RGD Reference Report - Angiotensin (1-7) protects against stress-induced gastric lesions in rats. - Rat Genome Database

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Angiotensin (1-7) protects against stress-induced gastric lesions in rats.

Authors: Zhu, D  Tong, Q  Liu, W  Tian, M  Xie, W  Ji, L  Shi, J 
Citation: Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
RGD ID: 11039418
Pubmed: PMID:24231511   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bcp.2013.10.026   (Journal Full-text)

Stress ulcers can develop with severe physiological stress, and have been proposed as being brain-driven events. New findings continue to suggest that stress ulcers can be more effectively managed through central manipulation rather than by simply altering local gastric factors. Angiotensin (1-7) (Ang (1-7)) is present as an endogenous constituent of the brain and stomach. The beneficial effects of Ang (1-7) have been confirmed in the vessels, brain, heart, kidney, liver and lungs, but not in the stomach. Given the accumulating evidence suggesting the anti-stress activities of Ang (1-7), its potential gastroprotective effect in the context of stress requires further investigation. In the present study, rat gastric mucosal lesions were induced by 2h of cold-restraint stress. We observed that these lesions were significantly attenuated after 1 week of intracerebroventricular treatment with Ang (1-7). This gastroprotective effect was associated with attenuated oxidative stress and suppressed acid secretion. Brain Ang (1-7) administration profoundly modified responses to stress, indicated by altered levels of several stress hormones, including Ang II, glucocorticoid, norepinephrine, serotonin, and dopamine, in blood or stress-related brain regions. These findings indicate that Ang (1-7) exerts anti-stress activities by restoring the gastric microenvironment and modulating the stress pathways. Ang (1-7) may be a promising agent for stress ulcer prophylaxis and therapy, administered through brain-permeable mimics or carriers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gastric ulcer treatmentISOAgt (Rattus norvegicus)11039418; 11039418 RGD 
gastric ulcer treatmentIDA 11039418 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)

Genes (Mus musculus)
Agt  (angiotensinogen)

Genes (Homo sapiens)
AGT  (angiotensinogen)


Additional Information