Acc Id: NM_012608   ⟹   NP_036740
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22147,722,844 - 147,803,808 (+)NCBI
Rnor_6.02153,799,585 - 153,880,910 (+)NCBI
Rnor_5.02173,193,501 - 173,278,946 (+)NCBI
RGSC_v3.42153,031,724 - 153,114,515 (+)RGD
Celera2142,009,686 - 142,090,693 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101718   ⟹   XP_038957646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22147,721,839 - 147,803,480 (+)NCBI
RefSeq Acc Id: XM_039101719   ⟹   XP_038957647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22147,686,913 - 147,803,480 (+)NCBI
RefSeq Acc Id: XM_039101720   ⟹   XP_038957648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22147,722,660 - 147,802,794 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036740   ⟸   NM_012608
- UniProtKB: P07861 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044578   ⟸   ENSRNOT00000042576
RefSeq Acc Id: ENSRNOP00000074307   ⟸   ENSRNOT00000088565
RefSeq Acc Id: XP_038957647   ⟸   XM_039101719
- Peptide Label: isoform X1
- UniProtKB: P07861 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957646   ⟸   XM_039101718
- Peptide Label: isoform X1
- UniProtKB: P07861 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957648   ⟸   XM_039101720
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07861-F1-model_v2 AlphaFold P07861 1-750 view protein structure
Nep pdb 1r1h P07861 52-750 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3098 AgrOrtholog
BioCyc Gene G2FUF-52933 BioCyc
Ensembl Genes ENSRNOG00000009514 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044578 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042576 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110842 IMAGE-MGC_LOAD
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MME/CD10/NEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24590 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93576 IMAGE-MGC_LOAD
NCBI Gene 24590 ENTREZGENE
PANTHER PTHR11733 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11733:SF114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mme PhenoGen
PRINTS NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
TIGR TC230363
UniProt A0A0H2UHX5_RAT UniProtKB/TrEMBL
  NEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-11 Mme  membrane metallo-endopeptidase  Mme  membrane metallo endopeptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mme  membrane metallo endopeptidase      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Mme  membrane metallo endopeptidase      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a single transmembrane spanning domain 729272
gene_process involved in control of cardiovascular homeostasis 727377
gene_protein 742 amino acids 729272