Slc18a3 (solute carrier family 18 member A3) - Rat Genome Database

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Gene: Slc18a3 (solute carrier family 18 member A3) Rattus norvegicus
Analyze
Symbol: Slc18a3
Name: solute carrier family 18 member A3
RGD ID: 62072
Description: Enables acetylcholine:proton antiporter activity. Involved in acetylcholine uptake and neurotransmitter loading into synaptic vesicle. Located in axon terminus and synaptic vesicle. Part of AP-1 adaptor complex and AP-2 adaptor complex. Is active in cholinergic synapse; neuromuscular junction; and synaptic vesicle membrane. Biomarker of asthma and bladder disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-nicotine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: rVAT; solute carrier family 18 (vesicular acetylcholine transporter), member 3; solute carrier family 18 (vesicular acetylcholine), member 3; solute carrier family 18 (vesicular monoamine) member 3; solute carrier family 18 (vesicular monoamine), member 3 ; solute carrier family 18 member 3; solute carrier family 18, member 3; VACht; vesicular acetylcholine transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2167,713,630 - 7,716,491 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx167,725,590 - 7,728,451 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0168,870,530 - 8,873,391 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0167,724,418 - 7,727,279 (-)NCBIRnor_WKY
Rnor_6.0168,682,668 - 8,685,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,682,669 - 8,685,529 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,648,850 - 10,651,711 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,969,738 - 7,972,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,969,739 - 7,972,597 (-)NCBI
Celera167,484,278 - 7,487,139 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Mutational and pH analysis of ionic residues in transmembrane domains of vesicular acetylcholine transporter. Bravo DT, etal., Biochemistry. 2005 Jun 7;44(22):7955-66.
2. Disturbed neurotransmitter transporter expression in Alzheimer's disease brain. Chen KH, etal., J Alzheimers Dis. 2011;26(4):755-66.
3. Time-dependent alterations of cholinergic markers after experimental traumatic brain injury. Donat CK, etal., Brain Res. 2008 Dec 30;1246:167-77. Epub 2008 Sep 30.
4. Spatial and intracellular relationships between the alpha7 nicotinic acetylcholine receptor and the vesicular acetylcholine transporter in the prefrontal cortex of rat and mouse. Duffy AM, etal., Neuroscience. 2009 Jul 21;161(4):1091-103. Epub 2009 Apr 15.
5. Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. Erickson JD, etal., J Biol Chem 1994 Sep 2;269(35):21929-32.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. Gilmor ML, etal., J Neurosci. 1996 Apr 1;16(7):2179-90.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus. Guidine PA, etal., Neurosci Lett. 2008 May 9;436(2):201-4. Epub 2008 Mar 13.
10. Ultrastructural evidence for mu-opioid modulation of cholinergic pathways in rat dentate gyrus. Kaplan TJ, etal., Brain Res. 2004 Sep 3;1019(1-2):28-38.
11. The vesicular acetylcholine transporter interacts with clathrin-associated adaptor complexes AP-1 and AP-2. Kim MH and Hersh LB, J Biol Chem. 2004 Mar 26;279(13):12580-7. Epub 2004 Jan 14.
12. Transcriptomic effects of depleted uranium on acetylcholine and cholesterol metabolisms in Alzheimer's disease model. Lestaevel P, etal., C R Biol. 2011 Feb;334(2):85-90. Epub 2011 Jan 26.
13. Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Lips KS, etal., Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Molecular cloning of a putative vesicular transporter for acetylcholine. Roghani A, etal., Proc Natl Acad Sci U S A 1994 Oct 25;91(22):10620-4.
19. Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Semmler A, etal., Exp Neurol. 2007 Apr;204(2):733-40. Epub 2007 Jan 13.
20. Cholinergic neuronal defect without cell loss in Huntington's disease. Smith R, etal., Hum Mol Genet. 2006 Nov 1;15(21):3119-31. Epub 2006 Sep 20.
21. Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging. Song H, etal., Neuron. 1997 May;18(5):815-26.
22. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Szutowicz A, etal., Neurochem Res. 2013 Aug;38(8):1523-42. doi: 10.1007/s11064-013-1060-x. Epub 2013 May 16.
23. Transient suppression of the vesicular acetylcholine transporter in urinary bladder pathways following spinal cord injury. Takahara Y, etal., Brain Res. 2007 Mar 16;1137(1):20-8. Epub 2006 Dec 21.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles. Weihe E, etal., Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3547-52.
Additional References at PubMed
PMID:4075114   PMID:7559575   PMID:8071313   PMID:9853118   PMID:11304756   PMID:12074840   PMID:15366926   PMID:17451554   PMID:17548533   PMID:17998100   PMID:19021024   PMID:19524025  
PMID:21557989   PMID:21606356   PMID:34071104  


Genomics

Comparative Map Data
Slc18a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2167,713,630 - 7,716,491 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx167,725,590 - 7,728,451 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0168,870,530 - 8,873,391 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0167,724,418 - 7,727,279 (-)NCBIRnor_WKY
Rnor_6.0168,682,668 - 8,685,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,682,669 - 8,685,529 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,648,850 - 10,651,711 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,969,738 - 7,972,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,969,739 - 7,972,597 (-)NCBI
Celera167,484,278 - 7,487,139 (+)NCBICelera
Cytogenetic Map16p16NCBI
SLC18A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,610,310 - 49,612,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1049,610,310 - 49,612,720 (+)EnsemblGRCh38hg38GRCh38
GRCh371050,818,356 - 50,820,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361050,488,353 - 50,490,772 (+)NCBINCBI36Build 36hg18NCBI36
Build 341050,488,352 - 50,490,771NCBI
Celera1044,404,433 - 44,406,852 (+)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1045,083,115 - 45,085,534 (+)NCBIHuRef
CHM1_11051,100,431 - 51,102,850 (+)NCBICHM1_1
T2T-CHM13v2.01050,459,116 - 50,461,526 (+)NCBIT2T-CHM13v2.0
Slc18a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,184,394 - 32,186,807 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,184,395 - 32,186,807 (-)EnsemblGRCm39 Ensembl
GRCm381432,462,437 - 32,464,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,462,438 - 32,464,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv371433,275,623 - 33,278,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,291,446 - 31,293,859 (-)NCBIMGSCv36mm8
Celera1428,720,138 - 28,722,551 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Slc18a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556696,974 - 698,566 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955556696,779 - 698,869 (-)NCBIChiLan1.0ChiLan1.0
SLC18A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01044,630,006 - 44,632,419 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC18A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,476,873 - 1,478,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,476,774 - 1,478,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,712,112 - 1,713,723 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,654,300 - 1,655,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,654,155 - 1,655,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,451,550 - 1,453,161 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,488,646 - 1,490,263 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,620,537 - 1,622,154 (+)NCBIUU_Cfam_GSD_1.0
Slc18a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,501,080 - 79,503,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728704,290 - 705,885 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936728703,688 - 706,317 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC18A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,113,844 - 90,115,430 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,113,534 - 90,115,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,021,703 - 98,023,442 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC18A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,216,187 - 42,219,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,216,568 - 42,218,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660481,961,084 - 1,963,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc18a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928403,503 - 405,095 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928403,114 - 405,560 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc18a3
6 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
UniSTS:547010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,714,288 - 7,715,197 (+)MAPPERmRatBN7.2
Rnor_6.0168,683,327 - 8,684,235NCBIRnor6.0
Rnor_5.01610,649,509 - 10,650,417UniSTSRnor5.0
Celera167,485,572 - 7,486,480UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium
Low 2 55 4
Below cutoff 6 4 4 4 8 4 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000092751   ⟹   ENSRNOP00000076023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl168,682,669 - 8,685,529 (-)Ensembl
RefSeq Acc Id: NM_031663   ⟹   NP_113851
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2167,713,630 - 7,716,491 (-)NCBI
Rnor_6.0168,682,668 - 8,685,529 (-)NCBI
Rnor_5.01610,648,850 - 10,651,711 (-)NCBI
RGSC_v3.4167,969,738 - 7,972,599 (-)RGD
Celera167,484,278 - 7,487,139 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113851 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20498 (Get FASTA)   NCBI Sequence Viewer  
  AAA50831 (Get FASTA)   NCBI Sequence Viewer  
  EDL88914 (Get FASTA)   NCBI Sequence Viewer  
  Q62666 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113851   ⟸   NM_031663
- UniProtKB: Q64351 (UniProtKB/Swiss-Prot),   Q62666 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076023   ⟸   ENSRNOT00000092751

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62666-F1-model_v2 AlphaFold Q62666 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62072 AgrOrtholog
BioCyc Gene G2FUF-12107 BioCyc
Ensembl Genes ENSRNOG00000062141 Ensembl
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:60422 UniProtKB/Swiss-Prot
NCBI Gene 60422 ENTREZGENE
Pfam MFS_1 UniProtKB/Swiss-Prot
PharmGKB SLC18A3 RGD
PhenoGen Slc18a3 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC233656
UniProt Q62666 ENTREZGENE
  Q64351 ENTREZGENE
  VACHT_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64351 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc18a3  solute carrier family 18 member A3  Slc18a3  solute carrier family 18 member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Slc18a3  solute carrier family 18 member 3  Slc18a3  solute carrier family 18 (vesicular acetylcholine transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc18a3  solute carrier family 18 (vesicular acetylcholine transporter), member 3  Slc18a3  solute carrier family 18 (vesicular acetylcholine), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc18a3  solute carrier family 18 (vesicular acetylcholine), member 3    solute carrier family 18, member 3   Name updated 1299863 APPROVED
2002-06-10 Slc18a3  solute carrier family 18, member 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in basal forebrain, basal ganglia, and spinal cord but not cerebellum or peripheral tissues 61752