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Gene: Agt (angiotensinogen) Rattus norvegicus
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Symbol: Agt
Name: angiotensinogen
Description: Exhibits hormone activity. Involved in several processes, including positive regulation of reactive oxygen species metabolic process; regulation of ion transport; and regulation of secretion. Localizes to cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
Orthologs:
Homo sapiens (human) : AGT (angiotensinogen)  HGNC  Alliance
Mus musculus (house mouse) : Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agt (angiotensinogen)
Pan paniscus (bonobo/pygmy chimpanzee) : AGT (angiotensinogen)
Canis lupus familiaris (dog) : AGT (angiotensinogen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agt (angiotensinogen)
Sus scrofa (pig) : AGT (angiotensinogen)
Chlorocebus sabaeus (African green monkey) : AGT (angiotensinogen)
Heterocephalus glaber (naked mole-rat) : Agt (angiotensinogen)
more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
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Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 6.0)