Agt (angiotensinogen) - Rat Genome Database

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Gene: Agt (angiotensinogen) Rattus norvegicus
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Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (IDA)
Aortic Coarctation  (ISO)
atherosclerosis  (IMP,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (IEP,ISO)
Fibrosis  (IDA,ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
gastric ulcer  (IDA)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (IEP,ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (IEP,ISO)
malignant hypertension  (ISO)
Mammary Neoplasms, Experimental  (IDA)
meconium aspiration syndrome  (IEP)
Metabolic Syndrome  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
prediabetes syndrome  (IEP)
Pregnancy-Induced Hypertension  (IEP)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (IDA)
Puromycin Aminonucleoside Nephrosis  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (IDA)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (IEP)
thrombosis  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
AACOCF3  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
amidotrizoic acid  (EXP)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
ANTIMYCIN  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
aspartame  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
BAPTA  (ISO)
benazepril  (EXP,ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (EXP,ISO)
brefeldin A  (EXP)
brimonidine tartrate  (EXP)
Brodifacoum  (EXP)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carmustine  (ISO)
carvedilol  (EXP,ISO)
CCCP  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chymostatin  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP,ISO)
diethyl malate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
famotidine  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycerol  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (EXP)
heparin  (EXP)
hydralazine  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
imidacloprid  (EXP)
imidaprilat  (ISO)
imperatorin  (EXP)
indometacin  (EXP,ISO)
iohexol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lactacystin  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malonaldehyde  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylglyoxal  (EXP)
Mibefradil  (ISO)
microcystin RR  (ISO)
midostaurin  (EXP)
miquelianin  (ISO)
mithramycin  (EXP)
MK-2206  (ISO)
monocrotaline  (EXP)
montelukast  (ISO)
mycophenolic acid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
omeprazole  (EXP)
ouabain  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 168393  (EXP)
PD123319  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP)
phosphoramidon  (EXP)
pindolol  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregabalin  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
prostaglandins E  (EXP)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
salubrinal  (EXP)
saralasin  (EXP)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
Soman  (EXP)
spironolactone  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiopental  (ISO)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trans-piceid  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
wortmannin  (EXP)
xestospongin C  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
activation of phospholipase C activity  (IMP)
aging  (IEP)
angiotensin-activated signaling pathway  (ISO,ISS)
angiotensin-mediated drinking behavior  (IDA,IMP)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IDA)
associative learning  (IDA)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell surface receptor signaling pathway  (IDA)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular sodium ion homeostasis  (IMP)
cytokine production  (IDA)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of blood-nerve barrier  (ISO)
excretion  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
fibroblast proliferation  (IDA)
G protein-coupled receptor signaling pathway  (IMP,ISO)
hormone metabolic process  (ISO)
kidney development  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IBA)
negative regulation of gene expression  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of tissue remodeling  (IDA)
operant conditioning  (IDA)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of activation of Janus kinase activity  (ISO)
positive regulation of blood pressure  (IDA)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of catalytic activity  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cholesterol esterification  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of extracellular matrix constituent secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of L-arginine import across plasma membrane  (IDA)
positive regulation of L-lysine import across plasma membrane  (IDA)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase C activity  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of renal sodium excretion  (IDA,IMP)
positive regulation of superoxide anion generation  (IDA)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein import into nucleus  (IDA)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (IDA)
regulation of cardiac conduction  (ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (IDA)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of norepinephrine secretion  (IMP)
regulation of renal output by angiotensin  (ISO)
regulation of renal sodium excretion  (IDA)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (IDA)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IDA,ISO)
response to cold  (ISO)
response to estradiol  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IMP)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IDA,ISO)
stress-activated MAPK cascade  (IDA)
uterine smooth muscle contraction  (IDA)
vasoconstriction  (IDA)
vasodilation  (IDA)

Cellular Component
cytoplasm  (IDA)
extracellular space  (IBA,IDA,ISO)
mitochondrion  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Aljabri MB, etal., Acta Physiol (Oxf). 2011 Apr;201(4):445-456. doi: 10.1111/j.1748-1716.2010.02234.x. Epub 2011 Feb 1.
3. Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
4. Alonso-Galicia M, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R60-8.
5. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
6. Alvin Z, etal., Can J Physiol Pharmacol. 2011 Mar;89(3):206-15.
7. Ando Y, etal., Mamm Genome 2001 Jan;12(1):80-2.
8. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
9. Asami R, etal., Brain Res. 2011 Apr 6;1383:179-86. Epub 2011 Jan 28.
10. Astin R, etal., Sci Rep. 2013;3:2467. doi: 10.1038/srep02467.
11. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
12. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
13. Bouhnik J, etal., Biochemistry 1981 Nov 24;20(24):7010-5.
14. Braszko JJ Peptides. 2004 Jul;25(7):1195-203.
15. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
16. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
17. Chakrabarty A, etal., Endocrinology. 2008 Jul;149(7):3452-60. doi: 10.1210/en.2008-0061. Epub 2008 Apr 3.
18. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
19. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
20. Colmenero J, etal., Gastroenterology. 2007 Feb;132(2):687-97. Epub 2006 Dec 20.
21. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
22. D'Amore A, etal., Hypertension. 2005 Dec;46(6):1347-54. Epub 2005 Nov 14.
23. da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
24. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
25. da Silva OG, etal., Peptides. 2011 Jan;32(1):112-7. Epub 2010 Oct 16.
26. Desong Liu, etal., J Renin Angiotensin Aldosterone Syst. 2010 Dec;11(4):248-55. doi: 10.1177/1470320310374214. Epub 2010 Aug 11.
27. Echeverria-Rodriguez O, etal., Peptides. 2014 Jan;51:26-30. doi: 10.1016/j.peptides.2013.10.022. Epub 2013 Oct 31.
28. Ehlers PI, etal., Life Sci. 2011 Jan 31;88(5-6):206-11. Epub 2010 Nov 4.
29. Fan YY, etal., Horm Metab Res. 2013 May;45(5):338-43. doi: 10.1055/s-0032-1331256. Epub 2013 Jan 15.
30. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
31. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
32. Fogarty DG, etal., Diabetes. 1996 Sep;45(9):1204-8.
33. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
34. Freitas SR, etal., Braz J Med Biol Res. 2007 Mar;40(3):309-16.
35. Fu H, etal., J Hypertens. 2011 Nov;29(11):2210-9. doi: 10.1097/HJH.0b013e32834bbb30.
36. Gard PR, etal., J Pharm Pharmacol. 2011 Apr;63(4):565-71. doi: 10.1111/j.2042-7158.2010.01247.x. Epub 2011 Mar 1.
37. Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
38. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39. GOA data from the GO Consortium
40. Gonzalez-Zuloeta Ladd AM, etal., Breast Cancer Res Treat. 2007 Mar;101(3):299-304. Epub 2006 Jul 6.
41. Gopi Chand M, etal., Biochem Genet. 2011 Feb 11.
42. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
43. Gouveia TL, etal., Neurochem Int. 2012 Jul;61(1):54-62. doi: 10.1016/j.neuint.2012.04.012. Epub 2012 Apr 20.
44. Greco M, etal., Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25.
45. Gross V, etal., Am J Physiol 1998 May;274(5 Pt 2):R1317-23.
46. Gutierrez C, etal., Metabolism. 1997 Aug;46(8):976-80.
47. Hager A, etal., Eur J Prev Cardiol. 2012 Apr;19(2):199-204. doi: 10.1177/1741826711399991. Epub 2011 Feb 25.
48. Hamilton TA, etal., Peptides. 2001 Jun;22(6):935-44.
49. Healy DP and Printz MP, Hypertension 1985 Sep-Oct;7(5):752-9.
50. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
51. Hering L, etal., Hypertension. 2010 Aug;56(2):311-8. doi: 10.1161/HYPERTENSIONAHA.110.150961. Epub 2010 Jun 7.
52. Hermann K, etal., Clin Exp Allergy. 1992 Sep;22(9):845-53.
53. Hodroj W, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):525-31. Epub 2006 Dec 14.
54. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
55. Hong F, etal., Int J Cardiol. 2011 Apr 1;148(1):76-84. doi: 10.1016/j.ijcard.2009.10.027. Epub 2009 Nov 24.
56. HONG HJ, etal., Acta Pharmacol Sin. 2010 Dec;31(12):1569-75. Epub 2010 Nov 22.
57. Hsieh TJ, etal., Endocrinology 2002 Aug;143(8):2975-85.
58. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
59. Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
60. Imauchi Y, etal., Otol Neurotol. 2008 Apr;29(3):295-301.
61. Ishanov A, etal., Am Heart J. 1997 Feb;133(2):184-9.
62. Jeunemaitre X, etal., Cell 1992 Oct 2;71(1):169-80.
63. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
64. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
65. Kawaguchi Y, etal., Arthritis Rheum. 2004 Jan;50(1):216-26.
66. Kemp BA, etal., Hypertension. 2012 Aug;60(2):387-95. doi: 10.1161/HYPERTENSIONAHA.112.191403. Epub 2012 Jun 11.
67. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
68. Kim JM, etal., Age (Dordr). 2011 Feb 12.
69. Klett CP, etal., J Hypertens Suppl 1996 Dec;14(5):S25-36.
70. Kobori H, etal., J Am Soc Nephrol. 2005 Jul;16(7):2073-80. Epub 2005 May 11.
71. Kramar EA, etal., Brain Res. 2001 Apr 6;897(1-2):114-21.
72. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
73. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
74. Li L, etal., Cardiovasc Res. 2011 Mar 2.
75. Liu L, etal., Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
76. Lochard N, etal., J Biol Chem 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.
77. Low BC and Grigor MR, J Biol Chem. 1995 Nov 17;270(46):27577-83.
78. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
79. Lu P, etal., Int J Clin Exp Pathol. 2012;5(7):698-706. Epub 2012 Sep 5.
80. Lu P, etal., Med Sci Monit. 2011 Sep;17(9):BR248-56.
81. Lukkarinen H, etal., Pediatr Res. 2004 Feb;55(2):326-33. Epub 2003 Nov 6.
82. Ma LQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Dec;28(6):770-5.
83. Marco J, etal., Nefrologia. 2005;25(6):629-36.
84. Mateos L, etal., J Alzheimers Dis. 2011 Feb 4.
85. Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.
86. MGD data from the GO Consortium
87. Miyata K, etal., Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F608-18. doi: 10.1152/ajprenal.00464.2013. Epub 2014 Jan 15.
88. Modgil A, etal., Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1116-22. doi: 10.1152/ajpheart.00832.2011. Epub 2011 Dec 23.
89. Mori T and Cowley AW Jr, Hypertension 2003 Oct;42(4):588-93. Epub 2003 Sep 15.
90. Mukohda M, etal., J Pharmacol Sci. 2010;114(4):390-8. Epub 2010 Nov 9.
91. Murano Y, etal., Pediatr Res. 2015 Dec;78(6):678-82. doi: 10.1038/pr.2015.153. Epub 2015 Aug 13.
92. NCBI rat LocusLink and RefSeq merged data July 26, 2002
93. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
94. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
95. Ohkubo H, etal., J Biol Chem 1986 Jan 5;261(1):319-23.
96. Ohkubo H, etal., Proc Natl Acad Sci U S A 1983 Apr;80(8):2196-200.
97. Olivieri O, etal., J Hypertens. 2001 May;19(5):879-84.
98. OMIM Disease Annotation Pipeline
99. Ozkaya O, etal., Clin Rheumatol. 2006 Nov;25(6):861-5. Epub 2006 Mar 7.
100. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
101. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
102. Padro-Miquel A, etal., Clin Biochem. 2009 Jan;42(1-2):5-11. doi: 10.1016/j.clinbiochem.2008.10.011. Epub 2008 Nov 5.
103. Peng J, etal., Regul Pept 2002 Dec 31;110(1):25-32.
104. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
105. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
106. Pilbrow AP, etal., Hypertension. 2007 Feb;49(2):322-7. Epub 2006 Dec 4.
107. Pipeline to import KEGG annotations from KEGG into RGD
108. Pipeline to import SMPDB annotations from SMPDB into RGD
109. Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
110. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
111. Rettig R, etal., Brain Res 1986 Feb 5;364(2):233-40.
112. Rettig R, etal., Clin Exp Hypertens A 1984;6(10-11):2031-5.
113. Reudelhuber TL Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14.
114. RGD automated data pipeline
115. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
116. RGD automated import pipeline for gene-chemical interactions
117. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
118. Rijn MJ, etal., J Neurol Neurosurg Psychiatry. 2007 Jan 12;.
119. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
120. Rojas M, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.
121. Sadoshima J and Izumo S, Circ Res. 1993 Sep;73(3):413-23.
122. Sadoshima J, etal., Cell. 1993 Dec 3;75(5):977-84.
123. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
124. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
125. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
126. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
127. Shen Y, etal., Zhong Xi Yi Jie He Xue Bao. 2011 Mar;9(3):313-319.
128. Shen YJ, etal., J Nat Med. 2014 Jul;68(3):623-9. doi: 10.1007/s11418-014-0825-0. Epub 2014 Mar 5.
129. Shi R, etal., Cardiovasc Res. 2011 Mar 2.
130. Souza AP, etal., Clin Sci (Lond). 2013 Nov;125(9):449-59. doi: 10.1042/CS20120519.
131. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
132. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
133. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
134. Suo M, etal., Hypertension 2002 Mar 1;39(3):803-8.
135. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
136. Szentivanyi M Jr, etal., Hypertension 1999 Jan;33(1 Pt 2):440-5.
137. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
138. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
139. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
140. Tanaka T, etal., J Biol Chem 1984 Jul 10;259(13):8063-5.
141. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
142. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
143. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
144. Tucker BJ, etal., J Clin Invest 1986 Sep;78(3):680-8.
145. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
146. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
147. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
148. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
149. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
150. Verma SK, etal., Cardiovasc Res. 2011 Apr 1;90(1):88-96. Epub 2010 Dec 3.
151. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
152. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9.
153. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
154. Xue H, etal., Regul Pept. 2012 Aug 20;177(1-3):12-20. doi: 10.1016/j.regpep.2012.04.002. Epub 2012 May 1.
155. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
156. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
157. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
158. Yayama K, etal., Nephron. 1993;63(1):89-93.
159. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
160. Zhang SL, etal., Endocrinology 2002 Dec;143(12):4627-35.
161. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
162. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:1378723   PMID:4344907   PMID:7622467   PMID:7989296   PMID:8675666   PMID:9196031   PMID:9310306   PMID:9507198   PMID:9557921   PMID:9734405   PMID:9788961   PMID:9852267  
PMID:9878677   PMID:10076178   PMID:10318840   PMID:10406457   PMID:10425188   PMID:11384650   PMID:11606482   PMID:12072911   PMID:12221292   PMID:12431451   PMID:12512691   PMID:12574102  
PMID:12623964   PMID:12657564   PMID:12660888   PMID:12660889   PMID:12697701   PMID:12730191   PMID:12782411   PMID:12874086   PMID:14517903   PMID:14523024   PMID:14674692   PMID:14697237  
PMID:15001568   PMID:15061159   PMID:15087286   PMID:15100095   PMID:15153556   PMID:15213258   PMID:15238256   PMID:15245869   PMID:15489334   PMID:15499027   PMID:15539634   PMID:15561758  
PMID:15582710   PMID:15642775   PMID:15652490   PMID:15659559   PMID:15692220   PMID:15710779   PMID:15803439   PMID:15826947   PMID:15869764   PMID:15922295   PMID:15942049   PMID:15944340  
PMID:16020656   PMID:16051229   PMID:16106038   PMID:16115032   PMID:16115033   PMID:16115039   PMID:16116425   PMID:16146787   PMID:16158334   PMID:16176966   PMID:16322063   PMID:16374517  
PMID:16478781   PMID:16502470   PMID:16522658   PMID:16569213   PMID:16574788   PMID:16585392   PMID:16650497   PMID:16728497   PMID:16780972   PMID:16807546   PMID:16837467   PMID:16864744  
PMID:16933034   PMID:16989733   PMID:17029249   PMID:17060503   PMID:17082724   PMID:17259738   PMID:17327451   PMID:17357790   PMID:17360810   PMID:17404180   PMID:17416596   PMID:17466950  
PMID:17483239   PMID:17491111   PMID:17496209   PMID:17507603   PMID:17513012   PMID:17526654   PMID:17553505   PMID:17616751   PMID:17626897   PMID:17646572   PMID:17664391   PMID:17693541  
PMID:17702818   PMID:17703433   PMID:17706954   PMID:17710629   PMID:17785632   PMID:17878754   PMID:17891894   PMID:17903697   PMID:17914985   PMID:17932313   PMID:17942570   PMID:17962624  
PMID:17980907   PMID:17989112   PMID:18047554   PMID:18077603   PMID:18158338   PMID:18172037   PMID:18192841   PMID:18195168   PMID:18205093   PMID:18216141   PMID:18242696   PMID:18250367  
PMID:18256139   PMID:18256274   PMID:18292392   PMID:18347230   PMID:18359898   PMID:18360053   PMID:18391104   PMID:18391105   PMID:18395010   PMID:18408132   PMID:18420589   PMID:18441197  
PMID:18456730   PMID:18467645   PMID:18559349   PMID:18560380   PMID:18566342   PMID:18607644   PMID:18688015   PMID:18712054   PMID:18760347   PMID:18779436   PMID:18789946   PMID:18790741  
PMID:18806627   PMID:18809792   PMID:18835922   PMID:18838625   PMID:18848828   PMID:18926830   PMID:18945823   PMID:18971210   PMID:18971559   PMID:18986337   PMID:19023134   PMID:19029977  
PMID:19075094   PMID:19118600   PMID:19129738   PMID:19131364   PMID:19147651   PMID:19151253   PMID:19171793   PMID:19211690   PMID:19224536   PMID:19247578   PMID:19258668   PMID:19289825  
PMID:19322025   PMID:19323983   PMID:19326569   PMID:19389807   PMID:19396617   PMID:19399400   PMID:19403863   PMID:19404405   PMID:19407469   PMID:19439822   PMID:19457762   PMID:19460779  
PMID:19587111   PMID:19667256   PMID:19703990   PMID:19710393   PMID:19713680   PMID:19716825   PMID:19717492   PMID:19781194   PMID:19808775   PMID:19811355   PMID:19861503   PMID:19864301  
PMID:19879325   PMID:19948989   PMID:20023119   PMID:20052676   PMID:20056918   PMID:20372825   PMID:20393598   PMID:20423855   PMID:20448043   PMID:20462965   PMID:20535114   PMID:20601126  
PMID:20666571   PMID:20686488   PMID:20724906   PMID:20848345   PMID:20850747   PMID:20962118   PMID:21055442   PMID:21056071   PMID:21108934   PMID:21151982   PMID:21183621   PMID:21186269  
PMID:21265100   PMID:21297982   PMID:21398399   PMID:21510818   PMID:21586345   PMID:21606202   PMID:21613610   PMID:21613793   PMID:21685447   PMID:21705470   PMID:21720156   PMID:21813872  
PMID:21831995   PMID:21900450   PMID:21946693   PMID:21952436   PMID:21959517   PMID:22057271   PMID:22100841   PMID:22101031   PMID:22108917   PMID:22125313   PMID:22302831   PMID:22389386  
PMID:22516433   PMID:22579820   PMID:22684035   PMID:22787147   PMID:22795463   PMID:22811473   PMID:22822941   PMID:22846885   PMID:22853187   PMID:22875344   PMID:22875785   PMID:22913624  
PMID:22923503   PMID:22925777   PMID:23058350   PMID:23117547   PMID:23142109   PMID:23174757   PMID:23220478   PMID:23283998   PMID:23326547   PMID:23365412   PMID:23376485   PMID:23412923  
PMID:23441479   PMID:23528515   PMID:23533145   PMID:23541316   PMID:23608099   PMID:23697773   PMID:23707238   PMID:23754618   PMID:23775122   PMID:23816464   PMID:23825067   PMID:23832698  
PMID:23891689   PMID:24145131   PMID:24184051   PMID:24191285   PMID:24204720   PMID:24296617   PMID:24436324   PMID:24481965   PMID:24710077   PMID:24710423   PMID:24731445   PMID:24771417  
PMID:24824997   PMID:24877125   PMID:24910532   PMID:24976155   PMID:25031298   PMID:25079175   PMID:25099270   PMID:25148511   PMID:25223907   PMID:25246357   PMID:25263961   PMID:25451261  
PMID:25529203   PMID:25732086   PMID:25793389   PMID:25923922   PMID:26090382   PMID:26147666   PMID:26156105   PMID:26310573   PMID:26384348   PMID:26431621   PMID:26674152   PMID:26728324  
PMID:26728369   PMID:26775713   PMID:26824355   PMID:26864937   PMID:26881025   PMID:26970306   PMID:27009340   PMID:27012211   PMID:27068509   PMID:27131988   PMID:27163380   PMID:27225249  
PMID:27465904   PMID:27590241   PMID:27660028   PMID:27871858   PMID:27932705   PMID:27960152   PMID:28011270   PMID:28161727   PMID:28189547   PMID:28283184   PMID:28331185   PMID:28582407  
PMID:28656283   PMID:28656296   PMID:28742157   PMID:28744711   PMID:28988741   PMID:29140411   PMID:29179208   PMID:29262413   PMID:29305157   PMID:29452090   PMID:29746862   PMID:29923351  
PMID:30046277   PMID:30315936   PMID:30412649   PMID:30680929   PMID:31030610   PMID:31708099   PMID:31836539   PMID:31994810   PMID:32000560   PMID:32338644   PMID:32851948   PMID:33010296  
PMID:33129833   PMID:33530085   PMID:33687310  


Genomics

Comparative Map Data
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBI
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0panPan3
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBI
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBI
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBI
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBI
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBI
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBI
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,672,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBI
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)Ensembl
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBI
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Related Rat Strains
The following Strains have been annotated to Agt

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:157
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000024917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6
Medium 1 42 31 8 31 38 8 6 7
Low 2 19 9 4 11 4 8 11 18 11 18 4 8
Below cutoff 18 4 12 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024917   ⟹   ENSRNOP00000024917
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)Ensembl
RefSeq Acc Id: NM_134432   ⟹   NP_602308
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,184 - 52,540,977 (-)NCBI
Rnor_6.01957,321,639 - 57,333,433 (-)NCBI
Rnor_5.01968,026,182 - 68,038,550 (-)NCBI
RGSC_v3.41954,738,556 - 54,750,349 (-)RGD
Celera1951,899,180 - 51,910,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772597   ⟹   XP_008770819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,139 - 52,541,276 (-)NCBI
Rnor_6.01957,321,594 - 57,333,460 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097466   ⟹   XP_038953394
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,529,139 - 52,549,618 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_602308   ⟸   NM_134432
- Peptide Label: precursor
- UniProtKB: P01015 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770819   ⟸   XM_008772597
- Peptide Label: isoform X2
- UniProtKB: P01015 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024917   ⟸   ENSRNOT00000024917
RefSeq Acc Id: XP_038953394   ⟸   XM_039097466
- Peptide Label: isoform X1

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AGT - Oxidized pdb 2x0b P01015 25-477 view protein structure view video
AGT - Reduced pdb 2x0b P01015 25-477 view protein structure view video
AGT - Renin pdb 2x0b P01015 25-477 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701234
Promoter ID:EPDNEW_R11758
Type:multiple initiation site
Name:Agt_1
Description:angiotensinogen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,333,292 - 57,333,352EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer