RGD Reference Report - Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. - Rat Genome Database

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Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease.

Authors: Altarescu, Gheona  Haim, Shimon  Elstein, Deborah 
Citation: Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
RGD ID: 13432161
Pubmed: (View Article at PubMed) PMID:24020479
DOI: Full-text: DOI:10.3109/1354750X.2013.836244


CONTEXT: Stroke and/or white matter lesions (WMLs) are significant in Fabry disease. Polymorphisms of angiotensinogen (AGT), AGT Promoter and angiotensinogen II receptor type 1 (AGTR1) are correlated with WMLs.
OBJECTIVES: We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).
METHODS: Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received. Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.
DISCUSSION/CONCLUSION: Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes.

Annotation

Disease Annotations    
Fabry disease  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)

Genes (Mus musculus)
Agt  (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

Genes (Homo sapiens)
AGT  (angiotensinogen)


Additional Information