Agt (angiotensinogen) - Rat Genome Database

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Gene: Agt (angiotensinogen) Rattus norvegicus
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Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of amine transport; and regulation of blood pressure. Located in extracellular space. Used to study several diseases, including artery disease (multiple); gastric ulcer; impotence; pulmonary fibrosis; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actin-Accumulation Myopathy  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (IDA)
Aortic Coarctation  (ISO)
atherosclerosis  (IMP,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congenital disorder of glycosylation type IIq  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (ISO)
Fetal Growth Retardation  (IEP,ISO)
Fibrosis  (IDA,ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
gastric ulcer  (IDA)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IEP,ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (IEP,ISO)
malignant hypertension  (ISO)
meconium aspiration syndrome  (IEP)
Metabolic Syndrome  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
prediabetes syndrome  (IEP)
Pregnancy-Induced Hypertension  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (IDA)
Puromycin Aminonucleoside Nephrosis  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (IDA)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (IEP)
thrombosis  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Malformations  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
AACOCF3  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
adefovir  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
alpha-Zearalanol  (EXP)
amidotrizoic acid  (EXP)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
ANTIMYCIN  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
aspartame  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
BAPTA  (ISO)
benazepril  (EXP,ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (EXP,ISO)
brefeldin A  (EXP)
brimonidine tartrate  (EXP)
Brodifacoum  (EXP)
bucladesine  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carmustine  (ISO)
carvedilol  (EXP,ISO)
CCCP  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chymostatin  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crotonaldehyde  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP,ISO)
diethyl malate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
famotidine  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycerol  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (EXP)
goralatide  (ISO)
Harpagide  (ISO)
heparin  (EXP)
hydralazine  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
icatibant  (EXP)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
imidaprilat  (ISO)
imperatorin  (EXP)
indometacin  (EXP,ISO)
iohexol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ketamine  (EXP,ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-erythro-biopterin  (ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lactacystin  (EXP)
lead(0)  (EXP,ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malonaldehyde  (EXP,ISO)
mangiferin  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methylglyoxal  (EXP)
mevalonic acid  (EXP)
Mibefradil  (ISO)
microcystin RR  (ISO)
midostaurin  (EXP)
miquelianin  (ISO)
mithramycin  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
montelukast  (ISO)
mycophenolic acid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
ouabain  (EXP)
ozone  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PD 168393  (EXP)
PD123319  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP)
phosphoramidon  (EXP)
pifithrin-?  (EXP)
pindolol  (ISO)
pioglitazone  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregabalin  (EXP)
probenecid  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
prostaglandins E  (EXP)
purine-6-thiol  (EXP)
purines  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
salubrinal  (EXP)
saralasin  (EXP)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
spironolactone  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiopental  (ISO)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trans-piceid  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
wortmannin  (EXP)
xanthone  (EXP)
xestospongin C  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IEA,ISO,ISS)
angiotensin-mediated drinking behavior  (IDA,IMP)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IDA)
associative learning  (IDA)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IDA)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to mechanical stimulus  (IEP)
cytokine production  (IDA)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
fibroblast proliferation  (IDA)
G protein-coupled receptor signaling pathway  (IMP,ISO)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (IMP)
kidney development  (IEA,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
operant conditioning  (IDA)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of blood pressure  (IDA)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of extracellular matrix constituent secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of L-arginine import across plasma membrane  (IDA)
positive regulation of L-lysine import across plasma membrane  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of norepinephrine secretion  (IDA)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of superoxide anion generation  (IDA)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein import into nucleus  (IDA)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (IDA)
regulation of cardiac conduction  (IEA,ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (IDA)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (IDA)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IDA,ISO)
response to angiotensin  (ISO)
response to cold  (ISO)
response to estradiol  (IEP)
response to mechanical stimulus  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IMP)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IDA,ISO)
stress-activated MAPK cascade  (IDA)
uterine smooth muscle contraction  (IDA)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IDA,IEA)
vasodilation  (IDA)
vasopressin secretion  (ISO)

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)
mitochondrion  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Attenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts. Aljabri MB, etal., Acta Physiol (Oxf). 2011 Apr;201(4):445-456. doi: 10.1111/j.1748-1716.2010.02234.x. Epub 2011 Feb 1.
3. Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
4. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. Alonso-Galicia M, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R60-8.
5. Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
6. Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts. Alvin Z, etal., Can J Physiol Pharmacol. 2011 Mar;89(3):206-15.
7. Genetic mapping of a neurological mutation cerebellar calcification in the rat. Ando Y, etal., Mamm Genome 2001 Jan;12(1):80-2.
8. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
9. Distinct mechanisms underlie the regulation of body fluid balance by neurokinin B and angiotensin II in the rat brain. Asami R, etal., Brain Res. 2011 Apr 6;1383:179-86. Epub 2011 Jan 28.
10. No evidence for a local renin-angiotensin system in liver mitochondria. Astin R, etal., Sci Rep. 2013;3:2467. doi: 10.1038/srep02467.
11. Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
12. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
13. Rat angiotensinogen and des(angiotensin I)angiotensinogen: purification, characterization, and partial sequencing. Bouhnik J, etal., Biochemistry 1981 Nov 24;20(24):7010-5.
14. Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Braszko JJ Peptides. 2004 Jul;25(7):1195-203.
15. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
16. The renin-angiotensin and the kallikrein-kinin systems. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
17. Genetic predisposition to thrombophilia in inflammatory bowel disease. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
18. Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system. Chakrabarty A, etal., Endocrinology. 2008 Jul;149(7):3452-60. doi: 10.1210/en.2008-0061. Epub 2008 Apr 3.
19. Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
20. Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
21. Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells. Chiu CZ, etal., J Biomed Sci. 2013 Jul 15;20(1):50. doi: 10.1186/1423-0127-20-50.
22. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Colmenero J, etal., Gastroenterology. 2007 Feb;132(2):687-97. Epub 2006 Dec 20.
23. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
24. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. D'Amore A, etal., Hypertension. 2005 Dec;46(6):1347-54. Epub 2005 Nov 14.
25. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
26. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
27. Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein. da Silva OG, etal., Peptides. 2011 Jan;32(1):112-7. Epub 2010 Oct 16.
28. Renin-angiotensin system gene polymorphisms in children with Henoch-Schonlein purpura in West China. Desong Liu, etal., J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):248-55. doi: 10.1177/1470320310374214. Epub 2010 Aug 11.
29. Angiotensin 1-7 improves insulin sensitivity by increasing skeletal muscle glucose uptake in vivo. Echeverria-Rodriguez O, etal., Peptides. 2014 Jan;51:26-30. doi: 10.1016/j.peptides.2013.10.022. Epub 2013 Oct 31.
30. Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation. Ehlers PI, etal., Life Sci. 2011 Jan 31;88(5-6):206-11. Epub 2010 Nov 4.
31. Aberrant activation of the intrarenal renin-angiotensin system in the developing kidneys of type 2 diabetic rats. Fan YY, etal., Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
32. AGT and ACE genes influence classic mitral valve prolapse predisposition in Marfan patients. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
33. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
34. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
35. A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM. Fogarty DG, etal., Diabetes. 1996 Sep;45(9):1204-8.
36. Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
37. Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. Freitas SR, etal., Braz J Med Biol Res. 2007 Mar;40(3):309-16.
38. Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia. Fu H, etal., J Hypertens. 2011 Nov;29(11):2210-9. doi: 10.1097/HJH.0b013e32834bbb30.
39. Assessment of biological activity of novel peptide analogues of angiotensin IV. Gard PR, etal., J Pharm Pharmacol. 2011 Apr;63(4):565-71. doi: 10.1111/j.2042-7158.2010.01247.x. Epub 2011 Mar 1.
40. Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage. Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
41. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
42. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
43. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. Gonzalez-Zuloeta Ladd AM, etal., Breast Cancer Res Treat. 2007 Mar;101(3):299-304. Epub 2006 Jul 6.
44. Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population. Gopi Chand M, etal., Biochem Genet. 2011 Feb 11.
45. The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
46. The levels of renin-angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. Gouveia TL, etal., Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20.
47. Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity. Greco M, etal., Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25.
48. Effects of daily sodium intake and ANG II on cortical and medullary renal blood flow in conscious rats. Gross V, etal., Am J Physiol 1998 May;274(5 Pt 2):R1317-23.
49. Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population. Gutierrez C, etal., Metabolism. 1997 Aug;46(8):976-80.
50. Exercise capacity after coarctation repair relates to the c.46A > G genomic polymorphism of the ss2-adrenoreceptor and the c.704T > C angiotensinogen polymorphism. Hager A, etal., Eur J Prev Cardiol. 2012 Apr;19(2):199-204. doi: 10.1177/1741826711399991. Epub 2011 Feb 25.
51. A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat. Hamilton TA, etal., Peptides. 2001 Jun;22(6):935-44.
52. Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat. Healy DP and Printz MP, Hypertension 1985 Sep-Oct;7(5):752-9.
53. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
54. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hering L, etal., Hypertension. 2010 Aug;56(2):311-8. doi: 10.1161/HYPERTENSIONAHA.110.150961. Epub 2010 Jun 7.
55. Urinary excretion of angiotensin I, II, arginine vasopressin and oxytocin in patients with anaphylactoid reactions. Hermann K, etal., Clin Exp Allergy. 1992 Sep;22(9):845-53.
56. Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma. Hodroj W, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):525-31. Epub 2006 Dec 14.
57. Association of 3 gene polymorphisms with atopic diseases. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
58. A vaccine for hypertension based on peptide AngI-R: a pilot study. Hong F, etal., Int J Cardiol. 2011 Apr 1;148(1):76-84. doi: 10.1016/j.ijcard.2009.10.027. Epub 2009 Nov 24.
59. Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes. HONG HJ, etal., Acta Pharmacol Sin. 2010 Dec;31(12):1569-75. Epub 2010 Nov 22.
60. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Hsieh TJ, etal., Endocrinology 2002 Aug;143(8):2975-85.
61. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
62. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
63. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
64. Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study. Imauchi Y, etal., Otol Neurotol. 2008 Apr;29(3):295-301.
65. Angiotensinogen gene polymorphism in Japanese patients with hypertrophic cardiomyopathy. Ishanov A, etal., Am Heart J. 1997 Feb;133(2):184-9.
66. Molecular basis of human hypertension: role of angiotensinogen. Jeunemaitre X, etal., Cell 1992 Oct 2;71(1):169-80.
67. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
68. Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
69. Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. Kawaguchi Y, etal., Arthritis Rheum. 2004 Jan;50(1):216-26.
70. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Kemp BA, etal., Hypertension. 2012 Aug;60(2):387-95. doi: 10.1161/HYPERTENSIONAHA.112.191403. Epub 2012 Jun 11.
71. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
72. Mechanism of Ang II involvement in activation of NF-kappaB through phosphorylation of p65 during aging. Kim JM, etal., Age (Dordr). 2011 Feb 12.
73. Angiotensinogen messenger RNA stabilization by angiotensin II. Klett CP, etal., J Hypertens Suppl 1996 Dec;14(5):S25-36.
74. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. Kobori H, etal., J Am Soc Nephrol. 2005 Jul;16(7):2073-80. Epub 2005 May 11.
75. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
76. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
77. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
78. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Li L, etal., Cardiovasc Res. 2011 Mar 2.
79. Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats. Liu L, etal., Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
80. Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. Lochard N, etal., J Biol Chem 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.
81. Angiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cells. Low BC and Grigor MR, J Biol Chem. 1995 Nov 17;270(46):27577-83.
82. The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
83. Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion. Lu P, etal., Int J Clin Exp Pathol. 2012;5(7):698-706. Epub 2012 Sep 5.
84. Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells. Lu P, etal., Med Sci Monit. 2011 Sep;17(9):BR248-56.
85. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration.