RGD Reference Report - Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. - Rat Genome Database

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Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.

Authors: Da Costa Goncalves, AC  Leite, R  Fraga-Silva, RA  Pinheiro, SV  Reis, AB  Reis, FM  Touyz, RM  Webb, RC  Alenina, N  Bader, M  Santos, RA 
Citation: da Costa Goncalves AC, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.
RGD ID: 8548892
Pubmed: PMID:17616753   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpheart.00173.2007   (Journal Full-text)

The vasodilator/antiproliferative peptide angiotensin-(1-7) [ANG-(1-7)] is released into the corpus cavernosum sinuses, but its role in erectile function has yet to be defined. In this study, we sought to determine whether ANG-(1-7) and its receptor Mas play a role in erectile function. The ANG-(1-7) receptor Mas was immunolocalized in rat corpus cavernosum by confocal microscopy. Infusion of ANG-(1-7) into corpus cavernosum at a rate of 15.5 pmol x kg(-1) x min(-1) potentiated the elevation of the corpus cavernosum pressure induced by electrical stimulation of the major pelvic ganglion (MPG) in rats. The facilitatory effect of ANG-(1-7) was completely blunted by the specific ANG-(1-7) receptor blocker A-779 and N(omega)-nitro-L-arginine methyl ester. Nitric oxide (NO) release in the corpus cavernosum was evaluated with the fluorescent dye 4-amino-5 methylamino-2',7'-difluorofluorescein diacetate. Electrical stimulated-release of NO in rat corpus cavernosum was potentiated by ANG-(1-7). Furthermore, incubation of rat and mouse corpus cavernosum strips with ANG-(1-7) at 10 nmol/l resulted in an increase of NO release. This effect was completely abolished in mas-deficient mice. More importantly, genetic deletion of Mas resulted in compromised erectile function as demonstrated by penile fibrosis and severely depressed response to electrical stimulation of the MPG. Furthermore, the attenuated erectile function of DOCA-salt hypertensive rats was fully restored by ANG-(1-7) administration. Together these data provide strong evidence for a key role of the ANG-(1-7)-Mas axis in erectile function.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
impotence treatmentISOAgt (Rattus norvegicus)8548892; 8548892 RGD 
impotence treatmentIDA 8548892 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of nitric oxide biosynthetic process  IDA 8548892 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)

Genes (Mus musculus)
Agt  (angiotensinogen)

Genes (Homo sapiens)
AGT  (angiotensinogen)


Additional Information