Cacna1h (calcium voltage-gated channel subunit alpha1 H) - Rat Genome Database

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Gene: Cacna1h (calcium voltage-gated channel subunit alpha1 H) Rattus norvegicus
Analyze
Symbol: Cacna1h
Name: calcium voltage-gated channel subunit alpha1 H
RGD ID: 68943
Description: Exhibits low voltage-gated calcium channel activity. Involved in several processes, including calcium ion import; positive regulation of cardiac muscle cell contraction; and primary alcohol biosynthetic process. Localizes to several cellular components, including dendrite; nucleus; and perikaryon. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy and primary hyperaldosteronism. Orthologous to human CACNA1H (calcium voltage-gated channel subunit alpha1 H); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; (S)-nicotine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel subunit alpha Cav3.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cacna1hem2Mcwi  
Genetic Models: SS-Cacna1hem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3-cyanoalanine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
herbimycin  (ISO)
hexamethylene diisocyanate  (ISO)
imidacloprid  (EXP)
leflunomide  (ISO)
linsidomine  (EXP)
methapyrilene  (ISO)
Mibefradil  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP,ISO)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
p-menthan-3-ol  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
telmisartan  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Additional References at PubMed
PMID:12530678   PMID:14729682   PMID:15616581   PMID:16567615   PMID:16644797   PMID:17690152   PMID:18759855   PMID:18765948   PMID:18832095   PMID:19641113   PMID:19666840   PMID:19940152  
PMID:20394732   PMID:20546998   PMID:21059758   PMID:21084288   PMID:21358644   PMID:21596106   PMID:21690417   PMID:21883220   PMID:22431737   PMID:22764245   PMID:23103495   PMID:23376589  
PMID:23508951   PMID:23669360   PMID:23813099   PMID:23867767   PMID:25099734   PMID:25377760   PMID:25931121   PMID:26331302   PMID:27149520   PMID:27902567   PMID:28912545   PMID:29468672  
PMID:29592785   PMID:29684385   PMID:31744861  


Genomics

Comparative Map Data
Cacna1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
CACNA1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,153,106 - 1,221,771 (+)EnsemblGRCh38hg38GRCh38
GRCh38161,153,106 - 1,221,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBINCBI36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
Cacna1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,593,259 - 25,655,308 (-)NCBIGRCm39mm39
GRCm39 Ensembl1725,593,259 - 25,652,757 (-)Ensembl
GRCm381725,374,285 - 25,436,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,374,285 - 25,433,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,511,232 - 25,570,728 (-)NCBIGRCm37mm9NCBIm37
MGSCv361725,101,887 - 25,161,368 (-)NCBImm8
Celera1725,902,087 - 25,961,468 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Cacna1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
CACNA1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1161,195,991 - 1,222,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,195,364 - 1,222,917 (+)Ensemblpanpan1.1panPan2
CACNA1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,510,129 - 39,533,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,510,121 - 39,533,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,776,915 - 40,826,321 (-)NCBI
ROS_Cfam_1.0639,855,337 - 39,904,743 (-)NCBI
UMICH_Zoey_3.1639,531,855 - 39,581,243 (-)NCBI
UNSW_CanFamBas_1.0639,504,487 - 39,553,874 (-)NCBI
UU_Cfam_GSD_1.0639,983,132 - 40,032,548 (-)NCBI
Cacna1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,984,951 - 104,007,239 (+)NCBI
SpeTri2.0NW_0049366942,702,224 - 2,724,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,637,436 - 40,694,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,637,420 - 40,694,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CACNA1H
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,039,709 - 1,106,212 (+)NCBI
ChlSab1.1 Ensembl51,078,973 - 1,106,507 (+)Ensembl
Cacna1h
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249131,926,405 - 1,952,426 (+)NCBI

Position Markers
RH128070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,390,232 - 14,390,447 (+)MAPPER
Rnor_6.01014,731,061 - 14,731,275NCBIRnor6.0
Rnor_5.01014,547,585 - 14,547,799UniSTSRnor5.0
RGSC_v3.41014,621,492 - 14,621,706UniSTSRGSC3.4
Celera1014,061,898 - 14,062,112UniSTS
Cytogenetic Map10q12UniSTS
RH139078  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q12UniSTS
Cacna1h  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,393,024 - 14,393,239 (+)MAPPER
Rnor_6.01014,733,853 - 14,734,067NCBIRnor6.0
Rnor_5.01014,550,377 - 14,550,591UniSTSRnor5.0
RGSC_v3.41014,624,285 - 14,624,499UniSTSRGSC3.4
Celera1014,064,690 - 14,064,904UniSTS
Cytogenetic Map10q12UniSTS
UniSTS:461910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,401,237 - 14,402,395 (+)MAPPER
Rnor_6.01014,742,066 - 14,743,223NCBIRnor6.0
Rnor_5.01014,558,590 - 14,559,747UniSTSRnor5.0
RGSC_v3.41014,632,498 - 14,633,655UniSTSRGSC3.4
Celera1014,072,903 - 14,074,060UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat


Genetic Models
This gene Cacna1h is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:87
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000043626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 10 2 2 58 18 34
Low 3 15 20 12 9 12 8 10 16 17 7 11 8
Below cutoff 24 24 10 24 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043626   ⟹   ENSRNOP00000042239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)Ensembl
RefSeq Acc Id: NM_153814   ⟹   NP_722521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,113 - 14,447,791 (-)NCBI
Rnor_6.01014,730,941 - 14,788,617 (-)NCBI
Rnor_5.01014,547,456 - 14,605,627 (-)NCBI
RGSC_v3.41014,621,372 - 14,679,051 (-)RGD
Celera1014,061,778 - 14,119,454 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767532   ⟹   XP_008765754
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767534   ⟹   XP_008765756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596952   ⟹   XP_017452441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596953   ⟹   XP_017452442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.01014,730,932 - 14,789,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596954   ⟹   XP_017452443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,390,104 - 14,408,938 (-)NCBI
Rnor_6.01014,730,932 - 14,749,707 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_722521   ⟸   NM_153814
- UniProtKB: Q9EQ60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765756   ⟸   XM_008767534
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008765754   ⟸   XM_008767532
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017452442   ⟸   XM_017596953
- Peptide Label: isoform X4
- UniProtKB: G3V9C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452441   ⟸   XM_017596952
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452443   ⟸   XM_017596954
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000042239   ⟸   ENSRNOT00000043626
Protein Domains
Ion_trans

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697052
Promoter ID:EPDNEW_R7575
Type:single initiation site
Name:Cacna1h_1
Description:calcium voltage-gated channel subunit alpha1 H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,788,541 - 14,788,601EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 14732424 14732425 T G snv LEW/Crl (RGD)
10 14732426 14732427 G T snv LEW/Crl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68943 AgrOrtholog
Ensembl Genes ENSRNOG00000033893 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042239 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043626 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_T_a1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114862 UniProtKB/Swiss-Prot
NCBI Gene 114862 ENTREZGENE
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CACNA1H RGD
PhenoGen Cacna1h PhenoGen
PRINTS TVDCCALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205129
UniProt CAC1H_RAT UniProtKB/Swiss-Prot
  G3V9C6 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ60 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cacna1h  calcium channel, voltage-dependent, T type, alpha 1H subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed throughout the newborn and juvenile brain 62421
gene_expression expressed throughout the newborn and juvenile brain 68748
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 62421
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 68748
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 62421
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 68748
gene_process may play a role in hormone secretion and smooth muscle excitability 62421
gene_process may play a role in hormone secretion and smooth muscle excitability 68748