Agt (angiotensinogen) - Rat Genome Database

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Gene: Agt (angiotensinogen) Rattus norvegicus
Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of amine transport; and regulation of blood pressure. Located in extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone.
Type: protein-coding
Previously known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKY
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actin-Accumulation Myopathy  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (IDA)
Aortic Coarctation  (ISO)
atherosclerosis  (IMP,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congenital disorder of glycosylation type IIq  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (ISO)
Fetal Growth Retardation  (IEP,ISO)
Fibrosis  (IDA,ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
gastric ulcer  (IDA)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IEP,ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (IEP,ISO)
malignant hypertension  (ISO)
meconium aspiration syndrome  (IEP)
Metabolic Syndrome  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
prediabetes syndrome  (IEP)
Pregnancy-Induced Hypertension  (IEP)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (IDA)
Puromycin Aminonucleoside Nephrosis  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (IDA)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (IEP)
thrombosis  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Malformations  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
adefovir  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
amidotrizoic acid  (EXP)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
aspartame  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
benazepril  (EXP,ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (EXP,ISO)
brefeldin A  (EXP)
brimonidine tartrate  (EXP)
Brodifacoum  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carmustine  (ISO)
carvedilol  (EXP,ISO)
CGP-42112A  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chymostatin  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP,ISO)
diethyl malate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
famotidine  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycerol  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (EXP)
goralatide  (ISO)
heparin  (EXP)
hydralazine  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
imidaprilat  (ISO)
imperatorin  (EXP)
indometacin  (EXP,ISO)
iohexol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lactacystin  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malonaldehyde  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methylglyoxal  (EXP)
mevalonic acid  (EXP)
Mibefradil  (ISO)
microcystin RR  (ISO)
midostaurin  (EXP)
miquelianin  (ISO)
mithramycin  (EXP)
MK-2206  (ISO)
monocrotaline  (EXP)
montelukast  (ISO)
mycophenolic acid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
ouabain  (EXP)
ozone  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PD 168393  (EXP)
PD123319  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP)
phosphoramidon  (EXP)
pindolol  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregabalin  (EXP)
probenecid  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
prostaglandins E  (EXP)
purine-6-thiol  (EXP)
purines  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
salubrinal  (EXP)
saralasin  (EXP)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
Soman  (EXP)
spironolactone  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiopental  (ISO)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trans-piceid  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
wortmannin  (EXP)
xestospongin C  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (IMP)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (ISO,ISS)
angiotensin-mediated drinking behavior  (IDA,IMP)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IDA)
associative learning  (IDA)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IDA)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to mechanical stimulus  (IEP)
cytokine production  (IDA)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
fibroblast proliferation  (IDA)
G protein-coupled receptor signaling pathway  (IEA,IMP,ISO)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (IMP)
kidney development  (IEA,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
operant conditioning  (IDA)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of activation of Janus kinase activity  (IEA,ISO)
positive regulation of blood pressure  (IDA)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of catalytic activity  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of CoA-transferase activity  (IEA,ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of extracellular matrix constituent secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of L-arginine import across plasma membrane  (IDA)
positive regulation of L-lysine import across plasma membrane  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein tyrosine kinase activity  (IEA,ISO)
positive regulation of superoxide anion generation  (IDA)
positive regulation of transforming growth factor beta1 activation  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein import into nucleus  (IDA)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (IDA)
regulation of cardiac conduction  (IEA,ISO)
regulation of extracellular matrix assembly  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (IDA)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of norepinephrine secretion  (IMP)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (IDA)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IDA,ISO)
response to cold  (ISO)
response to estradiol  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IMP)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IDA,ISO)
stress-activated MAPK cascade  (IDA)
uterine smooth muscle contraction  (IDA)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IDA,IEA)
vasodilation  (IDA)
vasopressin secretion  (ISO)

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)
mitochondrion  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
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108. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
109. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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115. GOA pipeline RGD automated data pipeline
116. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
117. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
118. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
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124. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
125. Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
126. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
127. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
128. [Effects of Chinese herbal medicine Xuefu Zhuyu Decoction on angiotensin II-induced proliferation and extracellular matrix synthesis of rat cardiac fibroblasts.] Shen Y, etal., Zhong Xi Yi Jie He Xue Bao. 2011 Mar;9(3):313-319.
129. Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation. Shen YJ, etal., J Nat Med. 2014 Jul;68(3):623-9. doi: 10.1007/s11418-014-0825-0. Epub 2014 Mar 5.
130. Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation. Shi R, etal., Cardiovasc Res. 2011 Mar 2.
131. Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts. Souza AP, etal., Clin Sci (Lond). 2013 Nov;125(9):449-59. doi: 10.1042/CS20120519.
132. Polymorphisms of renin-angiotensin system genes as a risk factor for high-altitude pulmonary oedema. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
133. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
134. Angiotensin-(1-7) inhibits vascular calcification in rats. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
135. Posttranscriptional Control of BNP Gene Expression in Angiotensin II-Induced Hypertension. Suo M, etal., Hypertension 2002 Mar 1;39(3):803-8.
136. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
137. Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment. Szentivanyi M Jr, etal., Hypertension 1999 Jan;33(1 Pt 2):440-5.
138. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
139. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
140. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
141. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
142. Common structural organization of the angiotensinogen and the alpha 1-antitrypsin genes. Tanaka T, etal., J Biol Chem 1984 Jul 10;259(13):8063-5.
143. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
144. Renin-angiotensin system gene polymorphisms and atrial fibrillation: a regression approach for the detection of gene-gene interactions in a large hospitalized population. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
145. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
146. Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats. Tucker BJ, etal., J Clin Invest 1986 Sep;78(3):680-8.
147. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
148. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
149. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
150. Angiotensinogen promoter sequence variants in essential hypertension. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
151. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
152. Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts. Verma SK, etal., Cardiovasc Res. 2011 Apr 1;90(1):88-96. Epub 2010 Dec 3.
153. A molecular variant of angiotensinogen associated with preeclampsia. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
154. Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9.
155. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
156. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Xue H, etal., Regul Pept. 2012 Aug 20;177(1-3):12-20. doi: 10.1016/j.regpep.2012.04.002. Epub 2012 May 1.
157. Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
158. Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
159. Activation of the renin-angiotensin system in anti-glomerular basement membrane antibody-induced glomerulonephritis. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
160. Elevation of plasma angiotensinogen in rats with experimentally induced nephrosis. Yayama K, etal., Nephron. 1993;63(1):89-93.
161. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
162. Impairment of Cardiac Function and Remodeling Induced by Myocardial Infarction in Rats are Attenuated by the Nonpeptide Angiotensin-(1-7) Analog AVE 0991. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
163. Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. Zhang SL, etal., Endocrinology 2002 Dec;143(12):4627-35.
164. Angiotensin (1-7) protects against stress-induced gastric lesions in rats. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
165. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:1378723   PMID:4344907   PMID:7622467   PMID:7989296   PMID:8675666   PMID:9196031   PMID:9310306   PMID:9507198   PMID:9557921   PMID:9734405   PMID:9788961   PMID:9852267  
PMID:9878677   PMID:10076178   PMID:10318840   PMID:10406457   PMID:10425188   PMID:11384650   PMID:11606482   PMID:12072911   PMID:12221292   PMID:12431451   PMID:12512691   PMID:12574102  
PMID:12623964   PMID:12657564   PMID:12660888   PMID:12660889   PMID:12697701   PMID:12730191   PMID:12782411   PMID:12874086   PMID:14517903   PMID:14523024   PMID:14674692   PMID:14697237  
PMID:15001568   PMID:15061159   PMID:15087286   PMID:15100095   PMID:15153556   PMID:15213258   PMID:15238256   PMID:15245869   PMID:15489334   PMID:15499027   PMID:15539634   PMID:15561758  
PMID:15582710   PMID:15642775   PMID:15652490   PMID:15659559   PMID:15692220   PMID:15710779   PMID:15803439   PMID:15826947   PMID:15869764   PMID:15922295   PMID:15942049   PMID:15944340  
PMID:16020656   PMID:16051229   PMID:16106038   PMID:16115032   PMID:16115033   PMID:16115039   PMID:16116425   PMID:16146787   PMID:16158334   PMID:16176966   PMID:16322063   PMID:16374517  
PMID:16478781   PMID:16502470   PMID:16522658   PMID:16569213   PMID:16574788   PMID:16585392   PMID:16650497   PMID:16728497   PMID:16780972   PMID:16807546   PMID:16837467   PMID:16864744  
PMID:16933034   PMID:16989733   PMID:17029249   PMID:17060503   PMID:17082724   PMID:17259738   PMID:17327451   PMID:17357790   PMID:17360810   PMID:17404180   PMID:17416596   PMID:17466950  
PMID:17483239   PMID:17491111   PMID:17496209   PMID:17507603   PMID:17513012   PMID:17526654   PMID:17553505   PMID:17616751   PMID:17626897   PMID:17646572   PMID:17664391   PMID:17693541  
PMID:17702818   PMID:17703433   PMID:17706954   PMID:17710629   PMID:17785632   PMID:17878754   PMID:17891894   PMID:17903697   PMID:17914985   PMID:17932313   PMID:17942570   PMID:17962624  
PMID:17980907   PMID:17989112   PMID:18047554   PMID:18077603   PMID:18158338   PMID:18172037   PMID:18192841   PMID:18195168   PMID:18205093   PMID:18216141   PMID:18242696   PMID:18250367  
PMID:18256139   PMID:18256274   PMID:18292392   PMID:18347230   PMID:18359898   PMID:18360053   PMID:18391104   PMID:18391105   PMID:18395010   PMID:18408132   PMID:18420589   PMID:18441197  
PMID:18456730   PMID:18467645   PMID:18559349   PMID:18560380   PMID:18566342   PMID:18607644   PMID:18688015   PMID:18712054   PMID:18760347   PMID:18779436   PMID:18789946   PMID:18790741  
PMID:18806627   PMID:18809792   PMID:18835922   PMID:18838625   PMID:18848828   PMID:18926830   PMID:18945823   PMID:18971210   PMID:18971559   PMID:18986337   PMID:19023134   PMID:19029977  
PMID:19075094   PMID:19118600   PMID:19129738   PMID:19131364   PMID:19147651   PMID:19151253   PMID:19171793   PMID:19211690   PMID:19224536   PMID:19247578   PMID:19258668   PMID:19289825  
PMID:19322025   PMID:19323983   PMID:19326569   PMID:19389807   PMID:19396617   PMID:19399400   PMID:19403863   PMID:19404405   PMID:19407469   PMID:19439822   PMID:19457762   PMID:19460779  
PMID:19587111   PMID:19667256   PMID:19703990   PMID:19710393   PMID:19713680   PMID:19716825   PMID:19717492   PMID:19781194   PMID:19808775   PMID:19811355   PMID:19861503   PMID:19864301  
PMID:19879325   PMID:19948989   PMID:20023119   PMID:20052676   PMID:20056918   PMID:20372825   PMID:20393598   PMID:20423855   PMID:20448043   PMID:20462965   PMID:20535114   PMID:20601126  
PMID:20666571   PMID:20686488   PMID:20724906   PMID:20848345   PMID:20850747   PMID:20962118   PMID:21055442   PMID:21056071   PMID:21108934   PMID:21151982   PMID:21183621   PMID:21186269  
PMID:21265100   PMID:21297982   PMID:21398399   PMID:21510818   PMID:21586345   PMID:21606202   PMID:21613610   PMID:21613793   PMID:21685447   PMID:21705470   PMID:21720156   PMID:21813872  
PMID:21831995   PMID:21900450   PMID:21946693   PMID:21952436   PMID:21959517   PMID:22057271   PMID:22100841   PMID:22101031   PMID:22108917   PMID:22125313   PMID:22302831   PMID:22389386  
PMID:22516433   PMID:22579820   PMID:22684035   PMID:22787147   PMID:22795463   PMID:22811473   PMID:22822941   PMID:22846885   PMID:22853187   PMID:22875344   PMID:22875785   PMID:22913624  
PMID:22923503   PMID:22925777   PMID:23058350   PMID:23117547   PMID:23142109   PMID:23174757   PMID:23220478   PMID:23283998   PMID:23326547   PMID:23365412   PMID:23376485   PMID:23412923  
PMID:23441479   PMID:23528515   PMID:23533145   PMID:23541316   PMID:23608099   PMID:23697773   PMID:23707238   PMID:23754618   PMID:23775122   PMID:23816464   PMID:23825067   PMID:23832698  
PMID:23891689   PMID:24145131   PMID:24184051   PMID:24191285   PMID:24204720   PMID:24296617   PMID:24436324   PMID:24481965   PMID:24710077   PMID:24710423   PMID:24731445   PMID:24771417  
PMID:24824997   PMID:24877125   PMID:24910532   PMID:24976155   PMID:25031298   PMID:25079175   PMID:25099270   PMID:25148511   PMID:25223907   PMID:25246357   PMID:25263961   PMID:25451261  
PMID:25529203   PMID:25732086   PMID:25793389   PMID:25923922   PMID:26090382   PMID:26147666   PMID:26156105   PMID:26310573   PMID:26384348   PMID:26431621   PMID:26674152   PMID:26728324  
PMID:26728369   PMID:26775713   PMID:26824355   PMID:26864937   PMID:26881025   PMID:26970306   PMID:27009340   PMID:27012211   PMID:27068509   PMID:27131988   PMID:27163380   PMID:27225249  
PMID:27465904   PMID:27590241   PMID:27660028   PMID:27871858   PMID:27932705   PMID:27960152   PMID:28011270   PMID:28161727   PMID:28189547   PMID:28283184   PMID:28331185   PMID:28582407  
PMID:28656283   PMID:28656296   PMID:28742157   PMID:28744711   PMID:28988741   PMID:29140411   PMID:29179208   PMID:29262413   PMID:29305157   PMID:29452090   PMID:29746862   PMID:29923351  
PMID:30046277   PMID:30315936   PMID:30412649   PMID:30680929   PMID:31030610   PMID:31708099   PMID:31836539   PMID:31994810   PMID:32000560   PMID:32338644   PMID:32851948   PMID:33010296  
PMID:33129833   PMID:33166587   PMID:33530085   PMID:33687310   PMID:33813849   PMID:34685676   PMID:35405300   PMID:36454502   PMID:36834901  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKY
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1118,684,644 - 18,696,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1459,643,292 - 59,656,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462477518,849,118 - 18,855,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Agt
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:157
Interacting mature miRNAs:172
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Related Rat Strains
The following Strains have been annotated to Agt