Gsta4 (glutathione S-transferase alpha 4) - Rat Genome Database

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Gene: Gsta4 (glutathione S-transferase alpha 4) Rattus norvegicus
Analyze
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
RGD ID: 1309970
Description: Enables organic cyclic compound binding activity and toxic substance binding activity. Involved in several processes, including cellular response to lithium ion; response to herbicide; and response to zinc ion. Predicted to be located in cytosol. Orthologous to human GSTA4 (glutathione S-transferase alpha 4); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (E)-4-hydroxynon-2-enal; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase A4; glutathione S-transferase alpha-4; glutathione S-transferase Yk; glutathione S-transferase, alpha 4; glutathione transferase; GST 8-8; GST A4-4; GST K; GST Yk; LOC300850
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gsta4-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,947,247 - 87,964,490 (+)NCBIGRCr8
mRatBN7.2879,066,967 - 79,084,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,066,934 - 79,084,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,554,453 - 84,571,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,831,109 - 82,848,101 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,653,832 - 80,670,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,497,557 - 85,514,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,062,036 - 85,078,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,165,139 - 83,183,055NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,811,797 - 78,829,038 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-4-hydroxynon-2-enal  (EXP)
(S)-nicotine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
13-oxo-9,11-octadecadienoic acid  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hexenal  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Allylamine  (EXP)
amitrole  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
Cyanoginosin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
deoxycholic acid  (ISO)
Diallyl sulfide  (EXP)
diazinon  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
etacrynic acid  (EXP)
ethanol  (ISO)
ethoxyquin  (EXP)
EUK-134  (EXP)
fenitrothion  (EXP)
fipronil  (EXP)
flutamide  (EXP)
gamma-glutamyl-glutathione  (EXP)
gentamycin  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iodide salt  (EXP)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
kojic acid  (EXP)
KT 5720  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP)
lithocholic acid sulfate  (EXP)
maneb  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-hydroxy-PhIP  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Ahmad I, etal., Chem Biol Interact. 2013 Jan 25;201(1-3):9-18. doi: 10.1016/j.cbi.2012.10.027. Epub 2012 Nov 16.
2. Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. Apidianakis Y, etal., FASEB J. 2012 Feb;26(2):730-7. Epub 2011 Oct 28.
3. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Bhagwat SV, etal., Biochem Pharmacol. 1998 Oct 1;56(7):831-9.
4. Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. Curtis JM, etal., Diabetes. 2010 May;59(5):1132-42. Epub 2010 Feb 11.
5. Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria. Edalat M, etal., Histochem Cell Biol. 2004 Aug;122(2):151-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Kumar A, etal., Free Radic Res. 2010 Aug;44(8):950-65.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Raza H, etal., Diabetes. 2004 Jan;53(1):185-94.
12. Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Reichard JF, etal., Biochim Biophys Acta. 2000 Sep 27;1487(2-3):222-32.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Shao L, etal., Neuroscience. 2008 Jan 24;151(2):518-24. Epub 2007 Nov 13.
16. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Singhal NK, etal., J Pineal Res. 2011 Mar;50(2):97-109. doi: 10.1111/j.1600-079X.2010.00819.x. Epub 2010 Oct 22.
17. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
18. Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons. Strom M, etal., Neuromolecular Med. 2011 Dec 8.
19. Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis. Wang H, etal., Chin Med. 2012 Oct 18;7(1):23. doi: 10.1186/1749-8546-7-23.
Additional References at PubMed
PMID:1599415   PMID:2775231   PMID:10329152   PMID:11851347   PMID:12477932   PMID:16189514   PMID:16940154   PMID:24771067   PMID:25416956   PMID:25931508   PMID:32792491  


Genomics

Comparative Map Data
Gsta4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,947,247 - 87,964,490 (+)NCBIGRCr8
mRatBN7.2879,066,967 - 79,084,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,066,934 - 79,084,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,554,453 - 84,571,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,831,109 - 82,848,101 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,653,832 - 80,670,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,497,557 - 85,514,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,062,036 - 85,078,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,165,139 - 83,183,055NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,811,797 - 78,829,038 (+)NCBICelera
Cytogenetic Map8q31NCBI
GSTA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,977,953 - 52,995,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,977,948 - 52,995,304 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,842,751 - 52,860,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,950,710 - 52,968,099 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,950,709 - 52,968,099NCBI
Celera654,504,520 - 54,521,952 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,674,221 - 52,691,656 (-)NCBIHuRef
CHM1_1652,844,511 - 52,861,941 (-)NCBICHM1_1
T2T-CHM13v2.0652,817,518 - 52,834,853 (-)NCBIT2T-CHM13v2.0
Gsta4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,099,248 - 78,116,631 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,090,056 - 78,116,631 (+)EnsemblGRCm39 Ensembl
GRCm38978,191,966 - 78,209,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,182,774 - 78,209,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,039,773 - 78,057,156 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,977,701 - 77,995,033 (+)NCBIMGSCv36mm8
Celera975,369,930 - 75,387,302 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
GSTA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,449,101 - 67,466,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,325,479 - 63,342,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0652,532,942 - 52,550,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,171,609 - 54,189,032 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,171,318 - 54,188,976 (-)Ensemblpanpan1.1panPan2
GSTA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,426,724 - 20,443,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1220,426,726 - 20,443,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,321,558 - 20,337,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,924,034 - 20,940,269 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,923,735 - 20,940,277 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,429,613 - 20,445,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,534,140 - 20,550,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,672,284 - 20,688,436 (-)NCBIUU_Cfam_GSD_1.0
LOC101958062
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,071,901 - 56,087,021 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,873,194 - 7,889,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,873,218 - 7,888,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,635,902 - 46,656,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,635,903 - 46,656,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27134,379,987 - 134,400,475 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,575,835 - 19,591,713 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,575,876 - 19,591,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,829,812 - 52,845,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsta4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850201,592 - 216,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850201,119 - 217,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gsta4
186 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000012348
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat

Markers in Region
RH131281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,541,165 - 87,541,377 (+)MAPPERmRatBN7.2
mRatBN7.24120,320,186 - 120,320,396 (+)MAPPERmRatBN7.2
Rnor_6.04119,765,305 - 119,765,514NCBIRnor6.0
Rnor_6.0885,518,643 - 85,518,854NCBIRnor6.0
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012348   ⟹   ENSRNOP00000012346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,072,633 - 79,084,182 (+)Ensembl
Rnor_6.0 Ensembl885,503,224 - 85,514,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090146   ⟹   ENSRNOP00000075572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,066,934 - 79,084,180 (+)Ensembl
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115538   ⟹   ENSRNOP00000086066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,071,470 - 79,084,182 (+)Ensembl
RefSeq Acc Id: NM_001106840   ⟹   NP_001100310
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,947,265 - 87,964,490 (+)NCBI
mRatBN7.2879,066,967 - 79,084,193 (+)NCBI
Rnor_6.0885,497,557 - 85,514,732 (+)NCBI
Rnor_5.0885,062,036 - 85,078,502 (+)NCBI
RGSC_v3.4883,165,139 - 83,183,055 (+)RGD
Celera878,811,797 - 78,829,038 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265184   ⟹   XP_063121254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,947,247 - 87,964,489 (+)NCBI
RefSeq Acc Id: XM_063265185   ⟹   XP_063121255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,959,106 - 87,964,489 (+)NCBI
RefSeq Acc Id: NP_001100310   ⟸   NM_001106840
- UniProtKB: P14942 (UniProtKB/Swiss-Prot),   A9UMW1 (UniProtKB/TrEMBL),   B6DYP9 (UniProtKB/TrEMBL),   A6HBU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075572   ⟸   ENSRNOT00000090146
Ensembl Acc Id: ENSRNOP00000012346   ⟸   ENSRNOT00000012348
Ensembl Acc Id: ENSRNOP00000086066   ⟸   ENSRNOT00000115538
RefSeq Acc Id: XP_063121254   ⟸   XM_063265184
- Peptide Label: isoform X1
- UniProtKB: P14942 (UniProtKB/Swiss-Prot),   A6HBU1 (UniProtKB/TrEMBL),   A9UMW1 (UniProtKB/TrEMBL),   B6DYP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121255   ⟸   XM_063265185
- Peptide Label: isoform X2
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14942-F1-model_v2 AlphaFold P14942 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696144
Promoter ID:EPDNEW_R6667
Type:initiation region
Name:Gsta4_1
Description:glutathione S-transferase alpha 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0885,497,534 - 85,497,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309970 AgrOrtholog
BioCyc Gene G2FUF-29769 BioCyc
Ensembl Genes ENSRNOG00000030449 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055001419 UniProtKB/Swiss-Prot
  ENSRNOG00055004669 UniProtKB/Swiss-Prot
  ENSRNOG00060019394 UniProtKB/Swiss-Prot
  ENSRNOG00065016685 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012348.7 UniProtKB/TrEMBL
  ENSRNOT00000090146.2 UniProtKB/Swiss-Prot
  ENSRNOT00000115538.1 UniProtKB/TrEMBL
  ENSRNOT00055002316 UniProtKB/Swiss-Prot
  ENSRNOT00055007434 UniProtKB/Swiss-Prot
  ENSRNOT00060033640 UniProtKB/Swiss-Prot
  ENSRNOT00065027821 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621777 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188402 IMAGE-MGC_LOAD
NCBI Gene 300850 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE A4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsta4 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030449 RatGTEx
  ENSRNOG00055001419 RatGTEx
  ENSRNOG00055004669 RatGTEx
  ENSRNOG00060019394 RatGTEx
  ENSRNOG00065016685 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A0I6_RAT UniProtKB/TrEMBL
  A0A8L2Q6M0_RAT UniProtKB/TrEMBL
  A6HBU1 ENTREZGENE, UniProtKB/TrEMBL
  A9UMW1 ENTREZGENE, UniProtKB/TrEMBL
  B6DYP9 ENTREZGENE, UniProtKB/TrEMBL
  GSTA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gsta4  glutathione S-transferase alpha 4  Gsta4  glutathione S-transferase A4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gsta4  glutathione S-transferase A4  Gsta4  glutathione S-transferase, alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gsta4  glutathione S-transferase, alpha 4  Gsta4_predicted  glutathione S-transferase, alpha 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gsta4_predicted  glutathione S-transferase, alpha 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED