Slc17a6 (solute carrier family 17 member 6) - Rat Genome Database

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Gene: Slc17a6 (solute carrier family 17 member 6) Rattus norvegicus
Analyze
Symbol: Slc17a6
Name: solute carrier family 17 member 6
RGD ID: 620531
Description: Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including hippocampus development; neurotransmitter loading into synaptic vesicle; and sodium-dependent phosphate transport. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is active in synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: differentation-associated Na-dependent inorganic phosphate cotransporter; differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Dnpi; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; vesicular glutamate transporter 2; VGLUT2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81110,348,447 - 110,388,499 (+)NCBIGRCr8
mRatBN7.21101,212,489 - 101,252,543 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1101,212,489 - 101,252,542 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1106,619,563 - 106,659,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01115,091,464 - 115,131,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01108,395,898 - 108,436,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01106,980,463 - 107,038,717 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,998,623 - 107,038,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01108,040,511 - 108,080,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41101,425,975 - 101,466,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11101,504,085 - 101,544,133 (+)NCBI
Celera195,386,910 - 95,426,949 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Boulland JL, etal., Cereb Cortex. 2009 Jan;19(1):241-8. doi: 10.1093/cercor/bhn077. Epub 2008 May 22.
2. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. Boulland JL, etal., J Comp Neurol. 2004 Dec 13;480(3):264-80.
3. Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism. Eriksen J, etal., Neuron. 2016 May 18;90(4):768-80. doi: 10.1016/j.neuron.2016.03.026. Epub 2016 Apr 28.
4. VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals. Fattorini G, etal., J Neurochem. 2009 Sep;110(5):1538-46. Epub 2009 Jul 15.
5. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Fremeau RT, etal., Neuron. 2001 Aug 2;31(2):247-60.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. Hayashi M, etal., J Biol Chem 2001 Nov 16;276(46):43400-6.
8. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. Herzog E, etal., J Neurosci. 2001 Nov 15;21(22):RC181.
9. Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex. Hioki H, etal., Neuroscience 2003;117(1):1-6.
10. Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2. Hrabovszky E, etal., Endocrinology 2005 Jan;146(1):341-7. Epub 2004 Oct 14.
11. Vesicular glutamate transporter contains two independent transport machineries. Juge N, etal., J Biol Chem. 2006 Dec 22;281(51):39499-506. doi: 10.1074/jbc.M607670200. Epub 2006 Oct 17.
12. Ion transport and regulation in a synaptic vesicle glutamate transporter. Li F, etal., Science. 2020 May 22;368(6493):893-897. doi: 10.1126/science.aba9202.
13. Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to coexpression. Li JL, etal., J Comp Neurol 2003 Aug 18;463(2):212-20.
14. Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat. Li JL, etal., J Comp Neurol 2003 Mar 10;457(3):236-49.
15. Relationship between two types of vesicular glutamate transporters and neurokinin-1 receptor-immunoreactive neurons in the pre-Botzinger complex of rats: light and electron microscopic studies. Liu YY, etal., Eur J Neurosci 2003 Jan;17(1):41-8.
16. Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. Llorente IL, etal., Brain Res Bull. 2013 May;94:90-7. doi: 10.1016/j.brainresbull.2013.02.006. Epub 2013 Feb 28.
17. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter. Preobraschenski J, etal., Cell Rep. 2018 Apr 10;23(2):535-545. doi: 10.1016/j.celrep.2018.03.055.
22. Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter. Preobraschenski J, etal., Neuron. 2014 Dec 17;84(6):1287-301. doi: 10.1016/j.neuron.2014.11.008. Epub 2014 Nov 26.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. Riedel A, etal., J Chem Neuroanat. 2008 Dec;36(3-4):177-90. doi: 10.1016/j.jchemneu.2008.06.003. Epub 2008 Jun 19.
27. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Stella SL Jr, etal., Brain Res. 2008 Jun 18;1215:20-9. doi: 10.1016/j.brainres.2008.03.038. Epub 2008 Apr 1.
28. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). Takamori S, etal., J Neurosci. 2001 Nov 15;21(22):RC182.
Additional References at PubMed
PMID:11432869   PMID:14667459   PMID:14677070   PMID:14681932   PMID:15009640   PMID:15028755   PMID:15065123   PMID:15205380   PMID:15224985   PMID:15305861   PMID:15379996   PMID:15382259  
PMID:15682395   PMID:15714284   PMID:15845085   PMID:15908131   PMID:15983996   PMID:16079394   PMID:16423326   PMID:16481069   PMID:16786558   PMID:16842872   PMID:17175111   PMID:17299752  
PMID:17337147   PMID:17825268   PMID:17826944   PMID:17965879   PMID:18291592   PMID:18358609   PMID:18381590   PMID:18436385   PMID:18973592   PMID:19058187   PMID:19191347   PMID:19264112  
PMID:19778580   PMID:19844994   PMID:20217347   PMID:20339872   PMID:20533365   PMID:20593358   PMID:21375596   PMID:21609737   PMID:21957077   PMID:21982845   PMID:22570693   PMID:22871113  
PMID:23047588   PMID:23326507   PMID:23380804   PMID:23543101   PMID:23835161   PMID:23897509   PMID:24308494   PMID:24639017   PMID:24906290   PMID:25290694   PMID:26362885   PMID:27210824  
PMID:29462701   PMID:29465786   PMID:29476059   PMID:29476240   PMID:29650024   PMID:32562720   PMID:32847971   PMID:33550485   PMID:34321562   PMID:35933616   PMID:36085433   PMID:38194067  


Genomics

Comparative Map Data
Slc17a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81110,348,447 - 110,388,499 (+)NCBIGRCr8
mRatBN7.21101,212,489 - 101,252,543 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1101,212,489 - 101,252,542 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1106,619,563 - 106,659,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01115,091,464 - 115,131,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01108,395,898 - 108,436,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01106,980,463 - 107,038,717 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,998,623 - 107,038,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01108,040,511 - 108,080,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41101,425,975 - 101,466,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11101,504,085 - 101,544,133 (+)NCBI
Celera195,386,910 - 95,426,949 (+)NCBICelera
Cytogenetic Map1q22NCBI
SLC17A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381122,338,381 - 22,379,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1122,338,381 - 22,379,503 (+)EnsemblGRCh38hg38GRCh38
GRCh371122,359,927 - 22,401,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361122,316,243 - 22,357,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 341122,316,242 - 22,357,619NCBI
Celera1122,492,722 - 22,534,075 (+)NCBICelera
Cytogenetic Map11p14.3NCBI
HuRef1122,042,899 - 22,084,263 (+)NCBIHuRef
CHM1_11122,359,385 - 22,400,763 (+)NCBICHM1_1
T2T-CHM13v2.01122,458,971 - 22,500,075 (+)NCBIT2T-CHM13v2.0
Slc17a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39751,271,578 - 51,320,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl751,271,754 - 51,320,867 (+)EnsemblGRCm39 Ensembl
GRCm38751,621,830 - 51,671,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl751,622,006 - 51,671,119 (+)EnsemblGRCm38mm10GRCm38
MGSCv37758,877,200 - 58,926,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36751,490,086 - 51,539,138 (+)NCBIMGSCv36mm8
Celera749,002,489 - 49,051,776 (+)NCBICelera
Cytogenetic Map7B4NCBI
cM Map732.78NCBI
Slc17a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554762,813,368 - 2,854,514 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554762,813,368 - 2,854,371 (+)NCBIChiLan1.0ChiLan1.0
SLC17A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2924,627,830 - 24,669,284 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11124,591,980 - 24,633,414 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01122,350,537 - 22,392,009 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,257,983 - 22,299,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,258,011 - 22,301,944 (+)Ensemblpanpan1.1panPan2
SLC17A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12144,015,161 - 44,056,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2144,016,133 - 44,054,931 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2143,491,537 - 43,529,754 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02145,131,589 - 45,172,308 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2145,132,360 - 45,172,255 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12144,132,863 - 44,170,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02144,305,349 - 44,343,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02144,698,060 - 44,736,170 (+)NCBIUU_Cfam_GSD_1.0
Slc17a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494740,843,801 - 40,886,442 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366543,040,312 - 3,083,669 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366543,039,825 - 3,082,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC17A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl237,098,992 - 37,138,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1237,098,983 - 37,138,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2240,309,860 - 40,349,435 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC17A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1142,634,754 - 42,677,309 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,636,512 - 42,677,165 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038139,944,822 - 139,988,881 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc17a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476613,335,130 - 13,376,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476613,335,186 - 13,376,634 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc17a6
393 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:145
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000022383
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
AI060126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21101,252,259 - 101,252,445 (+)MAPPERmRatBN7.2
Rnor_6.01107,038,421 - 107,038,606NCBIRnor6.0
Rnor_5.01108,080,228 - 108,080,413UniSTSRnor5.0
RGSC_v3.41101,465,740 - 101,465,925UniSTSRGSC3.4
Celera195,426,666 - 95,426,851UniSTS
RH 3.4 Map1944.1UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 4 2 100 25 23 10 6 10 2 35 13 93 2 43 13

Sequence


Ensembl Acc Id: ENSRNOT00000022383   ⟹   ENSRNOP00000022383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1101,212,489 - 101,252,542 (+)Ensembl
Rnor_6.0 Ensembl1106,998,623 - 107,038,704 (+)Ensembl
RefSeq Acc Id: NM_053427   ⟹   NP_445879
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81110,348,447 - 110,388,499 (+)NCBI
mRatBN7.21101,212,489 - 101,252,543 (+)NCBI
Rnor_6.01106,998,704 - 107,038,704 (+)NCBI
Rnor_5.01108,040,511 - 108,080,524 (+)NCBI
RGSC_v3.41101,425,975 - 101,466,023 (+)RGD
Celera195,386,910 - 95,426,949 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF76223 (Get FASTA)   NCBI Sequence Viewer  
  EDM07210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022383.3
GenBank Protein Q9JI12 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445879   ⟸   NM_053427
- UniProtKB: Q9JI12 (UniProtKB/Swiss-Prot),   A6JBH4 (UniProtKB/TrEMBL),   G3V851 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022383   ⟸   ENSRNOT00000022383
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI12-F1-model_v2 AlphaFold Q9JI12 1-582 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620531 AgrOrtholog
BioCyc Gene G2FUF-59542 BioCyc
Ensembl Genes ENSRNOG00000016147 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022383.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_Na/Anion_cotransporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84487 UniProtKB/Swiss-Prot
NCBI Gene 84487 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICULAR GLUTAMATE TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc17a6 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016147 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JBH4 ENTREZGENE, UniProtKB/TrEMBL
  G3V851 ENTREZGENE, UniProtKB/TrEMBL
  Q9JI12 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc17a6  solute carrier family 17 member 6  Slc17a6  solute carrier family 17 (vesicular glutamate transporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc17a6  solute carrier family 17 (vesicular glutamate transporter), member 6  Slc17a6  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc17a6  solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6  Dnpi  differentation-associated Na-dependent inorganic phosphate cotransporter  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dnpi  differentation-associated Na-dependent inorganic phosphate cotransporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes on early endosomes 628484
gene_expression mRNA expressed in the inferior olivary complex, most brainstem precerebellar nuclei sending mossy fibers, and in axon terminals of nociceptive primary afferent fibers 632573
gene_expression mRNA expressed in the inferior olivary complex, most brainstem precerebellar nuclei sending mossy fibers, and in axon terminals of nociceptive primary afferent fibers 632574
gene_expression present in neuronla cells,preferentially expressed in pinealocytes, pancreatic alpha cells, alpha cells of Langerhans islets, pancreatic polypeptide-secreting F cells of Langerhans islets 628484
gene_function transports L-glutamate involving an electrochemical gradient of protons generated by vacuolar proton pump; vesicular transporter in glutamatergic endocrine cells and neurons 628484
gene_function vesicular glutamate transporter 628484
gene_process responsible for vesicular storage of L-glutamate 628484
gene_process may be involved in a dominant excitatory synaptic pathway 632575