Cacna1h (calcium voltage-gated channel subunit alpha1 H) - Rat Genome Database

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Gene: Cacna1h (calcium voltage-gated channel subunit alpha1 H) Rattus norvegicus
Analyze
Symbol: Cacna1h
Name: calcium voltage-gated channel subunit alpha1 H
RGD ID: 68943
Description: Enables low voltage-gated calcium channel activity. Involved in several processes, including calcium ion import; positive regulation of cardiac muscle cell contraction; and steroid hormone biosynthetic process. Located in several cellular components, including dendrite; nucleus; and perikaryon. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy and primary hyperaldosteronism. Orthologous to human CACNA1H (calcium voltage-gated channel subunit alpha1 H); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; (S)-nicotine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel subunit alpha Cav3.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cacna1hem2Mcwi  
Genetic Models: SS-Cacna1hem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,390,104 - 14,448,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,130,825 - 19,188,496 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01018,619,694 - 18,677,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01014,118,873 - 14,176,544 (-)NCBIRnor_WKY
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3-cyanoalanine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
gentamycin  (EXP)
herbimycin  (ISO)
hexamethylene diisocyanate  (ISO)
imidacloprid  (EXP)
KN-93  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
methapyrilene  (ISO)
Mibefradil  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP,ISO)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
telmisartan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
2. Association between genetic variation of CACNA1H and childhood absence epilepsy. Chen Y, etal., Ann Neurol 2003 Aug;54(2):239-43.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Temperature dependence of T-type calcium channel gating. Iftinca M, etal., Neuroscience. 2006 Nov 3;142(4):1031-42. Epub 2006 Aug 28.
6. Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels. Maeda Y, etal., Pain. 2009 Mar;142(1-2):127-32. doi: 10.1016/j.pain.2008.12.021. Epub 2009 Jan 23.
7. Role of the T-type calcium channel CaV3.2 in the chronotropic action of corticosteroids in isolated rat ventricular myocytes. Maturana A, etal., Endocrinology. 2009 Aug;150(8):3726-34. doi: 10.1210/en.2008-1727. Epub 2009 May 14.
8. Molecular and functional characterization of a family of rat brain T-type calcium channels. McRory JE, etal., J Biol Chem 2001 Feb 9;276(6):3999-4011.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina. Witkovsky P, etal., J Comp Neurol. 2006 Jul 20;497(3):384-96.
19. Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury. Yue J, etal., Spine (Phila Pa 1976). 2013 Mar 15;38(6):463-70. doi: 10.1097/BRS.0b013e318272fbf8.
Additional References at PubMed
PMID:12530678   PMID:14729682   PMID:15616581   PMID:16567615   PMID:16644797   PMID:17690152   PMID:18759855   PMID:18765948   PMID:18832095   PMID:19641113   PMID:19666840   PMID:19940152  
PMID:20394732   PMID:20546998   PMID:21059758   PMID:21084288   PMID:21358644   PMID:21596106   PMID:21690417   PMID:21883220   PMID:22431737   PMID:22764245   PMID:23103495   PMID:23376589  
PMID:23508951   PMID:23669360   PMID:23813099   PMID:23867767   PMID:25099734   PMID:25377760   PMID:25931121   PMID:26331302   PMID:27149520   PMID:27902567   PMID:28912545   PMID:29468672  
PMID:29592785   PMID:29684385   PMID:31744861   PMID:32971090  


Genomics

Comparative Map Data
Cacna1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,390,104 - 14,448,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,130,825 - 19,188,496 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01018,619,694 - 18,677,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01014,118,873 - 14,176,544 (-)NCBIRnor_WKY
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
CACNA1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,153,106 - 1,221,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl161,153,106 - 1,221,771 (+)EnsemblGRCh38hg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBINCBI36Build 36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
T2T-CHM13v2.0161,165,753 - 1,237,078 (+)NCBIT2T-CHM13v2.0
Cacna1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,593,259 - 25,655,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,593,259 - 25,652,757 (-)EnsemblGRCm39 Ensembl
GRCm381725,374,285 - 25,436,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,374,285 - 25,433,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,511,232 - 25,570,728 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,101,887 - 25,161,368 (-)NCBIMGSCv36mm8
Celera1725,902,087 - 25,961,468 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Cacna1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
CACNA1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1161,195,991 - 1,222,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,195,364 - 1,222,917 (+)Ensemblpanpan1.1panPan2
CACNA1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,510,129 - 39,533,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,510,121 - 39,533,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,776,915 - 40,826,321 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,855,337 - 39,904,743 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,855,796 - 39,878,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,531,855 - 39,581,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,504,487 - 39,553,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,983,132 - 40,032,548 (-)NCBIUU_Cfam_GSD_1.0
Cacna1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,984,951 - 104,007,239 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366942,702,224 - 2,724,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,637,427 - 40,695,177 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,637,420 - 40,694,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CACNA1H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,039,709 - 1,106,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,078,973 - 1,106,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,985,587 - 30,052,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,891,156 - 1,949,633 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,926,405 - 1,952,426 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna1h
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:87
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000043626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
RH128070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,390,232 - 14,390,447 (+)MAPPERmRatBN7.2
Rnor_6.01014,731,061 - 14,731,275NCBIRnor6.0
Rnor_5.01014,547,585 - 14,547,799UniSTSRnor5.0
RGSC_v3.41014,621,492 - 14,621,706UniSTSRGSC3.4
Celera1014,061,898 - 14,062,112UniSTS
Cytogenetic Map10q12UniSTS
RH139078  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q12UniSTS
Cacna1h  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,393,024 - 14,393,239 (+)MAPPERmRatBN7.2
Rnor_6.01014,733,853 - 14,734,067NCBIRnor6.0
Rnor_5.01014,550,377 - 14,550,591UniSTSRnor5.0
RGSC_v3.41014,624,285 - 14,624,499UniSTSRGSC3.4
Celera1014,064,690 - 14,064,904UniSTS
Cytogenetic Map10q12UniSTS
UniSTS:461910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,401,237 - 14,402,395 (+)MAPPERmRatBN7.2
Rnor_6.01014,742,066 - 14,743,223NCBIRnor6.0
Rnor_5.01014,558,590 - 14,559,747UniSTSRnor5.0
RGSC_v3.41014,632,498 - 14,633,655UniSTSRGSC3.4
Celera1014,072,903 - 14,074,060UniSTS
Cytogenetic Map10q12UniSTS


Genetic Models
This gene Cacna1h is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 10 2 2 58 18 34
Low 3 15 20 12 9 12 8 10 16 17 7 11 8
Below cutoff 24 24 10 24 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043626   ⟹   ENSRNOP00000042239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110031   ⟹   ENSRNOP00000094098
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,417,421 - 14,448,376 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111325   ⟹   ENSRNOP00000097572
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117168   ⟹   ENSRNOP00000097334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
RefSeq Acc Id: NM_153814   ⟹   NP_722521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,113 - 14,447,791 (-)NCBI
Rnor_6.01014,730,941 - 14,788,617 (-)NCBI
Rnor_5.01014,547,456 - 14,605,627 (-)NCBI
RGSC_v3.41014,621,372 - 14,679,051 (-)RGD
Celera1014,061,778 - 14,119,454 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767532   ⟹   XP_008765754
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767534   ⟹   XP_008765756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596952   ⟹   XP_017452441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596953   ⟹   XP_017452442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596954   ⟹   XP_017452443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,408,938 (-)NCBI
Rnor_6.01014,730,932 - 14,749,707 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_722521   ⟸   NM_153814
- UniProtKB: Q9EQ60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765756   ⟸   XM_008767534
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008765754   ⟸   XM_008767532
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017452442   ⟸   XM_017596953
- Peptide Label: isoform X4
- UniProtKB: G3V9C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452441   ⟸   XM_017596952
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452443   ⟸   XM_017596954
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000042239   ⟸   ENSRNOT00000043626
RefSeq Acc Id: ENSRNOP00000097572   ⟸   ENSRNOT00000111325
RefSeq Acc Id: ENSRNOP00000094098   ⟸   ENSRNOT00000110031
RefSeq Acc Id: ENSRNOP00000097334   ⟸   ENSRNOT00000117168
Protein Domains
Ion_trans

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ60-F1-model_v2 AlphaFold Q9EQ60 1-2359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697052
Promoter ID:EPDNEW_R7575
Type:single initiation site
Name:Cacna1h_1
Description:calcium voltage-gated channel subunit alpha1 H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,788,541 - 14,788,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68943 AgrOrtholog
BioCyc Gene G2FUF-25781 BioCyc
Ensembl Genes ENSRNOG00000033893 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042239 ENTREZGENE
  ENSRNOP00000042239.4 UniProtKB/TrEMBL
  ENSRNOP00000094098.1 UniProtKB/TrEMBL
  ENSRNOP00000097334.1 UniProtKB/TrEMBL
  ENSRNOP00000097572 ENTREZGENE
  ENSRNOP00000097572.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043626 ENTREZGENE
  ENSRNOT00000043626.4 UniProtKB/TrEMBL
  ENSRNOT00000110031.1 UniProtKB/TrEMBL
  ENSRNOT00000111325 ENTREZGENE
  ENSRNOT00000111325.1 UniProtKB/TrEMBL
  ENSRNOT00000117168.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_T_a1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114862 UniProtKB/Swiss-Prot
NCBI Gene 114862 ENTREZGENE
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CACNA1H RGD
PhenoGen Cacna1h PhenoGen
PRINTS TVDCCALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205129
UniProt A0A8I6ASQ9_RAT UniProtKB/TrEMBL
  A0A8I6AUK1_RAT UniProtKB/TrEMBL
  A0A8I6GL03_RAT UniProtKB/TrEMBL
  CAC1H_RAT UniProtKB/Swiss-Prot
  G3V9C6 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ60 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cacna1h  calcium channel, voltage-dependent, T type, alpha 1H subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed throughout the newborn and juvenile brain 62421
gene_expression expressed throughout the newborn and juvenile brain 68748
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 62421
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 68748
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 62421
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 68748
gene_process may play a role in hormone secretion and smooth muscle excitability 62421
gene_process may play a role in hormone secretion and smooth muscle excitability 68748