RGD Reference Report - Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension. - Rat Genome Database

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Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension.

Authors: Procopciuc, LM  Pop, D  Zdrenghea, D  Jebeleanu, G 
Citation: Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
RGD ID: 1601141
Pubmed: PMID:16739866   (View Abstract at PubMed)

BACKGROUND: Several studies suggested the role of the genes of the rennin-angiotensin system in the pathogenesis of essential arterial hypertension. PATIENTS: We investigated 100 consecutive hypertensive patients (42 males and 58 females; mean +/- SD age, 55.14 +/- 9.49 years) for M235T and T174M polymorphisms. Seventy six normotensive patients (28 males and 48 females; mean +/- SD age, 54.94 +/- 9.56 years) formed the control group. METHODS: M235T and T174M polymorphisms were analyzed using PCR-RFLP methods. RESULTS: The carrier frequency of M235T polymorphism in the AGT gene was 73% in hypertensive patients and 34.21% in normotensive patients (OR 5.2, 95%CI [2.72-9.93], p<0.01, chi2 test). The carrier frequency of T174M polymorphism in the AGT gene was 42% in hypertensive patients and 11.84% in normotensive patients (OR 5.39, 95%CI [2.41-12.01], p<0.01, chi2 test). CONCLUSIONS: Essential arterial hypertension is associated with polymorphisms in the AGT gene, M235T and T174M.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
AGTHumanhypertension susceptibilityIAGP DNA:polymorphisms: :p.T174M and p.M235T (human)RGD 
AgtRathypertension susceptibilityISOAGT (Homo sapiens)DNA:polymorphisms: :p.T174M and p.M235T (human)RGD 
AgtMousehypertension susceptibilityISOAGT (Homo sapiens)DNA:polymorphisms: :p.T174M and p.M235T (human)RGD 


Genes (Rattus norvegicus)
Agt  (angiotensinogen)

Genes (Mus musculus)
Agt  (angiotensinogen)

Genes (Homo sapiens)
AGT  (angiotensinogen)