Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2069
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Agt
Name:	angiotensinogen

Acc ID:	CHEBI:64317
Term:	isoprenaline
Definition:	A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID:	MESH:D007545

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Agt	increases expression	EXP		6480464	CTD	Isoproterenol results in increased expression of AGT protein	PMID:11709406 PMID:1534315 PMID:20409916 PMID:24117263 PMID:27890915 PMID:36414029
Agt	multiple interactions	EXP		6480464	CTD	AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA]; AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; xanthone inhibits the reaction [Isoproterenol results in increased expression of AGT protein]	PMID:11709406 PMID:1534315 PMID:16731636 PMID:19483313 PMID:20409916 PMID:24117263 PMID:27890915 PMID:36414029
Agt	increases expression	ISO	Agt (Mus musculus)	6480464	CTD	Isoproterenol results in increased expression of AGT mRNA; Isoproterenol results in increased expression of AGT protein	PMID:19023134 PMID:20003209
Agt	increases expression	ISO	AGT (Homo sapiens)	6480464	CTD	Isoproterenol results in increased expression of AGT protein	PMID:1653766
Agt	multiple interactions	ISO	Agt (Mus musculus)	6480464	CTD	adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; ICI 118551 inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]	PMID:7843740
Agt	multiple interactions	ISO	AGT (Homo sapiens)	6480464	CTD	Propranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein]	PMID:1653766

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