Agt (angiotensinogen) - Rat Genome Database

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Gene: Agt (angiotensinogen) Rattus norvegicus
Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Type: protein-coding
Previously known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (IDA)
Aortic Coarctation  (ISO)
atherosclerosis  (IMP,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (IEP,ISO)
Fibrosis  (IDA,ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
gastric ulcer  (IDA)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (IEP,ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (IEP,ISO)
malignant hypertension  (ISO)
Mammary Neoplasms, Experimental  (IDA)
meconium aspiration syndrome  (IEP)
Metabolic Syndrome  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
prediabetes syndrome  (IEP)
Pregnancy-Induced Hypertension  (IEP)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (IDA)
Puromycin Aminonucleoside Nephrosis  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (IDA)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (IEP)
thrombosis  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
amidotrizoic acid  (EXP)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP)
aspartame  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
benazepril  (EXP,ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (EXP,ISO)
brefeldin A  (EXP)
brimonidine tartrate  (EXP)
Brodifacoum  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carmustine  (ISO)
carvedilol  (EXP,ISO)
CGP-42112A  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chymostatin  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP,ISO)
diethyl malate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
famotidine  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycerol  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (EXP)
heparin  (EXP)
hydralazine  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
imidaprilat  (ISO)
imperatorin  (EXP)
indometacin  (EXP,ISO)
iohexol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lactacystin  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malonaldehyde  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP,ISO)
methylglyoxal  (EXP)
Mibefradil  (ISO)
microcystin RR  (ISO)
midostaurin  (EXP)
miquelianin  (ISO)
mithramycin  (EXP)
MK-2206  (ISO)
monocrotaline  (EXP)
montelukast  (ISO)
mycophenolic acid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
ouabain  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 168393  (EXP)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP)
phosphoramidon  (EXP)
pindolol  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregabalin  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
prostaglandins E  (EXP)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
salubrinal  (EXP)
saralasin  (EXP)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
Soman  (EXP)
spironolactone  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiopental  (ISO)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trans-piceid  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
wortmannin  (EXP)
xestospongin C  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (IMP)
aging  (IEP)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (ISO,ISS)
angiotensin-mediated drinking behavior  (IDA,IMP)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IDA)
associative learning  (IDA)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IDA)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular sodium ion homeostasis  (IMP)
cytokine production  (IDA)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
fibroblast proliferation  (IDA)
G protein-coupled receptor signaling pathway  (IMP,ISO)
hormone metabolic process  (ISO)
kidney development  (ISO)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IBA)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
operant conditioning  (IDA)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of activation of Janus kinase activity  (ISO)
positive regulation of blood pressure  (IDA)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of catalytic activity  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of cholesterol esterification  (ISO)
positive regulation of CoA-transferase activity  (IEA,ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of extracellular matrix constituent secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of L-arginine import across plasma membrane  (IDA)
positive regulation of L-lysine import across plasma membrane  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of renal sodium excretion  (IDA,IMP)
positive regulation of superoxide anion generation  (IDA)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein import into nucleus  (IDA)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (IDA)
regulation of cardiac conduction  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (IDA)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of norepinephrine secretion  (IMP)
regulation of renal output by angiotensin  (ISO)
regulation of renal sodium excretion  (IDA)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (IDA)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IDA,ISO)
response to cold  (ISO)
response to estradiol  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IMP)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IDA,ISO)
stress-activated MAPK cascade  (IDA)
uterine smooth muscle contraction  (IDA)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IDA)
vasodilation  (IDA)
vasopressin secretion  (ISO)

Cellular Component
cytoplasm  (IDA)
extracellular space  (IBA,IDA,ISO)
mitochondrion  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View

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PMID:21831995   PMID:21900450   PMID:21946693   PMID:21952436   PMID:21959517   PMID:22057271   PMID:22100841   PMID:22101031   PMID:22108917   PMID:22125313   PMID:22302831   PMID:22389386  
PMID:22516433   PMID:22579820   PMID:22684035   PMID:22787147   PMID:22795463   PMID:22811473   PMID:22822941   PMID:22846885   PMID:22853187   PMID:22875344   PMID:22875785   PMID:22913624  
PMID:22923503   PMID:22925777   PMID:23058350   PMID:23117547   PMID:23142109   PMID:23174757   PMID:23220478   PMID:23283998   PMID:23326547   PMID:23365412   PMID:23376485   PMID:23412923  
PMID:23441479   PMID:23528515   PMID:23533145   PMID:23541316   PMID:23608099   PMID:23697773   PMID:23707238   PMID:23754618   PMID:23775122   PMID:23816464   PMID:23825067   PMID:23832698  
PMID:23891689   PMID:24145131   PMID:24184051   PMID:24191285   PMID:24204720   PMID:24296617   PMID:24436324   PMID:24481965   PMID:24710077   PMID:24710423   PMID:24731445   PMID:24771417  
PMID:24824997   PMID:24877125   PMID:24910532   PMID:24976155   PMID:25031298   PMID:25079175   PMID:25099270   PMID:25148511   PMID:25223907   PMID:25246357   PMID:25263961   PMID:25451261  
PMID:25529203   PMID:25732086   PMID:25793389   PMID:25923922   PMID:26090382   PMID:26147666   PMID:26156105   PMID:26310573   PMID:26384348   PMID:26431621   PMID:26674152   PMID:26728324  
PMID:26728369   PMID:26775713   PMID:26824355   PMID:26864937   PMID:26881025   PMID:26970306   PMID:27009340   PMID:27012211   PMID:27068509   PMID:27131988   PMID:27163380   PMID:27225249  
PMID:27465904   PMID:27590241   PMID:27660028   PMID:27871858   PMID:27932705   PMID:27960152   PMID:28011270   PMID:28161727   PMID:28189547   PMID:28283184   PMID:28331185   PMID:28582407  
PMID:28656283   PMID:28656296   PMID:28742157   PMID:28744711   PMID:28988741   PMID:29140411   PMID:29179208   PMID:29262413   PMID:29305157   PMID:29452090   PMID:29746862   PMID:29923351  
PMID:30046277   PMID:30315936   PMID:30412649   PMID:30680929   PMID:31030610   PMID:31708099   PMID:31836539   PMID:31994810   PMID:32000560   PMID:32338644   PMID:32851948   PMID:33010296  
PMID:33129833   PMID:33166587   PMID:33530085   PMID:33687310   PMID:33813849   PMID:34685676  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBI
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBI
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBI
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBI
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBI
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0hetGla2

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Related Rat Strains
The following Strains have been annotated to Agt

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:157
Interacting mature miRNAs:172
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6
Medium 1 42 31 8 31 38 8 6 7
Low 2 19 9 4 11 4 8 11 18 11 18 4 8
Below cutoff 18 4 12 10


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024917   ⟹   ENSRNOP00000024917
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)Ensembl
RefSeq Acc Id: NM_134432   ⟹   NP_602308
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,184 - 52,540,977 (-)NCBI
Rnor_6.01957,321,639 - 57,333,433 (-)NCBI
Rnor_5.01968,026,182 - 68,038,550 (-)NCBI
RGSC_v3.41954,738,556 - 54,750,349 (-)RGD
Celera1951,899,180 - 51,910,819 (-)RGD
RefSeq Acc Id: XM_008772597   ⟹   XP_008770819
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,139 - 52,541,276 (-)NCBI
Rnor_6.01957,321,594 - 57,333,460 (-)NCBI
RefSeq Acc Id: XM_039097466   ⟹   XP_038953394
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,139 - 52,549,618 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_602308   ⟸   NM_134432
- Peptide Label: precursor
- UniProtKB: P01015 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770819   ⟸   XM_008772597
- Peptide Label: isoform X2
- UniProtKB: P01015 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024917   ⟸   ENSRNOT00000024917
RefSeq Acc Id: XP_038953394   ⟸   XM_039097466
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P01015-F1-model_v2 AlphaFold P01015 1-477 view protein structure  
AGT - Oxidized pdb 2x0b P01015 25-477 view protein structure view video
AGT - Reduced pdb 2x0b P01015 25-477 view protein structure view video
AGT - Renin pdb 2x0b P01015 25-477 view protein structure view video


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701234
Promoter ID:EPDNEW_R11758
Type:multiple initiation site
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,333,292 - 57,333,352EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)